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Gene: NTHL1 (nth like DNA glycosylase 1) Homo sapiens
Symbol: NTHL1
Name: nth like DNA glycosylase 1
Description: The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase; bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase; DNA glycoslyase/AP lyase; DNA glycosylase/AP lyase; endonuclease III-like protein 1; FAP3; hNTH1; nth endonuclease III-like 1; nth-like DNA glycosylase 1; NTH1; OCTS3
Mus musculus (house mouse) : Nthl1 (nth (endonuclease III)-like 1 (E.coli))  MGI  Alliance
Rattus norvegicus (Norway rat) : Nthl1 (nth-like DNA glycosylase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nthl1 (nth like DNA glycosylase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NTHL1 (nth like DNA glycosylase 1)
Canis lupus familiaris (dog) : NTHL1 (nth like DNA glycosylase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nthl1 (nth like DNA glycosylase 1)
Sus scrofa (pig) : NTHL1 (nth like DNA glycosylase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38162,039,815 - 2,047,872 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37162,089,816 - 2,097,931 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,029,817 - 2,037,868 (-)NCBINCBI36hg18NCBI36
Build 34162,029,816 - 2,037,868NCBI
Celera162,301,923 - 2,309,974 (-)NCBI
Cytogenetic Map16p13.3NCBI
HuRef162,014,043 - 2,022,132 (-)NCBIHuRef
CHM1_1162,089,796 - 2,097,845 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NTHL1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319554
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.