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Gene: ICAM4 (intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)) Homo sapiens
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Symbol: ICAM4
Name: intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Description: This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD242; CD242 antigen; ICAM-4; intercellular adhesion molecule 4; intercellular adhesion molecule 4 (LW blood group); intercellular adhesion molecule 4 isoform 3 anitgen LWa; intercellular adhesion molecule 4, landsteiner-wiener blood group; Landsteiner-Wiener blood group antigen a; Landsteiner-Wiener blood group glycoprotein; LW; LW antigen a; LW blood group protein
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,286,955 - 10,288,520 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,397,643 - 10,399,260 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,258,650 - 10,260,198 (+)NCBINCBI36hg18NCBI36
Build 341910,258,679 - 10,260,198NCBI
Celera1910,293,046 - 10,294,594 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef199,977,622 - 9,979,239 (+)NCBIHuRef
CHM1_11910,397,908 - 10,399,525 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ICAM4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319054
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.