DUSP23 (dual specificity phosphatase 23) - Rat Genome Database

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Gene: DUSP23 (dual specificity phosphatase 23) Homo sapiens
Analyze
Symbol: DUSP23
Name: dual specificity phosphatase 23
RGD ID: 1319412
HGNC Page HGNC
Description: Enables protein tyrosine/serine/threonine phosphatase activity. Involved in dephosphorylation. Located in nucleoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dual specificity protein phosphatase 23; DUSP25; FLJ20442; LDP-3; LDP3; low molecular mass dual specificity phosphatase 3; low-molecular-mass dual-specificity phosphatase 3; MOSP; RP11-190A12.1; testicular tissue protein Li 59; VH1-like member Z; VH1-like phosphatase Z; VHZ
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1159,780,932 - 159,782,543 (+)EnsemblGRCh38hg38GRCh38
GRCh381159,780,962 - 159,782,543 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371159,750,752 - 159,752,333 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,017,383 - 158,018,957 (+)NCBINCBI36hg18NCBI36
Build 341156,563,831 - 156,565,406NCBI
Celera1132,819,186 - 132,820,760 (+)NCBI
Cytogenetic Map1q23.2NCBI
HuRef1131,107,191 - 131,108,765 (+)NCBIHuRef
CHM1_11161,146,109 - 161,147,683 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IEA)
nucleoplasm  (IDA)
nucleus  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
1. GOA_HUMAN data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:15147733   PMID:15201283   PMID:15281913   PMID:15489334   PMID:16169070   PMID:16344560   PMID:16710414   PMID:17498703   PMID:18029348   PMID:19913121  
PMID:20453000   PMID:20509867   PMID:20628086   PMID:20855292   PMID:21787189   PMID:21873635   PMID:21900206   PMID:22939635   PMID:23376485   PMID:23824909   PMID:24531476   PMID:25416956  
PMID:25910212   PMID:27432908   PMID:27737517   PMID:27880917   PMID:28330616   PMID:28514442   PMID:28515276   PMID:28675297   PMID:28986522   PMID:29509190   PMID:29955894   PMID:32296183  
PMID:33961781  


Genomics

Comparative Map Data
DUSP23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1159,780,932 - 159,782,543 (+)EnsemblGRCh38hg38GRCh38
GRCh381159,780,962 - 159,782,543 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371159,750,752 - 159,752,333 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,017,383 - 158,018,957 (+)NCBINCBI36hg18NCBI36
Build 341156,563,831 - 156,565,406NCBI
Celera1132,819,186 - 132,820,760 (+)NCBI
Cytogenetic Map1q23.2NCBI
HuRef1131,107,191 - 131,108,765 (+)NCBIHuRef
CHM1_11161,146,109 - 161,147,683 (+)NCBICHM1_1
Dusp23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,458,336 - 172,460,541 (-)NCBIGRCm39mm39
GRCm39 Ensembl1172,458,331 - 172,460,529 (-)Ensembl
GRCm381172,630,769 - 172,632,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,630,764 - 172,632,962 (-)EnsemblGRCm38mm10GRCm38
MGSCv371174,560,900 - 174,563,105 (-)NCBIGRCm37mm9NCBIm37
MGSCv361174,468,045 - 174,469,637 (-)NCBImm8
Celera1175,487,228 - 175,489,448 (-)NCBICelera
Cytogenetic Map1H3NCBI
Dusp23
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21385,098,792 - 85,099,984 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1385,097,899 - 85,100,093 (-)Ensembl
Rnor_6.01391,018,670 - 91,019,862 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,018,510 - 91,020,112 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,537,373 - 95,538,565 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,637,671 - 88,638,863 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11388,826,435 - 88,827,841 (-)NCBI
Celera1384,707,861 - 84,708,048 (-)NCBICelera
Cytogenetic Map13q24NCBI
Dusp23
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546811,579,817 - 11,581,174 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546811,579,624 - 11,581,975 (+)NCBIChiLan1.0ChiLan1.0
DUSP23
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11139,053,238 - 139,054,865 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1139,053,238 - 139,054,865 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01135,132,451 - 135,134,101 (+)NCBIMhudiblu_PPA_v0panPan3
DUSP23
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13822,341,052 - 22,344,861 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3822,417,809 - 22,423,310 (-)NCBI
ROS_Cfam_1.03822,463,300 - 22,469,314 (-)NCBI
ROS_Cfam_1.0 Ensembl3822,462,976 - 22,469,317 (-)Ensembl
UMICH_Zoey_3.13822,235,838 - 22,236,110 (-)NCBI
UNSW_CanFamBas_1.03822,762,744 - 22,768,279 (-)NCBI
UU_Cfam_GSD_1.03823,173,732 - 23,179,864 (-)NCBI
Dusp23
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408299257 - 1,735 (-)NCBI
SpeTri2.0NW_00494394331 - 1,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP23
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl490,720,696 - 90,721,946 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1490,720,655 - 90,722,675 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2498,692,567 - 98,695,616 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP23
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1204,169,422 - 4,171,092 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl204,169,418 - 4,170,947 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660383,274,497 - 3,276,202 (-)NCBIVero_WHO_p1.0
Dusp23
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247941,462,782 - 1,469,881 (-)NCBIHetGla_female_1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:813
Count of miRNA genes:242
Interacting mature miRNAs:263
Transcripts:ENST00000368107, ENST00000368108, ENST00000368109
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 14
Medium 2420 2641 1707 613 1531 454 4327 1993 3481 409 1407 1593 170 1204 2765 1
Low 14 350 12 5 330 5 29 194 231 5 29 17 4 1 23 4 2
Below cutoff 3 2 2 24 2 5 7 2 6

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000368107   ⟹   ENSP00000357087
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1159,780,962 - 159,782,543 (+)Ensembl
RefSeq Acc Id: ENST00000368108   ⟹   ENSP00000357088
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1159,780,960 - 159,782,543 (+)Ensembl
RefSeq Acc Id: ENST00000368109   ⟹   ENSP00000357089
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1159,780,932 - 159,782,543 (+)Ensembl
RefSeq Acc Id: NM_001319658   ⟹   NP_001306587
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,780,962 - 159,782,543 (+)NCBI
CHM1_11161,146,143 - 161,147,686 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001319659   ⟹   NP_001306588
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,780,962 - 159,782,543 (+)NCBI
CHM1_11161,146,086 - 161,147,686 (+)NCBI
Sequence:
RefSeq Acc Id: NM_017823   ⟹   NP_060293
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,780,962 - 159,782,543 (+)NCBI
GRCh371159,750,730 - 159,752,333 (+)NCBI
Build 361158,017,383 - 158,018,957 (+)NCBI Archive
Celera1132,819,186 - 132,820,760 (+)RGD
HuRef1131,107,191 - 131,108,765 (+)ENTREZGENE
CHM1_11161,146,086 - 161,147,686 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_060293   ⟸   NM_017823
- UniProtKB: Q9BVJ7 (UniProtKB/Swiss-Prot),   A0A140VJI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001306588   ⟸   NM_001319659
- UniProtKB: Q9BVJ7 (UniProtKB/Swiss-Prot),   A0A140VJI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001306587   ⟸   NM_001319658
- UniProtKB: Q9BVJ7 (UniProtKB/Swiss-Prot),   A0A140VJI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000357087   ⟸   ENST00000368107
RefSeq Acc Id: ENSP00000357089   ⟸   ENST00000368109
RefSeq Acc Id: ENSP00000357088   ⟸   ENST00000368108
Promoters
RGD ID:6785081
Promoter ID:HG_KWN:5703
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:ENST00000368107,   ENST00000368109,   OTTHUMT00000059111
Position:
Human AssemblyChrPosition (strand)Source
Build 361158,017,036 - 158,017,536 (+)MPROMDB
RGD ID:6857724
Promoter ID:EPDNEW_H2027
Type:initiation region
Name:DUSP23_1
Description:dual specificity phosphatase 23
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381159,780,969 - 159,781,029EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q23.2-24.1(chr1:159479887-166895086)x1 copy number loss See cases [RCV000051172] Chr1:159479887..166895086 [GRCh38]
Chr1:159449677..166864323 [GRCh37]
Chr1:157716301..165130947 [NCBI36]
Chr1:1q23.2-24.1
pathogenic
GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3 copy number gain See cases [RCV000051854] Chr1:157747246..176021247 [GRCh38]
Chr1:157717036..175990383 [GRCh37]
Chr1:155983660..174257006 [NCBI36]
Chr1:1q23.1-25.1
pathogenic
GRCh38/hg38 1q23.1-23.3(chr1:156664483-160727411)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051851]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051851]|See cases [RCV000051851] Chr1:156664483..160727411 [GRCh38]
Chr1:156634275..160697201 [GRCh37]
Chr1:154900899..158963825 [NCBI36]
Chr1:1q23.1-23.3
pathogenic
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q23.1-24.2(chr1:157321299-167391423)x1 copy number loss not provided [RCV000848773] Chr1:157321299..167391423 [GRCh37]
Chr1:1q23.1-24.2
pathogenic
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stroma tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:21480 AgrOrtholog
COSMIC DUSP23 COSMIC
Ensembl Genes ENSG00000158716 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000357087 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000357088 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000357089 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000368107 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000368108 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000368109 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000158716 GTEx
HGNC ID HGNC:21480 ENTREZGENE
Human Proteome Map DUSP23 Human Proteome Map
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dual_phosphatase_23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:54935 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 54935 ENTREZGENE
OMIM 618361 OMIM
PANTHER PTHR23339:SF26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134983082 PharmGKB
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140VJI5 ENTREZGENE, UniProtKB/TrEMBL
  DUS23_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9NX48 UniProtKB/Swiss-Prot