Efnb2 (ephrin B2) - Rat Genome Database

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Gene: Efnb2 (ephrin B2) Mus musculus
Analyze
Symbol: Efnb2
Name: ephrin B2
RGD ID: 1319868
MGI Page MGI
Description: Enables signaling receptor binding activity. Involved in several processes, including adherens junction organization; positive regulation of cardiac muscle cell differentiation; and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within several processes, including negative regulation of keratinocyte proliferation; positive regulation of aorta morphogenesis; and vasculature development. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in colon carcinoma; colorectal carcinoma; and esophagus squamous cell carcinoma. Orthologous to human EFNB2 (ephrin B2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ELF-; ELF-2; Ep; EPH-related receptor tyrosine kinase ligand 5; ephrin-B2; Epl; Epl5; Eplg5; HTK ligand; Htk-; Htk-L; Ler; LERK; LERK-5; Lerk5; NLER; NLERK-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3988,667,235 - 8,711,242 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl88,667,434 - 8,711,242 (-)EnsemblGRCm39 Ensembl
GRCm3888,617,235 - 8,661,242 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl88,617,434 - 8,661,242 (-)EnsemblGRCm38mm10GRCm38
MGSCv3788,617,439 - 8,660,773 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3688,617,406 - 8,660,745 (-)NCBIMGSCv36mm8
Celera88,790,063 - 8,833,410 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map83.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
celastrol  (ISO)
chlordecone  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
dibenz[a,h]anthracene  (EXP)
dorsomorphin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
isobutanol  (ISO)
L-methionine  (EXP)
Licochalcone B  (ISO)
lithocholic acid  (ISO)
menadione  (EXP)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
nitrofen  (ISO)
ozone  (EXP)
paracetamol  (ISO)
pentanal  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
tunicamycin  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal afferent lymphatic vessel morphology  (IAGP)
abnormal angiogenesis  (IAGP)
abnormal anogenital distance  (IAGP)
abnormal anterior cardinal vein morphology  (IAGP)
abnormal anterior commissure pars posterior morphology  (IAGP)
abnormal axon guidance  (IAGP)
abnormal axon morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal cardinal vein morphology  (IAGP)
abnormal cardiovascular development  (IAGP)
abnormal common crus morphology  (IAGP)
abnormal coronal suture morphology  (IAGP)
abnormal cranial neural crest cell migration  (IAGP)
abnormal developmental vascular remodeling  (IAGP)
abnormal dorsal-ventral polarity of the somites  (IAGP)
abnormal endocardium morphology  (IAGP)
abnormal endolymph  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart valve morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal intersomitic vessel morphology  (IAGP)
abnormal long term depression  (IAGP)
abnormal lymph circulation  (IAGP)
abnormal lymphatic vessel morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal neural crest cell migration  (IAGP)
abnormal penis morphology  (IAGP)
abnormal rostral-caudal patterning of the somites  (IAGP)
abnormal second pharyngeal arch morphology  (IAGP)
abnormal semicircular canal morphology  (IAGP)
abnormal septation of the cloaca  (IAGP)
abnormal skin physiology  (IAGP)
abnormal somite development  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T-helper 1 cell differentiation  (IAGP)
abnormal T-helper 17 cell differentiation  (IAGP)
abnormal tracheal cartilage morphology  (IAGP)
abnormal trunk neural crest cell migration  (IAGP)
abnormal urethra morphology  (IAGP)
abnormal vascular development  (IAGP)
abnormal vestibular endolymph  (IAGP)
abnormal vestibular endolymph ionic homeostasis  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent myocardial trabeculae  (IAGP)
absent pharyngeal arch arteries  (IAGP)
absent second pharyngeal arch  (IAGP)
anal atresia  (IAGP)
chylothorax  (IAGP)
circling  (IAGP)
cleft palate  (IAGP)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cranial neural crest cell number  (IAGP)
decreased DN4 thymocyte number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased endolymph production  (IAGP)
decreased posterior semicircular canal size  (IAGP)
decreased spleen weight  (IAGP)
decreased superior semicircular canal size  (IAGP)
decreased T cell number  (IAGP)
decreased thymus weight  (IAGP)
dilated endolymphatic duct  (IAGP)
dilated endolymphatic sac  (IAGP)
distended pericardium  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and placentation, incomplete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged aortic valve  (IAGP)
enlarged heart  (IAGP)
enlarged pericardium  (IAGP)
enlarged pulmonary valve  (IAGP)
failure of eyelid fusion  (IAGP)
flaky skin  (IAGP)
head bobbing  (IAGP)
hyperkeratosis  (IAGP)
hypospadia  (IAGP)
increased cranial neural crest cell apoptosis  (IAGP)
increased DN3 thymocyte number  (IAGP)
increased double-negative T cell number  (IAGP)
increased length of allograft survival  (IAGP)
increased susceptibility to Riboviria infection  (IAGP)
increased thymocyte apoptosis  (IAGP)
male infertility  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
persistent cloaca  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
reduced long term potentiation  (IAGP)
retarded hair growth  (IAGP)
small endolymphatic duct  (IAGP)
small first pharyngeal arch  (IAGP)
small hair follicles  (IAGP)
small pharyngeal arch  (IAGP)
small salivary gland  (IAGP)
small second pharyngeal arch  (IAGP)
small spleen  (IAGP)
small thymus  (IAGP)
small trigeminal ganglion  (IAGP)
splayed clitoris  (IAGP)
spleen hypoplasia  (IAGP)
thick aortic valve  (IAGP)
thick epidermis  (IAGP)
thick mitral valve cusps  (IAGP)
thick pulmonary valve  (IAGP)
thin hypodermis  (IAGP)
thymus hypoplasia  (IAGP)
tracheoesophageal fistula  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53. Alam SK, etal., Cell Death Differ. 2016 Apr;23(4):707-22. doi: 10.1038/cdd.2015.133. Epub 2015 Oct 23.
2. Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats. Bundesen LQ, etal., J Neurosci. 2003 Aug 27;23(21):7789-800.
3. Expression profile of EFNB1, EFNB2, two ligands of EPHB2 in human gastric cancer. Kataoka H, etal., J Cancer Res Clin Oncol. 2002 Jul;128(7):343-8. doi: 10.1007/s00432-002-0355-0. Epub 2002 Jun 26.
4. Increased EphB2 expression predicts cholangiocarcinoma metastasis. Khansaard W, etal., Tumour Biol. 2014 Oct;35(10):10031-41. doi: 10.1007/s13277-014-2295-0. Epub 2014 Jul 11.
5. Effects of overexpression of ephrin-B2 on tumour growth in human colorectal cancer. Liu W, etal., Br J Cancer. 2004 Apr 19;90(8):1620-6. doi: 10.1038/sj.bjc.6601723.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Expression levels of EPHB4, EFNB2 and caspase-8 are associated with clinicopathological features and progression of esophageal squamous cell cancer. Ni Q, etal., Oncol Lett. 2020 Jan;19(1):917-929. doi: 10.3892/ol.2019.11160. Epub 2019 Nov 28.
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy. Rivera JC, etal., Invest Ophthalmol Vis Sci. 2015 Dec;56(13):7897-907. doi: 10.1167/iovs.15-17146.
13. Downregulation of the endothelial genes Notch1 and ephrinB2 in patients with nodular regenerative hyperplasia. Rothweiler S, etal., Liver Int. 2014 Apr;34(4):594-603. doi: 10.1111/liv.12261. Epub 2013 Jul 21.
14. Ephrin-B2 reverse signaling regulates progression and lymph node metastasis of oral squamous cell carcinoma. Sasabe E, etal., PLoS One. 2017 Nov 30;12(11):e0188965. doi: 10.1371/journal.pone.0188965. eCollection 2017.
15. Arterialization and anomalous vein wall remodeling in varicose veins is associated with upregulated FoxC2-Dll4 pathway. Surendran S, etal., Lab Invest. 2016 Apr;96(4):399-408. doi: 10.1038/labinvest.2015.167. Epub 2016 Jan 25.
16. Expression and prognostic significance of EFNB2 and EphB4 genes in patients with oesophageal squamous cell carcinoma. Tachibana M, etal., Dig Liver Dis. 2007 Aug;39(8):725-32. doi: 10.1016/j.dld.2007.05.013. Epub 2007 Jul 3.
17. Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Urness LD, etal., Nat Genet 2000 Nov;26(3):328-31.
18. Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera. Wang CC, etal., Dev Biol 2000 Aug 15;224(2):152-67.
19. EphB2 knockdown decreases the formation of astroglial-fibrotic scars to promote nerve regeneration after spinal cord injury in rats. Wu J, etal., CNS Neurosci Ther. 2021 Jun;27(6):714-724. doi: 10.1111/cns.13641. Epub 2021 Apr 1.
20. EphrinB2/ephB2-mediated myenteric synaptic plasticity: mechanisms underlying the persistent muscle hypercontractility and pain in postinfectious IBS. Zhang L, etal., FASEB J. 2019 Dec;33(12):13644-13659. doi: 10.1096/fj.201901192R. Epub 2019 Oct 25.
21. [The expressions of EphrinB2 and VEGF in nasopharyngeal carcinoma and their clinical significance]. Zhang R, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Feb;27(4):178-80.
Additional References at PubMed
PMID:7534404   PMID:7651410   PMID:7833926   PMID:8559144   PMID:8598197   PMID:8755474   PMID:8808709   PMID:8878483   PMID:8947026   PMID:8954746   PMID:9267020   PMID:9630219  
PMID:9990854   PMID:10323857   PMID:10349636   PMID:10395784   PMID:10495276   PMID:10518221   PMID:10648835   PMID:10683176   PMID:10704386   PMID:10719886   PMID:10839360   PMID:10943840  
PMID:11042159   PMID:11076861   PMID:11133162   PMID:11161569   PMID:11163240   PMID:11182082   PMID:11217851   PMID:11297511   PMID:11301003   PMID:11306625   PMID:11439183   PMID:11562355  
PMID:11578869   PMID:11641270   PMID:11703926   PMID:11729236   PMID:11748150   PMID:11754836   PMID:11780069   PMID:11830578   PMID:11830579   PMID:11880349   PMID:11978390   PMID:12149214  
PMID:12217323   PMID:12435358   PMID:12466851   PMID:12477932   PMID:12486086   PMID:12588758   PMID:12654290   PMID:12684176   PMID:12816988   PMID:12834865   PMID:12923530   PMID:12941632  
PMID:12971893   PMID:13678579   PMID:14610273   PMID:14699416   PMID:15014111   PMID:15073150   PMID:15107403   PMID:15155583   PMID:15162501   PMID:15184386   PMID:15223333   PMID:15223334  
PMID:15239958   PMID:15240555   PMID:15466159   PMID:15466160   PMID:15489334   PMID:15509772   PMID:15510105   PMID:15599401   PMID:15687262   PMID:15745950   PMID:15851594   PMID:15875024  
PMID:15882861   PMID:15906234   PMID:15977181   PMID:16000382   PMID:16141072   PMID:16141073   PMID:16211213   PMID:16230531   PMID:16234353   PMID:16319111   PMID:16413489   PMID:16421308  
PMID:16430858   PMID:16446123   PMID:16511561   PMID:16514057   PMID:16565260   PMID:16602821   PMID:16611695   PMID:16678147   PMID:16806288   PMID:16890539   PMID:16943546   PMID:16951162  
PMID:16968134   PMID:17141159   PMID:17158005   PMID:17202185   PMID:17223098   PMID:17336907   PMID:17685488   PMID:17942722   PMID:17945206   PMID:17948123   PMID:17948875   PMID:17967521  
PMID:17972914   PMID:18043734   PMID:18055806   PMID:18093989   PMID:18206867   PMID:18213589   PMID:18245384   PMID:18287559   PMID:18397270   PMID:18445690   PMID:18463357   PMID:18528438  
PMID:18550715   PMID:18555774   PMID:18559979   PMID:18568073   PMID:18571496   PMID:18627264   PMID:18651661   PMID:18713744   PMID:18725519   PMID:18755772   PMID:18799693   PMID:18950979  
PMID:18952909   PMID:18957513   PMID:19032981   PMID:19109910   PMID:19113915   PMID:19160501   PMID:19218547   PMID:19268698   PMID:19289155   PMID:19303389   PMID:19411631   PMID:19463158  
PMID:19538749   PMID:19542359   PMID:19571816   PMID:19576202   PMID:19619540   PMID:19639173   PMID:19644017   PMID:19769959   PMID:19797707   PMID:19843150   PMID:19859539   PMID:19883626  
PMID:20101599   PMID:20112066   PMID:20336138   PMID:20346184   PMID:20346953   PMID:20445537   PMID:20445540   PMID:20504947   PMID:20568246   PMID:20616004   PMID:20627076   PMID:20629048  
PMID:20649938   PMID:20660266   PMID:20730909   PMID:20886601   PMID:20890042   PMID:21059214   PMID:21098570   PMID:21113149   PMID:21127290   PMID:21246652   PMID:21252157   PMID:21267068  
PMID:21273545   PMID:21311046   PMID:21423180   PMID:21460838   PMID:21515254   PMID:21539827   PMID:21658587   PMID:21677750   PMID:21735541   PMID:21765212   PMID:21765815   PMID:21793101  
PMID:21847105   PMID:21859843   PMID:21873635   PMID:21964490   PMID:21976681   PMID:22021100   PMID:22065784   PMID:22069310   PMID:22101302   PMID:22103419   PMID:22132096   PMID:22171039  
PMID:22222522   PMID:22243746   PMID:22261032   PMID:22354871   PMID:22371266   PMID:22434763   PMID:22622516   PMID:22673212   PMID:22783020   PMID:22789927   PMID:22983209   PMID:23042409  
PMID:23106883   PMID:23129351   PMID:23146940   PMID:23165727   PMID:23314057   PMID:23318582   PMID:23342162   PMID:23354168   PMID:23395391   PMID:23406903   PMID:23408838   PMID:23462468  
PMID:23492730   PMID:23518227   PMID:23529931   PMID:23558405   PMID:23571217   PMID:23578932   PMID:23604320   PMID:23623938   PMID:23649798   PMID:23696610   PMID:23742148   PMID:23797856  
PMID:23830865   PMID:24019535   PMID:24056079   PMID:24153254   PMID:24298057   PMID:24360543   PMID:24453220   PMID:24477991   PMID:24550118   PMID:24583262   PMID:24583642   PMID:24673722  
PMID:24894949   PMID:24906954   PMID:24949938   PMID:24952961   PMID:24969754   PMID:24982128   PMID:24997765   PMID:25051267   PMID:25072663   PMID:25091710   PMID:25138596   PMID:25139858  
PMID:25180700   PMID:25209249   PMID:25264302   PMID:25283993   PMID:25299585   PMID:25417117   PMID:25480420   PMID:25497097   PMID:25775517   PMID:25779027   PMID:25807892   PMID:25810451  
PMID:25848055   PMID:25865237   PMID:25923646   PMID:25958091   PMID:26027726   PMID:26063906   PMID:26269635   PMID:26321050   PMID:26385750   PMID:26481148   PMID:26503288   PMID:26549443  
PMID:26633881   PMID:26641715   PMID:26755702   PMID:26839344   PMID:26906676   PMID:26941654   PMID:26980243   PMID:27035151   PMID:27039370   PMID:27060907   PMID:27250641   PMID:27344203  
PMID:27350048   PMID:27356767   PMID:27445154   PMID:27470974   PMID:27530629   PMID:27551053   PMID:27568519   PMID:27789228   PMID:27820703   PMID:27894818   PMID:28137836   PMID:28254815  
PMID:28595615   PMID:28732675   PMID:28924218   PMID:28931948   PMID:28947178   PMID:28978486   PMID:29031500   PMID:29058717   PMID:29444449   PMID:29540665   PMID:29727635   PMID:29743679  
PMID:29874574   PMID:30015911   PMID:30075851   PMID:30347193   PMID:30639848   PMID:30796970   PMID:31073041   PMID:31112136   PMID:31138536   PMID:31264714   PMID:31366886   PMID:31434798  
PMID:31782728   PMID:31789590   PMID:31830612   PMID:31868583   PMID:31868584   PMID:32325033   PMID:32404061   PMID:32585189   PMID:32591430   PMID:32897857   PMID:32989254   PMID:33039109  
PMID:33253166   PMID:33454003   PMID:33789115   PMID:33830085   PMID:33907211   PMID:33934370   PMID:34157123   PMID:34281570   PMID:34403370   PMID:35288551   PMID:35294885   PMID:35297995  
PMID:35649376   PMID:35725568   PMID:36029930   PMID:36046192   PMID:36082581   PMID:36376513  


Genomics

Comparative Map Data
Efnb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3988,667,235 - 8,711,242 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl88,667,434 - 8,711,242 (-)EnsemblGRCm39 Ensembl
GRCm3888,617,235 - 8,661,242 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl88,617,434 - 8,661,242 (-)EnsemblGRCm38mm10GRCm38
MGSCv3788,617,439 - 8,660,773 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3688,617,406 - 8,660,745 (-)NCBIMGSCv36mm8
Celera88,790,063 - 8,833,410 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map83.42NCBI
EFNB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813106,489,745 - 106,535,662 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl13106,489,745 - 106,535,662 (-)EnsemblGRCh38hg38GRCh38
GRCh3713107,142,093 - 107,188,010 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613105,940,094 - 105,985,338 (-)NCBINCBI36Build 36hg18NCBI36
Build 3413105,940,097 - 105,985,338NCBI
Celera1387,986,327 - 88,031,570 (-)NCBICelera
Cytogenetic Map13q33.3NCBI
HuRef1387,733,581 - 87,778,804 (-)NCBIHuRef
CHM1_113107,110,751 - 107,156,066 (-)NCBICHM1_1
T2T-CHM13v2.013105,710,156 - 105,756,072 (-)NCBIT2T-CHM13v2.0
Efnb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21680,783,389 - 80,827,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1680,783,417 - 80,824,391 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1686,062,447 - 86,103,384 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01689,515,058 - 89,556,010 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01684,759,477 - 84,800,448 (+)NCBIRnor_WKY
Rnor_6.01686,631,151 - 86,672,050 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1686,631,064 - 86,675,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01686,044,304 - 86,085,652 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41686,187,639 - 86,228,023 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11686,173,265 - 86,214,062 (+)NCBI
Celera1678,561,525 - 78,602,409 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
Efnb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554045,000,906 - 5,030,126 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554045,000,906 - 5,030,068 (+)NCBIChiLan1.0ChiLan1.0
EFNB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.113106,770,296 - 106,815,542 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13106,770,296 - 106,815,548 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01387,629,831 - 87,675,652 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
EFNB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12255,567,992 - 55,609,210 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2255,566,039 - 55,609,443 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2255,325,721 - 55,366,922 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02256,079,969 - 56,121,281 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2256,078,458 - 56,121,514 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12255,672,831 - 55,714,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02255,659,581 - 55,700,849 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02255,698,309 - 55,739,598 (-)NCBIUU_Cfam_GSD_1.0
Efnb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945190,770,785 - 190,813,404 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364725,138,745 - 5,181,668 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364725,138,751 - 5,181,630 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EFNB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1174,186,640 - 74,233,354 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11174,188,337 - 74,232,768 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21181,565,082 - 81,609,512 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EFNB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1384,904,421 - 84,949,292 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl384,904,435 - 84,949,465 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604641,467,321 - 41,512,883 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Efnb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247935,089,639 - 5,130,503 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247935,089,675 - 5,130,022 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1248
Count of miRNA genes:665
Interacting mature miRNAs:810
Transcripts:ENSMUST00000001319, ENSMUST00000152698
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse

Markers in Region
Efnb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3888,619,362 - 8,620,091UniSTSGRCm38
MGSCv3788,619,362 - 8,620,091UniSTSGRCm37
Celera88,791,986 - 8,792,715UniSTS
Cytogenetic Map8A1.1UniSTS
cM Map82.0UniSTS
L38847  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3888,619,636 - 8,619,794UniSTSGRCm38
MGSCv3788,619,636 - 8,619,794UniSTSGRCm37
Celera88,792,260 - 8,792,418UniSTS
Cytogenetic Map8A1.1UniSTS
Whitehead_YAC8 UniSTS
Efnb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A1.1UniSTS
Efnb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A1.1UniSTS
Efnb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A1.1UniSTS
Efnb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3888,619,276 - 8,619,502UniSTSGRCm38
MGSCv3788,619,276 - 8,619,502UniSTSGRCm37
Celera88,791,900 - 8,792,126UniSTS
Cytogenetic Map8A1.1UniSTS
cM Map82.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001368299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC138368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC161867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L38847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U16819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U30244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000001319   ⟹   ENSMUSP00000001319
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl88,667,434 - 8,711,242 (-)Ensembl
GRCm38.p6 Ensembl88,617,434 - 8,661,242 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152698   ⟹   ENSMUSP00000116027
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl88,670,597 - 8,689,363 (-)Ensembl
GRCm38.p6 Ensembl88,620,597 - 8,639,363 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209169
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl88,708,422 - 8,711,239 (-)Ensembl
GRCm38.p6 Ensembl88,658,422 - 8,661,239 (-)Ensembl
RefSeq Acc Id: NM_001368299   ⟹   NP_001355228
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3988,667,434 - 8,711,242 (-)NCBI
GRCm3888,617,434 - 8,661,242 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010111   ⟹   NP_034241
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3988,667,434 - 8,711,242 (-)NCBI
GRCm3888,617,434 - 8,661,242 (-)NCBI
MGSCv3788,617,439 - 8,660,773 (-)RGD
Celera88,790,063 - 8,833,410 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011242036   ⟹   XP_011240338
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3988,667,235 - 8,697,015 (-)NCBI
GRCm3888,617,235 - 8,647,015 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034241   ⟸   NM_010111
- Peptide Label: isoform 1 precursor
- UniProtKB: P52800 (UniProtKB/Swiss-Prot),   Q4FJM3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240338   ⟸   XM_011242036
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001355228   ⟸   NM_001368299
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000001319   ⟸   ENSMUST00000001319
RefSeq Acc Id: ENSMUSP00000116027   ⟸   ENSMUST00000152698
Protein Domains
Ephrin RBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52800-F1-model_v2 AlphaFold P52800 1-336 view protein structure

Promoters
RGD ID:6848282
Promoter ID:MM_ACW:46752
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:EFNB2.DSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3688,620,581 - 8,621,081 (-)MPROMDB
RGD ID:6843063
Promoter ID:MM_KWN:53575
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   MEF_B4
Transcripts:ENSMUST00000098947,   OTTMUST00000052622
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3688,660,936 - 8,661,436 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105097 AgrOrtholog
Ensembl Genes ENSMUSG00000001300 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000001319 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000116027.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000001319 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000152698.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cupredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin-B_Ecto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13642 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:105097 ENTREZGENE
NCBI Gene 13642 ENTREZGENE
PANTHER PTHR11304 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ephrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB EFNB2 RGD
PhenoGen Efnb2 PhenoGen
PRINTS EPHRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EPHRIN_RBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPHRIN_RBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49503 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EFNB2_MOUSE UniProtKB/Swiss-Prot
  F6RSU6_MOUSE UniProtKB/TrEMBL
  P52800 ENTREZGENE
  Q3V1E0_MOUSE UniProtKB/TrEMBL
  Q4FJM3 ENTREZGENE, UniProtKB/TrEMBL