Nprl2 (NPR2 like, GATOR1 complex subunit) - Rat Genome Database
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Gene: Nprl2 (NPR2 like, GATOR1 complex subunit) Mus musculus
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Symbol: Nprl2
Name: NPR2 like, GATOR1 complex subunit
RGD ID: 1318979
MGI Page MGI
Description: Predicted to contribute to GTPase activator activity. Predicted to be involved in several processes, including cellular response to starvation; negative regulation of TOR signaling; and regulation of autophagy. Predicted to localize to GATOR1 complex and lysosomal membrane. Human ortholog(s) of this gene implicated in focal epilepsy. Orthologous to human NPRL2 (NPR2 like, GATOR1 complex subunit); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2810446G01Rik; G21; GATOR complex protein NPRL2; gene 21 protein; N; nitrogen permase homolog; nitrogen permease regulator 2-like protein; nitrogen permease regulator-like 2; NPR2-like protein; NPR2L; tumor suppressor candidate 4; Tusc; Tusc4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,419,405 - 107,422,905 (+)NCBIGRCm39mm39
GRCm389107,542,177 - 107,545,706 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,542,226 - 107,545,706 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,444,540 - 107,448,037 (+)NCBIGRCm37mm9NCBIm37
MGSCv369107,400,327 - 107,403,796 (+)NCBImm8
Celera9107,150,974 - 107,154,469 (+)NCBICelera
Cytogenetic Map9F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821   PMID:21677750  
PMID:21873635   PMID:26166573   PMID:29768191  


Genomics

Comparative Map Data
Nprl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,419,405 - 107,422,905 (+)NCBIGRCm39mm39
GRCm389107,542,177 - 107,545,706 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,542,226 - 107,545,706 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,444,540 - 107,448,037 (+)NCBIGRCm37mm9NCBIm37
MGSCv369107,400,327 - 107,403,796 (+)NCBImm8
Celera9107,150,974 - 107,154,469 (+)NCBICelera
Cytogenetic Map9F1NCBI
NPRL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl350,347,330 - 50,350,826 (-)EnsemblGRCh38hg38GRCh38
GRCh38350,347,330 - 50,350,821 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37350,384,918 - 50,388,486 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,359,923 - 50,363,490 (-)NCBINCBI36hg18NCBI36
Build 34350,359,922 - 50,363,490NCBI
Celera350,357,750 - 50,361,317 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef350,440,520 - 50,444,087 (-)NCBIHuRef
CHM1_1350,337,194 - 50,340,761 (-)NCBICHM1_1
Nprl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08116,297,950 - 116,301,123 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,297,950 - 116,301,122 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,654,210 - 115,657,383 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,789,664 - 112,792,837 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18112,809,139 - 112,812,182 (+)NCBI
Celera8107,522,243 - 107,525,416 (+)NCBICelera
Cytogenetic Map8q32NCBI
Nprl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,148,950 - 2,152,671 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,148,950 - 2,152,671 (-)NCBIChiLan1.0ChiLan1.0
NPRL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1351,508,932 - 51,512,791 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,508,932 - 51,512,776 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0350,273,611 - 50,277,175 (-)NCBIMhudiblu_PPA_v0panPan3
NPRL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2039,005,734 - 39,009,189 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12039,005,699 - 39,009,183 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nprl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049395301,745 - 5,100 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPRL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11332,830,895 - 32,834,205 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21336,009,112 - 36,012,405 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPRL2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,735,853 - 11,739,325 (-)NCBI
Nprl2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247304,196,154 - 4,200,100 (-)NCBI

Position Markers
UniSTS:236244  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389107,542,303 - 107,542,444UniSTSGRCm38
MGSCv379107,444,634 - 107,444,775UniSTSGRCm37
Celera9107,151,068 - 107,151,209UniSTS
Cytogenetic Map9F1UniSTS
BF396742  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389107,542,396 - 107,543,063UniSTSGRCm38
MGSCv379107,444,727 - 107,445,394UniSTSGRCm37
Celera9107,151,161 - 107,151,828UniSTS
Cytogenetic Map9F1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:115
Interacting mature miRNAs:120
Transcripts:ENSMUST00000010201
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_018879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006511768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006511769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003947955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004935491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_379769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF131207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI843290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL672219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY131176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000010201   ⟹   ENSMUSP00000010201
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9107,542,226 - 107,545,706 (+)Ensembl
RefSeq Acc Id: ENSMUST00000192951
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9107,543,978 - 107,544,460 (+)Ensembl
RefSeq Acc Id: ENSMUST00000193628
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9107,542,245 - 107,545,695 (+)Ensembl
RefSeq Acc Id: ENSMUST00000194848
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9107,542,261 - 107,543,689 (+)Ensembl
RefSeq Acc Id: ENSMUST00000195370   ⟹   ENSMUSP00000141746
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9107,542,241 - 107,544,634 (+)Ensembl
RefSeq Acc Id: NM_018879   ⟹   NP_061367
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,419,408 - 107,422,905 (+)NCBI
GRCm389107,542,209 - 107,545,706 (+)NCBI
MGSCv379107,444,540 - 107,448,037 (+)RGD
Celera9107,150,974 - 107,154,469 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006511768   ⟹   XP_006511831
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,419,405 - 107,422,905 (+)NCBI
GRCm389107,542,177 - 107,545,706 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006511769   ⟹   XP_006511832
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,419,419 - 107,422,905 (+)NCBI
GRCm389107,542,201 - 107,545,706 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036155141   ⟹   XP_036011034
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,419,405 - 107,422,303 (+)NCBI
RefSeq Acc Id: XR_003947955
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,419,405 - 107,422,905 (+)NCBI
GRCm389107,542,177 - 107,545,706 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004935491
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,419,405 - 107,422,905 (+)NCBI
RefSeq Acc Id: XR_379769
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,419,405 - 107,422,905 (+)NCBI
GRCm389107,542,177 - 107,545,706 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_061367   ⟸   NM_018879
- UniProtKB: Q9WUE4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006511831   ⟸   XM_006511768
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006511832   ⟸   XM_006511769
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSMUSP00000010201   ⟸   ENSMUST00000010201
RefSeq Acc Id: ENSMUSP00000141746   ⟸   ENSMUST00000195370
RefSeq Acc Id: XP_036011034   ⟸   XM_036155141
- Peptide Label: isoform X2

Promoters
RGD ID:6845319
Promoter ID:MM_KWN:58717
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_018879,   NM_019720,   UC009RLM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369107,442,841 - 107,444,612 (+)MPROMDB
RGD ID:8670788
Promoter ID:EPDNEW_M13425
Type:multiple initiation site
Name:Nprl2_1
Description:Mus musculus nitrogen permease regulator-like 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389107,542,247 - 107,542,307EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914482 AgrOrtholog
Ensembl Genes ENSMUSG00000010057 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000010201 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000141746 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000010201 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000195370 UniProtKB/TrEMBL
InterPro NPR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56032 UniProtKB/Swiss-Prot
MGD MGI:1914482 ENTREZGENE
NCBI Gene 56032 ENTREZGENE
PANTHER PTHR12991 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NPR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nprl2 PhenoGen
UniGene Mm.11337 ENTREZGENE
UniProt A0A0A6YWX8_MOUSE UniProtKB/TrEMBL
  NPRL2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-14 Nprl2  NPR2 like, GATOR1 complex subunit    nitrogen permease regulator-like 2  Symbol and/or name change 5135510 APPROVED
2012-07-05 Nprl2  nitrogen permease regulator-like 2  Nprl2  nitrogen permease regulator-like 2 (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED
2011-07-27 Nprl2  nitrogen permease regulator-like 2 (S. cerevisiae)  Tusc4  tumor suppressor candidate 4  Symbol and/or name change 5135510 APPROVED