LTK (leukocyte receptor tyrosine kinase) - Rat Genome Database
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Gene: LTK (leukocyte receptor tyrosine kinase) Homo sapiens
Analyze
Symbol: LTK
Name: leukocyte receptor tyrosine kinase
RGD ID: 1319608
HGNC Page HGNC
Description: Exhibits protein kinase activity. Involved in several processes, including cellular response to retinoic acid; phosphatidylinositol 3-kinase signaling; and regulation of apoptotic process. Localizes to membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: leukocyte tyrosine kinase receptor; protein tyrosine kinase 1; TYK1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1541,503,637 - 41,513,887 (-)EnsemblGRCh38hg38GRCh38
GRCh381541,503,637 - 41,513,887 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371541,795,835 - 41,806,025 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361539,583,132 - 39,593,369 (-)NCBINCBI36hg18NCBI36
Build 341539,583,131 - 39,593,369NCBI
Celera1518,563,799 - 18,574,044 (-)NCBI
Cytogenetic Map15q15.1NCBI
HuRef1518,644,053 - 18,654,294 (-)NCBIHuRef
CHM1_11541,914,406 - 41,924,652 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1655406   PMID:2156206   PMID:2320375   PMID:2836739   PMID:7650032   PMID:7685902   PMID:7851890   PMID:8084603   PMID:8427607   PMID:8910363   PMID:8995435   PMID:9223670  
PMID:10445845   PMID:12107410   PMID:12237455   PMID:12477932   PMID:14695357   PMID:16344560   PMID:17910947   PMID:19815557   PMID:21873635   PMID:22347506   PMID:24104479   PMID:25331893  
PMID:26418745   PMID:26630010   PMID:28065597   PMID:31227593   PMID:31586073   PMID:31753913  


Genomics

Comparative Map Data
LTK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1541,503,637 - 41,513,887 (-)EnsemblGRCh38hg38GRCh38
GRCh381541,503,637 - 41,513,887 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371541,795,835 - 41,806,025 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361539,583,132 - 39,593,369 (-)NCBINCBI36hg18NCBI36
Build 341539,583,131 - 39,593,369NCBI
Celera1518,563,799 - 18,574,044 (-)NCBI
Cytogenetic Map15q15.1NCBI
HuRef1518,644,053 - 18,654,294 (-)NCBIHuRef
CHM1_11541,914,406 - 41,924,652 (-)NCBICHM1_1
Ltk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392119,581,807 - 119,590,912 (-)NCBIGRCm39mm39
GRCm39 Ensembl2119,581,801 - 119,590,912 (-)Ensembl
GRCm382119,751,326 - 119,760,431 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2119,751,320 - 119,760,431 (-)EnsemblGRCm38mm10GRCm38
MGSCv372119,577,062 - 119,586,167 (-)NCBIGRCm37mm9NCBIm37
MGSCv362119,442,767 - 119,451,872 (-)NCBImm8
Celera2120,907,813 - 120,917,057 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.97NCBI
Ltk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23106,734,675 - 106,741,552 (-)NCBI
Rnor_6.0 Ensembl3111,553,680 - 111,560,556 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03111,553,679 - 111,560,556 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03118,102,134 - 118,109,011 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43106,266,245 - 106,273,122 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13106,162,954 - 106,174,551 (-)NCBI
Celera3105,645,555 - 105,652,432 (-)NCBICelera
Cytogenetic Map3q35NCBI
Ltk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554168,310,304 - 8,319,463 (-)NCBIChiLan1.0ChiLan1.0
LTK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11538,685,255 - 38,695,381 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1538,685,255 - 38,695,381 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01520,444,471 - 20,455,586 (-)NCBIMhudiblu_PPA_v0panPan3
LTK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1308,541,328 - 8,550,108 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha308,600,243 - 8,608,930 (-)NCBI
ROS_Cfam_1.0308,675,659 - 8,684,364 (-)NCBI
UMICH_Zoey_3.1308,596,963 - 8,605,660 (-)NCBI
UNSW_CanFamBas_1.0308,704,371 - 8,709,292 (-)NCBI
UU_Cfam_GSD_1.0308,836,123 - 8,844,819 (-)NCBI
Ltk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2NW_02440864087,000,904 - 87,010,026 (-)NCBI
SpeTri2.0NW_0049364714,849,261 - 4,857,892 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11129,863,837 - 129,867,254 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21144,931,290 - 144,938,987 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LTK
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12641,489,867 - 41,502,314 (+)NCBI
ChlSab1.1 Ensembl2641,490,902 - 41,501,956 (+)Ensembl
Ltk
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248048,664,682 - 8,673,686 (-)NCBI

Position Markers
G06356  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371541,795,417 - 41,795,745UniSTSGRCh37
Build 361539,582,709 - 39,583,037RGDNCBI36
Celera1518,563,376 - 18,563,704RGD
Cytogenetic Map15q15.1-q21.1UniSTS
Cytogenetic Map15q15.1UniSTS
HuRef1518,643,630 - 18,643,958UniSTS
RH80861  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371541,795,938 - 41,796,171UniSTSGRCh37
Build 361539,583,230 - 39,583,463RGDNCBI36
Celera1518,563,897 - 18,564,130RGD
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map15q15.1-q21.1UniSTS
HuRef1518,644,151 - 18,644,384UniSTS
GeneMap99-GB4 RH Map15147.62UniSTS
STS-X54938  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371541,795,364 - 41,795,577UniSTSGRCh37
GRCh371541,795,553 - 41,795,711UniSTSGRCh37
Build 361539,582,656 - 39,582,869RGDNCBI36
Celera1518,563,323 - 18,563,536RGD
Celera1518,563,512 - 18,563,670UniSTS
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map15q15.1-q21.1UniSTS
HuRef1518,643,766 - 18,643,924UniSTS
HuRef1518,643,577 - 18,643,790UniSTS
GeneMap99-GB4 RH Map15142.68UniSTS
NCBI RH Map1582.0UniSTS
STS-T16315  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371541,795,592 - 41,795,720UniSTSGRCh37
Build 361539,582,884 - 39,583,012RGDNCBI36
Celera1518,563,551 - 18,563,679RGD
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map15q15.1-q21.1UniSTS
HuRef1518,643,805 - 18,643,933UniSTS
GeneMap99-GB4 RH Map15146.46UniSTS
NCBI RH Map15109.9UniSTS
RH78391  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371541,795,556 - 41,795,683UniSTSGRCh37
Build 361539,582,848 - 39,582,975RGDNCBI36
Celera1518,563,515 - 18,563,642RGD
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map15q15.1-q21.1UniSTS
HuRef1518,643,769 - 18,643,896UniSTS
GeneMap99-GB4 RH Map15146.51UniSTS
NCBI RH Map15109.9UniSTS
SHGC-30069  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371541,795,620 - 41,795,745UniSTSGRCh37
Build 361539,582,912 - 39,583,037RGDNCBI36
Celera1518,563,579 - 18,563,704RGD
Cytogenetic Map15q15.1-q21.1UniSTS
Cytogenetic Map15q15.1UniSTS
HuRef1518,643,833 - 18,643,958UniSTS
STS-X54938  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q15.1-q21.1UniSTS
Cytogenetic Map15q15.1UniSTS
GeneMap99-GB4 RH Map15145.7UniSTS
NCBI RH Map1582.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2197
Count of miRNA genes:694
Interacting mature miRNAs:807
Transcripts:ENST00000263800, ENST00000355166, ENST00000453182, ENST00000561619, ENST00000563518, ENST00000569283
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 224 46 12 9 290 7 50 53 24 13 47 515 1 37 1
Low 1833 1774 1512 534 1264 379 2336 1172 2328 252 993 917 159 954 1285 3 2
Below cutoff 374 1156 190 76 350 74 1915 957 1354 135 401 162 11 1 250 1451 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001135685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_206961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011521556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011521557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001751277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001751279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC016134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC087721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC045607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX329448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA394397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS542498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D16105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA452723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB331746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X60702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000263800   ⟹   ENSP00000263800
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1541,503,637 - 41,513,827 (-)Ensembl
RefSeq Acc Id: ENST00000355166   ⟹   ENSP00000347293
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1541,503,638 - 41,513,879 (-)Ensembl
RefSeq Acc Id: ENST00000453182   ⟹   ENSP00000392196
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1541,503,967 - 41,513,887 (-)Ensembl
RefSeq Acc Id: ENST00000561619   ⟹   ENSP00000458111
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1541,503,951 - 41,513,796 (-)Ensembl
RefSeq Acc Id: ENST00000563518
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1541,503,642 - 41,513,860 (-)Ensembl
RefSeq Acc Id: ENST00000569283
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1541,505,258 - 41,508,236 (-)Ensembl
RefSeq Acc Id: NM_001135685   ⟹   NP_001129157
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381541,503,637 - 41,513,827 (-)NCBI
GRCh371541,795,840 - 41,806,085 (-)ENTREZGENE
HuRef1518,644,053 - 18,654,294 (-)ENTREZGENE
CHM1_11541,914,406 - 41,924,652 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002344   ⟹   NP_002335
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381541,503,637 - 41,513,827 (-)NCBI
GRCh371541,795,840 - 41,806,085 (-)ENTREZGENE
Build 361539,583,132 - 39,593,369 (-)NCBI Archive
HuRef1518,644,053 - 18,654,294 (-)ENTREZGENE
CHM1_11541,914,406 - 41,924,652 (-)NCBI
Sequence:
RefSeq Acc Id: NM_206961   ⟹   NP_996844
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381541,503,637 - 41,513,827 (-)NCBI
GRCh371541,795,840 - 41,806,085 (-)ENTREZGENE
Build 361539,583,132 - 39,593,369 (-)NCBI Archive
HuRef1518,644,053 - 18,654,294 (-)ENTREZGENE
CHM1_11541,914,406 - 41,924,652 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011521556   ⟹   XP_011519858
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381541,503,947 - 41,513,887 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011521557   ⟹   XP_011519859
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381541,503,947 - 41,513,887 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017022181   ⟹   XP_016877670
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381541,503,639 - 41,513,887 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017022182   ⟹   XP_016877671
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381541,503,947 - 41,513,887 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017022183   ⟹   XP_016877672
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381541,503,947 - 41,513,887 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024449918   ⟹   XP_024305686
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381541,503,947 - 41,513,887 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024449919   ⟹   XP_024305687
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381541,503,947 - 41,512,768 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001751277
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381541,503,947 - 41,513,887 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001751279
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381541,505,258 - 41,513,887 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001129157   ⟸   NM_001135685
- Peptide Label: isoform 3 precursor
- UniProtKB: P29376 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_996844   ⟸   NM_206961
- Peptide Label: isoform 2 precursor
- UniProtKB: P29376 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_002335   ⟸   NM_002344
- Peptide Label: isoform 1 precursor
- UniProtKB: P29376 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011519859   ⟸   XM_011521557
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_011519858   ⟸   XM_011521556
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016877670   ⟸   XM_017022181
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016877671   ⟸   XM_017022182
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016877672   ⟸   XM_017022183
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_024305686   ⟸   XM_024449918
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_024305687   ⟸   XM_024449919
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSP00000392196   ⟸   ENST00000453182
RefSeq Acc Id: ENSP00000458111   ⟸   ENST00000561619
RefSeq Acc Id: ENSP00000347293   ⟸   ENST00000355166
RefSeq Acc Id: ENSP00000263800   ⟸   ENST00000263800
Protein Domains
Protein kinase

Promoters
RGD ID:6792427
Promoter ID:HG_KWN:21091
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000360087,   NM_001135685,   UC001ZOA.2,   UC001ZOB.2
Position:
Human AssemblyChrPosition (strand)Source
Build 361539,593,234 - 39,593,734 (-)MPROMDB
RGD ID:7229187
Promoter ID:EPDNEW_H20339
Type:initiation region
Name:LTK_1
Description:leukocyte receptor tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381541,513,827 - 41,513,887EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001135685.1(LTK):c.457G>A (p.Gly153Arg) single nucleotide variant Malignant melanoma [RCV000070751] Chr15:41512168 [GRCh38]
Chr15:41804366 [GRCh37]
Chr15:39591658 [NCBI36]
Chr15:15q15.1
not provided
NM_001135685.1(LTK):c.429C>T (p.Phe143=) single nucleotide variant Malignant melanoma [RCV000070752] Chr15:41512196 [GRCh38]
Chr15:41804394 [GRCh37]
Chr15:39591686 [NCBI36]
Chr15:15q15.1
not provided
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q15.1-21.2(chr15:41689327-52446981)x1 copy number loss See cases [RCV000448968] Chr15:41689327..52446981 [GRCh37]
Chr15:15q15.1-21.2
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q14-15.1 chr15:34638237..42057083 complex variant complex Spindle cell sarcoma [RCV000714282] Chr15:34640169..42054561 [GRCh37]
Chr15:15q14-15.1
pathogenic
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3
pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
NM_002344.6(LTK):c.2447G>C (p.Arg816Thr) single nucleotide variant not provided [RCV000761904] Chr15:41504144 [GRCh38]
Chr15:41796342 [GRCh37]
Chr15:15q15.1
uncertain significance
NM_002344.6(LTK):c.203G>T (p.Trp68Leu) single nucleotide variant not provided [RCV000761905] Chr15:41512863 [GRCh38]
Chr15:41805061 [GRCh37]
Chr15:15q15.1
uncertain significance
NM_002344.6(LTK):c.2437G>T (p.Glu813Ter) single nucleotide variant not provided [RCV000972175] Chr15:41504154 [GRCh38]
Chr15:41796352 [GRCh37]
Chr15:15q15.1
likely benign
NM_002344.6(LTK):c.1170A>G (p.Gln390=) single nucleotide variant not provided [RCV000900892] Chr15:41508148 [GRCh38]
Chr15:41800346 [GRCh37]
Chr15:15q15.1
benign
NM_002344.6(LTK):c.1705C>A (p.Arg569Ser) single nucleotide variant not provided [RCV000966335] Chr15:41505523 [GRCh38]
Chr15:41797721 [GRCh37]
Chr15:15q15.1
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6721 AgrOrtholog
COSMIC LTK COSMIC
Ensembl Genes ENSG00000062524 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000263800 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000347293 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000392196 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000458111 UniProtKB/TrEMBL
Ensembl Transcript ENST00000263800 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000355166 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000453182 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000561619 UniProtKB/TrEMBL
GTEx ENSG00000062524 GTEx
HGNC ID HGNC:6721 ENTREZGENE
Human Proteome Map LTK Human Proteome Map
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4058 UniProtKB/Swiss-Prot
NCBI Gene 4058 ENTREZGENE
OMIM 151520 OMIM
PANTHER PTHR24416:SF294 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30483 PharmGKB
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R9Q5_HUMAN UniProtKB/TrEMBL
  H3BVG6_HUMAN UniProtKB/TrEMBL
  LTK_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q4G0N3_HUMAN UniProtKB/TrEMBL
UniProt Secondary A6NNJ8 UniProtKB/Swiss-Prot
  B4DL89 UniProtKB/Swiss-Prot
  E9PFX4 UniProtKB/Swiss-Prot