Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | multiple interactions | EXP | | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SP3 mRNA | CTD | PMID:24763279 | 1,2-dimethylhydrazine | decreases expression | ISO | Sp3 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of SP3 mRNA | CTD | PMID:22206623 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | increases expression | ISO | Sp3 (Mus musculus) | 6480464 | 1-Methyl-4-phenyl-1 more ... | CTD | PMID:29071302 | 17alpha-ethynylestradiol | multiple interactions | ISO | Sp3 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SP3 mRNA | CTD | PMID:17942748 | 17beta-estradiol | affects expression | ISO | Sp3 (Rattus norvegicus) | 6480464 | Estradiol affects the expression of SP3 mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Sp3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SP3 mRNA | CTD | PMID:24058054 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Sp3 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SP3 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Sp3 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SP3 mRNA | CTD | PMID:17942748 | 2-methylcholine | affects expression | EXP | | 6480464 | beta-methylcholine affects the expression of SP3 mRNA | CTD | PMID:21179406 | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol S co-treated with Fulvestrant] results in decreased methylation of SP3 gene | CTD | PMID:31601247 | 4,4'-sulfonyldiphenol | decreases methylation | EXP | | 6480464 | bisphenol S results in decreased methylation of SP3 gene | CTD | PMID:31601247 | 5-aza-2'-deoxycytidine | multiple interactions | EXP | | 6480464 | [Decitabine co-treated with trichostatin A] promotes the reaction [SP3 protein binds to CLDN3 promoter] more ... | CTD | PMID:17986852 and PMID:18033804 | 5-fluorouracil | multiple interactions | EXP | | 6480464 | TP53 protein affects the reaction [Fluorouracil results in decreased expression of SP3 mRNA] | CTD | PMID:15016801 | 7,12-dimethyltetraphene | increases expression | ISO | Sp3 (Rattus norvegicus) | 6480464 | 9 more ... | CTD | PMID:36863560 | aflatoxin B1 | increases expression | ISO | Sp3 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of SP3 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | EXP | | 6480464 | Aflatoxin B1 results in decreased methylation of SP3 gene | CTD | PMID:27153756 | antirheumatic drug | decreases expression | EXP | | 6480464 | Antirheumatic Agents results in decreased expression of SP3 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | EXP | | 6480464 | aristolochic acid I results in decreased expression of SP3 mRNA and aristolochic acid I results in decreased expression of SP3 protein | CTD | PMID:33212167 | arsenous acid | decreases expression | EXP | | 6480464 | Arsenic Trioxide results in decreased expression of SP3 mRNA and Arsenic Trioxide results in decreased expression of SP3 protein | CTD | PMID:20435036 | arsenous acid | decreases expression | ISO | Sp3 (Mus musculus) | 6480464 | Arsenic Trioxide results in decreased expression of SP3 mRNA | CTD | PMID:35676786 | benzene | increases expression | EXP | | 6480464 | Benzene results in increased expression of SP3 mRNA | CTD | PMID:21382456 | benzo[a]pyrene | decreases methylation | EXP | | 6480464 | Benzo(a)pyrene results in decreased methylation of SP3 promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | EXP | | 6480464 | 7 more ... | CTD | PMID:19150397 | biotin | increases expression | ISO | Sp3 (Mus musculus) | 6480464 | Biotin results in increased expression of SP3 mRNA | CTD | PMID:34699867 | bis(2-ethylhexyl) phthalate | decreases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in decreased expression of SP3 protein | CTD | PMID:25068794 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Sp3 (Rattus norvegicus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of SP3 protein | CTD | PMID:25068794 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Sp3 (Rattus norvegicus) | 6480464 | HDAC4 mutant form inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein] | CTD | PMID:25068794 | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein] more ... | CTD | PMID:25068794 | bisphenol A | increases expression | ISO | Sp3 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of SP3 mRNA | CTD | PMID:30816183 and PMID:32145629 | bisphenol A | increases expression | ISO | Sp3 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SP3 mRNA | CTD | PMID:37894381 | bisphenol A | decreases methylation | EXP | | 6480464 | bisphenol A results in decreased methylation of SP3 gene | CTD | PMID:31601247 | cadmium atom | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SP3 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | Sp3 (Mus musculus) | 6480464 | Cadmium Chloride inhibits the reaction [SP1 protein binds to SP3 protein binds to KLF4 protein binds to E2F1 protein binds to NECTIN2 promoter] | CTD | PMID:25046863 | cadmium dichloride | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SP3 mRNA | CTD | PMID:35301059 | caffeine | increases phosphorylation | EXP | | 6480464 | Caffeine results in increased phosphorylation of SP3 protein | CTD | PMID:35688186 | camptothecin | increases activity | EXP | | 6480464 | Camptothecin results in increased activity of SP3 protein | CTD | PMID:11261509 | camptothecin | multiple interactions | EXP | | 6480464 | mithramycin A inhibits the reaction [Camptothecin results in increased activity of SP3 protein] | CTD | PMID:11261509 | carbamazepine | affects expression | EXP | | 6480464 | Carbamazepine affects the expression of SP3 mRNA | CTD | PMID:25979313 | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SP3 gene] | CTD | PMID:28238834 | chlorpyrifos | decreases expression | ISO | Sp3 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of SP3 mRNA | CTD | PMID:37019170 | copper atom | affects expression | EXP | | 6480464 | Copper affects the expression of SP3 protein | CTD | PMID:22172574 | copper(0) | affects expression | EXP | | 6480464 | Copper affects the expression of SP3 protein | CTD | PMID:22172574 | copper(II) sulfate | increases expression | EXP | | 6480464 | Copper Sulfate results in increased expression of SP3 | CTD | PMID:22172574 | cordycepin | increases activity | EXP | | 6480464 | cordycepin results in increased activity of SP3 protein | CTD | PMID:19051361 | coumarin | increases phosphorylation | EXP | | 6480464 | coumarin results in increased phosphorylation of SP3 protein | CTD | PMID:35688186 | crocidolite asbestos | decreases expression | ISO | Sp3 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of SP3 mRNA | CTD | PMID:29279043 | curcumin | decreases expression | EXP | | 6480464 | Curcumin results in decreased expression of SP3 protein | CTD | PMID:18593936 | daunorubicin | increases expression | EXP | | 6480464 | Daunorubicin results in increased expression of SP3 protein | CTD | PMID:19698806 | decabromodiphenyl ether | increases expression | ISO | Sp3 (Rattus norvegicus) | 6480464 | decabromobiphenyl ether results in increased expression of SP3 mRNA | CTD | PMID:23914054 | diarsenic trioxide | decreases expression | EXP | | 6480464 | Arsenic Trioxide results in decreased expression of SP3 mRNA and Arsenic Trioxide results in decreased expression of SP3 protein | CTD | PMID:20435036 | diarsenic trioxide | decreases expression | ISO | Sp3 (Mus musculus) | 6480464 | Arsenic Trioxide results in decreased expression of SP3 mRNA | CTD | PMID:35676786 | dichloromethane | increases expression | ISO | Sp3 (Mus musculus) | 6480464 | Methylene Chloride results in increased expression of SP3 mRNA | CTD | PMID:28392392 | dicrotophos | decreases expression | EXP | | 6480464 | dicrotophos results in decreased expression of SP3 mRNA | CTD | PMID:28302478 | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SP3 mRNA | CTD | PMID:27188386 | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of SP3 mRNA | CTD | PMID:29803840 | enzyme inhibitor | multiple interactions | EXP | | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SP3 protein | CTD | PMID:23301498 | fenvalerate | increases expression | ISO | Sp3 (Rattus norvegicus) | 6480464 | fenvalerate results in increased expression of SP3 mRNA | CTD | PMID:30307764 | fluoranthene | multiple interactions | ISO | Sp3 (Mus musculus) | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in increased expression of SP3 mRNA | CTD | PMID:28329830 | folic acid | decreases expression | ISO | Sp3 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of SP3 mRNA | CTD | PMID:25629700 | FR900359 | increases phosphorylation | EXP | | 6480464 | FR900359 results in increased phosphorylation of SP3 protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | EXP | | 6480464 | [bisphenol S co-treated with Fulvestrant] results in decreased methylation of SP3 gene and Fulvestrant promotes the reaction [SP3 protein binds to ESRRA promoter] | CTD | PMID:20211987 and PMID:31601247 | gentamycin | decreases expression | ISO | Sp3 (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of SP3 mRNA | CTD | PMID:22061828 | glutathione | multiple interactions | EXP | | 6480464 | Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP3 protein] | CTD | PMID:20435036 | gold atom | decreases expression | EXP | | 6480464 | Gold results in decreased expression of SP3 mRNA | CTD | PMID:25523186 | gold(0) | decreases expression | EXP | | 6480464 | Gold results in decreased expression of SP3 mRNA | CTD | PMID:25523186 | homocysteic acid | multiple interactions | EXP | | 6480464 | mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP3 protein] | CTD | PMID:11261509 | homocysteic acid | increases activity | EXP | | 6480464 | homocysteic acid results in increased activity of SP3 protein | CTD | PMID:11261509 | hydrogen peroxide | multiple interactions | EXP | | 6480464 | Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP3 protein] | CTD | PMID:20435036 | hydrogen peroxide | decreases expression | EXP | | 6480464 | Hydrogen Peroxide results in decreased expression of SP3 protein | CTD | PMID:20435036 | L-ascorbic acid | decreases expression | EXP | | 6480464 | Ascorbic Acid results in decreased expression of SP3 protein | CTD | PMID:21919647 | lead nitrate | multiple interactions | ISO | Sp3 (Mus musculus) | 6480464 | lead nitrate affects the reaction [SP3 affects the expression of MT1 mRNA] and lead nitrate affects the reaction [SP3 affects the expression of MT2 mRNA] | CTD | PMID:11891201 | lead nitrate | decreases expression | ISO | Sp3 (Mus musculus) | 6480464 | lead nitrate results in decreased expression of SP3 mRNA | CTD | PMID:11891201 | lead(0) | increases expression | EXP | | 6480464 | Lead results in increased expression of SP3 protein | CTD | PMID:22272629 | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of SP3 mRNA | CTD | PMID:28988120 | MC1568 | multiple interactions | EXP | | 6480464 | MC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to NGB promoter]] more ... | CTD | PMID:25068794 | MC1568 | increases expression | EXP | | 6480464 | MC1568 results in increased expression of SP3 protein | CTD | PMID:25068794 | metformin | decreases expression | EXP | | 6480464 | Metformin results in decreased expression of SP3 protein | CTD | PMID:26317792 | methotrexate | affects expression | ISO | Sp3 (Mus musculus) | 6480464 | Methotrexate affects the expression of SP3 mRNA | CTD | PMID:18502557 | methylmercury chloride | decreases expression | EXP | | 6480464 | methylmercuric chloride results in decreased expression of SP3 mRNA | CTD | PMID:28001369 | N,N-diethyl-m-toluamide | multiple interactions | ISO | Sp3 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of SP3 gene | CTD | PMID:33148267 | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | multiple interactions | EXP | | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein] | CTD | PMID:25068794 | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | increases expression | EXP | | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SP3 protein | CTD | PMID:25068794 | nickel sulfate | increases expression | EXP | | 6480464 | nickel sulfate results in increased expression of SP3 mRNA | CTD | PMID:18651567 | paraquat | affects expression | ISO | Sp3 (Mus musculus) | 6480464 | Paraquat affects the expression of SP3 mRNA and Paraquat affects the expression of SP3 protein | CTD | PMID:31368498 | perfluorooctane-1-sulfonic acid | decreases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in decreased expression of SP3 mRNA | CTD | PMID:27153767 | permethrin | multiple interactions | ISO | Sp3 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of SP3 gene | CTD | PMID:33148267 | phenobarbital | increases expression | ISO | Sp3 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of SP3 mRNA | CTD | PMID:19270015 | phenobarbital | affects expression | ISO | Sp3 (Mus musculus) | 6480464 | Phenobarbital affects the expression of SP3 mRNA | CTD | PMID:23091169 | phenytoin | increases expression | EXP | | 6480464 | Phenytoin results in increased expression of SP3 mRNA | CTD | PMID:14741686 | pirinixic acid | increases expression | ISO | Sp3 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of SP3 mRNA | CTD | PMID:18301758 | potassium dichromate | increases expression | ISO | Sp3 (Mus musculus) | 6480464 | Potassium Dichromate results in increased expression of SP3 mRNA | CTD | PMID:23608068 | promegestone | multiple interactions | EXP | | 6480464 | mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]] and Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter] | CTD | PMID:16807381 | promegestone | increases expression | EXP | | 6480464 | Promegestone results in increased expression of SP3 mRNA and Promegestone results in increased expression of SP3 protein | CTD | PMID:16807381 | quercetin | multiple interactions | EXP | | 6480464 | [Quercetin co-treated with hyperoside] results in decreased expression of SP3 mRNA more ... | CTD | PMID:23530649 and PMID:24173369 | quercetin 3-O-beta-D-galactopyranoside | multiple interactions | EXP | | 6480464 | [Quercetin co-treated with hyperoside] results in decreased expression of SP3 mRNA and [Quercetin co-treated with hyperoside] results in decreased expression of SP3 protein | CTD | PMID:24173369 | resveratrol | multiple interactions | EXP | | 6480464 | [resveratrol co-treated with Quercetin] results in decreased expression of SP3 mRNA and [resveratrol co-treated with Quercetin] results in decreased expression of SP3 protein | CTD | PMID:23530649 | S-butyl-DL-homocysteine (S,R)-sulfoximine | multiple interactions | EXP | | 6480464 | mithramycin A inhibits the reaction [Buthionine Sulfoximine results in increased activity of SP3 protein] | CTD | PMID:11261509 | S-butyl-DL-homocysteine (S,R)-sulfoximine | increases activity | EXP | | 6480464 | Buthionine Sulfoximine results in increased activity of SP3 protein | CTD | PMID:11261509 | S-nitrosoglutathione | decreases activity | EXP | | 6480464 | S-Nitrosoglutathione results in decreased activity of SP3 protein | CTD | PMID:14766015 | S-nitrosoglutathione | increases activity | EXP | | 6480464 | S-Nitrosoglutathione results in increased activity of SP3 protein | CTD | PMID:14766015 | SB 431542 | multiple interactions | EXP | | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 and PMID:37664457 | Se-methyl-L-selenocysteine | multiple interactions | EXP | | 6480464 | selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter] | CTD | PMID:25321483 | Se-methylselenocysteine | multiple interactions | EXP | | 6480464 | selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter] | CTD | PMID:25321483 | silver atom | decreases expression | ISO | Sp3 (Mus musculus) | 6480464 | Silver results in decreased expression of SP3 mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | ISO | Sp3 (Mus musculus) | 6480464 | Silver results in decreased expression of SP3 mRNA | CTD | PMID:27131904 | sodium arsenate | increases expression | ISO | Sp3 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of SP3 mRNA | CTD | PMID:21795629 | sodium arsenate | decreases expression | ISO | Sp3 (Mus musculus) | 6480464 | sodium arsenate results in decreased expression of SP3 mRNA | CTD | PMID:21795629 | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of SP3 mRNA | CTD | PMID:12016162 | tamoxifen | multiple interactions | EXP | | 6480464 | Tamoxifen promotes the reaction [SP3 protein binds to ESRRA promoter] | CTD | PMID:20211987 | tetrathiomolybdate(2-) | decreases expression | EXP | | 6480464 | tetrathiomolybdate results in decreased expression of SP3 | CTD | PMID:22172574 | trichostatin A | multiple interactions | EXP | | 6480464 | [Decitabine co-treated with trichostatin A] promotes the reaction [SP3 protein binds to CLDN3 promoter] more ... | CTD | PMID:17986852 and PMID:27188386 | trichostatin A | increases expression | EXP | | 6480464 | trichostatin A results in increased expression of SP3 mRNA | CTD | PMID:24935251 and PMID:26272509 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of SP3 mRNA | CTD | PMID:25979313 | valproic acid | decreases methylation | EXP | | 6480464 | Valproic Acid results in decreased methylation of SP3 gene | CTD | PMID:28853863 more ... | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of SP3 mRNA | CTD | PMID:23179753 more ... | vinclozolin | increases expression | ISO | Sp3 (Rattus norvegicus) | 6480464 | vinclozolin results in increased expression of SP3 mRNA | CTD | PMID:23555832 | vorinostat | multiple interactions | EXP | | 6480464 | SP3 protein promotes the reaction [vorinostat results in increased expression of CDKN1A mRNA] | CTD | PMID:11126357 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
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