Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TTF2 mRNA | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Estradiol results in increased expression of TTF2 mRNA | CTD | PMID:31614463 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TTF2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | TTF2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TTF2 mRNA | CTD | PMID:22298810 and PMID:22574217 | 2,4-dinitrotoluene | affects expression | ISO | Ttf2 (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of TTF2 mRNA | CTD | PMID:21346803 | aflatoxin B1 | affects expression | ISO | TTF2 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of TTF2 protein | CTD | PMID:20106945 | aflatoxin B1 | increases methylation | ISO | TTF2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of TTF2 gene | CTD | PMID:27153756 | aflatoxin B1 | increases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of TTF2 mRNA | CTD | PMID:22100608 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of TTF2 mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | decreases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of TTF2 mRNA | CTD | PMID:33167477 | amphetamine | decreases expression | ISO | Ttf2 (Rattus norvegicus) | 6480464 | Amphetamine results in decreased expression of TTF2 mRNA | CTD | PMID:30779732 | antirheumatic drug | decreases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of TTF2 mRNA | CTD | PMID:24449571 | atrazine | decreases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of TTF2 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of TTF2 mRNA | CTD | PMID:19770486 and PMID:22228805 | benzo[b]fluoranthene | increases expression | EXP | | 6480464 | benzo(b)fluoranthene results in increased expression of TTF2 mRNA | CTD | PMID:26377693 | bisphenol A | decreases expression | ISO | Ttf2 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of TTF2 mRNA | CTD | PMID:25181051 more ... | bisphenol A | increases methylation | ISO | Ttf2 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of TTF2 gene | CTD | PMID:28505145 | butanal | decreases expression | ISO | TTF2 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of TTF2 mRNA | CTD | PMID:26079696 | cadmium dichloride | increases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of TTF2 mRNA | CTD | PMID:26472689 | caffeine | decreases phosphorylation | ISO | TTF2 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of TTF2 protein | CTD | PMID:35688186 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | TTF2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to TTF2 gene] | CTD | PMID:28238834 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TTF2 mRNA | CTD | PMID:20938992 | cobalt dichloride | decreases expression | ISO | TTF2 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of TTF2 mRNA | CTD | PMID:19320972 and PMID:19376846 | copper(II) sulfate | decreases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of TTF2 mRNA | CTD | PMID:19549813 | coumestrol | multiple interactions | ISO | TTF2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of TTF2 mRNA | CTD | PMID:19167446 | crocidolite asbestos | decreases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in decreased expression of TTF2 mRNA | CTD | PMID:29523930 | cyclosporin A | increases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of TTF2 mRNA | CTD | PMID:20106945 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of TTF2 mRNA | CTD | PMID:21266533 | dioxygen | decreases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Oxygen deficiency results in decreased expression of TTF2 mRNA | CTD | PMID:26516004 | doxorubicin | affects response to substance | ISO | TTF2 (Homo sapiens) | 6480464 | TTF2 protein affects the susceptibility to Doxorubicin | CTD | PMID:16217747 | doxorubicin | decreases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of TTF2 mRNA | CTD | PMID:29803840 | flutamide | decreases expression | ISO | Ttf2 (Rattus norvegicus) | 6480464 | Flutamide results in decreased expression of TTF2 mRNA | CTD | PMID:24793618 | folic acid | multiple interactions | EXP | | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of TTF2 mRNA | CTD | PMID:25629700 | FR900359 | decreases phosphorylation | ISO | TTF2 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of TTF2 protein | CTD | PMID:37730182 | genistein | increases expression | ISO | Ttf2 (Rattus norvegicus) | 6480464 | Genistein results in increased expression of TTF2 protein | CTD | PMID:24552547 | ketoconazole | affects expression | ISO | TTF2 (Homo sapiens) | 6480464 | Ketoconazole affects the expression of TTF2 mRNA | CTD | PMID:36621641 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TTF2 mRNA | CTD | PMID:20938992 | methotrexate | affects response to substance | ISO | TTF2 (Homo sapiens) | 6480464 | TTF2 protein affects the susceptibility to Methotrexate | CTD | PMID:16217747 | N,N-diethyl-m-toluamide | multiple interactions | ISO | Ttf2 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of TTF2 gene | CTD | PMID:33148267 | nickel atom | increases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Nickel results in increased expression of TTF2 mRNA | CTD | PMID:25583101 | oxaliplatin | multiple interactions | ISO | Ttf2 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of TTF2 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of TTF2 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of TTF2 mRNA | CTD | PMID:34911549 | paracetamol | increases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of TTF2 mRNA | CTD | PMID:22230336 | PCB138 | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | permethrin | multiple interactions | ISO | Ttf2 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of TTF2 gene | CTD | PMID:33148267 | pirinixic acid | multiple interactions | ISO | TTF2 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TTF2 mRNA and [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TTF2 mRNA | CTD | PMID:19710929 | progesterone | increases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Progesterone results in increased expression of TTF2 mRNA | CTD | PMID:18070364 | resveratrol | multiple interactions | ISO | TTF2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of TTF2 mRNA | CTD | PMID:19167446 | sodium arsenite | affects expression | ISO | TTF2 (Homo sapiens) | 6480464 | sodium arsenite affects the expression of TTF2 mRNA | CTD | PMID:29319823 | sodium arsenite | increases expression | ISO | TTF2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of TTF2 mRNA | CTD | PMID:34032870 | sunitinib | decreases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of TTF2 mRNA | CTD | PMID:31533062 | temozolomide | increases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of TTF2 mRNA | CTD | PMID:31758290 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of TTF2 mRNA | CTD | PMID:31919559 | thioacetamide | increases expression | ISO | Ttf2 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of TTF2 mRNA | CTD | PMID:23411599 | topotecan | multiple interactions | ISO | Ttf2 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of TTF2 mRNA | CTD | PMID:25729387 | trichostatin A | increases expression | ISO | TTF2 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of TTF2 mRNA | CTD | PMID:24935251 | trimellitic anhydride | increases expression | EXP | | 6480464 | trimellitic anhydride results in increased expression of TTF2 mRNA | CTD | PMID:19042947 | troglitazone | decreases expression | ISO | TTF2 (Homo sapiens) | 6480464 | troglitazone results in decreased expression of TTF2 mRNA | CTD | PMID:19140230 | trovafloxacin | decreases expression | EXP | | 6480464 | trovafloxacin results in decreased expression of TTF2 mRNA | CTD | PMID:35537566 | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of TTF2 mRNA | CTD | PMID:30912803 | urethane | decreases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Urethane results in decreased expression of TTF2 mRNA | CTD | PMID:28818685 | valproic acid | decreases methylation | ISO | TTF2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of TTF2 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | TTF2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of TTF2 mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | TTF2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of TTF2 mRNA | CTD | PMID:23179753 | vincaleukoblastine | affects response to substance | ISO | TTF2 (Homo sapiens) | 6480464 | TTF2 protein affects the susceptibility to Vinblastine | CTD | PMID:16217747 | |