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Gene: MLH3 (mutL homolog 3) Homo sapiens
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Symbol: MLH3
Name: mutL homolog 3
Description: Predicted to have ATPase activity. Predicted to be involved in mismatch repair. Localizes to the nucleoplasm. Implicated in Lynch syndrome; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 7.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA mismatch repair protein Mlh3; HNPCC7; MGC138372; mutL protein homolog 3
Orthologs:
Mus musculus (house mouse) : Mlh3 (mutL homolog 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mlh3 (mutL homolog 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mlh3 (mutL homolog 3)
Pan paniscus (bonobo/pygmy chimpanzee) : MLH3 (mutL homolog 3)
Canis lupus familiaris (dog) : MLH3 (mutL homolog 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mlh3 (mutL homolog 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381475,013,764 - 75,051,532 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371475,480,467 - 75,518,235 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,550,220 - 74,587,988 (-)NCBINCBI36hg18NCBI36
Build 341474,553,052 - 74,587,886NCBI
Celera1455,518,160 - 55,555,906 (-)NCBI
Cytogenetic Map14q24.3NCBI
HuRef1455,648,309 - 55,686,423 (-)NCBIHuRef
CHM1_11475,419,018 - 75,456,769 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MLH3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319451
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.