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Gene: Trex1 (three prime repair exonuclease 1) Mus musculus
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Symbol: Trex1
Name: three prime repair exonuclease 1
Description: Exhibits several functions, including DNA binding activity; WW domain binding activity; and magnesium ion binding activity. Involved in several processes, including DNA metabolic process; immunoglobulin mediated immune response; and negative regulation of cell cycle. Localizes to several cellular components, including the nuclear replication fork; oligosaccharyltransferase complex; and protein-DNA complex. Used to study Aicardi-Goutieres syndrome and cutaneous lupus erythematosus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; and systemic lupus erythematosus. Orthologous to human TREX1 (three prime repair exonuclease 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1661; 3'-5' exonuclease TREX1; AU041952; DNase III; three prime exonuclease 1; three-prime repair exonuclease 1; trophoblast expressed 1
Orthologs:
Homo sapiens (human) : TREX1 (three prime repair exonuclease 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Trex1 (three prime repair exonuclease 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trex1 (three prime repair exonuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TREX1 (three prime repair exonuclease 1)
Canis lupus familiaris (dog) : TREX1 (three prime repair exonuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trex1 (three prime repair exonuclease 1)
Sus scrofa (pig) : TREX1 (three prime repair exonuclease 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm389109,057,932 - 109,059,723 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379108,960,446 - 108,962,237 (-)NCBIGRCm37mm9NCBIm37
MGSCv369108,915,338 - 108,917,129 (-)NCBImm8
Celera9108,616,714 - 108,618,505 (-)NCBICelera
Cytogenetic Map9 F2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Trex1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320018
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.