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Gene: PRKCSH (protein kinase C substrate 80K-H) Homo sapiens
Symbol: PRKCSH
Name: protein kinase C substrate 80K-H
Description: This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: advanced glycation end-product receptor 2; AGE-binding receptor 2; AGE-R2; G19P1; GIIB; glucosidase 2 subunit beta; glucosidase II subunit beta; glucosidase II, beta subunit; hepatocystin; PCLD; PCLD1; PKCSH; PLD1; polycystic liver disease; protein kinase C substrate 60.1 kDa protein heavy chain; protein kinase C substrate, 80 Kda protein; VASAP-60
Mus musculus (house mouse) : Prkcsh (protein kinase C substrate 80K-H)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prkcsh (protein kinase C substrate 80K-H)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkcsh (protein kinase C substrate 80K-H)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKCSH (protein kinase C substrate 80K-H)
Canis lupus familiaris (dog) : PRKCSH (protein kinase C substrate 80K-H)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkcsh (protein kinase C substrate 80K-H)
Sus scrofa (pig) : PRKCSH (protein kinase C substrate 80K-H)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381911,435,257 - 11,450,968 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371911,546,111 - 11,561,783 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,407,269 - 11,422,783 (+)NCBINCBI36hg18NCBI36
Build 341911,407,268 - 11,422,783NCBI
Celera1911,441,004 - 11,456,521 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1911,121,465 - 11,136,774 (+)NCBIHuRef
CHM1_11911,546,100 - 11,561,813 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PRKCSH
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320068
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.