Ptk6 (PTK6 protein tyrosine kinase 6) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ptk6 (PTK6 protein tyrosine kinase 6) Mus musculus
Analyze
Symbol: Ptk6
Name: PTK6 protein tyrosine kinase 6
RGD ID: 1319247
MGI Page MGI
Description: Predicted to enable identical protein binding activity; non-membrane spanning protein tyrosine kinase activity; and signaling receptor binding activity. Involved in intestinal epithelial cell differentiation and negative regulation of growth. Located in nucleus. Is expressed in several structures, including gut; liver; and skin. Orthologous to human PTK6 (protein tyrosine kinase 6); INTERACTS WITH bisphenol A; lipopolysaccharide; rotenone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BRK; protein tyrosine kinase 6; protein-tyrosine kinase 6; S; Sik; src-related intestinal kinase; tks; Tksk; tyrosine kinase identified from skin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,836,917 - 180,845,408 (-)NCBIGRCm39mm39
GRCm39 Ensembl2180,835,514 - 180,844,582 (-)Ensembl
GRCm382181,195,124 - 181,202,789 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,193,721 - 181,202,789 (-)EnsemblGRCm38mm10GRCm38
MGSCv372180,929,829 - 180,937,494 (-)NCBIGRCm37mm9NCBIm37
MGSCv362181,124,531 - 181,132,196 (-)NCBImm8
Celera2185,277,943 - 185,285,608 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.62NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:7838533   PMID:7962951   PMID:8208550   PMID:9405638   PMID:10349636   PMID:10430081   PMID:10913193   PMID:11042159   PMID:11076861   PMID:11114734   PMID:11217851   PMID:12200423  
PMID:12477932   PMID:12624099   PMID:12725532   PMID:12833144   PMID:15471878   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16782882   PMID:18205771   PMID:18719096   PMID:20026641  
PMID:20606012   PMID:21267068   PMID:21677750   PMID:21741923   PMID:21873635   PMID:21923922   PMID:22084245   PMID:23027128   PMID:25446122   PMID:25938342   PMID:26013168   PMID:26247733  
PMID:27119373   PMID:32325033  


Genomics

Comparative Map Data
Ptk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,836,917 - 180,845,408 (-)NCBIGRCm39mm39
GRCm39 Ensembl2180,835,514 - 180,844,582 (-)Ensembl
GRCm382181,195,124 - 181,202,789 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,193,721 - 181,202,789 (-)EnsemblGRCm38mm10GRCm38
MGSCv372180,929,829 - 180,937,494 (-)NCBIGRCm37mm9NCBIm37
MGSCv362181,124,531 - 181,132,196 (-)NCBImm8
Celera2185,277,943 - 185,285,608 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.62NCBI
PTK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2063,528,001 - 63,537,376 (-)EnsemblGRCh38hg38GRCh38
GRCh382063,528,001 - 63,537,376 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372062,159,354 - 62,168,729 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,630,210 - 61,639,151 (-)NCBINCBI36hg18NCBI36
Build 342061,630,221 - 61,639,151NCBI
Celera2058,840,123 - 58,849,063 (-)NCBI
Cytogenetic Map20q13.33NCBI
HuRef2058,889,971 - 58,898,928 (-)NCBIHuRef
CHM1_12062,060,892 - 62,069,731 (-)NCBICHM1_1
Ptk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23168,307,073 - 168,315,664 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl3168,307,073 - 168,315,664 (-)Ensembl
Rnor_6.03176,698,305 - 176,706,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,698,305 - 176,706,896 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,408,336 - 180,417,078 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,336,505 - 170,345,096 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13170,242,877 - 170,251,132 (-)NCBI
Celera3164,270,220 - 164,278,811 (+)NCBICelera
Cytogenetic Map3q43NCBI
Ptk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528687,996 - 695,596 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955528687,996 - 695,596 (+)NCBIChiLan1.0ChiLan1.0
PTK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12061,453,386 - 61,462,951 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2061,453,386 - 61,462,951 (-)Ensemblpanpan1.1panPan2
LOC102156300
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12447,124,847 - 47,132,516 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2446,324,188 - 46,330,708 (-)NCBI
ROS_Cfam_1.02448,094,349 - 48,100,872 (-)NCBI
UNSW_CanFamBas_1.02447,234,634 - 47,241,155 (-)NCBI
UU_Cfam_GSD_1.02447,972,659 - 47,979,186 (-)NCBI
Ptk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,371,493 - 195,380,130 (-)NCBI
SpeTri2.0NW_00493651410,826,013 - 10,833,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,538,855 - 62,546,730 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,538,853 - 62,547,866 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PTK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12667,440 - 676,380 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2667,510 - 676,109 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605048,225,911 - 48,235,200 (+)NCBIVero_WHO_p1.0
Ptk6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474129,183,992 - 29,192,091 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163844614182113224Mouse
1558748Vacq1_mvoluntary alcohol consumption QTL 1 (mouse)Not determined2178800545181873487Mouse
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162791700182113224Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144673941181254801Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155982127182113224Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156354671182113224Mouse
1300676Prdt2_mprion disease incubation time 2 (mouse)Not determined2164873361182113224Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2150146982182113224Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151936377182113224Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163844614182113224Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150370301182113224Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149394987182113224Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148822973182113224Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150370301182113224Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150370301182113224Mouse
12738428Lfibq19_mliver fibrosis QTL 19 (mouse)2181090877181807525Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148396284182113224Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152487900182113224Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:889
Count of miRNA genes:471
Interacting mature miRNAs:572
Transcripts:ENSMUST00000016511
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000016511   ⟹   ENSMUSP00000016511
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2180,835,514 - 180,844,582 (-)Ensembl
GRCm38.p6 Ensembl2181,193,721 - 181,202,789 (-)Ensembl
RefSeq Acc Id: NM_001356304   ⟹   NP_001343233
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392180,836,917 - 180,844,582 (-)NCBI
GRCm382181,195,124 - 181,202,789 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009184   ⟹   NP_033210
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392180,836,917 - 180,844,582 (-)NCBI
GRCm382181,195,124 - 181,202,789 (-)NCBI
MGSCv372180,929,829 - 180,937,494 (-)RGD
Celera2185,277,943 - 185,285,608 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006500585   ⟹   XP_006500648
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392180,837,640 - 180,845,408 (-)NCBI
GRCm382181,195,847 - 181,202,652 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033210   ⟸   NM_009184
- Peptide Label: isoform 1
- UniProtKB: Q64434 (UniProtKB/Swiss-Prot),   Q05AA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006500648   ⟸   XM_006500585
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001343233   ⟸   NM_001356304
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000016511   ⟸   ENSMUST00000016511
Protein Domains
Protein kinase   SH2   SH3


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99683 AgrOrtholog
Ensembl Genes ENSMUSG00000038751 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000016511 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000016511 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTK6_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:99683 ENTREZGENE
NCBI Gene 20459 ENTREZGENE
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptk6 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt PTK6_MOUSE UniProtKB/Swiss-Prot
  Q05AA8 ENTREZGENE, UniProtKB/TrEMBL
  Q64036_MOUSE UniProtKB/TrEMBL
  Q64434 ENTREZGENE