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Gene: SOX6 (SRY-box transcription factor 6) Homo sapiens
Symbol: SOX6
Name: SRY-box transcription factor 6
Description: Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in cellular response to transforming growth factor beta stimulus; negative regulation of cardiac muscle cell differentiation; and positive regulation of cell differentiation. Localizes to nucleoplasm. Implicated in malignant glioma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HSSOX6; SOXD; SRY (sex determining region Y)-box 6; SRY box 6; SRY-box 6; SRY-box containing gene 6; transcription factor SOX-6
Mus musculus (house mouse) : Sox6 (SRY (sex determining region Y)-box 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sox6 (SRY-box transcription factor 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sox6 (SRY-box transcription factor 6)
Pan paniscus (bonobo/pygmy chimpanzee) : SOX6 (SRY-box transcription factor 6)
Canis lupus familiaris (dog) : SOX6 (SRY-box transcription factor 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sox6 (SRY-box transcription factor 6)
Sus scrofa (pig) : SOX6 (SRY-box transcription factor 6)
Chlorocebus sabaeus (African green monkey) : SOX6 (SRY-box transcription factor 6)
Heterocephalus glaber (naked mole-rat) : Sox6 (SRY-box transcription factor 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1115,966,449 - 16,739,591 (-)EnsemblGRCh38hg38GRCh38
GRCh381115,966,449 - 16,738,477 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371115,987,995 - 16,497,935 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361115,948,371 - 16,454,494 (-)NCBINCBI36hg18NCBI36
Build 341115,949,899 - 16,454,494NCBI
Celera1116,115,232 - 16,625,247 (-)NCBI
Cytogenetic Map11p15.2NCBI
HuRef1115,673,238 - 16,183,365 (-)NCBIHuRef
CHM1_11115,987,568 - 16,497,588 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SOX6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319098
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.