SDSL (serine dehydratase like) - Rat Genome Database

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Gene: SDSL (serine dehydratase like) Homo sapiens
Analyze
Symbol: SDSL
Name: serine dehydratase like
RGD ID: 1319395
HGNC Page HGNC:30404
Description: Enables identical protein binding activity. Predicted to be involved in L-serine catabolic process; isoleucine biosynthetic process; and threonine catabolic process. Predicted to be located in cytosol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cSDH; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; SDH; SDH 2; SDHL; SDS-RS1; serine dehydratase 2; serine dehydratase related sequence 1; serine dehydratase-like; TDH
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812113,422,380 - 113,438,276 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12113,422,380 - 113,438,276 (+)EnsemblGRCh38hg38GRCh38
GRCh3712113,860,185 - 113,876,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612112,344,599 - 112,360,464 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412112,322,935 - 112,338,800NCBI
Celera12113,487,476 - 113,503,320 (+)NCBICelera
Cytogenetic Map12q24.13NCBI
HuRef12110,871,400 - 110,887,228 (+)NCBIHuRef
CHM1_112113,828,434 - 113,844,299 (+)NCBICHM1_1
T2T-CHM13v2.012113,399,004 - 113,414,868 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (TAS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16189514   PMID:16580895   PMID:18342636   PMID:19060904   PMID:20877624   PMID:21516116   PMID:21873635   PMID:23376485   PMID:25416956   PMID:31515488  
PMID:32296183   PMID:34591612   PMID:35748872   PMID:35831314   PMID:36215168   PMID:37827155  


Genomics

Comparative Map Data
SDSL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812113,422,380 - 113,438,276 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12113,422,380 - 113,438,276 (+)EnsemblGRCh38hg38GRCh38
GRCh3712113,860,185 - 113,876,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612112,344,599 - 112,360,464 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412112,322,935 - 112,338,800NCBI
Celera12113,487,476 - 113,503,320 (+)NCBICelera
Cytogenetic Map12q24.13NCBI
HuRef12110,871,400 - 110,887,228 (+)NCBIHuRef
CHM1_112113,828,434 - 113,844,299 (+)NCBICHM1_1
T2T-CHM13v2.012113,399,004 - 113,414,868 (+)NCBIT2T-CHM13v2.0
Sdsl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395120,596,258 - 120,610,890 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5120,596,251 - 120,610,875 (-)EnsemblGRCm39 Ensembl
GRCm385120,458,193 - 120,472,825 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5120,458,186 - 120,472,810 (-)EnsemblGRCm38mm10GRCm38
MGSCv375120,908,211 - 120,922,772 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365120,718,819 - 120,733,380 (-)NCBIMGSCv36mm8
Celera5117,542,665 - 117,557,130 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.62NCBI
Sdsl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,760,252 - 41,770,465 (+)NCBIGRCr8
mRatBN7.21236,099,693 - 36,109,914 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1236,099,693 - 36,109,906 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1237,278,879 - 37,289,146 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,890,098 - 37,900,365 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,942,571 - 36,952,838 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01241,636,994 - 41,647,205 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,636,994 - 41,647,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,487,966 - 43,497,281 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41237,297,342 - 37,307,847 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11237,156,569 - 37,171,232 (+)NCBI
Celera1237,757,811 - 37,767,910 (+)NCBICelera
Cytogenetic Map12q16NCBI
Sdsl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554829,659,999 - 9,675,618 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554829,656,563 - 9,670,951 (+)NCBIChiLan1.0ChiLan1.0
SDSL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210121,509,056 - 121,524,998 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112121,505,454 - 121,521,396 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012111,024,957 - 111,040,900 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112114,406,590 - 114,422,347 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12114,406,738 - 114,422,347 (+)Ensemblpanpan1.1panPan2
SDSL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12610,731,972 - 10,759,768 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2610,743,947 - 10,759,777 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2610,855,844 - 10,883,608 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02610,977,874 - 11,010,015 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2610,990,071 - 11,015,079 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12610,951,813 - 10,979,463 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02611,014,470 - 11,042,112 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02611,063,615 - 11,091,344 (+)NCBIUU_Cfam_GSD_1.0
Sdsl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118148,723,917 - 148,735,377 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366683,222,904 - 3,232,626 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366683,222,894 - 3,232,736 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SDSL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1438,471,165 - 38,484,155 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11438,471,162 - 38,484,459 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21440,882,862 - 40,895,856 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SDSL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111108,673,058 - 108,693,748 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11108,673,075 - 108,693,815 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037136,399,423 - 136,420,348 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sdsl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474719,109,587 - 19,116,244 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474719,110,425 - 19,131,161 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SDSL
14 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_138432.3(SDSL):c.420C>A (p.Pro140=) single nucleotide variant Malignant melanoma [RCV000069829] Chr12:113434199 [GRCh38]
Chr12:113872004 [GRCh37]
Chr12:112356387 [NCBI36]
Chr12:12q24.13		 not provided
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12q24.13-24.21(chr12:113077775-114372366)x1 copy number loss See cases [RCV000143532] Chr12:113077775..114372366 [GRCh38]
Chr12:113515580..114810171 [GRCh37]
Chr12:111999963..113294554 [NCBI36]
Chr12:12q24.13-24.21		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
GRCh37/hg19 12q24.13-24.21(chr12:112963559-116095198)x1 copy number loss See cases [RCV000446400] Chr12:112963559..116095198 [GRCh37]
Chr12:12q24.13-24.21		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
NM_001304993.2(SDSL):c.360G>A (p.Trp120Ter) single nucleotide variant not provided [RCV000709792] Chr12:113434139 [GRCh38]
Chr12:113871944 [GRCh37]
Chr12:12q24.13		 not provided
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
NM_001304993.2(SDSL):c.685del (p.Leu229fs) deletion not provided [RCV000971399] Chr12:113436763 [GRCh38]
Chr12:113874568 [GRCh37]
Chr12:12q24.13		 likely benign
GRCh37/hg19 12q24.13(chr12:113695889-113904780)x1 copy number loss not provided [RCV000849800] Chr12:113695889..113904780 [GRCh37]
Chr12:12q24.13		 uncertain significance
NM_001304993.2(SDSL):c.151G>A (p.Gly51Ser) single nucleotide variant Inborn genetic diseases [RCV003273456] Chr12:113428133 [GRCh38]
Chr12:113865938 [GRCh37]
Chr12:12q24.13		 uncertain significance
NM_001304993.2(SDSL):c.729G>C (p.Gln243His) single nucleotide variant Inborn genetic diseases [RCV003275131] Chr12:113436808 [GRCh38]
Chr12:113874613 [GRCh37]
Chr12:12q24.13		 uncertain significance
NC_000012.11:g.113120652_115362584del deletion Abnormality of the upper limb [RCV001844324] Chr12:113120652..115362584 [GRCh37]
Chr12:12q24.13-24.21		 pathogenic
GRCh37/hg19 12q24.13-24.21(chr12:113445811-114933860) copy number loss not specified [RCV002053019] Chr12:113445811..114933860 [GRCh37]
Chr12:12q24.13-24.21		 pathogenic
NM_001304993.2(SDSL):c.905C>T (p.Thr302Ile) single nucleotide variant Inborn genetic diseases [RCV002685261] Chr12:113437994 [GRCh38]
Chr12:113875799 [GRCh37]
Chr12:12q24.13		 uncertain significance
NM_001304993.2(SDSL):c.148C>T (p.Arg50Trp) single nucleotide variant Inborn genetic diseases [RCV002926163] Chr12:113428130 [GRCh38]
Chr12:113865935 [GRCh37]
Chr12:12q24.13		 uncertain significance
NM_001304993.2(SDSL):c.290G>T (p.Ser97Ile) single nucleotide variant Inborn genetic diseases [RCV002702246] Chr12:113429235 [GRCh38]
Chr12:113867040 [GRCh37]
Chr12:12q24.13		 uncertain significance
NM_001304993.2(SDSL):c.89C>T (p.Ala30Val) single nucleotide variant Inborn genetic diseases [RCV002984597] Chr12:113428071 [GRCh38]
Chr12:113865876 [GRCh37]
Chr12:12q24.13		 uncertain significance
NM_001304993.2(SDSL):c.224C>T (p.Ala75Val) single nucleotide variant Inborn genetic diseases [RCV002961426] Chr12:113429169 [GRCh38]
Chr12:113866974 [GRCh37]
Chr12:12q24.13		 uncertain significance
NM_001304993.2(SDSL):c.937A>G (p.Asn313Asp) single nucleotide variant Inborn genetic diseases [RCV002966005] Chr12:113438026 [GRCh38]
Chr12:113875831 [GRCh37]
Chr12:12q24.13		 uncertain significance
NM_001304993.2(SDSL):c.422C>T (p.Pro141Leu) single nucleotide variant Inborn genetic diseases [RCV002656720] Chr12:113434201 [GRCh38]
Chr12:113872006 [GRCh37]
Chr12:12q24.13		 uncertain significance
NM_001304993.2(SDSL):c.286G>A (p.Glu96Lys) single nucleotide variant Inborn genetic diseases [RCV003189614] Chr12:113429231 [GRCh38]
Chr12:113867036 [GRCh37]
Chr12:12q24.13		 uncertain significance
NM_001304993.2(SDSL):c.490A>G (p.Thr164Ala) single nucleotide variant Inborn genetic diseases [RCV003214382] Chr12:113435375 [GRCh38]
Chr12:113873180 [GRCh37]
Chr12:12q24.13		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1657
Count of miRNA genes:678
Interacting mature miRNAs:777
Transcripts:ENST00000345635, ENST00000403593, ENST00000546672, ENST00000547802, ENST00000551760, ENST00000553248
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G54204  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712113,866,331 - 113,866,530UniSTSGRCh37
Build 3612112,350,714 - 112,350,913RGDNCBI36
Celera12113,493,591 - 113,493,790RGD
Cytogenetic Map12q24.13UniSTS
HuRef12110,877,515 - 110,877,714UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 308 98 1615 428 128 430 110 49 705 317 558 945 7 18 20
Low 2125 2802 108 193 1616 35 3856 1940 3012 102 867 651 163 1 1181 2484 4 2
Below cutoff 6 89 3 3 151 387 204 17 35 14 3 5 282 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000345635   ⟹   ENSP00000341117
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,422,411 - 113,438,276 (+)Ensembl
RefSeq Acc Id: ENST00000403593   ⟹   ENSP00000385790
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,422,380 - 113,438,276 (+)Ensembl
RefSeq Acc Id: ENST00000546672   ⟹   ENSP00000449136
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,428,419 - 113,438,241 (+)Ensembl
RefSeq Acc Id: ENST00000547802   ⟹   ENSP00000446867
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,422,453 - 113,428,070 (+)Ensembl
RefSeq Acc Id: ENST00000551760   ⟹   ENSP00000448950
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,435,507 - 113,437,109 (+)Ensembl
RefSeq Acc Id: ENST00000553248   ⟹   ENSP00000448868
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,422,405 - 113,436,769 (+)Ensembl
RefSeq Acc Id: NM_001304993   ⟹   NP_001291922
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,422,380 - 113,438,276 (+)NCBI
CHM1_112113,828,413 - 113,844,299 (+)NCBI
T2T-CHM13v2.012113,399,004 - 113,414,868 (+)NCBI
Sequence:
RefSeq Acc Id: NM_138432   ⟹   NP_612441
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,422,380 - 113,438,276 (+)NCBI
GRCh3712113,860,042 - 113,876,081 (+)NCBI
Build 3612112,344,599 - 112,360,464 (+)NCBI Archive
Celera12113,487,476 - 113,503,320 (+)RGD
HuRef12110,871,400 - 110,887,228 (+)RGD
CHM1_112113,828,413 - 113,844,299 (+)NCBI
T2T-CHM13v2.012113,399,004 - 113,414,868 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005253831   ⟹   XP_005253888
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,425,903 - 113,438,276 (+)NCBI
GRCh3712113,860,042 - 113,876,081 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017018763   ⟹   XP_016874252
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,425,897 - 113,438,276 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054370978   ⟹   XP_054226953
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012113,402,521 - 113,414,868 (+)NCBI
RefSeq Acc Id: XM_054370979   ⟹   XP_054226954
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012113,402,527 - 113,414,868 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_612441   ⟸   NM_138432
- UniProtKB: Q96GA7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005253888   ⟸   XM_005253831
- Peptide Label: isoform X2
- UniProtKB: Q96GA7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001291922   ⟸   NM_001304993
- UniProtKB: Q96GA7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016874252   ⟸   XM_017018763
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000341117   ⟸   ENST00000345635
RefSeq Acc Id: ENSP00000449136   ⟸   ENST00000546672
RefSeq Acc Id: ENSP00000446867   ⟸   ENST00000547802
RefSeq Acc Id: ENSP00000385790   ⟸   ENST00000403593
RefSeq Acc Id: ENSP00000448950   ⟸   ENST00000551760
RefSeq Acc Id: ENSP00000448868   ⟸   ENST00000553248
RefSeq Acc Id: XP_054226953   ⟸   XM_054370978
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054226954   ⟸   XM_054370979
- Peptide Label: isoform X2
- UniProtKB: Q96GA7 (UniProtKB/Swiss-Prot)
Protein Domains
Tryptophan synthase beta chain-like PALP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96GA7-F1-model_v2 AlphaFold Q96GA7 1-329 view protein structure

Promoters
RGD ID:6790469
Promoter ID:HG_KWN:16741
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000345635,   NM_138432,   UC001TVI.1,   UC009ZWH.1
Position:
Human AssemblyChrPosition (strand)Source
Build 3612112,344,371 - 112,344,871 (+)MPROMDB
RGD ID:7225497
Promoter ID:EPDNEW_H18495
Type:initiation region
Name:SDSL_2
Description:serine dehydratase like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18496  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,422,293 - 113,422,353EPDNEW
RGD ID:7225501
Promoter ID:EPDNEW_H18496
Type:initiation region
Name:SDSL_1
Description:serine dehydratase like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18495  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,422,413 - 113,422,473EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:30404 AgrOrtholog
COSMIC SDSL COSMIC
Ensembl Genes ENSG00000139410 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000345635 ENTREZGENE
  ENST00000345635.8 UniProtKB/Swiss-Prot
  ENST00000403593 ENTREZGENE
  ENST00000403593.9 UniProtKB/Swiss-Prot
  ENST00000546672.1 UniProtKB/TrEMBL
  ENST00000547802.1 UniProtKB/TrEMBL
  ENST00000551760.1 UniProtKB/TrEMBL
  ENST00000553248.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000139410 GTEx
HGNC ID HGNC:30404 ENTREZGENE
Human Proteome Map SDSL Human Proteome Map
InterPro PLP-dep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_deHydtase_PyrdxlP-BS UniProtKB/Swiss-Prot
  Trypto_synt_PLP_dependent UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:113675 UniProtKB/Swiss-Prot
NCBI Gene 113675 ENTREZGENE
OMIM 620735 OMIM
PANTHER SERINE DEHYDRATASE-LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PALP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134862016 PharmGKB
PROSITE DEHYDRATASE_SER_THR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53686 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F8VYZ3_HUMAN UniProtKB/TrEMBL
  F8VZ97_HUMAN UniProtKB/TrEMBL
  H0YIA2_HUMAN UniProtKB/TrEMBL
  H0YID3_HUMAN UniProtKB/TrEMBL
  Q96GA7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 SDSL  serine dehydratase like    serine dehydratase-like  Symbol and/or name change 5135510 APPROVED