Hs6st1 (heparan sulfate 6-O-sulfotransferase 1) - Rat Genome Database

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Gene: Hs6st1 (heparan sulfate 6-O-sulfotransferase 1) Mus musculus
Analyze
Symbol: Hs6st1
Name: heparan sulfate 6-O-sulfotransferase 1
RGD ID: 1319438
MGI Page MGI
Description: Exhibits heparan sulfate 6-O-sulfotransferase activity. Involved in blood vessel development; heparan sulfate proteoglycan biosynthetic process, enzymatic modification; and lung alveolus development. Predicted to localize to integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 15 with or without anosmia. Orthologous to human HS6ST1 (heparan sulfate 6-O-sulfotransferase 1); PARTICIPATES IN heparan sulfate biosynthetic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6OS; 6Ost1; heparan-sulfate 6-O-sulfotransferase 1; HS6ST-1; mHS6ST-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39136,107,481 - 36,145,527 (+)NCBIGRCm39mm39
GRCm39 Ensembl136,107,481 - 36,145,527 (+)Ensembl
GRCm38136,068,400 - 36,106,446 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl136,068,400 - 36,106,446 (+)EnsemblGRCm38mm10GRCm38
MGSCv37136,125,245 - 36,163,291 (+)NCBIGRCm37mm9NCBIm37
MGSCv36136,012,955 - 36,050,992 (+)NCBImm8
Celera135,889,714 - 35,892,649 (+)NCBICelera
Cytogenetic Map1BNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10644753   PMID:11042159   PMID:11076861   PMID:11242070   PMID:11431694   PMID:12460940   PMID:12477932   PMID:12520002   PMID:12611590   PMID:12904583  
PMID:14610273   PMID:14681479   PMID:15489334   PMID:15499561   PMID:15944372   PMID:16141072   PMID:16141073   PMID:16326709   PMID:16807321   PMID:17405882   PMID:18196599   PMID:18281280  
PMID:19889634   PMID:20410206   PMID:21247964   PMID:21267068   PMID:21307234   PMID:21357686   PMID:21873635   PMID:21951307   PMID:22745308   PMID:23074159   PMID:23223449   PMID:23281850  
PMID:24501377   PMID:24753163   PMID:24924191   PMID:27048738   PMID:29158323   PMID:30617207   PMID:32201365  


Genomics

Comparative Map Data
Hs6st1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39136,107,481 - 36,145,527 (+)NCBIGRCm39mm39
GRCm39 Ensembl136,107,481 - 36,145,527 (+)Ensembl
GRCm38136,068,400 - 36,106,446 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl136,068,400 - 36,106,446 (+)EnsemblGRCm38mm10GRCm38
MGSCv37136,125,245 - 36,163,291 (+)NCBIGRCm37mm9NCBIm37
MGSCv36136,012,955 - 36,050,992 (+)NCBImm8
Celera135,889,714 - 35,892,649 (+)NCBICelera
Cytogenetic Map1BNCBI
HS6ST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2128,236,716 - 128,318,868 (-)EnsemblGRCh38hg38GRCh38
GRCh382128,265,480 - 128,318,868 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372129,023,054 - 129,076,442 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362128,739,524 - 128,792,641 (-)NCBINCBI36hg18NCBI36
Build 342128,741,261 - 128,792,482NCBI
Celera2122,329,574 - 122,382,723 (-)NCBI
Cytogenetic Map2q14.3NCBI
HuRef2121,328,848 - 121,381,981 (-)NCBIHuRef
CHM1_12129,027,954 - 129,081,083 (-)NCBICHM1_1
Hs6st1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2938,283,502 - 38,322,684 (+)NCBI
Rnor_6.0 Ensembl942,620,006 - 42,659,184 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0942,620,006 - 42,659,184 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0942,274,321 - 42,313,302 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4934,978,441 - 35,018,289 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1934,979,565 - 35,017,486 (+)NCBI
Celera936,051,788 - 36,090,818 (+)NCBICelera
Cytogenetic Map9q21NCBI
Hs6st1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554592,273,100 - 2,310,993 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554592,273,100 - 2,310,993 (+)NCBIChiLan1.0ChiLan1.0
HS6ST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B128,935,748 - 128,961,536 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02B31,949,260 - 32,002,848 (+)NCBIMhudiblu_PPA_v0panPan3
HS6ST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11922,343,193 - 22,372,464 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1922,368,942 - 22,369,652 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1922,577,736 - 22,619,406 (+)NCBI
ROS_Cfam_1.01923,659,352 - 23,701,027 (+)NCBI
UMICH_Zoey_3.11922,312,680 - 22,354,323 (+)NCBI
UNSW_CanFamBas_1.01922,556,307 - 22,597,954 (+)NCBI
UU_Cfam_GSD_1.01923,687,676 - 23,729,328 (+)NCBI
Hs6st1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530398,531,679 - 98,578,226 (-)NCBI
SpeTri2.0NW_00493646943,039,494 - 43,086,041 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HS6ST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1559,066,603 - 59,108,777 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11559,066,448 - 59,108,780 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21565,657,113 - 65,699,333 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HS6ST1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1101,918,019 - 1,971,060 (+)NCBI
ChlSab1.1 Ensembl101,918,154 - 1,971,610 (+)Ensembl
Vero_WHO_p1.0NW_02366606120,804,220 - 20,857,695 (-)NCBI
Hs6st1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473217,210,315 - 17,249,930 (+)NCBI

Position Markers
Hs6st1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38136,103,513 - 36,104,514UniSTSGRCm38
MGSCv37136,161,767 - 36,162,301UniSTSGRCm37
MGSCv37136,161,951 - 36,162,301UniSTSGRCm37
Celera135,889,714 - 35,890,715UniSTS
Cytogenetic Map1BUniSTS
cM Map1 UniSTS
UniSTS:234108  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38136,104,522 - 36,104,817UniSTSGRCm38
MGSCv37136,161,367 - 36,161,662UniSTSGRCm37
Celera135,890,723 - 35,891,018UniSTS
Cytogenetic Map1BUniSTS
Hs6st1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1BUniSTS
Hs6st1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38136,104,922 - 36,105,456UniSTSGRCm38
MGSCv37136,161,767 - 36,162,301UniSTSGRCm37
Celera135,891,125 - 35,891,659UniSTS
Cytogenetic Map1BUniSTS
Hs6st1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38136,105,106 - 36,105,456UniSTSGRCm38
MGSCv37136,161,951 - 36,162,301UniSTSGRCm37
Celera135,891,309 - 35,891,659UniSTS
Cytogenetic Map1BUniSTS
cM Map1 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301275Sle10_msystematic lupus erythematosus susceptibility 10 (mouse)Not determined1281197036812128Mouse
1301370Adip1_madiposity 1 (mouse)Not determined1281197036812128Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1301471Obq2_mobesity QTL 2 (mouse)Not determined1387139637871663Mouse
10043970Obq23_mobesity QTL 23 (mouse)Not determined1494244138942441Mouse
1301011Cplaq4_mcircadian period of locomotor activity 4 (mouse)Not determined1963436143634520Mouse
14700685Civq2_mcerebral infarct volume QTL 2 (mouse)11130140145301401Mouse
1301240Sluc15_msusceptibility to lung cancer 15 (mouse)Not determined11902627053026373Mouse
1301073Orch5_mautoimmune orchitis resistance 5 (mouse)Not determined11902627053026373Mouse
1301756Pgia1_mproteoglycan induced arthritis 1 (mouse)Not determined11902627053026373Mouse
12880407V125Dq2_mvitamin D active form serum level QTL 2 (mouse)11930000053300000Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12307051073937756Mouse
4142433Hbnr1_mHeligmosomoides bakeri nematode resistance 1 (mouse)Not determined2551111058234112Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12551111062907723Mouse
12880409V125Dq1_mvitamin D active form serum level QTL 1 (mouse)12600000060000000Mouse
1357822Lvrq3_mliver weight QTL 3 (mouse)Not determined13472105773937756Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13472105773937756Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13472105773937756Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13472105773937756Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13472105773937756Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13472105773937756Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13472105773937756Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:952
Count of miRNA genes:517
Interacting mature miRNAs:633
Transcripts:ENSMUST00000088174
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000088174   ⟹   ENSMUSP00000085499
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl136,068,400 - 36,106,446 (+)Ensembl
RefSeq Acc Id: ENSMUST00000194670
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl136,101,690 - 36,104,980 (+)Ensembl
RefSeq Acc Id: NM_015818   ⟹   NP_056633
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39136,107,481 - 36,145,527 (+)NCBI
GRCm38136,068,400 - 36,106,446 (+)ENTREZGENE
MGSCv37136,125,245 - 36,163,291 (+)RGD
Celera135,889,714 - 35,892,649 (+)RGD
cM Map1 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_056633   ⟸   NM_015818
- UniProtKB: Q9QYK5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000085499   ⟸   ENSMUST00000088174

Promoters
RGD ID:6873416
Promoter ID:EPDNEW_M159
Type:multiple initiation site
Name:Hs6st1_1
Description:Mus musculus heparan sulfate 6-O-sulfotransferase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38136,068,381 - 36,068,441EPDNEW
RGD ID:6817894
Promoter ID:MM_KWN:417
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000073283
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36136,124,941 - 36,125,982 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1354958 AgrOrtholog
Ensembl Genes ENSMUSG00000045216 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000085499 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000088174 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Heparan_SO4-6-sulfoTrfase UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Sulfotransferase UniProtKB/Swiss-Prot
KEGG Report mmu:50785 UniProtKB/Swiss-Prot
MGD MGI:1354958 ENTREZGENE
NCBI Gene 50785 ENTREZGENE
PANTHER PTHR12812 UniProtKB/Swiss-Prot
Pfam Sulfotransfer_2 UniProtKB/Swiss-Prot
PhenoGen Hs6st1 PhenoGen
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt H6ST1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3TK52 UniProtKB/Swiss-Prot
  Q3TKK0 UniProtKB/Swiss-Prot
  Q3TND4 UniProtKB/Swiss-Prot
  Q3TZT5 UniProtKB/Swiss-Prot