SDHAF4 (succinate dehydrogenase complex assembly factor 4) - Rat Genome Database

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Gene: SDHAF4 (succinate dehydrogenase complex assembly factor 4) Homo sapiens
Analyze
Symbol: SDHAF4
Name: succinate dehydrogenase complex assembly factor 4
RGD ID: 1319485
HGNC Page HGNC:20957
Description: Predicted to enable enzyme activator activity. Involved in cellular respiration and mitochondrial respiratory chain complex II assembly. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C6orf57; hypothetical protein LOC135154; MGC104225; SDH assembly factor 4; Sdh8; succinate dehydrogenase assembly factor 4, mitochondrial; UPF0369 protein C6orf57
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38670,566,930 - 70,598,428 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl670,566,917 - 70,589,569 (+)EnsemblGRCh38hg38GRCh38
GRCh37671,276,633 - 71,299,272 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36671,333,346 - 71,355,327 (+)NCBINCBI36Build 36hg18NCBI36
Build 34671,333,345 - 71,355,327NCBI
Celera671,665,041 - 71,687,022 (+)NCBICelera
Cytogenetic Map6q13NCBI
HuRef668,474,783 - 68,496,774 (+)NCBIHuRef
CHM1_1671,442,976 - 71,464,957 (+)NCBICHM1_1
T2T-CHM13v2.0671,747,474 - 71,770,117 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14574404   PMID:15489334   PMID:17207965   PMID:20877624   PMID:21490949   PMID:21873635   PMID:24954416   PMID:26186194   PMID:27499296   PMID:28514442   PMID:32296183  
PMID:32694731   PMID:33961781   PMID:35831314   PMID:36672824  


Genomics

Comparative Map Data
SDHAF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38670,566,930 - 70,598,428 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl670,566,917 - 70,589,569 (+)EnsemblGRCh38hg38GRCh38
GRCh37671,276,633 - 71,299,272 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36671,333,346 - 71,355,327 (+)NCBINCBI36Build 36hg18NCBI36
Build 34671,333,345 - 71,355,327NCBI
Celera671,665,041 - 71,687,022 (+)NCBICelera
Cytogenetic Map6q13NCBI
HuRef668,474,783 - 68,496,774 (+)NCBIHuRef
CHM1_1671,442,976 - 71,464,957 (+)NCBICHM1_1
T2T-CHM13v2.0671,747,474 - 71,770,117 (+)NCBIT2T-CHM13v2.0
Sdhaf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,035,020 - 24,044,721 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,035,020 - 24,044,737 (-)EnsemblGRCm39 Ensembl
GRCm38123,995,939 - 24,005,640 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,995,939 - 24,005,656 (-)EnsemblGRCm38mm10GRCm38
MGSCv37124,002,778 - 24,012,479 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36123,950,221 - 23,959,915 (-)NCBIMGSCv36mm8
Celera123,832,137 - 23,841,860 (-)NCBICelera
Cytogenetic Map1A5NCBI
cM Map19.86NCBI
Sdhaf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8933,904,667 - 33,912,813 (-)NCBIGRCr8
mRatBN7.2926,408,332 - 26,416,478 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx934,918,115 - 34,926,261 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0940,036,410 - 40,044,557 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0938,346,158 - 38,354,304 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0930,243,261 - 30,251,478 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl930,243,610 - 30,251,388 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0929,067,898 - 29,076,116 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4922,713,335 - 22,721,491 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera923,945,793 - 23,953,994 (-)NCBICelera
Cytogenetic Map9q13NCBI
Sdhaf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554885,628,341 - 5,645,707 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554885,628,297 - 5,644,384 (+)NCBIChiLan1.0ChiLan1.0
SDHAF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2590,554,858 - 90,576,863 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1688,480,060 - 88,509,848 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0668,402,024 - 68,424,420 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1671,700,165 - 71,722,131 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl671,700,165 - 71,722,125 (+)Ensemblpanpan1.1panPan2
SDHAF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11233,080,545 - 33,089,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1233,069,013 - 33,089,930 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1232,927,894 - 32,948,859 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01233,608,662 - 33,629,628 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1233,608,696 - 33,629,614 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11233,139,123 - 33,160,035 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01233,180,881 - 33,201,819 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01233,293,517 - 33,314,461 (+)NCBIUU_Cfam_GSD_1.0
Sdhaf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494668,294,307 - 68,306,697 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366182,451,675 - 2,466,150 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366182,451,717 - 2,461,676 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SDHAF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1174,410,081 - 4,432,885 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl174,410,932 - 4,432,841 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605810,414,639 - 10,437,421 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sdhaf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248199,320,368 - 9,336,572 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248199,320,343 - 9,336,196 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SDHAF4
6 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q12-13(chr6:68735649-70794393)x4 copy number gain See cases [RCV000138053] Chr6:68735649..70794393 [GRCh38]
Chr6:69445541..71504096 [GRCh37]
Chr6:69502262..71560817 [NCBI36]
Chr6:6q12-13
pathogenic
GRCh38/hg38 6q13(chr6:70252200-70891985)x3 copy number gain See cases [RCV000139782] Chr6:70252200..70891985 [GRCh38]
Chr6:70961903..71601688 [GRCh37]
Chr6:71018624..71658409 [NCBI36]
Chr6:6q13
likely benign
GRCh38/hg38 6q13(chr6:70252257-70855775)x3 copy number gain See cases [RCV000141887] Chr6:70252257..70855775 [GRCh38]
Chr6:70961960..71565478 [GRCh37]
Chr6:71018681..71622199 [NCBI36]
Chr6:6q13
uncertain significance
GRCh38/hg38 6q12-14.2(chr6:64549655-83426791)x1 copy number loss See cases [RCV000142527] Chr6:64549655..83426791 [GRCh38]
Chr6:65259548..84136510 [GRCh37]
Chr6:65316269..84193229 [NCBI36]
Chr6:6q12-14.2
pathogenic
GRCh38/hg38 6q13(chr6:70026943-70923391)x3 copy number gain See cases [RCV000143243] Chr6:70026943..70923391 [GRCh38]
Chr6:70736835..71633094 [GRCh37]
Chr6:70793556..71689815 [NCBI36]
Chr6:6q13
uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q13(chr6:70716539-71620525)x3 copy number gain See cases [RCV000511284] Chr6:70716539..71620525 [GRCh37]
Chr6:6q13
uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
GRCh37/hg19 6q12-13(chr6:69481460-73185349)x1 copy number loss not provided [RCV000847757] Chr6:69481460..73185349 [GRCh37]
Chr6:6q12-13
pathogenic
NM_145267.3(SDHAF4):c.155A>C (p.Lys52Thr) single nucleotide variant Inborn genetic diseases [RCV003291423] Chr6:70579504 [GRCh38]
Chr6:71289207 [GRCh37]
Chr6:6q13
uncertain significance
GRCh37/hg19 6q13(chr6:70320224-71568417)x3 copy number gain not provided [RCV002472782] Chr6:70320224..71568417 [GRCh37]
Chr6:6q13
uncertain significance
GRCh37/hg19 6q13-14.1(chr6:70165296-79920769)x1 copy number loss not provided [RCV001834215] Chr6:70165296..79920769 [GRCh37]
Chr6:6q13-14.1
pathogenic
GRCh37/hg19 6q12-16.1(chr6:69938252-94379210) copy number gain not specified [RCV002053581] Chr6:69938252..94379210 [GRCh37]
Chr6:6q12-16.1
pathogenic
GRCh37/hg19 6q13(chr6:71105038-75200617)x1 copy number loss Autism [RCV002292213] Chr6:71105038..75200617 [GRCh37]
Chr6:6q13
pathogenic
GRCh37/hg19 6q12-14.1(chr6:64954687-79581678) copy number loss Chromosome 6q11-q14 deletion syndrome [RCV002280752] Chr6:64954687..79581678 [GRCh37]
Chr6:6q12-14.1
pathogenic
NM_145267.3(SDHAF4):c.187G>T (p.Asp63Tyr) single nucleotide variant Inborn genetic diseases [RCV002907360] Chr6:70579536 [GRCh38]
Chr6:71289239 [GRCh37]
Chr6:6q13
uncertain significance
NM_145267.3(SDHAF4):c.10T>A (p.Ser4Thr) single nucleotide variant Inborn genetic diseases [RCV002954593] Chr6:70566950 [GRCh38]
Chr6:71276653 [GRCh37]
Chr6:6q13
uncertain significance
NM_145267.3(SDHAF4):c.11C>T (p.Ser4Leu) single nucleotide variant Inborn genetic diseases [RCV002655209] Chr6:70566951 [GRCh38]
Chr6:71276654 [GRCh37]
Chr6:6q13
uncertain significance
NM_145267.3(SDHAF4):c.58G>A (p.Ala20Thr) single nucleotide variant Inborn genetic diseases [RCV003200364] Chr6:70566998 [GRCh38]
Chr6:71276701 [GRCh37]
Chr6:6q13
uncertain significance
NM_145267.3(SDHAF4):c.27G>T (p.Leu9Phe) single nucleotide variant Inborn genetic diseases [RCV003365883] Chr6:70566967 [GRCh38]
Chr6:71276670 [GRCh37]
Chr6:6q13
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:598
Count of miRNA genes:454
Interacting mature miRNAs:486
Transcripts:ENST00000370474, ENST00000468640
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D10S16   No map positions available.
D10S16  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3p24.2UniSTS
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map1p36.33UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map5q23.3-q31.1UniSTS
Cytogenetic Map7q32UniSTS
Cytogenetic Map1q21-q23UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map2q11.2-q12UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map3p22UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map2p12UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map9p13.3-p12UniSTS
Cytogenetic Map3p21.1UniSTS
Cytogenetic Map5p13.1UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map2p25.2UniSTS
Cytogenetic Map5q21-q22UniSTS
Cytogenetic Map2p22.1UniSTS
Cytogenetic Map1q32.3UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map18q12UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map3q27.3UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map20q13.32UniSTS
Cytogenetic Map10q26UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map7q21.13UniSTS
Cytogenetic Map1p33UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map9q22.3UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map12q13.2UniSTS
Cytogenetic Map22q13.31-q13.33UniSTS
Cytogenetic Map1q24.1UniSTS
Cytogenetic Map7q32.2UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map1q42.11UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map11q24UniSTS
Cytogenetic Map2q11.2-q12.1UniSTS
Cytogenetic Map3q21.2UniSTS
Cytogenetic Map19q13.1UniSTS
Cytogenetic Map19p13UniSTS
Cytogenetic Map8p11.21UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map20q12UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map17q22.2UniSTS
Cytogenetic Map18q21UniSTS
Cytogenetic Map11q14.2UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map4q34UniSTS
Cytogenetic Map2p22-p21UniSTS
Cytogenetic Map10q26.3UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map11q13.4UniSTS
Cytogenetic Map2q37.1UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map1p36.23UniSTS
Cytogenetic Map7p22.2UniSTS
Cytogenetic Map12q24.13UniSTS
Cytogenetic Map8p21.2UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map14q32.12UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map1p36.31UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic MapXq26.3UniSTS
Cytogenetic Map8p23.1UniSTS
Cytogenetic Map6q13UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map9p13.2UniSTS
Cytogenetic Map17q25UniSTS
Cytogenetic Map9q22.2UniSTS
Cytogenetic Map14q32.33UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map13q12.11UniSTS
Cytogenetic Map16p13.13UniSTS
Cytogenetic Map11p15.4UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map11q12.3UniSTS
Cytogenetic Map22q13UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map11p15.3-p15.1UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map10q22.2UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map7p22.3UniSTS
Cytogenetic Map3p21UniSTS
Cytogenetic MapXp22.3UniSTS
Cytogenetic Map1q42.3UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map6p24.3UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map1q25UniSTS
Cytogenetic Map15q11.2UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map3q26UniSTS
Cytogenetic Map12p12.1-p11.2UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map13q14.11UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map10q11.22UniSTS
Cytogenetic Map5p12UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map9q21.13UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic MapXq23UniSTS
Cytogenetic Map2p21UniSTS
Cytogenetic Map22q11.1UniSTS
Cytogenetic Map16q13UniSTS
Cytogenetic Map16pUniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map1q25.1UniSTS
Cytogenetic Map10q23-q24UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map7q31UniSTS
Cytogenetic Map6q23.3UniSTS
Cytogenetic MapXp22.2UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map20q11.22UniSTS
Cytogenetic Map4q35.1UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic Map5q12.3UniSTS
Cytogenetic Map6q25.1UniSTS
Cytogenetic Map14q24.1UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map14q23.2UniSTS
Cytogenetic Map15q24.1UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map8q23.1UniSTS
Cytogenetic Map2q14.3UniSTS
Cytogenetic Map20q13.33UniSTS
Cytogenetic Map21q22.11UniSTS
Cytogenetic Map5p15.1UniSTS
Cytogenetic Map15q13.1UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map7q32.1UniSTS
Cytogenetic Map8p21.3UniSTS
Cytogenetic Map1p31.1UniSTS
Cytogenetic Map17qterUniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map12q22UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic MapXp22.33UniSTS
Cytogenetic MapYp11.32UniSTS
Cytogenetic Map14q24.2UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map13q34UniSTS
Cytogenetic Map10p11.23UniSTS
Cytogenetic Map15q15.2UniSTS
Cytogenetic Map8p21.1UniSTS
Cytogenetic Map22q12.2UniSTS
Cytogenetic Map15q22.2UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map6p21.31UniSTS
Cytogenetic Map10q23.1UniSTS
Cytogenetic Map1p36.2UniSTS
Cytogenetic Map2p16.1UniSTS
Cytogenetic Map22q11.2UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map20q12-q13.12UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map5q31.2-q34UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map5q35.3UniSTS
Cytogenetic MapXq13-q21UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map1pter-q31.3UniSTS
Cytogenetic Map15q21.1UniSTS
Cytogenetic Map3q13.33UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic Map3p23-p21UniSTS
Cytogenetic Map11q22-q23UniSTS
Cytogenetic Map1p34.1UniSTS
Cytogenetic Map2q21.1UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map7p22.1UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map10q11.21UniSTS
Cytogenetic Map16q22UniSTS
Cytogenetic Map2q24UniSTS
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map3q13.13UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map16p13.1UniSTS
Cytogenetic Map19q13.11UniSTS
Cytogenetic MapXp22.12UniSTS
Cytogenetic Map9q21.33UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map16q11.2UniSTS
Cytogenetic Map10p12.31UniSTS
Cytogenetic Map3q25.33UniSTS
Cytogenetic Map8q21.2UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map15q14-q15UniSTS
Cytogenetic Map8p11.2UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map4p15.2UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map7p21.1UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map1p36.1-p34UniSTS
Cytogenetic Map4p13UniSTS
Cytogenetic Map7q31.1-q31.2UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map15q21.1-q21.2UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic Map7q36.1UniSTS
Cytogenetic Map7p14.1UniSTS
Cytogenetic Map6p23UniSTS
Cytogenetic Map3p11.1UniSTS
Cytogenetic Map15q21.3UniSTS
Cytogenetic Map13q12UniSTS
Cytogenetic Map12q23.2UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map16q22.3UniSTS
Cytogenetic MapXq21UniSTS
Cytogenetic Map15q15UniSTS
Cytogenetic Map4q25UniSTS
Cytogenetic Map3q22.1UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map11q14.3UniSTS
Cytogenetic Map10q21.3UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map15q24.2UniSTS
Cytogenetic Map2p14UniSTS
Cytogenetic Map7q11.1UniSTS
Cytogenetic Map6p21UniSTS
Cytogenetic Map2p25.1-p24.1UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map4q13.3UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map18q21.3UniSTS
Cytogenetic Map17p13UniSTS
Cytogenetic Map8q12UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map21q22.13UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map17q24.3UniSTS
Cytogenetic Map1p21UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic Map2q34UniSTS
Cytogenetic Map8p11.23UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map9q34.3UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map16p12UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map12q15UniSTS
Cytogenetic Map2q12.2UniSTS
Cytogenetic Map8p12UniSTS
Cytogenetic Map7q22.3UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map4q35UniSTS
Cytogenetic Map19q13.1-q13.2UniSTS
Cytogenetic Map16p13.12UniSTS
Cytogenetic Map9q34.1UniSTS
Cytogenetic Map7q36.2UniSTS
Cytogenetic Map3p23UniSTS
Cytogenetic Map6p25UniSTS
Cytogenetic Map9q22.1-q22.2UniSTS
Cytogenetic Map3q26.1-q26.2UniSTS
Cytogenetic Map5q31-q34UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map12p13UniSTS
Cytogenetic Map4q26UniSTS
Cytogenetic Map4p15.3UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map1p32-p31UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map3q13.2UniSTS
Cytogenetic Map2q33.3UniSTS
Cytogenetic Map8p22UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map15q26.3UniSTS
Cytogenetic Map12q14.2UniSTS
Cytogenetic Map2q31.1-q31.2UniSTS
Cytogenetic Map12q13.11UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map6p12.3UniSTS
Cytogenetic Map6q22.32UniSTS
Cytogenetic Map5q15UniSTS
Cytogenetic Map3p14.2UniSTS
Cytogenetic Map3p25.1UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map2q36.1UniSTS
Cytogenetic Map2q37UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map4q23UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map10q22.1UniSTS
Cytogenetic Map18q11.1UniSTS
Cytogenetic Map16q23.2UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map18q21.1UniSTS
Cytogenetic Map12q12-q13UniSTS
Cytogenetic Map9p22.3UniSTS
Cytogenetic Map6p21.2UniSTS
Cytogenetic Map6p22.1UniSTS
Cytogenetic Map11p15.1UniSTS
Cytogenetic Map19qterUniSTS
Cytogenetic Map20q13.3-qterUniSTS
Cytogenetic Map12q14.1UniSTS
Cytogenetic Map7p11UniSTS
Cytogenetic Map7p15UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map16p12.3UniSTS
Cytogenetic Map3q29UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map17pUniSTS
Cytogenetic Map11p14.1UniSTS
Cytogenetic Map2p13.2UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map20q13.12UniSTS
Cytogenetic Map13q22.1UniSTS
Cytogenetic Map17p13.1UniSTS
Cytogenetic Map14q23.3UniSTS
Cytogenetic Map3q26.2UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 606 1047 1145 180 744 95 2978 610 2785 331 947 1048 98 1 946 1734 6 2
Low 1833 1897 581 444 1161 370 1379 1585 949 88 513 565 76 258 1054
Below cutoff 47 46 2

Sequence


RefSeq Acc Id: ENST00000370474   ⟹   ENSP00000359505
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl670,566,930 - 70,589,569 (+)Ensembl
RefSeq Acc Id: ENST00000468640
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl670,566,917 - 70,567,659 (+)Ensembl
RefSeq Acc Id: NM_145267   ⟹   NP_660310
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38670,566,930 - 70,589,569 (+)NCBI
GRCh37671,276,625 - 71,298,606 (+)RGD
Build 36671,333,346 - 71,355,327 (+)NCBI Archive
Celera671,665,041 - 71,687,022 (+)RGD
HuRef668,474,783 - 68,496,774 (+)RGD
CHM1_1671,442,976 - 71,464,957 (+)NCBI
T2T-CHM13v2.0671,747,474 - 71,770,117 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047418210   ⟹   XP_047274166
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38670,566,930 - 70,598,428 (+)NCBI
RefSeq Acc Id: NP_660310   ⟸   NM_145267
- Peptide Label: precursor
- UniProtKB: E1P532 (UniProtKB/Swiss-Prot),   Q5VUM1 (UniProtKB/Swiss-Prot),   I6L976 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000359505   ⟸   ENST00000370474
RefSeq Acc Id: XP_047274166   ⟸   XM_047418210
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5VUM1-F1-model_v2 AlphaFold Q5VUM1 1-108 view protein structure

Promoters
RGD ID:7208453
Promoter ID:EPDNEW_H9973
Type:initiation region
Name:SDHAF4_1
Description:succinate dehydrogenase complex assembly factor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38670,566,930 - 70,566,990EPDNEW
RGD ID:6803862
Promoter ID:HG_KWN:54052
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000041140,   OTTHUMT00000041141
Position:
Human AssemblyChrPosition (strand)Source
Build 36671,333,199 - 71,333,699 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:20957 AgrOrtholog
COSMIC SDHAF4 COSMIC
Ensembl Genes ENSG00000154079 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000370474 ENTREZGENE
  ENST00000370474.4 UniProtKB/Swiss-Prot
GTEx ENSG00000154079 GTEx
HGNC ID HGNC:20957 ENTREZGENE
Human Proteome Map SDHAF4 Human Proteome Map
InterPro SDHF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:135154 UniProtKB/Swiss-Prot
NCBI Gene 135154 ENTREZGENE
OMIM 619198 OMIM
PANTHER SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL UniProtKB/Swiss-Prot
  SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL UniProtKB/Swiss-Prot
  SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL UniProtKB/TrEMBL
  SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam DUF1674 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134932684 PharmGKB
UniProt E1P532 ENTREZGENE
  I6L976 ENTREZGENE, UniProtKB/TrEMBL
  Q5VUM1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary E1P532 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-03 SDHAF4  succinate dehydrogenase complex assembly factor 4  C6orf57  chromosome 6 open reading frame 57  Symbol and/or name change 5135510 APPROVED