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Gene: NSMCE3 (NSE3 homolog, SMC5-SMC6 complex component) Homo sapiens
Symbol: NSMCE3
Name: NSE3 homolog, SMC5-SMC6 complex component
Description: Exhibits protein dimerization activity. Involved in several processes, including cellular response to UV; cellular response to hydroxyurea; and positive regulation of protein ubiquitination. Localizes to the Smc5-Smc6 complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HCA4; hepatocellular carcinoma-associated protein 4; hepatocellular carcinoma-associated protein HCA4; LICS; MAGE-G1 antigen; MAGEG1; MAGEL3; melanoma antigen, family G, 1; melanoma-associated antigen G1; NDNL2; necdin-like 2; necdin-like 2, SMC5-SMC6 complex component; necdin-like gene 2; necdin-like protein 2; non-SMC element 3 homolog; non-structural maintenance of chromosomes element 3 homolog; NSE3
Mus musculus (house mouse) : Nsmce3 (NSE3 homolog, SMC5-SMC6 complex component)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nsmce3 (NSE3 homolog, SMC5-SMC6 complex component)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nsmce3 (NSE3 homolog, SMC5-SMC6 complex component)
Pan paniscus (bonobo/pygmy chimpanzee) : NSMCE3 (NSE3 homolog, SMC5-SMC6 complex component)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nsmce3 (NSE3 homolog, SMC5-SMC6 complex component)
Sus scrofa (pig) : NSMCE3 (NSE3 homolog, SMC5-SMC6 complex component)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381529,264,989 - 29,269,822 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371529,560,353 - 29,562,020 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361527,347,650 - 27,349,309 (-)NCBINCBI36hg18NCBI36
Build 341527,347,650 - 27,349,309NCBI
Celera157,197,619 - 7,199,278 (-)NCBI
Cytogenetic Map15q13.1NCBI
HuRef157,218,489 - 7,220,156 (-)NCBIHuRef
CHM1_11529,527,055 - 29,528,722 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NSMCE3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319419
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.