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Gene: AP3B2 (adaptor related protein complex 3 subunit beta 2) Homo sapiens
Symbol: AP3B2
Name: adaptor related protein complex 3 subunit beta 2
Description: Adaptor protein complex 3 (AP-3 complex) is a heterotrimeric protein complex involved in the formation of clathrin-coated synaptic vesicles. The protein encoded by this gene represents the beta subunit of the neuron-specific AP-3 complex and was first identified as the target antigen in human paraneoplastic neurologic disorders. The encoded subunit binds clathrin and is phosphorylated by a casein kinase-like protein, which mediates synaptic vesicle coat assembly. Defects in this gene are a cause of early-onset epileptic encephalopathy. [provided by RefSeq, Feb 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: adapter-related protein complex 3 subunit beta-2; adaptor protein complex AP-3 subunit beta-2; adaptor related protein complex 3 beta 2 subunit; adaptor related protein complex 3, beta 2 subunit; adaptor-related protein complex 3 subunit beta-2; adaptor-related protein complex 3, beta 2 subunit; AP-3 complex subunit beta-2; beta-3B-adaptin; clathrin assembly protein complex 3 beta-2 large chain; DKFZp686D17136; EIEE48; NAPTB; neuron-specific vesicle coat protein beta-NAP; Neuronal adaptin-like protein, beta-subunit
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381582,659,281 - 82,709,908 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371583,328,033 - 83,378,660 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361581,125,088 - 81,175,689 (-)NCBINCBI36hg18NCBI36
Build 341581,125,088 - 81,175,689NCBI
Celera1561,202,181 - 61,252,080 (+)NCBI
Cytogenetic Map15q25.2NCBI
HuRef1559,598,225 - 59,648,196 (-)NCBIHuRef
CHM1_11583,069,649 - 83,120,279 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AP3B2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319021
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.