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Gene: TOP3A (DNA topoisomerase III alpha) Homo sapiens
Symbol: TOP3A
Name: DNA topoisomerase III alpha
RGD ID: 1319604
Description: Exhibits DNA topoisomerase type I (single strand cut, ATP-independent) activity and single-stranded DNA binding activity. Involved in DNA topological change; chromosome separation; and mitochondrial DNA metabolic process. Localizes to PML body. Implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA topoisomerase 3-alpha; MGRISCE2; PEOB5; TOP3; topo III-alpha; topoisomerase (DNA) III alpha; ZGRF7; zinc finger, GRF-type containing 7
Mus musculus (house mouse) : Top3a (topoisomerase (DNA) III alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Top3a (DNA topoisomerase III alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top3a (DNA topoisomerase III alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP3A (DNA topoisomerase III alpha)
Canis lupus familiaris (dog) : TOP3A (DNA topoisomerase III alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Top3a (DNA topoisomerase III alpha)
Sus scrofa (pig) : TOP3A (DNA topoisomerase III alpha)
Chlorocebus sabaeus (African green monkey) : TOP3A (DNA topoisomerase III alpha)
Heterocephalus glaber (naked mole-rat) : Top3a (DNA topoisomerase III alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1718,271,428 - 18,315,007 (-)EnsemblGRCh38hg38GRCh38
GRCh381718,269,958 - 18,314,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371718,177,235 - 18,218,321 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361718,117,960 - 18,159,046 (-)NCBINCBI36hg18NCBI36
Build 341718,117,959 - 18,159,046NCBI
Celera1719,118,328 - 19,159,392 (-)NCBI
Cytogenetic Map17p11.2NCBI
HuRef1717,930,468 - 17,971,853 (-)NCBIHuRef
CHM1_11718,183,522 - 18,227,165 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TOP3A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319604
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.