WAPL (WAPL cohesin release factor) - Rat Genome Database

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Gene: WAPL (WAPL cohesin release factor) Homo sapiens
Analyze
Symbol: WAPL
Name: WAPL cohesin release factor
RGD ID: 1319037
HGNC Page HGNC
Description: Involved in several processes, including negative regulation of DNA replication; negative regulation of chromatin binding activity; and regulation of sister chromatid cohesion. Located in several cellular components, including Golgi apparatus; intercellular bridge; and microtubule cytoskeleton; INTERACTS WITH 2-hydroxypropanoic acid; aflatoxin B1; alpha-naphthoflavone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FOE; friend of EBNA2 (Epstein-Barr virus nuclear protein 2); friend of EBNA2 protein; KIAA0261; WAPAL; wings apart-like homolog; wings apart-like protein homolog
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1086,435,256 - 86,521,792 (-)EnsemblGRCh38hg38GRCh38
GRCh381086,435,256 - 86,521,816 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371088,195,013 - 88,281,549 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361088,184,993 - 88,271,521 (-)NCBINCBI36hg18NCBI36
Build 341088,184,993 - 88,271,521NCBI
Celera1082,193,855 - 82,283,880 (-)NCBI
Cytogenetic Map10q23.2NCBI
HuRef1082,045,663 - 82,136,011 (-)NCBIHuRef
CHM1_11088,476,841 - 88,563,395 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:9039502   PMID:11111111   PMID:12477932   PMID:15164054   PMID:15231747   PMID:15302935   PMID:15345747   PMID:15383329   PMID:15620708   PMID:16159877   PMID:16385451   PMID:17081983  
PMID:17112726   PMID:17113138   PMID:17349791   PMID:17382297   PMID:18029348   PMID:18187866   PMID:18662753   PMID:19322201   PMID:19696148   PMID:19907496   PMID:20360068   PMID:20379614  
PMID:20467437   PMID:21111234   PMID:21275903   PMID:21873635   PMID:22145905   PMID:22699663   PMID:22751501   PMID:22939629   PMID:23383273   PMID:23776203   PMID:23793025   PMID:24055153  
PMID:24169447   PMID:24332808   PMID:24529757   PMID:25173175   PMID:25184681   PMID:25609649   PMID:25659891   PMID:25862789   PMID:25921289   PMID:26186194   PMID:26299517   PMID:26496610  
PMID:26514267   PMID:26638075   PMID:26722608   PMID:26972000   PMID:27248496   PMID:28475897   PMID:28514442   PMID:28561026   PMID:29138236   PMID:29217591   PMID:29263825   PMID:29467282  
PMID:29509190   PMID:29568061   PMID:29724914   PMID:29867216   PMID:30463901   PMID:30585729   PMID:30698808   PMID:30948266   PMID:31010829   PMID:31073040   PMID:31091453   PMID:31204999  
PMID:31530811   PMID:31617661   PMID:31753913   PMID:32065581   PMID:32084359   PMID:32239614   PMID:32416067   PMID:32786267   PMID:34079125  


Genomics

Comparative Map Data
WAPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1086,435,256 - 86,521,792 (-)EnsemblGRCh38hg38GRCh38
GRCh381086,435,256 - 86,521,816 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371088,195,013 - 88,281,549 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361088,184,993 - 88,271,521 (-)NCBINCBI36hg18NCBI36
Build 341088,184,993 - 88,271,521NCBI
Celera1082,193,855 - 82,283,880 (-)NCBI
Cytogenetic Map10q23.2NCBI
HuRef1082,045,663 - 82,136,011 (-)NCBIHuRef
CHM1_11088,476,841 - 88,563,395 (-)NCBICHM1_1
Wapl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391434,394,086 - 34,469,940 (+)NCBIGRCm39mm39
GRCm39 Ensembl1434,395,885 - 34,469,940 (+)Ensembl
GRCm381434,672,379 - 34,747,983 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1434,673,928 - 34,747,983 (+)EnsemblGRCm38mm10GRCm38
MGSCv371435,487,114 - 35,559,403 (+)NCBIGRCm37mm9NCBIm37
MGSCv361433,503,214 - 33,575,044 (+)NCBImm8
Celera1430,941,041 - 31,013,556 (+)NCBICelera
Cytogenetic Map14BNCBI
Wapl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21610,005,520 - 10,075,270 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1611,032,531 - 11,106,589 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01611,029,325 - 11,108,867 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0169,354,539 - 9,434,346 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41610,337,231 - 10,408,154 (+)NCBIRGSC3.4rn4RGSC3.4
Celera165,142,468 - 5,211,200 (-)NCBICelera
Cytogenetic Map16p15NCBI
Wapl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555105,593,335 - 5,674,221 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555105,596,622 - 5,674,221 (-)NCBIChiLan1.0ChiLan1.0
WAPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11086,422,170 - 86,512,224 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1086,422,170 - 86,512,207 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01082,862,852 - 82,953,284 (-)NCBIMhudiblu_PPA_v0panPan3
WAPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1434,219,644 - 34,297,456 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl434,219,645 - 34,302,839 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha434,208,790 - 34,290,635 (-)NCBI
ROS_Cfam_1.0434,549,886 - 34,631,818 (-)NCBI
UMICH_Zoey_3.1434,422,845 - 34,504,994 (-)NCBI
UNSW_CanFamBas_1.0434,592,237 - 34,674,023 (-)NCBI
UU_Cfam_GSD_1.0435,097,493 - 35,179,330 (-)NCBI
Wapl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721344,243,869 - 44,321,323 (+)NCBI
SpeTri2.0NW_004936804354,201 - 431,655 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WAPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1487,492,453 - 87,588,570 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11487,492,452 - 87,588,678 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21494,746,694 - 94,842,934 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WAPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1945,335,423 - 45,420,785 (+)NCBI
ChlSab1.1 Ensembl945,334,981 - 45,420,787 (+)Ensembl
Vero_WHO_p1.0NW_0236660485,449,262 - 5,535,020 (+)NCBI
Wapl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624841534,148 - 611,014 (+)NCBI

Position Markers
STS-H98757  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371088,231,730 - 88,231,899UniSTSGRCh37
Build 361088,221,710 - 88,221,879RGDNCBI36
Celera1082,230,559 - 82,230,728RGD
Cytogenetic Map10q23.2UniSTS
HuRef1082,082,642 - 82,082,811UniSTS
GeneMap99-GB4 RH Map10415.85UniSTS
RH79889  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371088,197,054 - 88,197,285UniSTSGRCh37
Build 361088,187,034 - 88,187,265RGDNCBI36
Celera1082,195,899 - 82,196,130RGD
Cytogenetic Map10q23.2UniSTS
HuRef1082,047,707 - 82,047,938UniSTS
RH120205  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371088,260,796 - 88,261,138UniSTSGRCh37
Build 361088,250,776 - 88,251,118RGDNCBI36
Celera1082,259,624 - 82,259,966RGD
Cytogenetic Map10q23.2UniSTS
HuRef1082,111,694 - 82,112,036UniSTS
SHGC-107756  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371088,232,237 - 88,232,524UniSTSGRCh37
Build 361088,222,217 - 88,222,504RGDNCBI36
Celera1082,231,066 - 82,231,353RGD
Cytogenetic Map10q23.2UniSTS
HuRef1082,083,149 - 82,083,436UniSTS
RH130055  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371088,195,114 - 88,195,326UniSTSGRCh37
Build 361088,185,094 - 88,185,306RGDNCBI36
Celera1082,193,956 - 82,194,168RGD
HuRef1082,045,764 - 82,045,976UniSTS
RH68106  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371088,195,263 - 88,195,347UniSTSGRCh37
Build 361088,185,243 - 88,185,327RGDNCBI36
Celera1082,194,105 - 82,194,189RGD
Cytogenetic Map10q23.2UniSTS
HuRef1082,045,913 - 82,045,997UniSTS
GeneMap99-GB4 RH Map10415.85UniSTS
MARC_12283-12284:1005150312:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371088,211,824 - 88,213,036UniSTSGRCh37
Celera1082,210,676 - 82,211,865UniSTS
HuRef1082,062,687 - 82,063,875UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1604
Count of miRNA genes:727
Interacting mature miRNAs:863
Transcripts:ENST00000263070, ENST00000298767, ENST00000372075, ENST00000484070, ENST00000489996, ENST00000495124
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2093 1675 1317 354 1459 224 4136 1479 1505 303 1414 1600 143 1162 2578 5
Low 346 1316 409 270 492 241 221 718 2229 116 46 13 32 1 42 210 1 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001318328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011539548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017015979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017015980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017015981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB065003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB426838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF479418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK000849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL731569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL844892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC140858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI438983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000263070   ⟹   ENSP00000263070
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1086,435,257 - 86,521,768 (-)Ensembl
RefSeq Acc Id: ENST00000298767   ⟹   ENSP00000298767
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1086,435,256 - 86,521,792 (-)Ensembl
RefSeq Acc Id: ENST00000372075   ⟹   ENSP00000361145
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1086,437,010 - 86,467,506 (-)Ensembl
RefSeq Acc Id: ENST00000484070
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1086,435,256 - 86,444,032 (-)Ensembl
RefSeq Acc Id: ENST00000489996
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1086,467,053 - 86,472,287 (-)Ensembl
RefSeq Acc Id: ENST00000618527   ⟹   ENSP00000481451
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1086,435,257 - 86,521,768 (-)Ensembl
RefSeq Acc Id: NM_001318328   ⟹   NP_001305257
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381086,435,256 - 86,521,792 (-)NCBI
CHM1_11088,476,841 - 88,563,395 (-)NCBI
Sequence:
RefSeq Acc Id: NM_015045   ⟹   NP_055860
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381086,435,256 - 86,521,792 (-)NCBI
GRCh371088,195,013 - 88,281,541 (-)ENTREZGENE
Build 361088,184,993 - 88,271,521 (-)NCBI Archive
HuRef1082,045,663 - 82,136,011 (-)ENTREZGENE
CHM1_11088,476,841 - 88,563,395 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011539548   ⟹   XP_011537850
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381086,435,256 - 86,521,816 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017015979   ⟹   XP_016871468
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381086,435,256 - 86,521,816 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017015980   ⟹   XP_016871469
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381086,435,256 - 86,521,777 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017015981   ⟹   XP_016871470
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381086,436,794 - 86,490,018 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001305257 (Get FASTA)   NCBI Sequence Viewer  
  NP_055860 (Get FASTA)   NCBI Sequence Viewer  
  XP_011537850 (Get FASTA)   NCBI Sequence Viewer  
  XP_016871468 (Get FASTA)   NCBI Sequence Viewer  
  XP_016871469 (Get FASTA)   NCBI Sequence Viewer  
  XP_016871470 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH17393 (Get FASTA)   NCBI Sequence Viewer  
  AAI40859 (Get FASTA)   NCBI Sequence Viewer  
  AAI50270 (Get FASTA)   NCBI Sequence Viewer  
  AAO14651 (Get FASTA)   NCBI Sequence Viewer  
  BAA13391 (Get FASTA)   NCBI Sequence Viewer  
  BAC78631 (Get FASTA)   NCBI Sequence Viewer  
  BAF82827 (Get FASTA)   NCBI Sequence Viewer  
  BAG55435 (Get FASTA)   NCBI Sequence Viewer  
  BAG55436 (Get FASTA)   NCBI Sequence Viewer  
  BAG55437 (Get FASTA)   NCBI Sequence Viewer  
  BAG55438 (Get FASTA)   NCBI Sequence Viewer  
  BAG55439 (Get FASTA)   NCBI Sequence Viewer  
  BAG55440 (Get FASTA)   NCBI Sequence Viewer  
  BAG55441 (Get FASTA)   NCBI Sequence Viewer  
  BAG55442 (Get FASTA)   NCBI Sequence Viewer  
  BAG55443 (Get FASTA)   NCBI Sequence Viewer  
  BAG55444 (Get FASTA)   NCBI Sequence Viewer  
  BAG55445 (Get FASTA)   NCBI Sequence Viewer  
  BAG55446 (Get FASTA)   NCBI Sequence Viewer  
  BAG55447 (Get FASTA)   NCBI Sequence Viewer  
  BAG55448 (Get FASTA)   NCBI Sequence Viewer  
  BAG55449 (Get FASTA)   NCBI Sequence Viewer  
  BAG55450 (Get FASTA)   NCBI Sequence Viewer  
  BAG55451 (Get FASTA)   NCBI Sequence Viewer  
  BAG55452 (Get FASTA)   NCBI Sequence Viewer  
  EAW80334 (Get FASTA)   NCBI Sequence Viewer  
  EAW80335 (Get FASTA)   NCBI Sequence Viewer  
  EAW80336 (Get FASTA)   NCBI Sequence Viewer  
  EAW80337 (Get FASTA)   NCBI Sequence Viewer  
  Q7Z5K2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_055860   ⟸   NM_015045
- Peptide Label: isoform 1
- UniProtKB: Q7Z5K2 (UniProtKB/Swiss-Prot),   A8K273 (UniProtKB/TrEMBL),   B2RTX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011537850   ⟸   XM_011539548
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001305257   ⟸   NM_001318328
- Peptide Label: isoform 2
- UniProtKB: Q7Z5K2 (UniProtKB/Swiss-Prot),   A8K273 (UniProtKB/TrEMBL),   B2RTX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016871468   ⟸   XM_017015979
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016871469   ⟸   XM_017015980
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016871470   ⟸   XM_017015981
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSP00000361145   ⟸   ENST00000372075
RefSeq Acc Id: ENSP00000298767   ⟸   ENST00000298767
RefSeq Acc Id: ENSP00000481451   ⟸   ENST00000618527
RefSeq Acc Id: ENSP00000263070   ⟸   ENST00000263070
Protein Domains
WAPL

Promoters
RGD ID:7218015
Promoter ID:EPDNEW_H14753
Type:initiation region
Name:WAPL_1
Description:WAPL cohesin release factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381086,521,792 - 86,521,852EPDNEW
RGD ID:6788216
Promoter ID:HG_KWN:10385
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000263070,   ENST00000342368,   NM_015045,   OTTHUMT00000049156,   UC001KDN.1,   UC009XSW.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361088,270,841 - 88,271,757 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q22.3-23.2(chr10:79719429-87358394)x1 copy number loss See cases [RCV000052534] Chr10:79719429..87358394 [GRCh38]
Chr10:81479185..89118151 [GRCh37]
Chr10:81149191..89108131 [NCBI36]
Chr10:10q22.3-23.2
pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79802022-87358394)x1 copy number loss See cases [RCV000052537] Chr10:79802022..87358394 [GRCh38]
Chr10:81561459..89118151 [GRCh37]
Chr10:81541288..89108131 [NCBI36]
Chr10:10q22.3-23.2
pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79882162-87068261)x1 copy number loss See cases [RCV000052539] Chr10:79882162..87068261 [GRCh38]
Chr10:81641918..88828018 [GRCh37]
Chr10:81631898..88817998 [NCBI36]
Chr10:10q22.3-23.2
pathogenic|conflicting data from submitters
GRCh38/hg38 10q22.3-23.2(chr10:79898516-86964367)x1 copy number loss See cases [RCV000052541] Chr10:79898516..86964367 [GRCh38]
Chr10:81658272..88724124 [GRCh37]
Chr10:81648252..88714104 [NCBI36]
Chr10:10q22.3-23.2
pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79898516-87358394)x1 copy number loss See cases [RCV000052542] Chr10:79898516..87358394 [GRCh38]
Chr10:81658272..89118151 [GRCh37]
Chr10:81648252..89108131 [NCBI36]
Chr10:10q22.3-23.2
pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79898516-87109827)x1 copy number loss See cases [RCV000052544] Chr10:79898516..87109827 [GRCh38]
Chr10:81658272..88869584 [GRCh37]
Chr10:81648252..88859564 [NCBI36]
Chr10:10q22.3-23.2
pathogenic
GRCh38/hg38 10q23.1-23.31(chr10:84925492-88002064)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052546]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052546]|See cases [RCV000052546] Chr10:84925492..88002064 [GRCh38]
Chr10:86685248..89761821 [GRCh37]
Chr10:86675228..89751801 [NCBI36]
Chr10:10q23.1-23.31
pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79881238-87182117)x3 copy number gain See cases [RCV000053558] Chr10:79881238..87182117 [GRCh38]
Chr10:81640994..88941874 [GRCh37]
Chr10:81630974..88931854 [NCBI36]
Chr10:10q22.3-23.2
pathogenic
GRCh38/hg38 10q23.1-23.31(chr10:84434981-89150802)x3 copy number gain See cases [RCV000053559] Chr10:84434981..89150802 [GRCh38]
Chr10:86194737..90910559 [GRCh37]
Chr10:86184717..90900539 [NCBI36]
Chr10:10q23.1-23.31
pathogenic
NM_015045.2(WAPAL):c.799G>A (p.Asp267Asn) single nucleotide variant Malignant melanoma [RCV000069059] Chr10:86500444 [GRCh38]
Chr10:88260201 [GRCh37]
Chr10:88250181 [NCBI36]
Chr10:10q23.2
not provided
NM_015045.2(WAPAL):c.639C>T (p.Ser213=) single nucleotide variant Malignant melanoma [RCV000069060] Chr10:86500604 [GRCh38]
Chr10:88260361 [GRCh37]
Chr10:88250341 [NCBI36]
Chr10:10q23.2
not provided
NM_015045.2(WAPAL):c.638C>T (p.Ser213Phe) single nucleotide variant Malignant melanoma [RCV000069061] Chr10:86500605 [GRCh38]
Chr10:88260362 [GRCh37]
Chr10:88250342 [NCBI36]
Chr10:10q23.2
not provided
GRCh38/hg38 10q22.3-23.2(chr10:79925613-86951708)x1 copy number loss See cases [RCV000135348] Chr10:79925613..86951708 [GRCh38]
Chr10:81685369..88711465 [GRCh37]
Chr10:81675349..88701445 [NCBI36]
Chr10:10q22.3-23.2
pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79802022-87068261)x1 copy number loss See cases [RCV000136565] Chr10:79802022..87068261 [GRCh38]
Chr10:81561459..88828018 [GRCh37]
Chr10:81263385..88817998 [NCBI36]
Chr10:10q22.3-23.2
pathogenic
GRCh38/hg38 10q11.23-23.2(chr10:50729367-87147204)x3 copy number gain See cases [RCV000138007] Chr10:50729367..87147204 [GRCh38]
Chr10:52489127..88906961 [GRCh37]
Chr10:52159133..88896941 [NCBI36]
Chr10:10q11.23-23.2
pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79689360-87223773)x1 copy number loss See cases [RCV000141724] Chr10:79689360..87223773 [GRCh38]
Chr10:81449116..88983530 [GRCh37]
Chr10:81119122..88973510 [NCBI36]
Chr10:10q22.3-23.2
pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79881238-87180672)x1 copy number loss See cases [RCV000143178] Chr10:79881238..87180672 [GRCh38]
Chr10:81640994..88940429 [GRCh37]
Chr10:81630974..88930409 [NCBI36]
Chr10:10q22.3-23.2
pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79882162-87068261)x1 copy number loss See cases [RCV000148069] Chr10:79882162..87068261 [GRCh38]
Chr10:81641918..88828018 [GRCh37]
Chr10:81631898..88817998 [NCBI36]
Chr10:10q22.3-23.2
pathogenic
GRCh37/hg19 10q23.1-23.31(chr10:86766571-92609514)x1 copy number loss See cases [RCV000447104] Chr10:86766571..92609514 [GRCh37]
Chr10:10q23.1-23.31
pathogenic
GRCh37/hg19 10q22.3-23.2(chr10:81630468-88975551)x1 copy number loss See cases [RCV000447214] Chr10:81630468..88975551 [GRCh37]
Chr10:10q22.3-23.2
pathogenic
GRCh37/hg19 10q22.3-23.2(chr10:81892411-88722952)x1 copy number loss See cases [RCV000447520] Chr10:81892411..88722952 [GRCh37]
Chr10:10q22.3-23.2
pathogenic
GRCh37/hg19 10q23.1-25.1(chr10:85557432-105804295)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000431909] Chr10:85557432..105804295 [GRCh37]
Chr10:10q23.1-25.1
pathogenic|drug response
GRCh37/hg19 10q22.3-23.2(chr10:81630468-88973570)x3 copy number gain See cases [RCV000448704] Chr10:81630468..88973570 [GRCh37]
Chr10:10q22.3-23.2
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q22.3-23.2(chr10:81597767-88951347)x1 copy number loss See cases [RCV000511644] Chr10:81597767..88951347 [GRCh37]
Chr10:10q22.3-23.2
pathogenic
GRCh37/hg19 10q23.1-23.2(chr10:82013260-89166455)x1 copy number loss See cases [RCV000511659] Chr10:82013260..89166455 [GRCh37]
Chr10:10q23.1-23.2
pathogenic
GRCh37/hg19 10q22.3-23.2(chr10:81617260-88980961)x1 copy number loss See cases [RCV000511693] Chr10:81617260..88980961 [GRCh37]
Chr10:10q22.3-23.2
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q22.3-23.2(chr10:81697811-88768847) copy number loss not provided [RCV000767565] Chr10:81697811..88768847 [GRCh37]
Chr10:10q22.3-23.2
pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3
drug response
NM_015045.4(WAPL):c.2192G>A (p.Arg731His) single nucleotide variant WAPL-related disorder [RCV000680250] Chr10:86467457 [GRCh38]
Chr10:88227214 [GRCh37]
Chr10:10q23.2
uncertain significance
GRCh37/hg19 10q22.3-23.2(chr10:81644079-88973306)x3 copy number gain not provided [RCV000683282] Chr10:81644079..88973306 [GRCh37]
Chr10:10q22.3-23.2
pathogenic
GRCh37/hg19 10q23.1-23.32(chr10:83379241-93219169)x1 copy number loss not provided [RCV000683284] Chr10:83379241..93219169 [GRCh37]
Chr10:10q23.1-23.32
pathogenic
GRCh37/hg19 10q21.3-23.32(chr10:69040366-93194993)x3 copy number gain not provided [RCV000683289] Chr10:69040366..93194993 [GRCh37]
Chr10:10q21.3-23.32
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q22.3-23.2(chr10:81617260-88980961)x1 copy number loss not provided [RCV001006339] Chr10:81617260..88980961 [GRCh37]
Chr10:10q22.3-23.2
pathogenic
GRCh37/hg19 10q23.2(chr10:88211498-88621031)x3 copy number gain not provided [RCV001006343] Chr10:88211498..88621031 [GRCh37]
Chr10:10q23.2
uncertain significance
GRCh37/hg19 10q23.2(chr10:87975634-88619777)x3 copy number gain not provided [RCV001258456] Chr10:87975634..88619777 [GRCh37]
Chr10:10q23.2
uncertain significance
Single allele deletion not provided [RCV001260503] Chr10:81585301..89101700 [GRCh37]
Chr10:10q22.3-23.2
pathogenic
GRCh37/hg19 10q22.3-23.2(chr10:81457752-89253430)x1 copy number loss not provided [RCV001258451] Chr10:81457752..89253430 [GRCh37]
Chr10:10q22.3-23.2
pathogenic
GRCh37/hg19 10q22.3-23.2(chr10:81617260-89146780)x1 copy number loss not provided [RCV001258450] Chr10:81617260..89146780 [GRCh37]
Chr10:10q22.3-23.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:23293 AgrOrtholog
COSMIC WAPL COSMIC
Ensembl Genes ENSG00000062650 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000298767 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000361145 UniProtKB/TrEMBL
Ensembl Transcript ENST00000298767 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000372075 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000062650 GTEx
HGNC ID HGNC:23293 ENTREZGENE
Human Proteome Map WAPL Human Proteome Map
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WAPL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WAPL_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WAPL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:23063 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 23063 ENTREZGENE
OMIM 610754 OMIM
PANTHER PTHR22100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WAPL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134872402 PharmGKB
PROSITE WAPL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K273 ENTREZGENE, UniProtKB/TrEMBL
  B2RTX8 ENTREZGENE, UniProtKB/TrEMBL
  B3Y1W2_HUMAN UniProtKB/TrEMBL
  B3Y1W5_HUMAN UniProtKB/TrEMBL
  B3Y1W8_HUMAN UniProtKB/TrEMBL
  B3Y1W9_HUMAN UniProtKB/TrEMBL
  B3Y1X2_HUMAN UniProtKB/TrEMBL
  B3Y1X4_HUMAN UniProtKB/TrEMBL
  B3Y1X5_HUMAN UniProtKB/TrEMBL
  B3Y1X6_HUMAN UniProtKB/TrEMBL
  B3Y1X7_HUMAN UniProtKB/TrEMBL
  B3Y1X8_HUMAN UniProtKB/TrEMBL
  F6QZY1_HUMAN UniProtKB/TrEMBL
  Q7Z5K2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A7E2B5 UniProtKB/Swiss-Prot
  Q5VSK5 UniProtKB/Swiss-Prot
  Q8IX10 UniProtKB/Swiss-Prot
  Q92549 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-04 WAPL  WAPL cohesin release factor  WAPAL  wings apart-like homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED