Urah (urate (5-hydroxyiso-) hydrolase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Urah (urate (5-hydroxyiso-) hydrolase) Mus musculus
Analyze
Symbol: Urah
Name: urate (5-hydroxyiso-) hydrolase
RGD ID: 1319651
MGI Page MGI
Description: Enables hydroxyisourate hydrolase activity. Involved in allantoin metabolic process; purine-containing compound catabolic process; and urate catabolic process. Located in peroxisome. Orthologous to human URAHP (urate (hydroxyiso-) hydrolase, pseudogene); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; benzo[a]pyrene; folic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1190003J15Rik; 2810420C16Rik; 5-hydroxyisourate hydrolase; HIU hydrolase; HIUHase; transthyretin-related protein
RGD Orthologs
Human
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,414,936 - 140,417,884 (+)NCBIGRCm39mm39
GRCm39 Ensembl7140,414,931 - 140,417,879 (+)Ensembl
GRCm387140,834,958 - 140,837,971 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,835,018 - 140,837,966 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,021,395 - 148,023,867 (+)NCBIGRCm37mm9NCBIm37
MGSCv367140,686,338 - 140,689,289 (+)NCBImm8
Celera7140,627,819 - 140,630,291 (+)NCBICelera
Cytogenetic Map7F4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrion  (HDA)
peroxisome  (IDA,ISM)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15747579   PMID:16141072   PMID:16141073   PMID:16462750   PMID:16742956   PMID:17085964  
PMID:20823251   PMID:21267068   PMID:21677750   PMID:21873635   PMID:30383838   PMID:31118497  


Genomics

Comparative Map Data
Urah
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,414,936 - 140,417,884 (+)NCBIGRCm39mm39
GRCm39 Ensembl7140,414,931 - 140,417,879 (+)Ensembl
GRCm387140,834,958 - 140,837,971 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,835,018 - 140,837,966 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,021,395 - 148,023,867 (+)NCBIGRCm37mm9NCBIm37
MGSCv367140,686,338 - 140,689,289 (+)NCBImm8
Celera7140,627,819 - 140,630,291 (+)NCBICelera
Cytogenetic Map7F4NCBI
URAHP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1690,039,761 - 90,047,773 (-)EnsemblGRCh38hg38GRCh38
GRCh381690,039,761 - 90,047,783 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371690,106,169 - 90,114,191 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361688,637,096 - 88,641,692 (-)NCBINCBI36hg18NCBI36
Celera1675,170,699 - 75,178,567 (-)NCBI
Cytogenetic Map16q24.3NCBI
HuRef1675,797,784 - 75,805,903 (-)NCBIHuRef
CHM1_11691,517,951 - 91,525,969 (-)NCBICHM1_1


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127757504145441459Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111564398145441459Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119530844145441459Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111564398145441459Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127844414145441459Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111564398145441459Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7117032360145441459Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7113321003145441459Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7119094158144844577Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7111365511145365612Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112950524145441459Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7110108163144108163Mouse
13207594Nigsq1_mneuroglucopenia-induced glucagon secretion QTL 1 (mouse)7127436844145441459Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7111365511145365612Mouse
14746988Manh63_mmandible shape 63 (mouse)7128181700145441459Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7110108163144108163Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7110108163144108163Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:396
Count of miRNA genes:282
Interacting mature miRNAs:307
Transcripts:ENSMUST00000026554, ENSMUST00000106050, ENSMUST00000127986
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001347605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001359805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_029821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA510160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC107815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP776625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY145477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ225768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000026554   ⟹   ENSMUSP00000026554
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,415,192 - 140,417,879 (+)Ensembl
GRCm38.p6 Ensembl7140,835,279 - 140,837,966 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106050   ⟹   ENSMUSP00000101665
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,414,931 - 140,417,800 (+)Ensembl
GRCm38.p6 Ensembl7140,835,018 - 140,837,887 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127986
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,415,247 - 140,416,981 (+)Ensembl
GRCm38.p6 Ensembl7140,835,334 - 140,837,068 (+)Ensembl
RefSeq Acc Id: ENSMUST00000185612   ⟹   ENSMUSP00000140559
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,415,210 - 140,417,879 (+)Ensembl
GRCm38.p6 Ensembl7140,835,297 - 140,837,966 (+)Ensembl
RefSeq Acc Id: ENSMUST00000209978   ⟹   ENSMUSP00000147888
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,415,537 - 140,417,697 (+)Ensembl
GRCm38.p6 Ensembl7140,835,624 - 140,837,784 (+)Ensembl
RefSeq Acc Id: ENSMUST00000210916   ⟹   ENSMUSP00000147435
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,415,555 - 140,417,858 (+)Ensembl
GRCm38.p6 Ensembl7140,835,642 - 140,837,945 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211372   ⟹   ENSMUSP00000147522
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,415,185 - 140,417,879 (+)Ensembl
GRCm38.p6 Ensembl7140,835,272 - 140,837,966 (+)Ensembl
RefSeq Acc Id: NM_001347605   ⟹   NP_001334534
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,415,051 - 140,417,884 (+)NCBI
GRCm387140,835,138 - 140,837,971 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001359805   ⟹   NP_001346734
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,415,192 - 140,417,884 (+)NCBI
GRCm387140,835,279 - 140,837,971 (+)NCBI
Sequence:
RefSeq Acc Id: NM_029821   ⟹   NP_084097
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,415,192 - 140,417,884 (+)NCBI
GRCm387140,835,279 - 140,837,971 (+)NCBI
MGSCv377148,021,395 - 148,023,867 (+)RGD
Celera7140,627,819 - 140,630,291 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030243092   ⟹   XP_030098952
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,414,936 - 140,417,881 (+)NCBI
GRCm387140,834,958 - 140,837,968 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030243093   ⟹   XP_030098953
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,415,192 - 140,417,881 (+)NCBI
GRCm387140,835,279 - 140,837,968 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036153556   ⟹   XP_036009449
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,415,205 - 140,417,881 (+)NCBI
RefSeq Acc Id: XM_036153557   ⟹   XP_036009450
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,415,187 - 140,417,881 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_084097   ⟸   NM_029821
- Peptide Label: isoform 2
- UniProtKB: Q9CRB3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030098952   ⟸   XM_030243092
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001334534   ⟸   NM_001347605
- Peptide Label: isoform 1
- UniProtKB: A0A0A0MQC3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001346734   ⟸   NM_001359805
- Peptide Label: isoform 2
RefSeq Acc Id: XP_030098953   ⟸   XM_030243093
- Peptide Label: isoform X3
RefSeq Acc Id: ENSMUSP00000026554   ⟸   ENSMUST00000026554
RefSeq Acc Id: ENSMUSP00000147522   ⟸   ENSMUST00000211372
RefSeq Acc Id: ENSMUSP00000140559   ⟸   ENSMUST00000185612
RefSeq Acc Id: ENSMUSP00000147435   ⟸   ENSMUST00000210916
RefSeq Acc Id: ENSMUSP00000101665   ⟸   ENSMUST00000106050
RefSeq Acc Id: ENSMUSP00000147888   ⟸   ENSMUST00000209978
RefSeq Acc Id: XP_036009450   ⟸   XM_036153557
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036009449   ⟸   XM_036153556
- Peptide Label: isoform X2
Protein Domains
TR_THY

Promoters
RGD ID:8666021
Promoter ID:EPDNEW_M11042
Type:initiation region
Name:Urah_1
Description:Mus musculus urate (5-hydroxyiso-) hydrolase , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11043  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387140,835,236 - 140,835,296EPDNEW
RGD ID:8666023
Promoter ID:EPDNEW_M11043
Type:initiation region
Name:Urah_2
Description:Mus musculus urate (5-hydroxyiso-) hydrolase , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11042  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387140,835,591 - 140,835,651EPDNEW
RGD ID:6840375
Promoter ID:MM_KWN:53186
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Liver,   Lung
Transcripts:ENSMUST00000106050,   OTTMUST00000060194,   OTTMUST00000060195
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367148,020,981 - 148,021,481 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916142 AgrOrtholog
Ensembl Genes ENSMUSG00000025481 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000026554 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000101665 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000140559 UniProtKB/Swiss-Prot
  ENSMUSP00000147435 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000147522 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000147888 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026554 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000106050 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000185612 UniProtKB/Swiss-Prot
  ENSMUST00000209978 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000210916 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000211372 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Hydroxyisourate_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transthyretin/HIU_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transthyretin/HIU_hydrolase_d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transthyretin/HIU_hydrolase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transthyretin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:76974 UniProtKB/Swiss-Prot
MGD MGI:1916142 ENTREZGENE
NCBI Gene 76974 ENTREZGENE
PANTHER PTHR10395 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Transthyretin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Urah PhenoGen
PRINTS TRNSTHYRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRANSTHYRETIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TR_THY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49472 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs hdxy_isourate UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MQC3 ENTREZGENE, UniProtKB/TrEMBL
  A0A1B0GR99_MOUSE UniProtKB/TrEMBL
  A0A1B0GSD0_MOUSE UniProtKB/TrEMBL
  HIUH_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-02 Urah  urate (5-hydroxyiso-) hydrolase  1190003J15Rik  RIKEN cDNA 1190003J15 gene  Symbol and/or name change 5135510 APPROVED