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Gene: ICAM4 (intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)) Homo sapiens
Symbol: ICAM4
Name: intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Description: This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD242; CD242 antigen; ICAM-4; intercellular adhesion molecule 4; intercellular adhesion molecule 4 (LW blood group); intercellular adhesion molecule 4 isoform 3 anitgen LWa; intercellular adhesion molecule 4, landsteiner-wiener blood group; Landsteiner-Wiener blood group antigen a; Landsteiner-Wiener blood group glycoprotein; LW; LW antigen a; LW blood group protein
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381910,286,955 - 10,288,520 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,397,643 - 10,399,260 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,258,650 - 10,260,198 (+)NCBINCBI36hg18NCBI36
Build 341910,258,679 - 10,260,198NCBI
Celera1910,293,046 - 10,294,594 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef199,977,622 - 9,979,239 (+)NCBIHuRef
CHM1_11910,397,908 - 10,399,525 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ICAM4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319054
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.