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Gene: Trex1 (three prime repair exonuclease 1) Mus musculus
Symbol: Trex1
Name: three prime repair exonuclease 1
Description: Exhibits several functions, including DNA binding activity; WW domain binding activity; and magnesium ion binding activity. Involved in several processes, including DNA metabolic process; immunoglobulin mediated immune response; and negative regulation of cell cycle. Localizes to several cellular components, including the nuclear replication fork; oligosaccharyltransferase complex; and protein-DNA complex. Used to study Aicardi-Goutieres syndrome and cutaneous lupus erythematosus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; and systemic lupus erythematosus. Orthologous to human TREX1 (three prime repair exonuclease 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1661; 3'-5' exonuclease TREX1; AU041952; DNase III; three prime exonuclease 1; three-prime repair exonuclease 1; trophoblast expressed 1
Homo sapiens (human) : TREX1 (three prime repair exonuclease 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Trex1 (three prime repair exonuclease 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trex1 (three prime repair exonuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TREX1 (three prime repair exonuclease 1)
Canis lupus familiaris (dog) : TREX1 (three prime repair exonuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trex1 (three prime repair exonuclease 1)
Sus scrofa (pig) : TREX1 (three prime repair exonuclease 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm389109,057,932 - 109,059,723 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379108,960,446 - 108,962,237 (-)NCBIGRCm37mm9NCBIm37
MGSCv369108,915,338 - 108,917,129 (-)NCBImm8
Celera9108,616,714 - 108,618,505 (-)NCBICelera
Cytogenetic Map9 F2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Trex1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320018
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.