Dipk2a (divergent protein kinase domain 2A) - Rat Genome Database
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Gene: Dipk2a (divergent protein kinase domain 2A) Mus musculus
Analyze
Symbol: Dipk2a
Name: divergent protein kinase domain 2A
RGD ID: 1319219
MGI Page MGI
Description: Involved in negative regulation of smooth muscle cell apoptotic process. Localizes to COPI-coated vesicle and extracellular region. Is expressed in several structures, including embryo mesenchyme; face; hair follicle; jaw; and nervous system. Orthologous to human DIPK2A (divergent protein kinase domain 2A); INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; bisphenol A; bisphenol F.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1190002N15Rik; deleted in autism protein 1 homolog; Golgi protein GoPro49; Golgi Protein of 49 kDa; GoP; GoPro49; HASF; hypoxia and AKT-induced stem cell factor; RIKEN cDNA 1190002N15 gene; UPF0672 protein C3orf58 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39994,399,917 - 94,420,134 (-)NCBIGRCm39mm39
GRCm38994,517,864 - 94,538,081 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl994,517,864 - 94,538,081 (-)EnsemblGRCm38mm10GRCm38
MGSCv37994,418,283 - 94,438,500 (-)NCBIGRCm37mm9NCBIm37
MGSCv36994,328,875 - 94,347,162 (-)NCBImm8
Celera994,068,306 - 94,088,285 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:14610273   PMID:14681479   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:18651652   PMID:19587158   PMID:21677750   PMID:21862448   PMID:21873635   PMID:22726835   PMID:23431145   PMID:24269490   PMID:28096202  


Genomics

Comparative Map Data
Dipk2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39994,399,917 - 94,420,134 (-)NCBIGRCm39mm39
GRCm38994,517,864 - 94,538,081 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl994,517,864 - 94,538,081 (-)EnsemblGRCm38mm10GRCm38
MGSCv37994,418,283 - 94,438,500 (-)NCBIGRCm37mm9NCBIm37
MGSCv36994,328,875 - 94,347,162 (-)NCBImm8
Celera994,068,306 - 94,088,285 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
DIPK2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3143,971,798 - 144,048,719 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl3143,971,823 - 144,048,719 (+)EnsemblGRCh38hg38GRCh38
GRCh383143,971,798 - 143,992,368 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373143,690,640 - 143,711,210 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363145,173,603 - 145,193,895 (+)NCBINCBI36hg18NCBI36
Celera3142,113,447 - 142,133,972 (+)NCBI
Cytogenetic Map3q24NCBI
HuRef3141,062,432 - 141,083,248 (+)NCBIHuRef
CHM1_13143,654,076 - 143,674,614 (+)NCBICHM1_1
Dipk2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08102,140,713 - 102,159,828 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8102,088,505 - 102,159,828 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08101,571,619 - 101,642,666 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4899,571,924 - 99,591,067 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1899,544,806 - 99,753,225 (-)NCBI
Celera894,546,476 - 94,565,667 (-)NCBICelera
Cytogenetic Map8q31NCBI
Dipk2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555081,953,923 - 1,975,842 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555081,954,600 - 1,975,842 (-)NCBIChiLan1.0ChiLan1.0
DIPK2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13148,589,849 - 148,610,055 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3148,590,378 - 148,607,520 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03140,999,699 - 141,019,908 (+)NCBIMhudiblu_PPA_v0panPan3
DIPK2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12339,472,090 - 39,496,000 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dipk2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493651910,966,822 - 10,988,311 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIPK2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1384,634,030 - 84,657,371 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11384,634,716 - 84,656,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21392,370,409 - 92,390,845 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DIPK2A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11546,616,961 - 46,643,784 (-)NCBI
ChlSab1.1 Ensembl1546,616,961 - 46,643,583 (-)Ensembl
Dipk2a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473020,633,816 - 20,655,815 (+)NCBI

Position Markers
UniSTS:224516  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38994,568,543 - 94,568,696UniSTSGRCm38
MGSCv37994,468,962 - 94,469,115UniSTSGRCm37
Celera994,118,999 - 94,119,152UniSTS
Cytogenetic Map9E3.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96224248596242599Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
11081165Psl6_mpromotion susceptibility QTL 6 (mouse)96513390995640755Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966207024100207122Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96936046598819654Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:726
Count of miRNA genes:429
Interacting mature miRNAs:517
Transcripts:ENSMUST00000113028
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000113028   ⟹   ENSMUSP00000108651
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl994,517,864 - 94,538,081 (-)Ensembl
RefSeq Acc Id: NM_001033145   ⟹   NP_001028317
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39994,399,917 - 94,420,134 (-)NCBI
GRCm38994,517,864 - 94,538,081 (-)ENTREZGENE
MGSCv37994,418,283 - 94,438,500 (-)RGD
Celera994,068,306 - 94,088,284 (-)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001028317 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAE36786 (Get FASTA)   NCBI Sequence Viewer  
  Q3USZ8 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001028317   ⟸   NM_001033145
- Peptide Label: precursor
- UniProtKB: Q3USZ8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000108651   ⟸   ENSMUST00000113028
Protein Domains
PIP49_C

Promoters
RGD ID:6843926
Promoter ID:MM_KWN:58385
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4
Transcripts:ENSMUST00000061904,   NM_001033145
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36994,437,711 - 94,439,317 (-)MPROMDB
RGD ID:8670452
Promoter ID:EPDNEW_M13257
Type:initiation region
Name:1190002N15Rik_1
Description:Mus musculus RIKEN cDNA 1190002N15 gene , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38994,538,083 - 94,538,143EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916111 AgrOrtholog
Ensembl Genes ENSMUSG00000045414 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000108651 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000113028 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro DIPK2A/B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAM69_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:68861 UniProtKB/Swiss-Prot
MGD MGI:1916111 ENTREZGENE
NCBI Gene 68861 ENTREZGENE
PANTHER PTHR32073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PIP49_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dipk2a PhenoGen
UniGene Mm.258746 ENTREZGENE
UniProt DIK2A_MOUSE UniProtKB/Swiss-Prot
  Q3TS89_MOUSE UniProtKB/TrEMBL
  Q3USZ8 ENTREZGENE
UniProt Secondary E9Q9E9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-26 Dipk2a  divergent protein kinase domain 2A  1190002N15Rik  RIKEN cDNA 1190002N15 gene  Symbol and/or name change 5135510 APPROVED