SCARA3 (scavenger receptor class A member 3) - Rat Genome Database
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Gene: SCARA3 (scavenger receptor class A member 3) Homo sapiens
Analyze
Symbol: SCARA3
Name: scavenger receptor class A member 3
RGD ID: 1319520
HGNC Page HGNC
Description: Predicted to have scavenger receptor activity. Predicted to be involved in UV protection and response to oxidative stress. Localizes to endoplasmic reticulum.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: APC7; cellular stress response gene protein; cellular stress response protein; CSR; CSR1; macrophage scavenger receptor-like 1; MSLR1; MSRL1; scavenger receptor class A, member 3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl827,633,868 - 27,676,776 (+)EnsemblGRCh38hg38GRCh38
GRCh38827,633,665 - 27,736,594 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37827,491,419 - 27,534,288 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,547,496 - 27,590,205 (+)NCBINCBI36hg18NCBI36
Build 34827,547,495 - 27,590,205NCBI
Celera826,451,665 - 26,494,373 (+)NCBI
Cytogenetic Map8p21.1NCBI
HuRef826,036,621 - 26,079,326 (+)NCBIHuRef
CHM1_1827,693,466 - 27,736,166 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:9580669   PMID:9747040   PMID:12477932   PMID:15489334   PMID:16436673   PMID:17207965   PMID:18806823   PMID:20485444   PMID:21516116   PMID:21855113   PMID:21873635   PMID:22138034  
PMID:22658674   PMID:22683311   PMID:23537707   PMID:23728617   PMID:24491563   PMID:24623722   PMID:25204797   PMID:25416956   PMID:25956032   PMID:26167880   PMID:26186194   PMID:27148859  
PMID:28514442   PMID:28611215   PMID:28975986   PMID:29705808   PMID:31577778  


Genomics

Comparative Map Data
SCARA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl827,633,868 - 27,676,776 (+)EnsemblGRCh38hg38GRCh38
GRCh38827,633,665 - 27,736,594 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37827,491,419 - 27,534,288 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,547,496 - 27,590,205 (+)NCBINCBI36hg18NCBI36
Build 34827,547,495 - 27,590,205NCBI
Celera826,451,665 - 26,494,373 (+)NCBI
Cytogenetic Map8p21.1NCBI
HuRef826,036,621 - 26,079,326 (+)NCBIHuRef
CHM1_1827,693,466 - 27,736,166 (+)NCBICHM1_1
Scara3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,156,844 - 66,191,427 (-)NCBIGRCm39mm39
GRCm39 Ensembl1466,156,843 - 66,191,384 (-)Ensembl
GRCm381465,919,394 - 65,953,978 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,919,394 - 65,953,935 (-)EnsemblGRCm38mm10GRCm38
MGSCv371466,538,232 - 66,572,581 (-)NCBIGRCm37mm9NCBIm37
MGSCv361464,873,505 - 64,907,854 (-)NCBImm8
Celera1463,672,278 - 63,706,586 (-)NCBICelera
Cytogenetic Map14D1NCBI
Scara3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21540,139,873 - 40,172,866 (-)NCBI
Rnor_6.0 Ensembl1542,605,473 - 42,638,392 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01542,605,505 - 42,638,409 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01548,953,960 - 48,986,864 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,344,539 - 45,377,576 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11545,360,319 - 45,393,691 (-)NCBI
Celera1539,811,744 - 39,844,508 (-)NCBICelera
Cytogenetic Map15p12NCBI
Scara3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540350,185,037 - 50,226,030 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540350,185,857 - 50,223,340 (+)NCBIChiLan1.0ChiLan1.0
SCARA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1824,106,075 - 24,148,465 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl824,106,075 - 24,148,465 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0826,903,924 - 27,032,048 (+)NCBIMhudiblu_PPA_v0panPan3
SCARA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2529,917,335 - 29,968,076 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12529,891,099 - 29,966,846 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Scara3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936675541,829 - 561,110 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCARA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,367,427 - 11,410,978 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,367,402 - 11,403,173 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,546,504 - 12,582,044 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCARA3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1825,741,988 - 25,779,224 (+)NCBI
ChlSab1.1 Ensembl825,742,127 - 25,782,247 (+)Ensembl
Scara3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475822,454,181 - 22,488,431 (+)NCBI

Position Markers
D8S500  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,518,282 - 27,518,466UniSTSGRCh37
Build 36827,574,201 - 27,574,385RGDNCBI36
Celera826,478,382 - 26,478,554RGD
Cytogenetic Map8p21UniSTS
HuRef826,063,319 - 26,063,495UniSTS
Marshfield Genetic Map854.98UniSTS
SCARA3_2473  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,529,724 - 27,530,560UniSTSGRCh37
Build 36827,585,643 - 27,586,479RGDNCBI36
Celera826,489,810 - 26,490,646RGD
HuRef826,074,764 - 26,075,600UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:941
Count of miRNA genes:637
Interacting mature miRNAs:695
Transcripts:ENST00000301904, ENST00000337221
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 8
Medium 1856 1536 979 230 199 71 3295 937 3375 197 1014 1392 165 1005 1978 2
Low 536 731 717 369 416 369 886 1098 353 212 430 170 7 1 199 673 3 1
Below cutoff 27 688 25 24 813 25 156 155 6 10 7 27 1 137 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000301904   ⟹   ENSP00000301904
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,633,902 - 27,673,018 (+)Ensembl
RefSeq Acc Id: ENST00000337221   ⟹   ENSP00000337985
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl827,633,868 - 27,676,776 (+)Ensembl
RefSeq Acc Id: NM_016240   ⟹   NP_057324
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,633,902 - 27,673,018 (+)NCBI
GRCh37827,491,100 - 27,534,286 (+)NCBI
Build 36827,547,496 - 27,586,456 (+)NCBI Archive
Celera826,451,665 - 26,494,373 (+)RGD
HuRef826,036,621 - 26,079,326 (+)RGD
CHM1_1827,693,466 - 27,732,417 (+)NCBI
Sequence:
RefSeq Acc Id: NM_182826   ⟹   NP_878185
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,633,902 - 27,676,771 (+)NCBI
GRCh37827,491,100 - 27,534,286 (+)NCBI
Build 36827,547,496 - 27,590,205 (+)NCBI Archive
Celera826,451,665 - 26,494,373 (+)RGD
HuRef826,036,621 - 26,079,326 (+)RGD
CHM1_1827,693,466 - 27,736,166 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017013535   ⟹   XP_016869024
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,633,665 - 27,673,018 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017013536   ⟹   XP_016869025
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,633,889 - 27,736,594 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017013537   ⟹   XP_016869026
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,633,889 - 27,719,532 (+)NCBI
Sequence:
RefSeq Acc Id: XR_949419
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,633,889 - 27,700,373 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_878185   ⟸   NM_182826
- Peptide Label: isoform 2
- UniProtKB: Q6AZY7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_057324   ⟸   NM_016240
- Peptide Label: isoform 1
- UniProtKB: Q6AZY7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016869024   ⟸   XM_017013535
- Peptide Label: isoform X1
- UniProtKB: Q6AZY7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016869025   ⟸   XM_017013536
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016869026   ⟸   XM_017013537
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000337985   ⟸   ENST00000337221
RefSeq Acc Id: ENSP00000301904   ⟸   ENST00000301904
Protein Domains
Collagen-like

Promoters
RGD ID:6806677
Promoter ID:HG_KWN:61001
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:ENST00000337221,   ENST00000397432
Position:
Human AssemblyChrPosition (strand)Source
Build 36827,547,126 - 27,547,626 (+)MPROMDB
RGD ID:7212959
Promoter ID:EPDNEW_H12225
Type:initiation region
Name:SCARA3_2
Description:scavenger receptor class A member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12226  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,633,463 - 27,633,523EPDNEW
RGD ID:7212961
Promoter ID:EPDNEW_H12226
Type:initiation region
Name:SCARA3_1
Description:scavenger receptor class A member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12225  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,633,902 - 27,633,962EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000050294] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p21.2-q11.21(chr8:25832130-48521849)x3 copy number gain See cases [RCV000050904] Chr8:25832130..48521849 [GRCh38]
Chr8:25689646..49434409 [GRCh37]
Chr8:25745563..49596962 [NCBI36]
Chr8:8p21.2-q11.21		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000050912] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12383584-36370018)x3 copy number gain See cases [RCV000051145] Chr8:12383584..36370018 [GRCh38]
Chr8:12241093..36227536 [GRCh37]
Chr8:12285464..36347088 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-41928741)x3 copy number gain See cases [RCV000051110] Chr8:12728904..41928741 [GRCh38]
Chr8:12586413..41786259 [GRCh37]
Chr8:12630784..41905416 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:12609975-37892000)x3 copy number gain See cases [RCV000053629] Chr8:12609975..37892000 [GRCh38]
Chr8:12467484..37749518 [GRCh37]
Chr8:12511855..37868676 [NCBI36]
Chr8:8p23.1-11.23		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43336172)x3 copy number gain See cases [RCV000053630] Chr8:12609975..43336172 [GRCh38]
Chr8:12467484..43191315 [GRCh37]
Chr8:12511855..43310472 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43255410)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|See cases [RCV000053631] Chr8:12609975..43255410 [GRCh38]
Chr8:12467484..43110553 [GRCh37]
Chr8:12511855..43229710 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12750796-43532444)x3 copy number gain See cases [RCV000053632] Chr8:12750796..43532444 [GRCh38]
Chr8:12608305..43387587 [GRCh37]
Chr8:12652676..43506744 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12750796-29445409)x3 copy number gain See cases [RCV000053633] Chr8:12750796..29445409 [GRCh38]
Chr8:12608305..29302926 [GRCh37]
Chr8:12652676..29358845 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p22-q11.21(chr8:14940110-47929925)x3 copy number gain See cases [RCV000053635] Chr8:14940110..47929925 [GRCh38]
Chr8:14797619..48842485 [GRCh37]
Chr8:14841990..49005038 [NCBI36]
Chr8:8p22-q11.21		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-12(chr8:96310-30614703)x3 copy number gain See cases [RCV000053599] Chr8:96310..30614703 [GRCh38]
Chr8:46310..30472220 [GRCh37]
Chr8:36310..30591762 [NCBI36]
Chr8:8p23.3-12		 pathogenic
GRCh38/hg38 8p21.2-12(chr8:24910364-31210737)x1 copy number loss See cases [RCV000054237] Chr8:24910364..31210737 [GRCh38]
Chr8:24767877..31068253 [GRCh37]
Chr8:24823781..31187795 [NCBI36]
Chr8:8p21.2-12		 pathogenic
NM_016240.2(SCARA3):c.727G>A (p.Glu243Lys) single nucleotide variant Malignant melanoma [RCV000068272] Chr8:27658897 [GRCh38]
Chr8:27516414 [GRCh37]
Chr8:27572333 [NCBI36]
Chr8:8p21.1		 not provided
NM_016240.2(SCARA3):c.857C>T (p.Ser286Phe) single nucleotide variant Malignant melanoma [RCV000061789] Chr8:27659027 [GRCh38]
Chr8:27516544 [GRCh37]
Chr8:27572463 [NCBI36]
Chr8:8p21.1		 not provided
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43673207)x3 copy number gain See cases [RCV000135786] Chr8:12609975..43673207 [GRCh38]
Chr8:12467484..43528350 [GRCh37]
Chr8:12511855..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12383584-43673207)x3 copy number gain See cases [RCV000135566] Chr8:12383584..43673207 [GRCh38]
Chr8:12241093..43528350 [GRCh37]
Chr8:12285464..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-40169194)x3 copy number gain See cases [RCV000136516] Chr8:12728904..40169194 [GRCh38]
Chr8:12586413..40026713 [GRCh37]
Chr8:12630784..40145870 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p21.2-12(chr8:24910364-31196357)x1 copy number loss See cases [RCV000136120] Chr8:24910364..31196357 [GRCh38]
Chr8:24767877..31053873 [GRCh37]
Chr8:24823781..31173415 [NCBI36]
Chr8:8p21.2-12		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12725750-30180521)x3 copy number gain See cases [RCV000136825] Chr8:12725750..30180521 [GRCh38]
Chr8:12583259..30038037 [GRCh37]
Chr8:12627630..30157579 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12182421-43673207)x3 copy number gain See cases [RCV000137249] Chr8:12182421..43673207 [GRCh38]
Chr8:12039930..43528350 [GRCh37]
Chr8:12077339..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12698495-35476082)x3 copy number gain See cases [RCV000138058] Chr8:12698495..35476082 [GRCh38]
Chr8:12556004..35333600 [GRCh37]
Chr8:12600375..35453142 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p21.2-12(chr8:25171103-31750600)x1 copy number loss See cases [RCV000138081] Chr8:25171103..31750600 [GRCh38]
Chr8:25028618..31608116 [GRCh37]
Chr8:25084535..31727658 [NCBI36]
Chr8:8p21.2-12		 pathogenic
GRCh38/hg38 8p23.3-11.23(chr8:226452-38021728)x3 copy number gain See cases [RCV000137807] Chr8:226452..38021728 [GRCh38]
Chr8:176452..37879246 [GRCh37]
Chr8:166452..37998403 [NCBI36]
Chr8:8p23.3-11.23		 pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-12(chr8:241605-31091074)x3 copy number gain See cases [RCV000138831] Chr8:241605..31091074 [GRCh38]
Chr8:191605..30948590 [GRCh37]
Chr8:181605..31068132 [NCBI36]
Chr8:8p23.3-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-21.1(chr8:12382844-28625564)x3 copy number gain See cases [RCV000138244] Chr8:12382844..28625564 [GRCh38]
Chr8:12240353..28483081 [GRCh37]
Chr8:12284724..28539000 [NCBI36]
Chr8:8p23.1-21.1		 pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:7141697-38695546)x3 copy number gain See cases [RCV000139891] Chr8:7141697..38695546 [GRCh38]
Chr8:6999219..38553064 [GRCh37]
Chr8:6986629..38672221 [NCBI36]
Chr8:8p23.1-11.22		 pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:12729023-39235934)x3 copy number gain See cases [RCV000139770] Chr8:12729023..39235934 [GRCh38]
Chr8:12586532..39093453 [GRCh37]
Chr8:12630903..39212610 [NCBI36]
Chr8:8p23.1-11.22		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12646123-43686843)x3 copy number gain See cases [RCV000139796] Chr8:12646123..43686843 [GRCh38]
Chr8:12503632..43541986 [GRCh37]
Chr8:12548003..43661143 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:11851113-37216333)x3 copy number gain See cases [RCV000139549] Chr8:11851113..37216333 [GRCh38]
Chr8:11708622..37073851 [GRCh37]
Chr8:11746031..37193009 [NCBI36]
Chr8:8p23.1-11.23		 pathogenic
GRCh38/hg38 8p23.3-12(chr8:226452-34491890)x3 copy number gain See cases [RCV000141410] Chr8:226452..34491890 [GRCh38]
Chr8:176452..34349408 [GRCh37]
Chr8:166452..34468950 [NCBI36]
Chr8:8p23.3-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12383584-29033946)x1 copy number loss See cases [RCV000142516] Chr8:12383584..29033946 [GRCh38]
Chr8:12241093..28891463 [GRCh37]
Chr8:12285464..28947382 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p22-12(chr8:18972996-33619264)x1 copy number loss See cases [RCV000142747] Chr8:18972996..33619264 [GRCh38]
Chr8:18830506..33476782 [GRCh37]
Chr8:18874786..33596324 [NCBI36]
Chr8:8p22-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12633490-40685533)x3 copy number gain See cases [RCV000143508] Chr8:12633490..40685533 [GRCh38]
Chr8:12490999..40543052 [GRCh37]
Chr8:12535370..40662209 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000148249] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000148237] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p21.3-12(chr8:20478546-28986438)x3 copy number gain See cases [RCV000203434] Chr8:20478546..28986438 [GRCh37]
Chr8:8p21.3-12		 pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12528482-39593802)x3 copy number gain See cases [RCV000511325] Chr8:12528482..39593802 [GRCh37]
Chr8:8p23.1-11.22		 pathogenic
Single allele duplication not provided [RCV000768452] Chr8:12546855..35816855 [GRCh37]
Chr8:8p23.1-12		 likely pathogenic
GRCh37/hg19 8p23.3-12(chr8:158048-30262760)x3 copy number gain See cases [RCV000449225] Chr8:158048..30262760 [GRCh37]
Chr8:8p23.3-12		 pathogenic
GRCh37/hg19 8p21.2-q12.1(chr8:24772064-24813176)x3 copy number gain See cases [RCV000446588] Chr8:24772064..24813176 [GRCh37]
Chr8:8p21.2-q12.1		 uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:158048-43786723)x3 copy number gain See cases [RCV000447909] Chr8:158048..43786723 [GRCh37]
Chr8:8p23.3-11.1		 pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:12580132-43388233)x3 copy number gain See cases [RCV000447913] Chr8:12580132..43388233 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p21.2-12(chr8:24514488-34808438) copy number gain See cases [RCV000448582] Chr8:24514488..34808438 [GRCh37]
Chr8:8p21.2-12		 pathogenic
GRCh37/hg19 8p21.1-12(chr8:27501662-29342607)x3 copy number gain See cases [RCV000510519] Chr8:27501662..29342607 [GRCh37]
Chr8:8p21.1-12		 uncertain significance
GRCh37/hg19 8p22-12(chr8:16992973-32612724)x1 copy number loss not provided [RCV000509389] Chr8:16992973..32612724 [GRCh37]
Chr8:8p22-12		 not provided
GRCh37/hg19 8p23.1-12(chr8:12528482-33684786)x3 copy number gain See cases [RCV000510571] Chr8:12528482..33684786 [GRCh37]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:11935023-43824035)x3 copy number gain See cases [RCV000511028] Chr8:11935023..43824035 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:11945855-34875355)x3 copy number gain See cases [RCV000510899] Chr8:11945855..34875355 [GRCh37]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:12552775-35935825)x3 copy number gain not provided [RCV000683043] Chr8:12552775..35935825 [GRCh37]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:12556004-34374150)x3 copy number gain not provided [RCV000762735] Chr8:12556004..34374150 [GRCh37]
Chr8:8p23.1-12		 likely pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p21.2-21.1(chr8:24305969-28673405)x1 copy number loss not provided [RCV001006090] Chr8:24305969..28673405 [GRCh37]
Chr8:8p21.2-21.1		 pathogenic
GRCh37/hg19 8p21.1(chr8:27496253-27563222)x1 copy number loss not provided [RCV001259472] Chr8:27496253..27563222 [GRCh37]
Chr8:8p21.1		 uncertain significance
GRCh37/hg19 8p21.1(chr8:27417421-27643275)x3 copy number gain not provided [RCV001259473] Chr8:27417421..27643275 [GRCh37]
Chr8:8p21.1		 uncertain significance
GRCh37/hg19 8p23.1-12(chr8:12528482-29886483)x3 copy number gain not provided [RCV001260030] Chr8:12528482..29886483 [GRCh37]
Chr8:8p23.1-12		 likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19000 AgrOrtholog
COSMIC SCARA3 COSMIC
Ensembl Genes ENSG00000168077 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000301904 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000337985 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000301904 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000337221 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000168077 GTEx
HGNC ID HGNC:19000 ENTREZGENE
Human Proteome Map SCARA3 Human Proteome Map
InterPro Collagen UniProtKB/Swiss-Prot
KEGG Report hsa:51435 UniProtKB/Swiss-Prot
NCBI Gene 51435 ENTREZGENE
OMIM 602728 OMIM
Pfam Collagen UniProtKB/Swiss-Prot
PharmGKB PA38775 PharmGKB
UniProt Q6AZY7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9UM15 UniProtKB/Swiss-Prot
  Q9UM16 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 SCARA3  scavenger receptor class A member 3    scavenger receptor class A, member 3  Symbol and/or name change 5135510 APPROVED
2011-09-01 SCARA3  scavenger receptor class A, member 3  SCARA3  scavenger receptor class A, member 3  Symbol and/or name change 5135510 APPROVED