Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-demecolcine | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Demecolcine results in decreased expression of PPP4R3B mRNA | CTD | PMID:23649840 | (1->4)-beta-D-glucan | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PPP4R3B mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of SMEK2 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of PPP4R3B mRNA | CTD | PMID:17555576 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | PPP4R3B (Homo sapiens) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PPP4R3B mRNA | CTD | PMID:19684285 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Ppp4r3b (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PPP4R3B mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Ppp4r3b (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PPP4R3B mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PPP4R3B promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PPP4R3B mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PPP4R3B mRNA | CTD | PMID:19684285 | 2,4,6-tribromophenol | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2-hydroxypropanoic acid | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of PPP4R3B mRNA | CTD | PMID:30851411 | 2-methylcholine | affects expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of PPP4R3B mRNA | CTD | PMID:21179406 | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PPP4R3B mRNA | CTD | PMID:26251327 | 6-propyl-2-thiouracil | decreases expression | ISO | Ppp4r3b (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of SMEK2 mRNA | CTD | PMID:30047161 | acrolein | multiple interactions | ISO | PPP4R3B (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PPP4R3B mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PPP4R3B mRNA | CTD | PMID:32699268 | afimoxifene | multiple interactions | ISO | PPP4R3B (Homo sapiens) | 6480464 | afimoxifene inhibits the reaction [Estrogens results in decreased expression of PPP4R3B mRNA] | CTD | PMID:21233418 | aflatoxin B1 | decreases methylation | ISO | PPP4R3B (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of PPP4R3B gene | CTD | PMID:27153756 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of PPP4R3B mRNA | CTD | PMID:19770486 | alpha-pinene | multiple interactions | ISO | PPP4R3B (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PPP4R3B mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PPP4R3B mRNA | CTD | PMID:32699268 | amitrole | decreases expression | ISO | Ppp4r3b (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of SMEK2 mRNA | CTD | PMID:30047161 | antirheumatic drug | increases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of PPP4R3B mRNA | CTD | PMID:24449571 | Aroclor 1254 | decreases expression | EXP | | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of PPP4R3B mRNA | CTD | PMID:23650126 | atrazine | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Atrazine results in decreased expression of PPP4R3B mRNA | CTD | PMID:22378314 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of PPP4R3B mRNA | CTD | PMID:22228805 | bisphenol A | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of PPP4R3B mRNA and bisphenol A results in decreased expression of PPP4R3B protein | CTD | PMID:20678512 and PMID:31675489 | bisphenol A | decreases methylation | ISO | PPP4R3B (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of PPP4R3B gene | CTD | PMID:31601247 | bisphenol A | increases expression | ISO | Ppp4r3b (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of PPP4R3B mRNA | CTD | PMID:30816183 | bisphenol A | decreases expression | ISO | Ppp4r3b (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of PPP4R3B mRNA | CTD | PMID:25181051 | butanal | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of PPP4R3B mRNA | CTD | PMID:26079696 | cadmium atom | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SMEK2 mRNA | CTD | PMID:37325564 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of PPP4R3B mRNA | CTD | PMID:24982889 | cadmium dichloride | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SMEK2 mRNA | CTD | PMID:37325564 | caffeine | decreases phosphorylation | ISO | PPP4R3B (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of PPP4R3B protein | CTD | PMID:35688186 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes and Carbon analog results in decreased expression of PPP4R3B mRNA | CTD | PMID:25554681 | cobalt dichloride | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of PPP4R3B mRNA | CTD | PMID:19376846 | copper(II) sulfate | affects expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Copper Sulfate affects the expression of PPP4R3B mRNA | CTD | PMID:19549813 | crocidolite asbestos | increases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in increased expression of PPP4R3B mRNA | CTD | PMID:18687144 | cycloheximide | multiple interactions | ISO | PPP4R3B (Homo sapiens) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PPP4R3B mRNA | CTD | PMID:19684285 | cyclosporin A | increases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of PPP4R3B mRNA | CTD | PMID:20106945 | decabromodiphenyl ether | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of PPP4R3B protein | CTD | PMID:31675489 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of PPP4R3B mRNA | CTD | PMID:21266533 | dicrotophos | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of SMEK2 mRNA | CTD | PMID:28302478 | dorsomorphin | multiple interactions | ISO | PPP4R3B (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | increases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of PPP4R3B mRNA | CTD | PMID:29803840 | ethyl methanesulfonate | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of PPP4R3B mRNA | CTD | PMID:23649840 | flutamide | increases expression | ISO | Ppp4r3b (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of PPP4R3B mRNA | CTD | PMID:24136188 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of SMEK2 mRNA | CTD | PMID:25629700 | formaldehyde | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of PPP4R3B mRNA | CTD | PMID:23649840 | FR900359 | decreases phosphorylation | ISO | PPP4R3B (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of PPP4R3B protein | CTD | PMID:37730182 | gentamycin | increases expression | ISO | Ppp4r3b (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of PPP4R3B mRNA | CTD | PMID:22061828 | hydrogen peroxide | multiple interactions | ISO | PPP4R3B (Homo sapiens) | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PPP4R3B protein | CTD | PMID:18951874 | Indeno[1,2,3-cd]pyrene | decreases expression | EXP | | 6480464 | indeno(1 more ... | CTD | PMID:26377693 | irinotecan | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Irinotecan analog results in decreased expression of PPP4R3B mRNA | CTD | PMID:18927307 | methimazole | decreases expression | ISO | Ppp4r3b (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of SMEK2 mRNA | CTD | PMID:30047161 | methylmercury chloride | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of SMEK2 mRNA | CTD | PMID:28001369 | miconazole | decreases expression | EXP | | 6480464 | Miconazole results in decreased expression of PPP4R3B mRNA | CTD | PMID:27462272 | nimesulide | decreases expression | ISO | Ppp4r3b (Rattus norvegicus) | 6480464 | nimesulide results in decreased expression of PPP4R3B mRNA | CTD | PMID:24136188 | ozone | multiple interactions | ISO | PPP4R3B (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PPP4R3B mRNA more ... | CTD | PMID:32699268 | paracetamol | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PPP4R3B mRNA | CTD | PMID:21420995 | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PPP4R3B mRNA | CTD | PMID:36331819 | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of PPP4R3B mRNA | CTD | PMID:23091169 | phenylmercury acetate | multiple interactions | ISO | PPP4R3B (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP4R3B mRNA | CTD | PMID:27188386 | phenylmercury acetate | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of PPP4R3B mRNA | CTD | PMID:26272509 | rac-lactic acid | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of PPP4R3B mRNA | CTD | PMID:30851411 | resveratrol | multiple interactions | ISO | PPP4R3B (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of PPP4R3B mRNA | CTD | PMID:23557933 | SB 431542 | multiple interactions | ISO | PPP4R3B (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sunitinib | increases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PPP4R3B mRNA | CTD | PMID:31533062 | theophylline | multiple interactions | ISO | PPP4R3B (Homo sapiens) | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PPP4R3B protein | CTD | PMID:18951874 | trichostatin A | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of PPP4R3B mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | PPP4R3B (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP4R3B mRNA | CTD | PMID:27188386 | triptonide | decreases expression | EXP | | 6480464 | triptonide results in decreased expression of PPP4R3B mRNA | CTD | PMID:33045310 | valproic acid | affects expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PPP4R3B mRNA | CTD | PMID:23179753 and PMID:25979313 | valproic acid | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SMEK2 mRNA | CTD | PMID:28001369 | vinclozolin | affects expression | ISO | Ppp4r3b (Rattus norvegicus) | 6480464 | vinclozolin affects the expression of PPP4R3B mRNA | CTD | PMID:19015723 | vinclozolin | increases expression | ISO | Ppp4r3b (Rattus norvegicus) | 6480464 | vinclozolin results in increased expression of PPP4R3B mRNA | CTD | PMID:23034163 | vincristine | decreases expression | ISO | PPP4R3B (Homo sapiens) | 6480464 | Vincristine results in decreased expression of PPP4R3B mRNA | CTD | PMID:23649840 | |