FEM1C (fem-1 homolog C) - Rat Genome Database

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Gene: FEM1C (fem-1 homolog C) Homo sapiens
Analyze
Symbol: FEM1C
Name: fem-1 homolog C
RGD ID: 1319607
HGNC Page HGNC:16933
Description: Enables ubiquitin ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in cytosol and nucleoplasm. Part of Cul2-RING ubiquitin ligase complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EUROIMAGE686608; EUROIMAGE783647; fem-1 homolog c (C. elegans); fem-1 homolog c (c.elegans); FEM1-gamma; FEM1A; KIAA1785; protein fem-1 homolog C
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385115,520,908 - 115,544,775 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5115,520,908 - 115,544,775 (-)EnsemblGRCh38hg38GRCh38
GRCh375114,856,605 - 114,880,472 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365114,884,507 - 114,908,490 (-)NCBINCBI36Build 36hg18NCBI36
Build 345114,884,506 - 114,908,490NCBI
Celera5110,805,894 - 110,829,879 (-)NCBICelera
Cytogenetic Map5q22.3NCBI
HuRef5110,038,231 - 110,062,214 (-)NCBIHuRef
CHM1_15114,289,245 - 114,313,228 (-)NCBICHM1_1
T2T-CHM13v2.05116,033,707 - 116,057,577 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Autism  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11347906   PMID:11733146   PMID:12477932   PMID:14527725   PMID:18757445   PMID:19322201   PMID:19615732   PMID:21145461   PMID:21873635   PMID:21988832   PMID:25416956   PMID:26138980  
PMID:27565346   PMID:28118078   PMID:28514442   PMID:28786561   PMID:29775578   PMID:29779948   PMID:30720688   PMID:31253590   PMID:32296183   PMID:32707033   PMID:33398168   PMID:33398170  
PMID:33961781  


Genomics

Comparative Map Data
FEM1C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385115,520,908 - 115,544,775 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5115,520,908 - 115,544,775 (-)EnsemblGRCh38hg38GRCh38
GRCh375114,856,605 - 114,880,472 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365114,884,507 - 114,908,490 (-)NCBINCBI36Build 36hg18NCBI36
Build 345114,884,506 - 114,908,490NCBI
Celera5110,805,894 - 110,829,879 (-)NCBICelera
Cytogenetic Map5q22.3NCBI
HuRef5110,038,231 - 110,062,214 (-)NCBIHuRef
CHM1_15114,289,245 - 114,313,228 (-)NCBICHM1_1
T2T-CHM13v2.05116,033,707 - 116,057,577 (-)NCBIT2T-CHM13v2.0
Fem1c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391846,637,673 - 46,659,038 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1846,634,813 - 46,659,038 (-)EnsemblGRCm39 Ensembl
GRCm381846,504,606 - 46,525,971 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1846,501,746 - 46,525,971 (-)EnsemblGRCm38mm10GRCm38
MGSCv371846,664,260 - 46,685,625 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361846,629,937 - 46,651,302 (-)NCBIMGSCv36mm8
Celera1847,864,874 - 47,886,277 (-)NCBICelera
Cytogenetic Map18CNCBI
cM Map1824.62NCBI
Fem1c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81841,419,511 - 41,445,300 (-)NCBIGRCr8
mRatBN7.21839,232,900 - 39,258,692 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1839,232,900 - 39,258,692 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1841,266,128 - 41,291,917 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01841,968,370 - 41,994,160 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01839,761,485 - 39,787,275 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01840,493,156 - 40,518,988 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1840,493,156 - 40,518,988 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01840,147,977 - 40,173,809 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41840,710,247 - 40,740,448 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11840,754,604 - 40,777,989 (-)NCBI
Celera1837,484,817 - 37,510,604 (-)NCBICelera
Cytogenetic Map18q11NCBI
Fem1c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540835,291,685 - 35,316,330 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540835,291,791 - 35,315,628 (-)NCBIChiLan1.0ChiLan1.0
FEM1C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24110,769,034 - 110,823,393 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15108,922,695 - 108,977,054 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05110,878,460 - 110,902,650 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15116,675,163 - 116,699,085 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5116,675,163 - 116,699,085 (-)Ensemblpanpan1.1panPan2
FEM1C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1115,248,564 - 5,271,370 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl115,180,798 - 5,271,891 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha115,397,620 - 5,422,864 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0115,239,025 - 5,264,290 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl115,239,028 - 5,264,277 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1115,194,370 - 5,219,592 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0115,263,388 - 5,288,834 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0115,517,087 - 5,542,313 (-)NCBIUU_Cfam_GSD_1.0
Fem1c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213127,977,400 - 128,005,204 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936742677,746 - 705,350 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936742678,171 - 706,019 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FEM1C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2119,699,598 - 119,722,806 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12119,699,594 - 119,723,040 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22124,598,704 - 124,600,560 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FEM1C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12318,773,359 - 18,797,316 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2318,771,956 - 18,797,128 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603459,600,709 - 59,624,705 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fem1c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247336,380,506 - 6,413,006 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FEM1C
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q22.3(chr5:114504911-115696544)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053647]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053647]|See cases [RCV000053647] Chr5:114504911..115696544 [GRCh38]
Chr5:113840608..115032241 [GRCh37]
Chr5:113868507..115060140 [NCBI36]
Chr5:5q22.3
benign
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
NM_020177.2(FEM1C):c.545-3300G>A single nucleotide variant Lung cancer [RCV000095216] Chr5:115528917 [GRCh38]
Chr5:114864614 [GRCh37]
Chr5:5q22.3
uncertain significance
NM_020177.2(FEM1C):c.544+4687G>C single nucleotide variant Lung cancer [RCV000095217] Chr5:115538263 [GRCh38]
Chr5:114873960 [GRCh37]
Chr5:5q22.3
uncertain significance
NM_020177.3(FEM1C):c.376G>A (p.Asp126Asn) single nucleotide variant not provided [RCV003126350] Chr5:115543118 [GRCh38]
Chr5:114878815 [GRCh37]
Chr5:5q22.3
uncertain significance
GRCh38/hg38 5q21.3-23.1(chr5:108585264-116815075)x1 copy number loss See cases [RCV000133813] Chr5:108585264..116815075 [GRCh38]
Chr5:107920965..116150771 [GRCh37]
Chr5:107948864..116178670 [NCBI36]
Chr5:5q21.3-23.1
pathogenic
GRCh38/hg38 5q22.3-23.2(chr5:114707561-126507744)x1 copy number loss See cases [RCV000134895] Chr5:114707561..126507744 [GRCh38]
Chr5:114043258..125843436 [GRCh37]
Chr5:114071157..125871335 [NCBI36]
Chr5:5q22.3-23.2
pathogenic
GRCh38/hg38 5q21.3-23.1(chr5:107002209-118025316)x1 copy number loss See cases [RCV000135699] Chr5:107002209..118025316 [GRCh38]
Chr5:106337910..117361011 [GRCh37]
Chr5:106365809..117388910 [NCBI36]
Chr5:5q21.3-23.1
pathogenic
GRCh38/hg38 5q22.1-23.2(chr5:111463016-127193038)x1 copy number loss See cases [RCV000135549] Chr5:111463016..127193038 [GRCh38]
Chr5:110798714..126528730 [GRCh37]
Chr5:110826613..126556629 [NCBI36]
Chr5:5q22.1-23.2
pathogenic
GRCh38/hg38 5q22.3-23.1(chr5:115387674-115916830)x1 copy number loss See cases [RCV000137739] Chr5:115387674..115916830 [GRCh38]
Chr5:114723371..115252527 [GRCh37]
Chr5:114751270..115280426 [NCBI36]
Chr5:5q22.3-23.1
uncertain significance
GRCh38/hg38 5q22.1-23.3(chr5:110687442-130103838)x1 copy number loss See cases [RCV000139235] Chr5:110687442..130103838 [GRCh38]
Chr5:110023143..129439531 [GRCh37]
Chr5:110051042..129467430 [NCBI36]
Chr5:5q22.1-23.3
pathogenic|uncertain significance
GRCh38/hg38 5q22.3(chr5:115320895-115754204)x1 copy number loss See cases [RCV000138950] Chr5:115320895..115754204 [GRCh38]
Chr5:114656592..115089901 [GRCh37]
Chr5:114684491..115117800 [NCBI36]
Chr5:5q22.3
uncertain significance
GRCh38/hg38 5q14.3-23.3(chr5:90374606-128076423)x1 copy number loss See cases [RCV000139893] Chr5:90374606..128076423 [GRCh38]
Chr5:89670423..127412115 [GRCh37]
Chr5:89706179..127440014 [NCBI36]
Chr5:5q14.3-23.3
pathogenic
GRCh38/hg38 5q14.3-23.1(chr5:92899734-119614119)x1 copy number loss See cases [RCV000141252] Chr5:92899734..119614119 [GRCh38]
Chr5:92235441..118949814 [GRCh37]
Chr5:92261197..118977713 [NCBI36]
Chr5:5q14.3-23.1
pathogenic
GRCh38/hg38 5q22.2-23.1(chr5:112323517-117773507)x1 copy number loss See cases [RCV000140791] Chr5:112323517..117773507 [GRCh38]
Chr5:111659214..117109202 [GRCh37]
Chr5:111687113..117137101 [NCBI36]
Chr5:5q22.2-23.1
pathogenic
GRCh38/hg38 5q21.3-23.2(chr5:108308463-125777797)x1 copy number loss See cases [RCV000143326] Chr5:108308463..125777797 [GRCh38]
Chr5:107644164..125113490 [GRCh37]
Chr5:107672063..125141389 [NCBI36]
Chr5:5q21.3-23.2
pathogenic
GRCh38/hg38 5q14.3-31.1(chr5:91411708-131319563)x1 copy number loss See cases [RCV000143746] Chr5:91411708..131319563 [GRCh38]
Chr5:90707525..130655256 [GRCh37]
Chr5:90743281..130683155 [NCBI36]
Chr5:5q14.3-31.1
pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
GRCh37/hg19 5q22.1-23.2(chr5:110407606-122522885)x1 copy number loss See cases [RCV000446959] Chr5:110407606..122522885 [GRCh37]
Chr5:5q22.1-23.2
pathogenic
GRCh37/hg19 5q21.1-23.2(chr5:100607918-125900735)x1 copy number loss See cases [RCV000445968] Chr5:100607918..125900735 [GRCh37]
Chr5:5q21.1-23.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NM_020177.3(FEM1C):c.440G>A (p.Arg147Gln) single nucleotide variant Inborn genetic diseases [RCV003282935] Chr5:115543054 [GRCh38]
Chr5:114878751 [GRCh37]
Chr5:5q22.3
uncertain significance
NM_020177.3(FEM1C):c.189A>T (p.Gln63His) single nucleotide variant Inborn genetic diseases [RCV003262658] Chr5:115543305 [GRCh38]
Chr5:114879002 [GRCh37]
Chr5:5q22.3
uncertain significance
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV002231249]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
Single allele duplication Autism [RCV000754292] Chr5:114046360..118610426 [GRCh38]
Chr5:5q22.3-23.1
likely pathogenic
GRCh37/hg19 5q14.3-23.3(chr5:89949118-129317455)x3 copy number gain not provided [RCV000849289] Chr5:89949118..129317455 [GRCh37]
Chr5:5q14.3-23.3
pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
NM_020177.3(FEM1C):c.1462C>T (p.Leu488=) single nucleotide variant not provided [RCV000960856] Chr5:115524700 [GRCh38]
Chr5:114860397 [GRCh37]
Chr5:5q22.3
benign
GRCh37/hg19 5q21.3-23.1(chr5:108304806-121335239)x1 copy number loss not provided [RCV000846246] Chr5:108304806..121335239 [GRCh37]
Chr5:5q21.3-23.1
pathogenic
NM_020177.3(FEM1C):c.376G>C (p.Asp126His) single nucleotide variant not provided [RCV003232032] Chr5:115543118 [GRCh38]
Chr5:114878815 [GRCh37]
Chr5:5q22.3
uncertain significance
GRCh37/hg19 5q22.1-23.1(chr5:111443783-116255660) copy number loss not specified [RCV002053518] Chr5:111443783..116255660 [GRCh37]
Chr5:5q22.1-23.1
pathogenic
GRCh37/hg19 5q21.1-23.2(chr5:100607918-125900735) copy number loss not specified [RCV002053515] Chr5:100607918..125900735 [GRCh37]
Chr5:5q21.1-23.2
pathogenic
GRCh37/hg19 5q15-22.3(chr5:93650000-114969108) copy number loss not specified [RCV002053511] Chr5:93650000..114969108 [GRCh37]
Chr5:5q15-22.3
pathogenic
NM_020177.3(FEM1C):c.1103A>G (p.Gln368Arg) single nucleotide variant not provided [RCV003123301] Chr5:115525059 [GRCh38]
Chr5:114860756 [GRCh37]
Chr5:5q22.3
uncertain significance
NM_020177.3(FEM1C):c.685A>G (p.Ile229Val) single nucleotide variant Inborn genetic diseases [RCV003286622] Chr5:115525477 [GRCh38]
Chr5:114861174 [GRCh37]
Chr5:5q22.3
uncertain significance
NM_020177.3(FEM1C):c.160C>T (p.Leu54Phe) single nucleotide variant Inborn genetic diseases [RCV002772441] Chr5:115543334 [GRCh38]
Chr5:114879031 [GRCh37]
Chr5:5q22.3
uncertain significance
GRCh37/hg19 5q22.2-23.3(chr5:112557391-128106299)x1 copy number loss not provided [RCV002475732] Chr5:112557391..128106299 [GRCh37]
Chr5:5q22.2-23.3
pathogenic
NM_020177.3(FEM1C):c.1072A>G (p.Ile358Val) single nucleotide variant Inborn genetic diseases [RCV002884888] Chr5:115525090 [GRCh38]
Chr5:114860787 [GRCh37]
Chr5:5q22.3
uncertain significance
NM_020177.3(FEM1C):c.1526A>G (p.Gln509Arg) single nucleotide variant Inborn genetic diseases [RCV002986456] Chr5:115524636 [GRCh38]
Chr5:114860333 [GRCh37]
Chr5:5q22.3
uncertain significance
NM_020177.3(FEM1C):c.166A>G (p.Met56Val) single nucleotide variant Inborn genetic diseases [RCV002709741] Chr5:115543328 [GRCh38]
Chr5:114879025 [GRCh37]
Chr5:5q22.3
uncertain significance
NM_020177.3(FEM1C):c.1297G>C (p.Ala433Pro) single nucleotide variant Inborn genetic diseases [RCV002813112] Chr5:115524865 [GRCh38]
Chr5:114860562 [GRCh37]
Chr5:5q22.3
uncertain significance
NM_020177.3(FEM1C):c.168G>T (p.Met56Ile) single nucleotide variant Inborn genetic diseases [RCV003189880] Chr5:115543326 [GRCh38]
Chr5:114879023 [GRCh37]
Chr5:5q22.3
uncertain significance
NM_020177.3(FEM1C):c.1138G>A (p.Ala380Thr) single nucleotide variant Inborn genetic diseases [RCV003191699] Chr5:115525024 [GRCh38]
Chr5:114860721 [GRCh37]
Chr5:5q22.3
uncertain significance
NM_020177.3(FEM1C):c.928G>A (p.Gly310Ser) single nucleotide variant Inborn genetic diseases [RCV003309172] Chr5:115525234 [GRCh38]
Chr5:114860931 [GRCh37]
Chr5:5q22.3
uncertain significance
NM_020177.3(FEM1C):c.1693A>G (p.Ser565Gly) single nucleotide variant Inborn genetic diseases [RCV003367109] Chr5:115524469 [GRCh38]
Chr5:114860166 [GRCh37]
Chr5:5q22.3
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1046
Count of miRNA genes:648
Interacting mature miRNAs:732
Transcripts:ENST00000274457
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH65256  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375114,857,112 - 114,857,250UniSTSGRCh37
Build 365114,885,011 - 114,885,149RGDNCBI36
Celera5110,806,398 - 110,806,536RGD
Cytogenetic Map5q22UniSTS
HuRef5110,038,735 - 110,038,873UniSTS
G43610  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375114,856,636 - 114,856,736UniSTSGRCh37
Build 365114,884,535 - 114,884,635RGDNCBI36
Celera5110,805,922 - 110,806,022RGD
Cytogenetic Map5q22UniSTS
HuRef5110,038,259 - 110,038,359UniSTS
FEM1C  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375114,860,153 - 114,860,444UniSTSGRCh37
Celera5110,809,439 - 110,809,730UniSTS
HuRef5110,041,776 - 110,042,067UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2099 2157 758 257 1443 210 3894 1650 1707 250 1279 1336 61 1149 2432 3
Low 338 833 968 367 508 255 463 546 2027 169 181 277 114 1 55 356 3 2
Below cutoff 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_020177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB058688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC010226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF391093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK025265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL050087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL110246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL365409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL365415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL831817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY249188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  W07603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000274457   ⟹   ENSP00000274457
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5115,520,908 - 115,544,775 (-)Ensembl
RefSeq Acc Id: NM_020177   ⟹   NP_064562
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385115,520,908 - 115,544,775 (-)NCBI
GRCh375114,856,605 - 114,880,591 (-)NCBI
Build 365114,884,507 - 114,908,490 (-)NCBI Archive
Celera5110,805,894 - 110,829,879 (-)RGD
HuRef5110,038,231 - 110,062,214 (-)ENTREZGENE
CHM1_15114,289,245 - 114,313,228 (-)NCBI
T2T-CHM13v2.05116,033,707 - 116,057,577 (-)NCBI
Sequence:
RefSeq Acc Id: NP_064562   ⟸   NM_020177
- UniProtKB: Q9NPL6 (UniProtKB/Swiss-Prot),   Q9H704 (UniProtKB/Swiss-Prot),   Q8N3V8 (UniProtKB/Swiss-Prot),   B2RE47 (UniProtKB/Swiss-Prot),   Q9NPL9 (UniProtKB/Swiss-Prot),   Q96JP0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000274457   ⟸   ENST00000274457

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96JP0-F1-model_v2 AlphaFold Q96JP0 1-617 view protein structure

Promoters
RGD ID:6814744
Promoter ID:HG_XEF:6446
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid,   NB4
Transcripts:NM_001096694
Position:
Human AssemblyChrPosition (strand)Source
Build 365114,907,456 - 114,907,956 (-)MPROMDB
RGD ID:6803197
Promoter ID:HG_KWN:50849
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000250857
Position:
Human AssemblyChrPosition (strand)Source
Build 365114,907,996 - 114,908,496 (-)MPROMDB
RGD ID:6870310
Promoter ID:EPDNEW_H8320
Type:initiation region
Name:FEM1C_1
Description:fem-1 homolog C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385115,544,775 - 115,544,835EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16933 AgrOrtholog
COSMIC FEM1C COSMIC
Ensembl Genes ENSG00000145780 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000274457 ENTREZGENE
  ENST00000274457.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
  1.25.40.20 UniProtKB/Swiss-Prot
GTEx ENSG00000145780 GTEx
HGNC ID HGNC:16933 ENTREZGENE
Human Proteome Map FEM1C Human Proteome Map
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
KEGG Report hsa:56929 UniProtKB/Swiss-Prot
NCBI Gene 56929 ENTREZGENE
OMIM 608767 OMIM
PANTHER ANKYRIN REPEAT CONTAINING UniProtKB/Swiss-Prot
  ANKYRIN REPEAT DOMAIN 16 UniProtKB/Swiss-Prot
Pfam Ank UniProtKB/Swiss-Prot
  Ank_2 UniProtKB/Swiss-Prot
PharmGKB PA134891999 PharmGKB
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
UniProt B2RE47 ENTREZGENE
  FEM1C_HUMAN UniProtKB/Swiss-Prot
  Q8N3V8 ENTREZGENE
  Q96JP0 ENTREZGENE
  Q9H704 ENTREZGENE
  Q9NPL6 ENTREZGENE
  Q9NPL9 ENTREZGENE
UniProt Secondary B2RE47 UniProtKB/Swiss-Prot
  Q8N3V8 UniProtKB/Swiss-Prot
  Q9H704 UniProtKB/Swiss-Prot
  Q9NPL6 UniProtKB/Swiss-Prot
  Q9NPL9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-28 FEM1C  fem-1 homolog C    fem-1 homolog c (C. elegans)  Symbol and/or name change 5135510 APPROVED