RFC5 (replication factor C subunit 5) - Rat Genome Database
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Gene: RFC5 (replication factor C subunit 5) Homo sapiens
Analyze
Symbol: RFC5
Name: replication factor C subunit 5
RGD ID: 1319540
Description: Contributes to DNA clamp loader activity and single-stranded DNA helicase activity. Involved in positive regulation of DNA-directed DNA polymerase activity. Localizes to Ctf18 RFC-like complex and DNA replication factor C complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A1 36 kDa subunit; activator 1 36 kDa subunit; activator 1 subunit 5; MGC1155; replication factor C (activator 1) 5, 36.5kDa; replication factor C 36 kDa subunit; replication factor C, 36-kDa subunit; RF-C 36 kDa subunit; RFC, 36.5 kD subunit; RFC36
Orthologs:
Mus musculus (house mouse) : Rfc5 (replication factor C (activator 1) 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rfc5 (replication factor C subunit 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rfc5 (replication factor C subunit 5)
Pan paniscus (bonobo/pygmy chimpanzee) : RFC5 (replication factor C subunit 5)
Canis lupus familiaris (dog) : RFC5 (replication factor C subunit 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rfc5 (replication factor C subunit 5)
Sus scrofa (pig) : RFC5 (replication factor C subunit 5)
Chlorocebus sabaeus (African green monkey) : RFC5 (replication factor C subunit 5)
Heterocephalus glaber (naked mole-rat) : Rfc5 (replication factor C subunit 5)
more info ...
Related Pseudogenes: RFC5P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12118,013,588 - 118,033,130 (+)EnsemblGRCh38hg38GRCh38
GRCh3812118,016,661 - 118,033,564 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712118,454,506 - 118,470,044 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612116,938,893 - 116,954,422 (+)NCBINCBI36hg18NCBI36
Build 3412116,917,229 - 116,932,758NCBI
Celera12118,085,448 - 118,100,501 (+)NCBI
Cytogenetic Map12q24.23NCBI
HuRef12115,465,092 - 115,480,369 (+)NCBIHuRef
CHM1_112118,422,177 - 118,437,716 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP)
AM-251  (EXP)
arsenite(3-)  (ISO)
azathioprine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
C60 fullerene  (ISO)
carbon nanotube  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
cyclosporin A  (EXP)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
Enterolactone  (EXP)
flutamide  (ISO)
folic acid  (ISO)
isoprenaline  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
methyl methanesulfonate  (EXP)
methylseleninic acid  (EXP)
microcystin RR  (EXP)
N-nitrosodiethylamine  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
paclitaxel  (EXP)
palbociclib  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
piroxicam  (EXP)
propiconazole  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
simvastatin  (EXP)
sodium arsenite  (EXP)
Soman  (ISO)
tamibarotene  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
vincaleukoblastine  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7774928   PMID:8441605   PMID:8692848   PMID:8999859   PMID:9092549   PMID:9111189   PMID:9121429   PMID:9228079   PMID:9396813   PMID:9488738   PMID:9751713   PMID:9822671  
PMID:10051561   PMID:11572977   PMID:11907025   PMID:12171929   PMID:12192049   PMID:12237462   PMID:12477932   PMID:12766176   PMID:12791985   PMID:12930902   PMID:14605214   PMID:14702039  
PMID:15489334   PMID:15635413   PMID:16169070   PMID:16189514   PMID:16196087   PMID:16344560   PMID:16980295   PMID:17079134   PMID:17207965   PMID:17314511   PMID:17353931   PMID:17643375  
PMID:18245774   PMID:19237606   PMID:20221901   PMID:20226869   PMID:20467437   PMID:20522537   PMID:20545769   PMID:20574454   PMID:20800603   PMID:20826785   PMID:21139048   PMID:21145461  
PMID:21415862   PMID:21549307   PMID:21654808   PMID:21873635   PMID:21906983   PMID:21907836   PMID:22053931   PMID:22197378   PMID:22268729   PMID:22505724   PMID:22678362   PMID:22939629  
PMID:22990118   PMID:23251661   PMID:23383273   PMID:23684800   PMID:23688817   PMID:24332808   PMID:24457600   PMID:24711643   PMID:24797263   PMID:24816145   PMID:24958773   PMID:25147182  
PMID:25315684   PMID:25416956   PMID:25921289   PMID:26095369   PMID:26186194   PMID:26264872   PMID:26300262   PMID:26344197   PMID:26474068   PMID:26496610   PMID:26618866   PMID:26638075  
PMID:26870752   PMID:26972000   PMID:27025967   PMID:27248496   PMID:27320910   PMID:27462463   PMID:27637333   PMID:27664980   PMID:27684187   PMID:27703410   PMID:28185110   PMID:28192407  
PMID:28380382   PMID:28514442   PMID:28515276   PMID:28700943   PMID:28718761   PMID:29229926   PMID:29467282   PMID:29490077   PMID:29509190   PMID:29513927   PMID:29568061   PMID:29802200  
PMID:29845934   PMID:29892012   PMID:29955894   PMID:29991511   PMID:30021884   PMID:30033366   PMID:30196744   PMID:30209976   PMID:30463901   PMID:30804502   PMID:30833792   PMID:30948266  
PMID:31048545   PMID:31067453   PMID:31091453   PMID:31160570   PMID:31180492   PMID:31240132   PMID:31343991   PMID:31515488   PMID:31527615   PMID:31536960   PMID:31586073   PMID:31685992  
PMID:31753913   PMID:32296183   PMID:32877691  


Genomics

Comparative Map Data
RFC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12118,013,588 - 118,033,130 (+)EnsemblGRCh38hg38GRCh38
GRCh3812118,016,661 - 118,033,564 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712118,454,506 - 118,470,044 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612116,938,893 - 116,954,422 (+)NCBINCBI36hg18NCBI36
Build 3412116,917,229 - 116,932,758NCBI
Celera12118,085,448 - 118,100,501 (+)NCBI
Cytogenetic Map12q24.23NCBI
HuRef12115,465,092 - 115,480,369 (+)NCBIHuRef
CHM1_112118,422,177 - 118,437,716 (+)NCBICHM1_1
Rfc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395117,517,210 - 117,527,088 (-)NCBI
GRCm385117,379,145 - 117,389,023 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5117,378,103 - 117,389,047 (-)EnsemblGRCm38mm10GRCm38
MGSCv375117,829,154 - 117,839,032 (-)NCBIGRCm37mm9NCBIm37
MGSCv365117,829,154 - 117,839,032 (-)NCBImm8
Celera5114,470,100 - 114,479,973 (-)NCBICelera
Cytogenetic Map5FNCBI
Rfc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01244,931,494 - 44,941,051 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1244,931,494 - 44,941,324 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01246,752,012 - 46,761,569 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41240,395,942 - 40,405,498 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11240,239,703 - 40,268,387 (+)NCBI
Celera1240,850,700 - 40,860,283 (+)NCBICelera
Cytogenetic Map12q16NCBI
Rfc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545513,326,271 - 13,338,050 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545513,325,912 - 13,337,241 (-)NCBIChiLan1.0ChiLan1.0
RFC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112118,973,645 - 118,990,308 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12118,973,560 - 118,990,308 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012115,595,398 - 115,611,442 (+)NCBIMhudiblu_PPA_v0panPan3
RFC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2614,428,695 - 14,438,986 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12614,428,661 - 14,439,641 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Rfc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365584,736,332 - 4,747,323 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RFC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1434,613,943 - 34,642,588 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11434,630,374 - 34,642,598 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21436,791,707 - 36,804,213 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RFC5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl11113,352,378 - 113,370,829 (+)Ensembl
ChlSab1.111113,352,342 - 113,368,147 (+)NCBI
Rfc5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474715,441,338 - 15,454,577 (-)NCBI

Position Markers
D12S1776  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712118,470,815 - 118,471,037UniSTSGRCh37
Build 3612116,955,198 - 116,955,420RGDNCBI36
Celera12118,092,470 - 118,092,692RGD
Celera12118,101,277 - 118,101,499UniSTS
Cytogenetic Map12q24.23UniSTS
HuRef12115,481,140 - 115,481,362UniSTS
GeneMap99-GB4 RH Map12464.39UniSTS
Whitehead-RH Map12578.0UniSTS
Whitehead-YAC Contig Map12 UniSTS
NCBI RH Map12737.8UniSTS
RH65239  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712118,469,138 - 118,469,275UniSTSGRCh37
Build 3612116,953,521 - 116,953,658RGDNCBI36
Celera12118,099,600 - 118,099,737RGD
Cytogenetic Map12q24.23UniSTS
HuRef12115,479,463 - 115,479,600UniSTS
G64848  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712118,463,610 - 118,463,815UniSTSGRCh37
Build 3612116,947,993 - 116,948,198RGDNCBI36
Cytogenetic Map12q24.23UniSTS
HuRef12115,473,935 - 115,474,140UniSTS
A007E48  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712118,469,818 - 118,470,013UniSTSGRCh37
Build 3612116,954,201 - 116,954,396RGDNCBI36
Celera12118,100,280 - 118,100,475RGD
Cytogenetic Map12q24.23UniSTS
HuRef12115,480,143 - 115,480,338UniSTS
GeneMap99-GB4 RH Map12464.08UniSTS
D12S1874  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712118,459,835 - 118,459,952UniSTSGRCh37
Build 3612116,944,218 - 116,944,335RGDNCBI36
Celera12118,090,775 - 118,090,892RGD
Cytogenetic Map12q24.23UniSTS
HuRef12115,470,639 - 115,470,756UniSTS
TNG Radiation Hybrid Map1257375.0UniSTS
Stanford-G3 RH Map125064.0UniSTS
D12S1213E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712118,470,807 - 118,470,952UniSTSGRCh37
Build 3612116,955,190 - 116,955,335RGDNCBI36
Celera12118,101,269 - 118,101,414UniSTS
Celera12118,092,555 - 118,092,700RGD
Cytogenetic Map12q24.23UniSTS
HuRef12115,481,132 - 115,481,277UniSTS
GeneMap99-GB4 RH Map12457.27UniSTS
NCBI RH Map12742.4UniSTS
WI-13177  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712118,470,925 - 118,471,050UniSTSGRCh37
Build 3612116,955,308 - 116,955,433RGDNCBI36
Celera12118,101,387 - 118,101,512UniSTS
Celera12118,092,457 - 118,092,582RGD
Cytogenetic Map12q24.23UniSTS
HuRef12115,481,250 - 115,481,375UniSTS
GeneMap99-GB4 RH Map12464.39UniSTS
Whitehead-RH Map12578.0UniSTS
NCBI RH Map12737.8UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1933
Count of miRNA genes:797
Interacting mature miRNAs:918
Transcripts:ENST00000229043, ENST00000392542, ENST00000420967, ENST00000449641, ENST00000454402, ENST00000472603, ENST00000484086, ENST00000535092, ENST00000537315, ENST00000543153
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 488 127 709 111 898 106 1201 124 897 194 1056 962 24 1 152 684 4
Low 1951 2819 1017 513 1031 359 3156 2050 2836 225 404 651 151 1052 2104 2 2
Below cutoff 45 22 23 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001130112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001130113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001206801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001346815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_181578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_144504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB208992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC131159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI567945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK094575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU121576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY254323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM153733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR407651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB270923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L07540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000392542   ⟹   ENSP00000376325
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12118,016,722 - 118,032,234 (+)Ensembl
RefSeq Acc Id: ENST00000420967   ⟹   ENSP00000390340
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12118,016,704 - 118,022,314 (+)Ensembl
RefSeq Acc Id: ENST00000449641   ⟹   ENSP00000393636
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12118,013,588 - 118,024,981 (+)Ensembl
RefSeq Acc Id: ENST00000454402   ⟹   ENSP00000408295
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12118,016,703 - 118,032,234 (+)Ensembl
RefSeq Acc Id: ENST00000472603
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12118,024,916 - 118,027,392 (+)Ensembl
RefSeq Acc Id: ENST00000484086   ⟹   ENSP00000445917
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12118,016,704 - 118,020,960 (+)Ensembl
RefSeq Acc Id: ENST00000535092   ⟹   ENSP00000438252
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12118,016,729 - 118,019,754 (+)Ensembl
RefSeq Acc Id: ENST00000537315   ⟹   ENSP00000443187
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12118,016,701 - 118,024,996 (+)Ensembl
RefSeq Acc Id: ENST00000543153
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12118,026,890 - 118,033,130 (+)Ensembl
RefSeq Acc Id: NM_001130112   ⟹   NP_001123584
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812118,016,703 - 118,032,234 (+)NCBI
GRCh3712118,454,506 - 118,470,044 (+)ENTREZGENE
HuRef12115,465,092 - 115,480,369 (+)ENTREZGENE
CHM1_112118,422,177 - 118,437,716 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001130113   ⟹   NP_001123585
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812118,016,703 - 118,032,234 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001206801   ⟹   NP_001193730
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812118,016,703 - 118,032,234 (+)NCBI
GRCh3712118,454,506 - 118,470,044 (+)ENTREZGENE
HuRef12115,465,092 - 115,480,369 (+)ENTREZGENE
CHM1_112118,422,177 - 118,437,716 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001346815   ⟹   NP_001333744
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812118,016,703 - 118,032,234 (+)NCBI
Sequence:
RefSeq Acc Id: NM_007370   ⟹   NP_031396
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812118,016,703 - 118,032,234 (+)NCBI
GRCh3712118,454,506 - 118,470,044 (+)ENTREZGENE
Build 3612116,938,893 - 116,954,422 (+)NCBI Archive
HuRef12115,465,092 - 115,480,369 (+)ENTREZGENE
CHM1_112118,422,177 - 118,437,716 (+)NCBI
Sequence:
RefSeq Acc Id: NM_181578   ⟹   NP_853556
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812118,016,703 - 118,032,234 (+)NCBI
GRCh3712118,454,506 - 118,470,044 (+)ENTREZGENE
Build 3612116,938,893 - 116,954,422 (+)NCBI Archive
HuRef12115,465,092 - 115,480,369 (+)ENTREZGENE
CHM1_112118,422,177 - 118,437,716 (+)NCBI
Sequence:
RefSeq Acc Id: NR_144504
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812118,016,703 - 118,032,234 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011538643   ⟹   XP_011536945
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812118,016,704 - 118,033,564 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011538645   ⟹   XP_011536947
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812118,016,704 - 118,033,124 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017019779   ⟹   XP_016875268
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812118,016,704 - 118,033,564 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024449118   ⟹   XP_024304886
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812118,016,661 - 118,033,564 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024449119   ⟹   XP_024304887
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812118,016,661 - 118,033,564 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_853556   ⟸   NM_181578
- Peptide Label: isoform 2
- UniProtKB: P40937 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001123584   ⟸   NM_001130112
- Peptide Label: isoform 3
- UniProtKB: P40937 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_031396   ⟸   NM_007370
- Peptide Label: isoform 1
- UniProtKB: P40937 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001193730   ⟸   NM_001206801
- Peptide Label: isoform 4
- UniProtKB: Q59GW7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011536945   ⟸   XM_011538643
- Peptide Label: isoform X1
- UniProtKB: P40937 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011536947   ⟸   XM_011538645
- Peptide Label: isoform X1
- UniProtKB: P40937 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016875268   ⟸   XM_017019779
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_024304886   ⟸   XM_024449118
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_024304887   ⟸   XM_024449119
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: NP_001333744   ⟸   NM_001346815
- Peptide Label: isoform 5
- Sequence:
RefSeq Acc Id: NP_001123585   ⟸   NM_001130113
- Peptide Label: isoform 2
- UniProtKB: P40937 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000408295   ⟸   ENST00000454402
RefSeq Acc Id: ENSP00000438252   ⟸   ENST00000535092
RefSeq Acc Id: ENSP00000443187   ⟸   ENST00000537315
RefSeq Acc Id: ENSP00000445917   ⟸   ENST00000484086
RefSeq Acc Id: ENSP00000376325   ⟸   ENST00000392542
RefSeq Acc Id: ENSP00000390340   ⟸   ENST00000420967
RefSeq Acc Id: ENSP00000393636   ⟸   ENST00000449641
Protein Domains
AAA

Promoters
RGD ID:6790437
Promoter ID:HG_KWN:16780
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001130112,   NM_001130113,   NM_007370,   NM_181578,   OTTHUMT00000344197,   OTTHUMT00000344198,   UC009ZWR.1
Position:
Human AssemblyChrPosition (strand)Source
Build 3612116,938,709 - 116,939,209 (+)MPROMDB
RGD ID:6790438
Promoter ID:HG_KWN:16781
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000344199
Position:
Human AssemblyChrPosition (strand)Source
Build 3612116,947,066 - 116,947,566 (+)MPROMDB
RGD ID:6810385
Promoter ID:HG_ACW:19179
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:PLUCHO.AAPR07-UNSPLICED,   RFC5.KAPR07-UNSPLICED,   RFC5.LAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 3612116,952,181 - 116,952,681 (-)MPROMDB
RGD ID:7225541
Promoter ID:EPDNEW_H18516
Type:initiation region
Name:RFC5_1
Description:replication factor C subunit 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18515  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812118,016,704 - 118,016,764EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q24.21-24.33(chr12:115131583-133166920)x3 copy number gain See cases [RCV000053689] Chr12:115131583..133166920 [GRCh38]
Chr12:115569388..133743506 [GRCh37]
Chr12:114053771..132253579 [NCBI36]
Chr12:12q24.21-24.33
pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q24.21-24.33(chr12:114268403-133201316)x3 copy number gain See cases [RCV000143656] Chr12:114268403..133201316 [GRCh38]
Chr12:114706208..133777902 [GRCh37]
Chr12:113190591..132287975 [NCBI36]
Chr12:12q24.21-24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12q24.21-24.23(chr12:116028864-118791808)x1 copy number loss See cases [RCV000445736] Chr12:116028864..118791808 [GRCh37]
Chr12:12q24.21-24.23
pathogenic
GRCh37/hg19 12q24.22-24.23(chr12:118014801-118716129)x1 copy number loss See cases [RCV000447726] Chr12:118014801..118716129 [GRCh37]
Chr12:12q24.22-24.23
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q24.23(chr12:118258061-118726805)x3 copy number gain not provided [RCV000683436] Chr12:118258061..118726805 [GRCh37]
Chr12:12q24.23
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q24.21-24.23(chr12:116718607-119728623)x1 copy number loss not provided [RCV000847173] Chr12:116718607..119728623 [GRCh37]
Chr12:12q24.21-24.23
uncertain significance
GRCh37/hg19 12q24.22-24.23(chr12:117858408-118668114)x4 copy number gain not provided [RCV001006538] Chr12:117858408..118668114 [GRCh37]
Chr12:12q24.22-24.23
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9973 AgrOrtholog
COSMIC RFC5 COSMIC
Ensembl Genes ENSG00000111445 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000376325 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000390340 UniProtKB/TrEMBL
  ENSP00000393636 UniProtKB/TrEMBL
  ENSP00000408295 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000438252 UniProtKB/TrEMBL
  ENSP00000443187 UniProtKB/TrEMBL
  ENSP00000445917 UniProtKB/TrEMBL
Ensembl Transcript ENST00000392542 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000420967 UniProtKB/TrEMBL
  ENST00000449641 UniProtKB/TrEMBL
  ENST00000454402 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000484086 UniProtKB/TrEMBL
  ENST00000535092 UniProtKB/TrEMBL
  ENST00000537315 UniProtKB/TrEMBL
GTEx ENSG00000111445 GTEx
HGNC ID HGNC:9973 ENTREZGENE
Human Proteome Map RFC5 Human Proteome Map
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_pol3_clamp-load_cplx_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rep_factorC_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5985 UniProtKB/Swiss-Prot
NCBI Gene 5985 ENTREZGENE
OMIM 600407 OMIM
Pfam AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rep_fac_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA34342 PharmGKB
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48019 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.731908 ENTREZGENE
UniProt C9JH72_HUMAN UniProtKB/TrEMBL
  E9PEP3_HUMAN UniProtKB/TrEMBL
  F5H0U6_HUMAN UniProtKB/TrEMBL
  F5H304_HUMAN UniProtKB/TrEMBL
  F5H5S0_HUMAN UniProtKB/TrEMBL
  P40937 ENTREZGENE
  Q59GW7 ENTREZGENE, UniProtKB/TrEMBL
  Q6LES9_HUMAN UniProtKB/TrEMBL
  RFC5_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A8MZ62 UniProtKB/Swiss-Prot
  B3KSX8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 RFC5  replication factor C subunit 5    replication factor C (activator 1) 5, 36.5kDa  Symbol and/or name change 5135510 APPROVED