CHRAC1 (chromatin accessibility complex subunit 1) - Rat Genome Database

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Gene: CHRAC1 (chromatin accessibility complex subunit 1) Homo sapiens
Analyze
Symbol: CHRAC1
Name: chromatin accessibility complex subunit 1
RGD ID: 1319606
HGNC Page HGNC
Description: Predicted to have protein heterodimerization activity. Predicted to be involved in DNA biosynthetic process. Predicted to localize to CHRAC.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CHARC1; CHARC15; CHRAC-1; CHRAC-15; CHRAC15; chromatin accessibility complex 1; chromatin accessibility complex 15 kDa protein; chromatin accessibility complex protein 1; DNA polymerase epsilon subunit p15; histone-fold protein CHRAC15; huCHRAC15; YCL1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC391707  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8140,511,311 - 140,517,154 (+)EnsemblGRCh38hg38GRCh38
GRCh388140,511,322 - 140,517,154 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378141,521,421 - 141,527,253 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368141,590,586 - 141,596,434 (+)NCBINCBI36hg18NCBI36
Build 348141,590,585 - 141,596,434NCBI
Celera8137,690,513 - 137,696,362 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8136,832,956 - 136,838,809 (+)NCBIHuRef
CHM1_18141,562,050 - 141,567,894 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10880450   PMID:11000277   PMID:12434153   PMID:12477932   PMID:14702039   PMID:14759371   PMID:15489334   PMID:16344560   PMID:19322201   PMID:19505873   PMID:21172662   PMID:21516116  
PMID:21832049   PMID:21873635   PMID:22242598   PMID:22863883   PMID:22939629   PMID:24148822   PMID:25416956   PMID:26344197   PMID:28319085   PMID:28514442   PMID:29509190   PMID:30021884  
PMID:30804502   PMID:31515488   PMID:32296183  


Genomics

Comparative Map Data
CHRAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8140,511,311 - 140,517,154 (+)EnsemblGRCh38hg38GRCh38
GRCh388140,511,322 - 140,517,154 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378141,521,421 - 141,527,253 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368141,590,586 - 141,596,434 (+)NCBINCBI36hg18NCBI36
Build 348141,590,585 - 141,596,434NCBI
Celera8137,690,513 - 137,696,362 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8136,832,956 - 136,838,809 (+)NCBIHuRef
CHM1_18141,562,050 - 141,567,894 (+)NCBICHM1_1
Chrac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391572,962,261 - 72,965,924 (+)NCBIGRCm39mm39
GRCm39 Ensembl1572,962,241 - 72,969,403 (+)Ensembl
GRCm381573,090,412 - 73,094,075 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1573,090,392 - 73,097,554 (+)EnsemblGRCm38mm10GRCm38
MGSCv371572,920,842 - 72,924,505 (+)NCBIGRCm37mm9NCBIm37
MGSCv361572,917,668 - 72,921,331 (+)NCBImm8
Celera1574,590,731 - 74,594,307 (+)NCBICelera
Cytogenetic Map15D3NCBI
Chrac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27105,013,047 - 105,016,435 (+)NCBI
Rnor_6.0 Ensembl7114,323,542 - 114,326,930 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07114,323,542 - 114,326,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07114,258,513 - 114,261,901 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47110,811,566 - 110,814,954 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17110,840,781 - 110,849,184 (+)NCBI
Celera7101,423,189 - 101,426,577 (+)NCBICelera
Cytogenetic Map7q34NCBI
Chrac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546114,185,737 - 14,189,645 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546114,184,318 - 14,189,645 (+)NCBIChiLan1.0ChiLan1.0
CHRAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18140,267,024 - 140,272,206 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8140,267,024 - 140,270,757 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08137,180,420 - 137,185,657 (+)NCBIMhudiblu_PPA_v0panPan3
CHRAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11335,162,189 - 35,164,286 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1335,161,767 - 35,164,101 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1335,020,252 - 35,038,381 (+)NCBI
ROS_Cfam_1.01335,545,762 - 35,563,889 (+)NCBI
UMICH_Zoey_3.11335,266,152 - 35,284,293 (+)NCBI
UNSW_CanFamBas_1.01335,356,128 - 35,374,272 (+)NCBI
UU_Cfam_GSD_1.01335,775,896 - 35,794,033 (+)NCBI
Chrac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053033,267,434 - 3,271,343 (-)NCBI
SpeTri2.0NW_00493647010,693,601 - 10,698,139 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl43,024,615 - 3,028,725 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.143,014,171 - 3,028,808 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.242,426,289 - 2,427,110 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHRAC1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18134,745,776 - 134,751,830 (+)NCBI
ChlSab1.1 Ensembl8134,746,549 - 134,752,018 (+)Ensembl
Chrac1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473515,843,539 - 15,862,700 (-)NCBI

Position Markers
SGC31771  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378141,526,645 - 141,526,775UniSTSGRCh37
Build 368141,595,827 - 141,595,957RGDNCBI36
Celera8137,695,755 - 137,695,885RGD
Cytogenetic Map8q24.3UniSTS
HuRef8136,838,202 - 136,838,332UniSTS
GeneMap99-GB4 RH Map8543.02UniSTS
Whitehead-RH Map8712.5UniSTS
CHRAC1__4568  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378141,526,603 - 141,527,446UniSTSGRCh37
Build 368141,595,785 - 141,596,628RGDNCBI36
Celera8137,695,713 - 137,696,556RGD
HuRef8136,838,160 - 136,839,003UniSTS
RH68212  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378141,526,541 - 141,526,640UniSTSGRCh37
Build 368141,595,723 - 141,595,822RGDNCBI36
Celera8137,695,651 - 137,695,750RGD
Cytogenetic Map8q24.3UniSTS
HuRef8136,838,098 - 136,838,197UniSTS
GeneMap99-GB4 RH Map8540.51UniSTS
NCBI RH Map81597.8UniSTS
D16S325  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q34.13UniSTS
Cytogenetic Map9q22.33UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map6q25.3UniSTS
Cytogenetic Map2q32.3UniSTS
Cytogenetic Map6q22UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map17q21.2-q21.3UniSTS
Cytogenetic Map13q14.3UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map2q33.3UniSTS
Cytogenetic Map20q13.32UniSTS
Cytogenetic Map1p21.2UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map12q13.2UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map12p13.32UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map5q35.3UniSTS
Cytogenetic Map1p13.1UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map4q25UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map7p22.2UniSTS
Cytogenetic Map7q33UniSTS
Cytogenetic Map1p31.3UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map6q13UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map10q11.2UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map3q13.32UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map6p22.3UniSTS
Cytogenetic Map12q22UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map3q22.1UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map6q25.2-q25.3UniSTS
Cytogenetic Map1p36.1UniSTS
Cytogenetic Map22q11.2UniSTS
Cytogenetic Map3q26.31UniSTS
Cytogenetic Map7p12.3UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map5p12UniSTS
Cytogenetic Map9q21.13UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map20p12.3-p11.21UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map2p13-p12UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map3q25.33UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map8q21.13UniSTS
Cytogenetic Map7q32.1UniSTS
Cytogenetic Map8p21.3UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map3p24.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic MapXp22.33UniSTS
Cytogenetic MapYp11.32UniSTS
Cytogenetic Map10q24.31UniSTS
Cytogenetic Map4q34.3UniSTS
Cytogenetic Map10p11.23UniSTS
Cytogenetic Map10p15.1UniSTS
Cytogenetic Map14q21.2UniSTS
Cytogenetic Map6p21.31UniSTS
Cytogenetic Map9p24.1-p23UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic Map12q12UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map10pter-q25.3UniSTS
Cytogenetic Map6q25.2-q27UniSTS
Cytogenetic Map15q26.3UniSTS
Cytogenetic Map15q14UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map11p11.2UniSTS
Cytogenetic Map17q21.32UniSTS
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map7p21.1UniSTS
Cytogenetic Map17q23.2UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map1p36.3-p34.3UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map4p15.2UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map2q24.3UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map6q27UniSTS
Cytogenetic Map12q14.3UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map15q11.2UniSTS
Cytogenetic Map6p21.33UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map2q12.2UniSTS
Cytogenetic Map11q13.4UniSTS
Cytogenetic Map3p26UniSTS
Cytogenetic MapXq28UniSTS
Cytogenetic Map3p14.3UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map10q21-q22UniSTS
Cytogenetic Map5q22UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map10q22.2UniSTS
Cytogenetic Map8p22UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map12q14.2UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map10q26.11UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map6q22.32UniSTS
Cytogenetic Map20q13.12UniSTS
Cytogenetic Map1q21.1UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map17p13.1UniSTS
Cytogenetic Map12q23.3UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map13q14.11UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map4q26UniSTS
Cytogenetic Map19qterUniSTS
Cytogenetic Map7p13-p12UniSTS
Cytogenetic Map2p22UniSTS
Cytogenetic Map2q14.3UniSTS
Cytogenetic Map19q13.4UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2071
Count of miRNA genes:809
Interacting mature miRNAs:898
Transcripts:ENST00000220913, ENST00000518971, ENST00000519533, ENST00000519618, ENST00000523569
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2266 1763 1295 290 1409 161 4175 1622 1233 364 1412 1598 143 1193 2617 3
Low 173 1227 431 334 541 304 181 575 2501 55 48 15 32 1 11 171 3 2
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000220913   ⟹   ENSP00000220913
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8140,511,322 - 140,517,154 (+)Ensembl
RefSeq Acc Id: ENST00000518971   ⟹   ENSP00000430484
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8140,511,918 - 140,515,185 (+)Ensembl
RefSeq Acc Id: ENST00000519533   ⟹   ENSP00000428697
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8140,511,311 - 140,516,467 (+)Ensembl
RefSeq Acc Id: ENST00000519618   ⟹   ENSP00000430003
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8140,511,982 - 140,515,765 (+)Ensembl
RefSeq Acc Id: ENST00000523569
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8140,514,294 - 140,515,541 (+)Ensembl
RefSeq Acc Id: NM_017444   ⟹   NP_059140
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388140,511,322 - 140,517,154 (+)NCBI
GRCh378141,521,397 - 141,527,252 (+)NCBI
Build 368141,590,586 - 141,596,434 (+)NCBI Archive
Celera8137,690,513 - 137,696,362 (+)RGD
HuRef8136,832,956 - 136,838,809 (+)NCBI
CHM1_18141,562,050 - 141,567,894 (+)NCBI
Sequence:
RefSeq Acc Id: NR_023360
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388140,511,322 - 140,517,154 (+)NCBI
GRCh378141,521,397 - 141,527,252 (+)NCBI
Celera8137,690,513 - 137,696,362 (+)RGD
HuRef8136,832,956 - 136,838,809 (+)NCBI
CHM1_18141,562,050 - 141,567,894 (+)NCBI
Sequence:
RefSeq Acc Id: NR_040712
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388140,511,996 - 140,517,154 (+)NCBI
GRCh378141,521,397 - 141,527,252 (+)NCBI
HuRef8136,832,956 - 136,838,809 (+)NCBI
CHM1_18141,562,734 - 141,567,894 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_059140 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF72416 (Get FASTA)   NCBI Sequence Viewer  
  AAH15891 (Get FASTA)   NCBI Sequence Viewer  
  BAB14601 (Get FASTA)   NCBI Sequence Viewer  
  EAW92206 (Get FASTA)   NCBI Sequence Viewer  
  Q9NRG0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_059140   ⟸   NM_017444
- UniProtKB: Q9NRG0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000430484   ⟸   ENST00000518971
RefSeq Acc Id: ENSP00000428697   ⟸   ENST00000519533
RefSeq Acc Id: ENSP00000430003   ⟸   ENST00000519618
RefSeq Acc Id: ENSP00000220913   ⟸   ENST00000220913
Protein Domains
CBFD_NFYB_HMF

Promoters
RGD ID:7214255
Promoter ID:EPDNEW_H12873
Type:initiation region
Name:CHRAC1_1
Description:chromatin accessibility complex 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12874  EPDNEW_H12875  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388140,511,325 - 140,511,385EPDNEW
RGD ID:7214257
Promoter ID:EPDNEW_H12874
Type:initiation region
Name:CHRAC1_3
Description:chromatin accessibility complex 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12873  EPDNEW_H12875  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388140,511,449 - 140,511,509EPDNEW
RGD ID:7214259
Promoter ID:EPDNEW_H12875
Type:initiation region
Name:CHRAC1_2
Description:chromatin accessibility complex 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12873  EPDNEW_H12874  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388140,511,996 - 140,512,056EPDNEW
RGD ID:6806580
Promoter ID:HG_KWN:62185
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_017444,   UC010MEM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 368141,590,461 - 141,590,961 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q24.21-24.3(chr8:128220912-145049449)x3 copy number gain See cases [RCV000050830] Chr8:128220912..145049449 [GRCh38]
Chr8:129233158..146274835 [GRCh37]
Chr8:129302340..146245639 [NCBI36]
Chr8:8q24.21-24.3
pathogenic
GRCh38/hg38 8q23.3-24.3(chr8:113580402-145054634)x3 copy number gain See cases [RCV000050638] Chr8:113580402..145054634 [GRCh38]
Chr8:114592631..146280020 [GRCh37]
Chr8:114661807..146250824 [NCBI36]
Chr8:8q23.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:140060745-140721324)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052820]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052820]|See cases [RCV000052820] Chr8:140060745..140721324 [GRCh38]
Chr8:141070843..141731423 [GRCh37]
Chr8:141140025..141800605 [NCBI36]
Chr8:8q24.3
uncertain significance
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000053678] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:139447227-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|See cases [RCV000053701] Chr8:139447227..145054775 [GRCh38]
Chr8:140459470..146280161 [GRCh37]
Chr8:140528652..146250965 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q24.21-24.3(chr8:130115518-141228210)x3 copy number gain See cases [RCV000133621] Chr8:130115518..141228210 [GRCh38]
Chr8:131127764..142238309 [GRCh37]
Chr8:131196946..142307491 [NCBI36]
Chr8:8q24.21-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:139864393-141031612)x3 copy number gain See cases [RCV000134143] Chr8:139864393..141031612 [GRCh38]
Chr8:140876636..142041711 [GRCh37]
Chr8:140945818..142110893 [NCBI36]
Chr8:8q24.3
uncertain significance
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.22-24.3(chr8:130639182-145068712)x3 copy number gain See cases [RCV000137644] Chr8:130639182..145068712 [GRCh38]
Chr8:131651428..146294098 [GRCh37]
Chr8:131720610..146264902 [NCBI36]
Chr8:8q24.22-24.3
pathogenic|conflicting data from submitters
GRCh38/hg38 8q24.3(chr8:139236824-145068712)x3 copy number gain See cases [RCV000137466] Chr8:139236824..145068712 [GRCh38]
Chr8:140249067..146294098 [GRCh37]
Chr8:140318249..146264902 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.3(chr8:139004218-145049449)x3 copy number gain See cases [RCV000137340] Chr8:139004218..145049449 [GRCh38]
Chr8:140016461..146274835 [GRCh37]
Chr8:140085643..146245639 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124498498-145068712)x3 copy number gain See cases [RCV000137346] Chr8:124498498..145068712 [GRCh38]
Chr8:125510739..146294098 [GRCh37]
Chr8:125579920..146264902 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000148117] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:141447774-141542712)x3 copy number gain See cases [RCV000447662] Chr8:141447774..141542712 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:134825277-146280828)x3 copy number gain See cases [RCV000448348] Chr8:134825277..146280828 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:141446055-141538656)x3 copy number gain See cases [RCV000448357] Chr8:141446055..141538656 [GRCh37]
Chr8:8q24.3
likely benign
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:136378789-146295771)x3 copy number gain See cases [RCV000512003] Chr8:136378789..146295771 [GRCh37]
Chr8:8q24.22-24.3
likely pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q23.3-24.3(chr8:114853126-146295771)x3 copy number gain See cases [RCV000512401] Chr8:114853126..146295771 [GRCh37]
Chr8:8q23.3-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121694649-146295771)x3 copy number gain not provided [RCV000683044] Chr8:121694649..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.13-24.3(chr8:126892814-143750028)x1 copy number loss not provided [RCV001006144] Chr8:126892814..143750028 [GRCh37]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:141431936-141542147)x3 copy number gain not provided [RCV000846800] Chr8:141431936..141542147 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8q24.23-24.3(chr8:139188797-146295771)x3 copy number gain not provided [RCV000846814] Chr8:139188797..146295771 [GRCh37]
Chr8:8q24.23-24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:122193546-146295771)x3 copy number gain not provided [RCV000849762] Chr8:122193546..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:136059859-146295771)x3 copy number gain not provided [RCV000847171] Chr8:136059859..146295771 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8q24.13-24.3(chr8:125496223-146295771)x3 copy number gain not provided [RCV000845705] Chr8:125496223..146295771 [GRCh37]
Chr8:8q24.13-24.3
pathogenic
Single allele duplication not provided [RCV000844900] Chr8:141081122..141623752 [GRCh37]
Chr8:8q24.3
not provided
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:141081122-141623752)x3 copy number gain not provided [RCV000846830] Chr8:141081122..141623752 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.21-24.3(chr8:128877995-146295771)x3 copy number gain not provided [RCV001006146] Chr8:128877995..146295771 [GRCh37]
Chr8:8q24.21-24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121042467-146295771)x3 copy number gain not provided [RCV001006140] Chr8:121042467..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:13544 AgrOrtholog
COSMIC CHRAC1 COSMIC
Ensembl Genes ENSG00000104472 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000220913 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000428697 UniProtKB/TrEMBL
  ENSP00000430003 UniProtKB/TrEMBL
  ENSP00000430484 UniProtKB/TrEMBL
Ensembl Transcript ENST00000220913 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000518971 UniProtKB/TrEMBL
  ENST00000519533 UniProtKB/TrEMBL
  ENST00000519618 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000104472 GTEx
HGNC ID HGNC:13544 ENTREZGENE
Human Proteome Map CHRAC1 Human Proteome Map
InterPro CBFA_NFYB_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:54108 UniProtKB/Swiss-Prot
NCBI Gene 54108 ENTREZGENE
OMIM 607268 OMIM
Pfam CBFD_NFYB_HMF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26481 PharmGKB
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CHRC1_HUMAN UniProtKB/Swiss-Prot
  E5RGS9_HUMAN UniProtKB/TrEMBL
  H0YBP8_HUMAN UniProtKB/TrEMBL
  H0YBX4_HUMAN UniProtKB/TrEMBL
  Q9NRG0 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-07-17 CHRAC1  chromatin accessibility complex subunit 1  CHRAC1  chromatin accessibility complex 1  Symbol and/or name change 5135510 APPROVED