Gene: Trex1 (three prime repair exonuclease 1) Mus musculus
Analyze
Symbol:
Trex1
Name:
three prime repair exonuclease 1
Description:
Exhibits several functions, including DNA binding activity; WW domain binding activity; and magnesium ion binding activity. Involved in several processes, including DNA metabolic process; immunoglobulin mediated immune response; and negative regulation of cell cycle. Localizes to several cellular components, including the nuclear replication fork; oligosaccharyltransferase complex; and protein-DNA complex. Used to study Aicardi-Goutieres syndrome and cutaneous lupus erythematosus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; and systemic lupus erythematosus. Orthologous to human TREX1 (three prime repair exonuclease 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
1661; 3'-5' exonuclease TREX1; AU041952; DNase III; three prime exonuclease 1; three-prime repair exonuclease 1; trophoblast expressed 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TREX1 (three prime repair exonuclease 1) HGNC
Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Rattus norvegicus (Norway rat):
Trex1 (three prime repair exonuclease 1) HGNC
NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Trex1 (three prime repair exonuclease 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TREX1 (three prime repair exonuclease 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TREX1 (three prime repair exonuclease 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Trex1 (three prime repair exonuclease 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TREX1 (three prime repair exonuclease 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
TREX2 (three prime repair exonuclease 2) HGNC
OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Trex1 (three prime repair exonuclease 1)
Alliance
DIOPT (Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
TREX1 (three prime repair exonuclease 1)
Alliance
DIOPT (HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
si:ch1073-385f13.3
Alliance
DIOPT (InParanoid, OrthoFinder, PhylomeDB)
Danio rerio (zebrafish):
si:ch1073-296i8.2
Alliance
DIOPT (InParanoid, OrthoFinder, PhylomeDB)
Drosophila melanogaster (fruit fly):
CG3165
Alliance
DIOPT (InParanoid, OrthoFinder, OrthoInspector, PhylomeDB, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 109,057,932 - 109,059,723 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 108,960,446 - 108,962,237 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 108,915,338 - 108,917,129 (-) NCBI mm8 Celera 9 108,616,714 - 108,618,505 (-) NCBI Celera Cytogenetic Map 9 F2 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Aicardi-Goutieres syndrome ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome ClinVar PMID:26467025 , PMID:28492532 Aicardi-Goutieres syndrome ISO RGD:1323748 8554872 ClinVar Annotator: match by term: PSEUDOTOXOPLASMOSIS SYNDROME ClinVar PMID:23602593 more ... Aicardi-Goutieres syndrome ISO RGD:1323748 8554872 ClinVar Annotator: match by term: PSEUDOTOXOPLASMOSIS SYNDROME ClinVar PMID:25741868 Aicardi-Goutieres syndrome ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome ClinVar PMID:24033266 more ... Aicardi-Goutieres syndrome ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome ClinVar PMID:25741868 more ... Aicardi-Goutieres syndrome ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome ClinVar PMID:16845398 more ... Aicardi-Goutieres syndrome ISO RGD:1323748 8554872 ClinVar Annotator: match by OMIM:225750 ClinVar Aicardi-Goutieres syndrome ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome ClinVar PMID:25741868 , PMID:28492532 Aicardi-Goutieres syndrome ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:28492532 Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:23602593 more ... Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1, autosomal dominant ClinVar PMID:16960810 more ... Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:20131292 more ... Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:17660818 more ... Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:30219631 Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:26467025 more ... Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:17846997 more ... Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:17660818 , PMID:28492532 Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:25741868 more ... Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:17846997 more ... Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:17357087 , PMID:21808053 Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:25741868 Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:17660820 more ... Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:26467025 , PMID:28492532 Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:25741868 , PMID:26938784 Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:25604658 Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:25741868 , PMID:28492532 Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:28492532 Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:16845398 more ... Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:16845398 Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:24183309 more ... Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Aicardi Goutieres syndrome 1 ClinVar PMID:24088041 more ... Chilblain lupus ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Chilblain lupus erythematosus ClinVar PMID:17357087 Chilblain lupus ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Chilblain lupus erythematosus ClinVar PMID:16960810 more ... Chilblain lupus ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Chilblain Lupus ClinVar PMID:23602593 more ... Chilblain Lupus 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Chilblain lupus 1 ClinVar PMID:16960810 more ... Chilblain Lupus 1 ISO RGD:1323748 8554872 ClinVar Annotator: match by OMIM:610448 ClinVar PMID:17357087 Retinal Vasculopathy with Cerebral Leukodystrophy ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Vasculopathy, retinal, with cerebral leukodystrophy ClinVar PMID:26467025 , PMID:28492532 Retinal Vasculopathy with Cerebral Leukodystrophy ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Vasculopathy, retinal, with cerebral leukodystrophy ClinVar PMID:23602593 more ... Retinal Vasculopathy with Cerebral Leukodystrophy ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Vasculopathy, retinal, with cerebral leukodystrophy ClinVar PMID:24033266 more ... Retinal Vasculopathy with Cerebral Leukodystrophy ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Vasculopathy, retinal, with cerebral leukodystrophy ClinVar PMID:25741868 more ... Retinal Vasculopathy with Cerebral Leukodystrophy ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Vasculopathy, retinal, with cerebral leukodystrophy ClinVar PMID:16845398 more ... Retinal Vasculopathy with Cerebral Leukodystrophy ISO RGD:1323748 8554872 ClinVar Annotator: match by OMIM:192315 ClinVar Retinal Vasculopathy with Cerebral Leukodystrophy ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Vasculopathy, retinal, with cerebral leukodystrophy ClinVar PMID:28492532 Retinal Vasculopathy with Cerebral Leukodystrophy ISO RGD:1323748 8554872 ClinVar Annotator: match by null ClinVar PMID:17660820 more ... Retinal Vasculopathy with Cerebral Leukodystrophy ISO RGD:1323748 8554872 ClinVar Annotator: match by null ClinVar PMID:17660820 , PMID:9371916 Retinal Vasculopathy with Cerebral Leukodystrophy ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Vasculopathy, retinal, with cerebral leukodystrophy ClinVar PMID:25741868 , PMID:28492532 systemic lupus erythematosus ISO RGD:1323748 8554872 ClinVar Annotator: match by term: Systemic lupus erythematosus, susceptibility to ClinVar PMID:16845398 more ...
Imported Annotations - CTD
Aicardi-Goutieres syndrome ISO RGD:1323748 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16845398 brain disease ISO RGD:1323748 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16845398 Chilblain Lupus 1 ISO RGD:1323748 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27566796 Human Influenza ISO RGD:1323748 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23326326 Inflammation ISO RGD:1323748 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16845398 systemic lupus erythematosus ISO RGD:1323748 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17660818
Imported Annotations - MGI
Aicardi-Goutieres syndrome IEA 13592920 OMIM:225750 more ... MouseDO Chilblain lupus ISS RGD:1323748 13592920 OMIM:610448 , OMIM:614415MouseDO cutaneous lupus erythematosus IEA 13592920 MouseDO Imported Annotations - OMIM
Aicardi-Goutieres Syndrome 1 ISO RGD:1323748 7240710 OMIM Chilblain Lupus 1 ISO RGD:1323748 7240710 OMIM Retinal Vasculopathy with Cerebral Leukodystrophy ISO RGD:1323748 7240710 OMIM systemic lupus erythematosus ISO RGD:1323748 7240710 OMIM
(+)-pilocarpine increases expression ISO RGD:1311998 6480464 Pilocarpine results in increased expression of TREX1 mRNA CTD PMID:17971868 (RS)-amphetamine multiple interactions ISO RGD:1311998 6480464 eticlopride inhibits the reaction [Amphetamine results in increased expression of TREX1 mRNA] more ... CTD PMID:20298760 (RS)-amphetamine increases expression ISO RGD:1311998 6480464 Amphetamine results in increased expression of TREX1 mRNA, Amphetamine results in increased expression of TREX1 protein CTD PMID:20298760 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions ISO RGD:1323748 6480464 FOS mutant form inhibits the reaction [Topotecan results in increased expression of TREX1 mRNA] more ... CTD PMID:23578789 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions ISO RGD:1311998 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of TREX1 mRNA CTD PMID:25729387 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE affects response to substance ISO RGD:1323748 6480464 TREX1 affects the susceptibility to Topotecan CTD PMID:23578789 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE increases expression ISO RGD:1323748 6480464 Topotecan results in increased expression of TREX1 mRNA, Topotecan results in increased expression of TREX1 protein CTD PMID:23578789 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:1311998 6480464 Dinitrochlorobenzene results in increased expression of TREX1 mRNA CTD PMID:21893156 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of TREX1 mRNA CTD PMID:19484750 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of TREX1 mRNA CTD PMID:21570461 , PMID:24680724 2,4-dinitrotoluene affects expression ISO RGD:1311998 6480464 2, 4-dinitrotoluene affects the expression of TREX1 mRNA CTD PMID:21346803 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO RGD:1311998 6480464 Oxazolone results in increased expression of TREX1 mRNA CTD PMID:21893156 6-propyl-2-thiouracil increases expression ISO RGD:1311998 6480464 Propylthiouracil results in increased expression of TREX1 mRNA CTD PMID:24780913 amiodarone increases expression ISO RGD:1323748 6480464 Amiodarone results in increased expression of TREX1 mRNA CTD PMID:19774075 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of TREX1 mRNA CTD PMID:25270620 benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to TREX1 promoter] CTD PMID:19654925 benzo[a]pyrene affects localization EXP 6480464 Benzo(a)pyrene affects the localization of TREX1 protein CTD PMID:20511593 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of TREX1 mRNA, Benzo(a)pyrene results in increased expression of TREX1 protein CTD PMID:20511593 benzo[a]pyrene increases expression ISO RGD:1323748 6480464 Benzo(a)pyrene results in increased expression of TREX1 mRNA, Benzo(a)pyrene results in increased expression of TREX1 protein CTD PMID:20511593 , PMID:27694624 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1323748 6480464 7 more ... CTD PMID:19150397 biphenyl-4-amine decreases expression ISO RGD:1323748 6480464 4-biphenylamine results in decreased expression of TREX1 mRNA CTD PMID:24857880 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of TREX1 mRNA CTD PMID:26063408 bisphenol A increases methylation ISO RGD:1311998 6480464 bisphenol A results in increased methylation of TREX1 gene CTD PMID:28505145 bisphenol A increases expression ISO RGD:1311998 6480464 bisphenol A results in increased expression of TREX1 mRNA CTD PMID:25181051 Brevetoxin B increases expression ISO RGD:1323748 6480464 brevetoxin 2 results in increased expression of TREX1 mRNA CTD PMID:20498034 calcitriol decreases expression ISO RGD:1323748 6480464 Calcitriol results in decreased expression of TREX1 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1323748 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of TREX1 mRNA CTD PMID:21592394 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of TREX1 mRNA, Nanotubes, Carbon results in increased expression of TREX1 mRNA CTD PMID:25554681 carmustine increases expression ISO RGD:1323748 6480464 Carmustine results in increased expression of TREX1 mRNA CTD PMID:23578789 cisplatin multiple interactions ISO RGD:1323748 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of TREX1 mRNA CTD PMID:27392435 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of TREX1 mRNA CTD PMID:23811191 cobalt dichloride decreases expression ISO RGD:1323748 6480464 cobaltous chloride results in decreased expression of TREX1 mRNA CTD PMID:19320972 copper(II) sulfate increases expression ISO RGD:1323748 6480464 Copper Sulfate results in increased expression of TREX1 mRNA CTD PMID:19549813 cypermethrin increases expression EXP 6480464 cypermethrin results in increased expression of TREX1 mRNA CTD PMID:21142847 diazinon increases methylation ISO RGD:1323748 6480464 Diazinon results in increased methylation of TREX1 gene CTD PMID:22964155 dorsomorphin multiple interactions ISO RGD:1323748 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TREX1 mRNA CTD PMID:27188386 elemental selenium increases expression ISO RGD:1323748 6480464 Selenium results in increased expression of TREX1 mRNA CTD PMID:19244175 flutamide increases expression ISO RGD:1311998 6480464 Flutamide results in increased expression of TREX1 mRNA CTD PMID:24136188 fotemustine multiple interactions ISO RGD:1323748 6480464 FOS mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA] more ... CTD PMID:23578789 fotemustine increases expression ISO RGD:1323748 6480464 fotemustine results in increased expression of TREX1 mRNA, fotemustine results in increased expression of TREX1 protein CTD PMID:23578789 fotemustine affects response to substance ISO RGD:1323748 6480464 TREX1 affects the susceptibility to fotemustine CTD PMID:23578789 Genipin multiple interactions EXP 6480464 genipin inhibits the reaction [Lipopolysaccharides results in increased expression of TREX1 mRNA] CTD PMID:22687549 hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of TREX1 mRNA, Hydrogen Peroxide results in increased expression of TREX1 protein CTD PMID:20511593 imiquimod increases expression EXP 6480464 imiquimod results in increased expression of TREX1 mRNA CTD PMID:21878529 lipopolysaccharide multiple interactions EXP 6480464 (+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of TREX1 mRNA], genipin inhibits the reaction [Lipopolysaccharides results in increased expression of TREX1 mRNA] CTD PMID:22687549 , PMID:25890327 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of TREX1 mRNA CTD PMID:22687549 , PMID:25890327 mifepristone multiple interactions ISO RGD:1311998 6480464 Mifepristone inhibits the reaction [Amphetamine results in increased expression of TREX1 mRNA] CTD PMID:20298760 myristicin decreases expression ISO RGD:1323748 6480464 myristicin results in decreased expression of TREX1 mRNA CTD PMID:24792648 nimustine multiple interactions ISO RGD:1323748 6480464 FOS mutant form inhibits the reaction [Nimustine results in increased expression of TREX1 mRNA] more ... CTD PMID:23578789 nimustine affects response to substance ISO RGD:1323748 6480464 TREX1 affects the susceptibility to Nimustine CTD PMID:23578789 nimustine increases expression ISO RGD:1323748 6480464 Nimustine results in increased expression of TREX1 mRNA, Nimustine results in increased expression of TREX1 protein CTD PMID:23578789 oxaliplatin multiple interactions ISO RGD:1311998 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of TREX1 mRNA CTD PMID:25729387 p-chloromercuribenzoic acid increases expression ISO RGD:1323748 6480464 p-Chloromercuribenzoic Acid results in increased expression of TREX1 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:1323748 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TREX1 mRNA CTD PMID:27188386 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of TREX1 mRNA CTD PMID:17562736 pentachlorophenol increases expression EXP 6480464 Pentachlorophenol results in increased expression of TREX1 mRNA CTD PMID:23892564 quinpirole increases expression ISO RGD:1311998 6480464 Quinpirole results in increased expression of TREX1 mRNA CTD PMID:20298760 SB 431542 multiple interactions ISO RGD:1323748 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TREX1 mRNA CTD PMID:27188386 selenium atom increases expression ISO RGD:1323748 6480464 Selenium results in increased expression of TREX1 mRNA CTD PMID:19244175 selenomethionine affects expression ISO RGD:1323748 6480464 Selenomethionine affects the expression of TREX1 mRNA CTD PMID:17222674 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of TREX1 mRNA CTD PMID:19073995 silver atom decreases expression EXP 6480464 Silver results in decreased expression of TREX1 mRNA CTD PMID:27131904 silver(0) decreases expression EXP 6480464 Silver results in decreased expression of TREX1 mRNA CTD PMID:27131904 silver(1+) decreases expression EXP 6480464 Silver results in decreased expression of TREX1 mRNA CTD PMID:27131904 succimer multiple interactions EXP 6480464 [Succimer binds to Magnetite Nanoparticles] which results in increased expression of TREX1 mRNA, [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TREX1 mRNA CTD PMID:21641980 , PMID:26378955 testosterone multiple interactions ISO RGD:1323748 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of TREX1 mRNA CTD PMID:21592394 testosterone decreases expression ISO RGD:1323748 6480464 Testosterone results in decreased expression of TREX1 mRNA CTD PMID:21592394 topotecan multiple interactions ISO RGD:1311998 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of TREX1 mRNA CTD PMID:25729387 topotecan increases expression ISO RGD:1323748 6480464 Topotecan results in increased expression of TREX1 mRNA, Topotecan results in increased expression of TREX1 protein CTD PMID:23578789 topotecan multiple interactions ISO RGD:1323748 6480464 FOS mutant form inhibits the reaction [Topotecan results in increased expression of TREX1 mRNA] more ... CTD PMID:23578789 topotecan affects response to substance ISO RGD:1323748 6480464 TREX1 affects the susceptibility to Topotecan CTD PMID:23578789 trimellitic anhydride increases expression ISO RGD:1311998 6480464 trimellitic anhydride results in increased expression of TREX1 mRNA CTD PMID:21893156 valproic acid increases methylation ISO RGD:1323748 6480464 Valproic Acid results in increased methylation of TREX1 gene CTD PMID:29154799 valproic acid affects expression ISO RGD:1323748 6480464 Valproic Acid affects the expression of TREX1 mRNA CTD PMID:25979313 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of TREX1 mRNA CTD PMID:17963808 vanadyl sulfate increases expression ISO RGD:1323748 6480464 vanadyl sulfate results in increased expression of TREX1 mRNA CTD PMID:16330358 vancomycin decreases expression EXP 6480464 Vancomycin results in decreased expression of TREX1 mRNA CTD PMID:18930951 vincristine decreases expression ISO RGD:1323748 6480464 Vincristine results in decreased expression of TREX1 mRNA CTD PMID:23649840 vitamin E decreases expression ISO RGD:1323748 6480464 Vitamin E results in decreased expression of TREX1 mRNA CTD PMID:19244175
Biological Process activation of immune response IMP 2290270 (MGI:MGI:3818783, PMID:18045533) MGI MGI:MGI:3818783 , PMID:18045533 adaptive immune response IMP MGI:MGI:5751220 2290270 (MGI:MGI:5637600, PMID:25848017) MGI MGI:MGI:5637600 , PMID:25848017 apoptotic cell clearance IMP MGI:MGI:3052754 2290270 (MGI:MGI:5554502, PMID:24218451) MGI MGI:MGI:5554502 , PMID:24218451 atrial cardiac muscle tissue development IMP MGI:MGI:3052754 2290270 (MGI:MGI:3052278, PMID:15254239) MGI MGI:MGI:3052278 , PMID:15254239 blood vessel development IMP MGI:MGI:5751220 2290270 (MGI:MGI:5637600, PMID:25848017) MGI MGI:MGI:5637600 , PMID:25848017 CD86 biosynthetic process IMP MGI:MGI:3052754 2290270 (MGI:MGI:5554502, PMID:24218451) MGI MGI:MGI:5554502 , PMID:24218451 cellular response to DNA damage stimulus IDA 2290270 (MGI:MGI:5014018, PMID:20511593) MGI MGI:MGI:5014018 , PMID:20511593 cellular response to gamma radiation IMP 2290270 (MGI:MGI:3818783, PMID:18045533) MGI MGI:MGI:3818783 , PMID:18045533 cellular response to hydroxyurea IMP 2290270 (MGI:MGI:3818783, PMID:18045533) MGI MGI:MGI:3818783 , PMID:18045533 cellular response to interferon-beta IDA 2290270 (MGI:MGI:3836373, PMID:19158679) MGI MGI:MGI:3836373 , PMID:19158679 cellular response to organic substance IMP MGI:MGI:3052754 2290270 (MGI:MGI:5908297, PMID:28351661) MGI MGI:MGI:5908297 , PMID:28351661 cellular response to oxidative stress IMP MGI:MGI:3052754 2290270 (MGI:MGI:5562498, PMID:23993650) MGI MGI:MGI:5562498 , PMID:23993650 cellular response to reactive oxygen species IMP MGI:MGI:3052754 2290270 (MGI:MGI:5562498, PMID:23993650) MGI MGI:MGI:5562498 , PMID:23993650 cellular response to type I interferon IMP 2290270 (MGI:MGI:6103025, PMID:28835460) MGI MGI:MGI:6103025 , PMID:28835460 cellular response to UV IDA 2290270 (MGI:MGI:5014018, PMID:20511593) MGI MGI:MGI:5014018 , PMID:20511593 defense response to virus IMP MGI:MGI:3052754 2290270 (MGI:MGI:5460923, PMID:23160154) MGI MGI:MGI:5460923 , PMID:23160154 defense response to virus IMP 2290270 (MGI:MGI:4848004, PMID:20871604) MGI MGI:MGI:4848004 , PMID:20871604 detection of DNA damage stimulus involved in DNA damage checkpoint IMP MGI:MGI:3052754 2290270 (MGI:MGI:5562498, PMID:23993650) MGI MGI:MGI:5562498 , PMID:23993650 detection of stimulus involved in cell cycle checkpoint IMP 2290270 (MGI:MGI:3818783, PMID:18045533) MGI MGI:MGI:3818783 , PMID:18045533 determination of adult lifespan IGI MGI:MGI:104663 2290270 (MGI:MGI:5829115, PMID:28069950) MGI MGI:MGI:5829115 , PMID:28069950 determination of adult lifespan IMP MGI:MGI:3052754 2290270 (MGI:MGI:3052278, PMID:15254239) MGI MGI:MGI:3052278 , PMID:15254239 determination of adult lifespan IGI MGI:MGI:2442261 2290270 (MGI:MGI:5699498, PMID:26371324) MGI MGI:MGI:5699498 , PMID:26371324 DNA catabolic process IMP MGI:MGI:3052754 2290270 (MGI:MGI:3834787 more ... MGI MGI:MGI:3834787 more ... DNA catabolic process IDA 2290270 (MGI:MGI:4848004, PMID:20871604) MGI MGI:MGI:4848004 , PMID:20871604 DNA catabolic process IMP MGI:MGI:5751220 2290270 (MGI:MGI:5637600, PMID:25848017) MGI MGI:MGI:5637600 , PMID:25848017 DNA duplex unwinding IDA 2290270 (MGI:MGI:5637600, PMID:25848017) MGI MGI:MGI:5637600 , PMID:25848017 DNA metabolic process IDA 2290270 (MGI:MGI:5493219, PMID:11279105) UniProtKB MGI:MGI:5493219 , PMID:11279105 DNA modification IMP MGI:MGI:3052754 2290270 (MGI:MGI:5566725, PMID:24205360) MGI MGI:MGI:5566725 , PMID:24205360 DNA replication IMP 2290270 (MGI:MGI:5014018, PMID:20511593) MGI MGI:MGI:5014018 , PMID:20511593 DNA synthesis involved in UV-damage excision repair IMP MGI:MGI:3052754 2290270 (MGI:MGI:5562498, PMID:23993650) MGI MGI:MGI:5562498 , PMID:23993650 establishment of protein localization IMP MGI:MGI:3052754 2290270 (MGI:MGI:5460923, PMID:23160154) MGI MGI:MGI:5460923 , PMID:23160154 generation of precursor metabolites and energy IMP MGI:MGI:3052754 2290270 (MGI:MGI:5829115, PMID:28069950) MGI MGI:MGI:5829115 , PMID:28069950 heart morphogenesis IMP MGI:MGI:3052754 2290270 (MGI:MGI:3052278, PMID:15254239) MGI MGI:MGI:3052278 , PMID:15254239 heart process IMP MGI:MGI:3052754 2290270 (MGI:MGI:3052278, PMID:15254239) MGI MGI:MGI:3052278 , PMID:15254239 immune complex formation IMP MGI:MGI:5751220 2290270 (MGI:MGI:5637600, PMID:25848017) MGI MGI:MGI:5637600 , PMID:25848017 immune response IMP 2290270 (MGI:MGI:6103025, PMID:28835460) MGI MGI:MGI:6103025 , PMID:28835460 immune response in brain or nervous system IMP MGI:MGI:3052754 2290270 (MGI:MGI:5554502, PMID:24218451) MGI MGI:MGI:5554502 , PMID:24218451 immunoglobulin biosynthetic process involved in immune response IMP MGI:MGI:5751220 2290270 (MGI:MGI:5637600, PMID:25848017) MGI MGI:MGI:5637600 , PMID:25848017 inflammatory response IMP MGI:MGI:3052754 2290270 (MGI:MGI:3052278 more ... MGI MGI:MGI:3052278 more ... inflammatory response IMP MGI:MGI:5751220 2290270 (MGI:MGI:5637600, PMID:25848017) MGI MGI:MGI:5637600 , PMID:25848017 inflammatory response to antigenic stimulus IMP MGI:MGI:3052754 2290270 (MGI:MGI:5554502, PMID:24218451) MGI MGI:MGI:5554502 , PMID:24218451 innate immune response IMP MGI:MGI:3052754 2290270 (MGI:MGI:5460923, PMID:23160154) MGI MGI:MGI:5460923 , PMID:23160154 interferon-alpha production IMP MGI:MGI:3052754 2290270 (MGI:MGI:5554502, PMID:24218451) MGI MGI:MGI:5554502 , PMID:24218451 kidney development IMP MGI:MGI:5751220 2290270 (MGI:MGI:5637600, PMID:25848017) MGI MGI:MGI:5637600 , PMID:25848017 lymphoid progenitor cell differentiation IMP MGI:MGI:5751220 2290270 (MGI:MGI:5637600, PMID:25848017) MGI MGI:MGI:5637600 , PMID:25848017 macrophage activation involved in immune response IMP MGI:MGI:3052754 2290270 (MGI:MGI:5554502, PMID:24218451) MGI MGI:MGI:5554502 , PMID:24218451 negative regulation of type I interferon-mediated signaling pathway IMP MGI:MGI:3052754 2290270 (MGI:MGI:3834787, PMID:18724932) MGI MGI:MGI:3834787 , PMID:18724932 organ or tissue specific immune response IMP MGI:MGI:3052754 2290270 (MGI:MGI:5554502, PMID:24218451) MGI MGI:MGI:5554502 , PMID:24218451 protein stabilization IDA 2290270 (MGI:MGI:5787754, PMID:26320659) MGI MGI:MGI:5787754 , PMID:26320659 regulation of catalytic activity IMP MGI:MGI:3052754 2290270 (MGI:MGI:5460923, PMID:23160154) MGI MGI:MGI:5460923 , PMID:23160154 regulation of cellular metabolic process IMP MGI:MGI:3052754 2290270 (MGI:MGI:5829115, PMID:28069950) MGI MGI:MGI:5829115 , PMID:28069950 regulation of cellular metabolic process IGI MGI:MGI:1919762 , MGI:MGI:1929658 2290270 (MGI:MGI:5829115, PMID:28069950) MGI MGI:MGI:5829115 , PMID:28069950 regulation of cellular respiration IMP MGI:MGI:3052754 2290270 (MGI:MGI:5829115, PMID:28069950) MGI MGI:MGI:5829115 , PMID:28069950 regulation of fatty acid metabolic process IMP MGI:MGI:3052754 2290270 (MGI:MGI:5829115, PMID:28069950) MGI MGI:MGI:5829115 , PMID:28069950 regulation of gene expression IGI MGI:MGI:1859179 more ... 2290270 (MGI:MGI:5460923, PMID:23160154) MGI MGI:MGI:5460923 , PMID:23160154 regulation of gene expression IMP MGI:MGI:3052754 2290270 (MGI:MGI:5460923, PMID:23160154) MGI MGI:MGI:5460923 , PMID:23160154 regulation of glycolytic process IMP MGI:MGI:3052754 2290270 (MGI:MGI:5829115, PMID:28069950) MGI MGI:MGI:5829115 , PMID:28069950 regulation of immunoglobulin production IGI MGI:MGI:2442261 2290270 (MGI:MGI:5699498, PMID:26371324) MGI MGI:MGI:5699498 , PMID:26371324 regulation of immunoglobulin production IMP 2290270 (MGI:MGI:5787754, PMID:26320659) MGI MGI:MGI:5787754 , PMID:26320659 regulation of inflammatory response IGI MGI:MGI:1859179 , MGI:MGI:1919762 2290270 (MGI:MGI:5829115, PMID:28069950) MGI MGI:MGI:5829115 , PMID:28069950 regulation of innate immune response IMP 2290270 (MGI:MGI:4848004 more ... MGI MGI:MGI:4848004 more ... regulation of lipid biosynthetic process IGI MGI:MGI:104663 2290270 (MGI:MGI:5829115, PMID:28069950) MGI MGI:MGI:5829115 , PMID:28069950 regulation of lysosome organization IMP MGI:MGI:3052754 2290270 (MGI:MGI:5460923, PMID:23160154) MGI MGI:MGI:5460923 , PMID:23160154 regulation of protein complex stability IMP 2290270 (MGI:MGI:5787754, PMID:26320659) MGI MGI:MGI:5787754 , PMID:26320659 regulation of T cell activation IGI MGI:MGI:2442261 2290270 (MGI:MGI:5699498, PMID:26371324) MGI MGI:MGI:5699498 , PMID:26371324 regulation of tumor necrosis factor production IMP MGI:MGI:3052754 2290270 (MGI:MGI:5554502, PMID:24218451) MGI MGI:MGI:5554502 , PMID:24218451 regulation of type I interferon production IGI MGI:MGI:2442261 2290270 (MGI:MGI:5699498, PMID:26371324) MGI MGI:MGI:5699498 , PMID:26371324 regulation of type I interferon production IMP 2290270 (MGI:MGI:4848004, PMID:20871604) MGI MGI:MGI:4848004 , PMID:20871604 regulation of type I interferon production IMP MGI:MGI:3052754 2290270 (MGI:MGI:5523362, PMID:24154727) MGI MGI:MGI:5523362 , PMID:24154727 response to UV IMP MGI:MGI:3052754 2290270 (MGI:MGI:5908297, PMID:28351661) MGI MGI:MGI:5908297 , PMID:28351661 signal transduction involved in DNA damage checkpoint IMP 2290270 (MGI:MGI:3818783, PMID:18045533) MGI MGI:MGI:3818783 , PMID:18045533 T cell antigen processing and presentation IMP MGI:MGI:3052754 2290270 (MGI:MGI:5554502, PMID:24218451) MGI MGI:MGI:5554502 , PMID:24218451 transposition, RNA-mediated IMP 2290270 (MGI:MGI:6103025, PMID:28835460) MGI MGI:MGI:6103025 , PMID:28835460 type I interferon signaling pathway IMP MGI:MGI:3052754 2290270 (MGI:MGI:5908297, PMID:28351661) MGI MGI:MGI:5908297 , PMID:28351661 Cellular Component cytoplasm IDA 2290270 (MGI:MGI:3714672 more ... MGI MGI:MGI:3714672 more ... cytosol IDA 2290270 (MGI:MGI:5908297, PMID:28351661) MGI MGI:MGI:5908297 , PMID:28351661 cytosol ISO UniProtKB:Q9NSU2 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 endoplasmic reticulum IDA 2290270 (MGI:MGI:3834787 more ... MGI MGI:MGI:3834787 more ... membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 nuclear replication fork IDA 2290270 (MGI:MGI:3818783, PMID:18045533) MGI MGI:MGI:3818783 , PMID:18045533 nucleus IDA 2290270 (MGI:MGI:3818783 more ... MGI MGI:MGI:3818783 more ... oligosaccharyltransferase complex IDA 2290270 (MGI:MGI:5787754, PMID:26320659) MGI MGI:MGI:5787754 , PMID:26320659 protein-DNA complex IDA 2290270 (MGI:MGI:5637600, PMID:25848017) MGI MGI:MGI:5637600 , PMID:25848017 Molecular Function 3'-5' exonuclease activity IMP MGI:MGI:3052754 2290270 (MGI:MGI:3052278, PMID:15254239) MGI MGI:MGI:3052278 , PMID:15254239 3'-5' exonuclease activity ISO UniProtKB:Q9NSU2 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 3'-5'-exodeoxyribonuclease activity IDA 2290270 (MGI:MGI:5493219, PMID:11279105) UniProtKB MGI:MGI:5493219 , PMID:11279105 3'-5'-exodeoxyribonuclease activity IBA MGI:MGI:1328317 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 adenyl deoxyribonucleotide binding IDA 2290270 (MGI:MGI:3709447, PMID:17293595) MGI MGI:MGI:3709447 , PMID:17293595 DNA binding IDA 2290270 (MGI:MGI:4848004, PMID:20871604) MGI MGI:MGI:4848004 , PMID:20871604 DNA binding, bending IDA 2290270 (MGI:MGI:5637600, PMID:25848017) MGI MGI:MGI:5637600 , PMID:25848017 double-stranded DNA binding IDA 2290270 (MGI:MGI:3836373 more ... MGI MGI:MGI:3836373 more ... exodeoxyribonuclease III activity IEA EC:3.1.11.2 2290270 UniProtKB GO_REF:0000003, MGI:MGI:2152096 exonuclease activity IEA UniProtKB-KW:KW-0269 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 hydrolase activity IEA UniProtKB-KW:KW-0378 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 magnesium ion binding IDA 2290270 (MGI:MGI:5637600, PMID:25848017) MGI MGI:MGI:5637600 , PMID:25848017 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 MutLalpha complex binding ISO UniProtKB:Q9NSU2 2290270 (MGI:MGI:3653556, PMID:16713580) MGI MGI:MGI:3653556 , PMID:16713580 MutSalpha complex binding ISO UniProtKB:Q9NSU2 2290270 (MGI:MGI:3653556, PMID:16713580) MGI MGI:MGI:3653556 , PMID:16713580 nuclease activity IEA UniProtKB-KW:KW-0540 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 nucleic acid binding IEA InterPro:IPR036397 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 protein binding IPI UniProtKB:P35564 2290270 (MGI:MGI:3834787, PMID:18724932) MGI MGI:MGI:3834787 , PMID:18724932 protein binding IPI UniProtKB:Q9BQ50 2290270 (MGI:MGI:5493219, PMID:11279105) UniProtKB MGI:MGI:5493219 , PMID:11279105 protein binding IPI UniProtKB:Q91XB0 2290270 (MGI:MGI:5493219, PMID:11279105) UniProtKB MGI:MGI:5493219 , PMID:11279105 protein homodimerization activity IPI UniProtKB:Q91XB0 2290270 (MGI:MGI:3709447 more ... UniProtKB MGI:MGI:3709447 more ... single-stranded DNA binding IDA 2290270 (MGI:MGI:3709447 more ... MGI MGI:MGI:3709447 more ... WW domain binding IDA 2290270 (MGI:MGI:3714672, PMID:17355961) MGI MGI:MGI:3714672 , PMID:17355961
Gene-Chemical Interaction Annotations
