Cep68 (centrosomal protein 68) - Rat Genome Database

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Gene: Cep68 (centrosomal protein 68) Mus musculus
Analyze
Symbol: Cep68
Name: centrosomal protein 68
RGD ID: 1319253
MGI Page MGI
Description: Predicted to enable protein domain specific binding activity and protein kinase binding activity. Predicted to be involved in centriole-centriole cohesion and protein localization to organelle. Predicted to be located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. Is expressed in several structures, including ganglia; incisor; submandibular gland primordium; telencephalon ventricular layer; and thymus primordium. Orthologous to human CEP68 (centrosomal protein 68).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 6030463E10Rik; AI481761; BC027174; centrosomal protein of 68 kDa; Kiaa0582; MGC6990; RP23-19L22.5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,177,037 - 20,199,424 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1120,177,037 - 20,199,429 (-)EnsemblGRCm39 Ensembl
GRCm381120,227,037 - 20,249,424 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,227,037 - 20,249,429 (-)EnsemblGRCm38mm10GRCm38
MGSCv371120,127,040 - 20,149,427 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361120,128,509 - 20,149,420 (-)NCBIMGSCv36mm8
Celera1122,376,409 - 22,398,791 (-)NCBICelera
Cytogenetic Map11A3.1NCBI
cM Map1112.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12174196   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15368895  
PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17967808   PMID:18799693   PMID:21267068   PMID:21873635  


Genomics

Comparative Map Data
Cep68
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,177,037 - 20,199,424 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1120,177,037 - 20,199,429 (-)EnsemblGRCm39 Ensembl
GRCm381120,227,037 - 20,249,424 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,227,037 - 20,249,429 (-)EnsemblGRCm38mm10GRCm38
MGSCv371120,127,040 - 20,149,427 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361120,128,509 - 20,149,420 (-)NCBIMGSCv36mm8
Celera1122,376,409 - 22,398,791 (-)NCBICelera
Cytogenetic Map11A3.1NCBI
cM Map1112.92NCBI
CEP68
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38265,056,416 - 65,087,004 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl265,056,354 - 65,087,004 (+)EnsemblGRCh38hg38GRCh38
GRCh37265,283,550 - 65,314,138 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36265,136,999 - 65,167,646 (+)NCBINCBI36Build 36hg18NCBI36
Build 34265,195,249 - 65,222,622NCBI
Celera265,129,881 - 65,160,529 (+)NCBICelera
Cytogenetic Map2p14NCBI
HuRef265,017,251 - 65,048,120 (+)NCBIHuRef
CHM1_1265,214,440 - 65,245,100 (+)NCBICHM1_1
T2T-CHM13v2.0265,066,038 - 65,096,632 (+)NCBIT2T-CHM13v2.0
Cep68
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81498,649,993 - 98,671,892 (-)NCBIGRCr8
mRatBN7.21494,447,973 - 94,470,533 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1494,449,055 - 94,470,517 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.014104,501,759 - 104,523,330 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14104,505,319 - 104,523,297 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014104,236,508 - 104,258,520 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414101,031,918 - 101,051,380 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114101,052,249 - 101,064,017 (-)NCBI
Celera1493,474,639 - 93,493,251 (-)NCBICelera
Cytogenetic Map14q22NCBI
Cep68
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542419,426,642 - 19,439,126 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542419,424,088 - 19,439,126 (-)NCBIChiLan1.0ChiLan1.0
CEP68
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21261,313,471 - 61,344,167 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A61,317,422 - 61,348,117 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A65,119,388 - 65,147,624 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A66,244,826 - 66,274,963 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A66,244,826 - 66,274,963 (+)Ensemblpanpan1.1panPan2
CEP68
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11064,545,010 - 64,561,481 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1064,538,166 - 64,561,684 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1064,423,849 - 64,449,309 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01065,546,500 - 65,571,954 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1065,546,538 - 65,570,469 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11065,225,349 - 65,250,762 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01065,534,030 - 65,559,472 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01065,827,634 - 65,853,098 (+)NCBIUU_Cfam_GSD_1.0
Cep68
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629218,714,431 - 18,741,561 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364919,829,721 - 9,854,966 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364919,829,746 - 9,858,409 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CEP68
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl376,869,622 - 76,901,126 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1376,869,350 - 76,932,673 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2380,712,106 - 80,728,539 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CEP68
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11441,934,740 - 41,961,853 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1441,935,996 - 41,949,335 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604569,919,167 - 69,946,880 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cep68
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247628,454,117 - 8,476,053 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247628,449,759 - 8,476,001 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cep68
801 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1070
Count of miRNA genes:669
Interacting mature miRNAs:800
Transcripts:ENSMUST00000050611, ENSMUST00000109596, ENSMUST00000161218, ENSMUST00000162811
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
10412216Eae44_mexperimental allergic encephalomyelitis susceptibility 44 (mouse)Not determined111226863739950840Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
13524844Ppiq9_mprepulse inhibition QTL 9 (mouse)11904999735077325Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
1357518Tgyl1_mtriglyceride level 1 (mouse)Not determined11688027733916219Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
10053676Eae44a_mexperimental allergic encephalomyelitis susceptibility 44a (mouse)Not determined11450789621379532Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse

Markers in Region
AI481761  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381120,238,737 - 20,238,821UniSTSGRCm38
MGSCv371120,138,740 - 20,138,824UniSTSGRCm37
Celera1122,388,101 - 22,388,185UniSTS
Cytogenetic Map11A3.1UniSTS
D11Hjk3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381120,242,194 - 20,242,255UniSTSGRCm38
MGSCv371120,142,197 - 20,142,258UniSTSGRCm37
Celera1122,391,557 - 22,391,618UniSTS
Cytogenetic Map11A3.1UniSTS
cM Map1111.0UniSTS
WI-13176  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381715,831,638 - 15,831,749UniSTSGRCm38
GRCm381120,226,719 - 20,226,830UniSTSGRCm38
MGSCv371715,968,602 - 15,968,713UniSTSGRCm37
MGSCv371120,126,722 - 20,126,833UniSTSGRCm37
Celera1716,622,120 - 16,622,231UniSTS
Celera1122,376,091 - 22,376,202UniSTS
Cytogenetic Map11A3.1UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000050611   ⟹   ENSMUSP00000054943
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1120,177,037 - 20,199,418 (-)Ensembl
GRCm38.p6 Ensembl1120,227,037 - 20,249,418 (-)Ensembl
RefSeq Acc Id: ENSMUST00000109596   ⟹   ENSMUSP00000105225
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1120,188,386 - 20,199,418 (-)Ensembl
GRCm38.p6 Ensembl1120,238,386 - 20,249,418 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161218
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1120,191,523 - 20,199,383 (-)Ensembl
GRCm38.p6 Ensembl1120,241,523 - 20,249,383 (-)Ensembl
RefSeq Acc Id: ENSMUST00000162811   ⟹   ENSMUSP00000125113
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1120,188,387 - 20,199,429 (-)Ensembl
GRCm38.p6 Ensembl1120,238,387 - 20,249,429 (-)Ensembl
RefSeq Acc Id: NM_172260   ⟹   NP_758464
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391120,177,037 - 20,199,424 (-)NCBI
GRCm381120,227,037 - 20,249,424 (-)NCBI
MGSCv371120,127,040 - 20,149,427 (-)RGD
Celera1122,376,409 - 22,398,791 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_758464   ⟸   NM_172260
- UniProtKB: Q5SW85 (UniProtKB/Swiss-Prot),   Q3US49 (UniProtKB/Swiss-Prot),   Q8R2V0 (UniProtKB/Swiss-Prot),   Q8C0D9 (UniProtKB/Swiss-Prot),   Q3ULV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000105225   ⟸   ENSMUST00000109596
RefSeq Acc Id: ENSMUSP00000125113   ⟸   ENSMUST00000162811
RefSeq Acc Id: ENSMUSP00000054943   ⟸   ENSMUST00000050611

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C0D9-F1-model_v2 AlphaFold Q8C0D9 1-733 view protein structure

Promoters
RGD ID:6820606
Promoter ID:MM_KWN:6566
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:UC007ICX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361120,141,926 - 20,142,967 (-)MPROMDB
RGD ID:6820605
Promoter ID:MM_KWN:6567
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000116392,   NM_172260,   UC007ICY.1,   UC007ICZ.1,   UC007IDA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361120,149,276 - 20,149,776 (-)MPROMDB
RGD ID:8674050
Promoter ID:EPDNEW_M15055
Type:initiation region
Name:Cep68_1
Description:Mus musculus centrosomal protein 68 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381120,249,412 - 20,249,472EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2667663 AgrOrtholog
Ensembl Genes ENSMUSG00000044066 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000050611 ENTREZGENE
  ENSMUST00000050611.14 UniProtKB/Swiss-Prot
  ENSMUST00000109596.8 UniProtKB/Swiss-Prot
  ENSMUST00000162811.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:216543 UniProtKB/Swiss-Prot
MGD MGI:2667663 ENTREZGENE
NCBI Gene 216543 ENTREZGENE
PhenoGen Cep68 PhenoGen
Superfamily-SCOP Spectrin repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CEP68_MOUSE UniProtKB/Swiss-Prot
  Q3T9T3_MOUSE UniProtKB/TrEMBL
  Q3TRP8_MOUSE UniProtKB/TrEMBL
  Q3UFW2_MOUSE UniProtKB/TrEMBL
  Q3ULV4 ENTREZGENE, UniProtKB/TrEMBL
  Q3US49 ENTREZGENE
  Q5SW85 ENTREZGENE
  Q6A043_MOUSE UniProtKB/TrEMBL
  Q8C0D9 ENTREZGENE
  Q8R2V0 ENTREZGENE
UniProt Secondary Q3US49 UniProtKB/Swiss-Prot
  Q5SW85 UniProtKB/Swiss-Prot
  Q8R2V0 UniProtKB/Swiss-Prot