Dok1 (docking protein 1) - Rat Genome Database

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Gene: Dok1 (docking protein 1) Mus musculus
Analyze
Symbol: Dok1
Name: docking protein 1
RGD ID: 1319872
MGI Page MGI
Description: Acts upstream of or within Ras protein signal transduction; macrophage colony-stimulating factor signaling pathway; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human DOK1 (docking protein 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW557123; downstream of tyrosine kinase 1; p62(dok); p62D; p62DOK
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,007,915 - 83,010,448 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,007,915 - 83,010,452 (-)EnsemblGRCm39 Ensembl
GRCm38683,030,932 - 83,033,495 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,030,934 - 83,033,471 (-)EnsemblGRCm38mm10GRCm38
MGSCv37682,980,928 - 82,983,465 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36682,996,592 - 82,999,123 (-)NCBIMGSCv36mm8
Celera685,012,444 - 85,014,981 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone marrow cell morphology/development  (IAGP)
abnormal fat cell morphology  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal T cell proliferation  (IAGP)
decreased body weight  (IAGP)
decreased brown adipose tissue mass  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased fat cell size  (IAGP)
decreased IgM level  (IAGP)
decreased inguinal fat pad weight  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased susceptibility to weight gain  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
enlarged thymus  (IAGP)
extramedullary hematopoiesis  (IAGP)
improved glucose tolerance  (IAGP)
increased B cell proliferation  (IAGP)
increased bone marrow cell number  (IAGP)
increased bronchioalveolar stem cell number  (IAGP)
increased chronic myelocytic leukemia incidence  (IAGP)
increased circulating adiponectin level  (IAGP)
increased erythroblast number  (IAGP)
increased fibroblast proliferation  (IAGP)
increased histiocytic sarcoma incidence  (IAGP)
increased insulin sensitivity  (IAGP)
increased leukemia incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased macrophage cell number  (IAGP)
increased megakaryocyte cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased oxygen consumption  (IAGP)
increased sarcoma incidence  (IAGP)
increased tumor incidence  (IAGP)
increased type II pneumocyte number  (IAGP)
premature death  (IAGP)
pulmonary hyperplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Identification of DOK genes as lung tumor suppressors. Berger AH, etal., Nat Genet. 2010 Mar;42(3):216-23. doi: 10.1038/ng.527. Epub 2010 Feb 7.
2. Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family. Encinas JA, etal., Proc Natl Acad Sci U S A 1999 Mar 2;96(5):2491-6.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7544435   PMID:8889548   PMID:9008161   PMID:9221755   PMID:9233798   PMID:9620604   PMID:9790776   PMID:9806835   PMID:9927484   PMID:10202139   PMID:10349636   PMID:10567556  
PMID:10585470   PMID:10640270   PMID:10669731   PMID:10755621   PMID:10823839   PMID:10922068   PMID:11031258   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11470823   PMID:11489947  
PMID:11585923   PMID:11927552   PMID:11970986   PMID:12087092   PMID:12466851   PMID:12477932   PMID:12606711   PMID:14607833   PMID:14610273   PMID:14647425   PMID:14747716   PMID:15148308  
PMID:15189452   PMID:15489334   PMID:15592455   PMID:15611294   PMID:15611295   PMID:15655368   PMID:15699069   PMID:16141072   PMID:16141073   PMID:16547230   PMID:16602821   PMID:16705178  
PMID:17092301   PMID:17329234   PMID:17827176   PMID:18156175   PMID:18204460   PMID:18422655   PMID:20548287   PMID:20697350   PMID:21267068   PMID:21690289   PMID:21732353   PMID:21873635  
PMID:22370159   PMID:22736313   PMID:23205702   PMID:23659921   PMID:24963146   PMID:25859222   PMID:26790499   PMID:27183638   PMID:27450811   PMID:27664281   PMID:27926878   PMID:28490594  
PMID:29548825   PMID:32325033   PMID:32554809  


Genomics

Comparative Map Data
Dok1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,007,915 - 83,010,448 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,007,915 - 83,010,452 (-)EnsemblGRCm39 Ensembl
GRCm38683,030,932 - 83,033,495 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,030,934 - 83,033,471 (-)EnsemblGRCm38mm10GRCm38
MGSCv37682,980,928 - 82,983,465 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36682,996,592 - 82,999,123 (-)NCBIMGSCv36mm8
Celera685,012,444 - 85,014,981 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
DOK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,549,105 - 74,557,551 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,549,026 - 74,557,551 (+)EnsemblGRCh38hg38GRCh38
GRCh37274,776,232 - 74,784,678 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,635,368 - 74,638,171 (+)NCBINCBI36Build 36hg18NCBI36
Build 34274,693,514 - 74,696,317NCBI
Celera274,612,968 - 74,615,771 (+)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,512,408 - 74,520,939 (+)NCBIHuRef
CHM1_1274,705,542 - 74,714,073 (+)NCBICHM1_1
T2T-CHM13v2.0274,557,671 - 74,566,117 (+)NCBIT2T-CHM13v2.0
Dok1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,095,171 - 117,098,251 (-)NCBIGRCr8
mRatBN7.24115,537,453 - 115,540,464 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,537,462 - 115,540,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,014,035 - 121,016,498 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,789,236 - 116,791,699 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,403,804 - 115,406,266 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,864,211 - 113,866,695 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,864,215 - 113,866,674 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,549,313 - 178,551,776 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,242,746 - 117,245,209 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,487,230 - 117,489,690 (-)NCBI
Celera4104,532,133 - 104,534,596 (-)NCBICelera
Cytogenetic Map4q34NCBI
Dok1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,232,376 - 11,236,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,233,601 - 11,236,397 (-)NCBIChiLan1.0ChiLan1.0
DOK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,831,679 - 51,840,536 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,834,433 - 51,843,313 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,615,542 - 74,624,183 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A76,121,718 - 76,130,162 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,126,749 - 76,130,162 (+)Ensemblpanpan1.1panPan2
DOK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,588,579 - 48,591,523 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,589,023 - 48,591,721 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,230,464 - 48,235,681 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,448,003 - 49,453,227 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,447,213 - 49,451,189 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,465,182 - 48,470,394 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,531,935 - 48,537,130 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,089,579 - 49,094,795 (-)NCBIUU_Cfam_GSD_1.0
Dok1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,959,267 - 9,971,862 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556766,613 - 771,316 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936556766,522 - 769,557 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,494,520 - 68,497,407 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,494,516 - 68,497,374 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,666,760 - 71,669,589 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DOK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,720,237 - 32,723,578 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,720,026 - 32,723,286 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,447,658 - 79,451,063 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dok1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474928,956,479 - 28,958,895 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474928,956,120 - 28,958,959 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dok1
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:507
Count of miRNA genes:367
Interacting mature miRNAs:409
Transcripts:ENSMUST00000089651, ENSMUST00000149918
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65115613485156284Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5435041188356155Mouse
15039373Adip28_madiposity 28 (mouse)65628519490285194Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65628519490285194Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65842456692424693Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65851741692517416Mouse
10412119Stv_mstriatal volumne (mouse)Not determined660026991100026967Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66003466394034782Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66346172197461888Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666690851100691013Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670402880104403016Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670402880104403016Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670402880104403016Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7129960586252701Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67129960593441074Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671552042105552160Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671958006105958152Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671958006105958152Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
12792979Fbmd2_mfemoral bone mineral density 2, females only (mouse)675026989115026943Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675424566104480516Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67552133992584431Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67552133994202936Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67552133994202936Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675584287109584431Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675693484109693678Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676440930110441074Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67707698389976982Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67797698396976961Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681476981102176961Mouse

Markers in Region
AW557123  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,031,153 - 83,031,263UniSTSGRCm38
MGSCv37682,981,147 - 82,981,257UniSTSGRCm37
Celera685,012,663 - 85,012,773UniSTS
Cytogenetic Map6C3UniSTS
cM Map634.73UniSTS
Whitehead/MRC_RH6850.48UniSTS
Dok1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS
cM Map634.73UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001409625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_176878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_176879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_176880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA790529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC003061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC104324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC134899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF084363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI135039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY114582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY645588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ053718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U78818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000089651   ⟹   ENSMUSP00000087079
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl683,007,915 - 83,010,452 (-)Ensembl
GRCm38.p6 Ensembl683,030,934 - 83,033,471 (-)Ensembl
RefSeq Acc Id: ENSMUST00000149918   ⟹   ENSMUSP00000145318
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl683,007,921 - 83,010,449 (-)Ensembl
GRCm38.p6 Ensembl683,030,940 - 83,033,468 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204900   ⟹   ENSMUSP00000145347
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl683,008,832 - 83,009,542 (-)Ensembl
GRCm38.p6 Ensembl683,031,851 - 83,032,561 (-)Ensembl
RefSeq Acc Id: NM_001409625   ⟹   NP_001396554
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,009,094 - 83,010,448 (-)NCBI
RefSeq Acc Id: NM_001409626   ⟹   NP_001396555
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,007,915 - 83,010,448 (-)NCBI
RefSeq Acc Id: NM_010070   ⟹   NP_034200
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,007,915 - 83,010,448 (-)NCBI
GRCm38683,030,934 - 83,033,471 (-)NCBI
MGSCv37682,980,928 - 82,983,465 (-)RGD
Celera685,012,444 - 85,014,981 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_176878
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,007,915 - 83,010,448 (-)NCBI
RefSeq Acc Id: NR_176879
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,009,094 - 83,010,448 (-)NCBI
RefSeq Acc Id: NR_176880
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,007,915 - 83,010,448 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_034200   ⟸   NM_010070
- Peptide Label: isoform 1
- UniProtKB: Q9R213 (UniProtKB/Swiss-Prot),   P97465 (UniProtKB/Swiss-Prot),   Q3UWF9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000145347   ⟸   ENSMUST00000204900
RefSeq Acc Id: ENSMUSP00000145318   ⟸   ENSMUST00000149918
RefSeq Acc Id: ENSMUSP00000087079   ⟸   ENSMUST00000089651
RefSeq Acc Id: NP_001396555   ⟸   NM_001409626
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001396554   ⟸   NM_001409625
- Peptide Label: isoform 3
Protein Domains
IRS-type PTB   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97465-F1-model_v2 AlphaFold P97465 1-482 view protein structure

Promoters
RGD ID:6839188
Promoter ID:MM_KWN:46559
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000056545,   OTTMUST00000056546
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36682,982,971 - 82,984,292 (-)MPROMDB
RGD ID:6890106
Promoter ID:EPDNEW_M8503
Type:single initiation site
Name:Dok1_2
Description:Mus musculus docking protein 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8504  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38683,033,206 - 83,033,266EPDNEW
RGD ID:6890108
Promoter ID:EPDNEW_M8504
Type:initiation region
Name:Dok1_1
Description:Mus musculus docking protein 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8503  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38683,033,467 - 83,033,527EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:893587 AgrOrtholog
Ensembl Genes ENSMUSG00000068335 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000089651 ENTREZGENE
  ENSMUST00000089651.6 UniProtKB/Swiss-Prot
  ENSMUST00000149918 ENTREZGENE
  ENSMUST00000149918.2 UniProtKB/TrEMBL
  ENSMUST00000204900.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dok1/2/3_PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRS_PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13448 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:893587 ENTREZGENE
NCBI Gene 13448 ENTREZGENE
PANTHER DOCKING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOCKING PROTEIN RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IRS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dok1 PhenoGen
PROSITE IRS_PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IRS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTBI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SW01_MOUSE UniProtKB/TrEMBL
  A0A0N4SW29_MOUSE UniProtKB/TrEMBL
  DOK1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UWF9 ENTREZGENE, UniProtKB/TrEMBL
  Q9R213 ENTREZGENE
UniProt Secondary Q9R213 UniProtKB/Swiss-Prot