Lin37 (lin-37 DREAM MuvB core complex component)

Gene: Lin37 (lin-37 DREAM MuvB core complex component) Mus musculus

Analyze

Symbol:

Lin37

Name:

lin-37 DREAM MuvB core complex component

RGD ID:

1318936

MGI Page

MGI

Description:

Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of Myb complex. Orthologous to human LIN37 (lin-37 DREAM MuvB core complex component).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

1810054G18Rik; antolefinin; antolefinine; lin-37 homolog; lin-37 homolog (C. elegans); protein lin-37 homolog

RGD Orthologs

Alliance Genes

More Info

more info ...

Related Pseudogenes:

Gm18386 Gm8802

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	30,254,866 - 30,259,289 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	30,254,866 - 30,259,263 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	30,555,441 - 30,559,721 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	30,555,441 - 30,559,838 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	31,340,460 - 31,344,665 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	30,264,201 - 30,268,406 (-)	NCBI		MGSCv36	mm8
Celera	7	25,147,203 - 25,151,408 (-)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	18.58	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brugada syndrome 5 (ISO)

dystonia (ISO)

genetic disease (ISO)

hereditary spastic paraplegia 75 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(+)-schisandrin B (ISO)

1,2-dimethylhydrazine (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (EXP)

4,4'-sulfonyldiphenol (ISO)

Aflatoxin B2 alpha (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP)

cisplatin (ISO)

coumarin (ISO)

cyclosporin A (ISO)

endosulfan (ISO)

ethyl methanesulfonate (ISO)

fenvalerate (ISO)

finasteride (ISO)

flutamide (ISO)

folic acid (EXP)

formaldehyde (ISO)

FR900359 (ISO)

hydralazine (ISO)

hydrogen cyanide (EXP)

leflunomide (ISO)

methyl methanesulfonate (ISO)

N-nitrosodiethylamine (ISO)

nefazodone (ISO)

paracetamol (ISO)

phenobarbital (ISO)

potassium cyanide (EXP)

senecionine (EXP)

tamoxifen (EXP)

tetrachloromethane (EXP,ISO)

thioacetamide (ISO)

titanium dioxide (EXP)

trichloroethene (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of transcription by RNA polymerase II (IBA)

Cellular Component

Myb complex (IBA)

transcription repressor complex (IEA)

Molecular Function

molecular_function (ND)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:10725249	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12466851	PMID:12477932	PMID:14610273	PMID:16141072	PMID:16141073	PMID:18799693
PMID:21267068	PMID:21873635	PMID:28920576

Genomics

Comparative Map Data

Lin37
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	30,254,866 - 30,259,289 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	30,254,866 - 30,259,263 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	30,555,441 - 30,559,721 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	30,555,441 - 30,559,838 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	31,340,460 - 31,344,665 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	30,264,201 - 30,268,406 (-)	NCBI		MGSCv36	mm8
Celera	7	25,147,203 - 25,151,408 (-)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	18.58	NCBI

LIN37
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	35,748,576 - 35,754,519 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	35,748,361 - 35,754,519 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	36,239,477 - 36,245,420 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	40,931,352 - 40,937,260 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	32,952,989 - 32,958,898 (+)	NCBI		Celera
Cytogenetic Map	19	q13.12	NCBI
HuRef	19	32,744,250 - 32,750,415 (+)	NCBI		HuRef
CHM1_1	19	36,240,571 - 36,246,733 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	38,293,885 - 38,299,832 (+)	NCBI		T2T-CHM13v2.0

Lin37
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	94,936,512 - 94,940,444 (-)	NCBI		GRCr8
mRatBN7.2	1	85,809,065 - 85,813,235 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	85,809,074 - 85,812,991 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	91,225,801 - 91,229,721 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	99,691,966 - 99,695,886 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	92,984,081 - 92,988,001 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	89,010,254 - 89,014,481 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	89,010,257 - 89,014,189 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	90,165,072 - 90,169,231 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	85,601,215 - 85,605,147 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	85,679,331 - 85,683,235 (-)	NCBI
Celera	1	80,180,589 - 80,184,521 (-)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

Lin37
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	2,799,641 - 2,804,462 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	2,799,641 - 2,803,880 (-)	NCBI	ChiLan1.0	ChiLan1.0

LIN37
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	41,742,819 - 41,748,797 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	43,728,143 - 43,734,123 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	32,678,141 - 32,684,305 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	41,412,445 - 41,418,608 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	41,412,809 - 41,418,563 (+)	Ensembl	panpan1.1		panPan2

LIN37
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	116,880,910 - 116,886,056 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	116,880,914 - 116,885,987 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	116,286,170 - 116,291,316 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	117,483,886 - 117,489,031 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	117,483,890 - 117,489,221 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	117,047,262 - 117,052,407 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	116,670,880 - 116,676,028 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	117,726,260 - 117,731,408 (-)	NCBI		UU_Cfam_GSD_1.0

Lin37
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	11,070,177 - 11,074,736 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936570	567,860 - 575,788 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936570	571,146 - 575,539 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LIN37
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	45,175,500 - 45,181,391 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	45,175,454 - 45,181,383 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	40,630,722 - 40,636,840 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LIN37
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	30,657,951 - 30,664,302 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666073	8,449,324 - 8,455,668 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lin37
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	10,056,258 - 10,060,679 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624794	10,056,180 - 10,060,679 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Lin37
213 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	975
Count of miRNA genes:	459
Interacting mature miRNAs:	530
Transcripts:	ENSMUST00000043975, ENSMUST00000108164, ENSMUST00000146548, ENSMUST00000149400, ENSMUST00000156241
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301572	Sluc30_m	susceptibility to lung cancer 30 (mouse)			Not determined		7	2431696	36431844	Mouse
1300722	Sle3_m	systemic lupus erythmatosus susceptibility 3 (mouse)			Not determined		7	3511728	87142720	Mouse
38501068	Tip1_m	tuberculosis immunophenotype 1, spleen CFU (mouse)					7	3602999	72549748	Mouse
25314307	Mlh1fc2_m	MLH1 foci count 2 (mouse)					7	6502999	133501729	Mouse
12792978	Fbmd3_m	femoral bone mineral density 3, females only (mouse)					7	7050288	142367832	Mouse
1357699	Nhdlq6_m	non-HDL QTL 6 (mouse)			Not determined		7	9988867	43988984	Mouse
1558893	Spir1_m	Streptococcus pneumoniae infection resistance 1 (mouse)			Not determined		7	10305798	44305936	Mouse
10449139	Eosn1_m	eosinophil differential 1 (mouse)					7	12480877	46480877	Mouse
10449158	Eosn3_m	eosinophil differential 3 (mouse)					7	12480877	46480877	Mouse
4141566	Femwf8_m	femur work to failure 8 (mouse)			Not determined			13032485	47032621	Mouse
11522751	Cocia17_m	cocaine-induced activity, QTL 17 (mouse)					7	13135204	47135204	Mouse
25314314	Sccor1_m	synaptonemal complex length to mean MLH1 count ratio 1 (mouse)					7	13333925	47349748	Mouse
1559016	Drsi_m	DCC-related Spp1 induction (mouse)			Not determined		7	16637293	49159331	Mouse
1301041	Prnr2_m	prion resistance 2 (mouse)			Not determined		7	18728794	39674033	Mouse
10412199	Sst2_m	susceptibility to tuberculosis 2 (mouse)			Not determined		7	18728794	119485380	Mouse
1301158	Eae4_m	susceptibility to experimental allergic encephalomyelitis 4 (mouse)			Not determined		7	19147398	141919804	Mouse
1301622	Eae12_m	susceptibility to experimental allergic encephalomyelitis 12 (mouse)			Not determined		7	19280015	53280104	Mouse
1301052	Bhr6_m	bronchial hyperresponsiveness 6 (mouse)			Not determined		7	19842250	53842367	Mouse
12904742	Litsq2_m	litter size QTL 2 (mouse)					7	22673887	56674033	Mouse
1301709	Bdt4_m	bone density traits 4 (mouse)			Not determined		7	22888572	56888716	Mouse
11354952	Pdcc1_m	plasmacytoid dentritic cell compartment 1 (mouse)					7	23066531	57066531	Mouse
1301969	Lbw5_m	lupus NZB x NZW 5 (mouse)			Not determined		7	26847615	60851775	Mouse
7394747	asp3_m	audiogenic seizure prone 3 (mouse)			Not determined		7	27305798	36842367	Mouse
12790989	Tgl6_m	triglyceride 6 (mouse)					7	27540549	61540549	Mouse
4141805	Sle19_m	systematic lupus erythematosus susceptibility 19 (mouse)			Not determined			30032485	81135653	Mouse
26884404	Huml1_m	humerus length 1, 5 week (mouse)					7	30199425	108999207	Mouse

Markers in Region

RH136454

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	7	B1	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001290569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_029377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_011250734	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017312369	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_036153535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC167970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK007858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY428767	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC013546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY707863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000043975 ⟹ ENSMUSP00000048557

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	30,254,866 - 30,259,071 (-)	Ensembl
GRCm38.p6 Ensembl	7	30,555,441 - 30,559,646 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000108164 ⟹ ENSMUSP00000103799

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	30,254,870 - 30,259,263 (-)	Ensembl
GRCm38.p6 Ensembl	7	30,555,445 - 30,559,838 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000146548

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	30,254,869 - 30,255,446 (-)	Ensembl
GRCm38.p6 Ensembl	7	30,555,444 - 30,556,021 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000149400

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	30,256,518 - 30,259,064 (-)	Ensembl
GRCm38.p6 Ensembl	7	30,557,093 - 30,559,639 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000156241 ⟹ ENSMUSP00000122248

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	30,255,285 - 30,259,084 (-)	Ensembl
GRCm38.p6 Ensembl	7	30,555,860 - 30,559,659 (-)	Ensembl

RefSeq Acc Id:

NM_001290569 ⟹ NP_001277498

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	30,254,866 - 30,259,071 (-)	NCBI
GRCm38	7	30,555,441 - 30,559,646 (-)	NCBI
Celera	7	25,147,203 - 25,151,408 (-)	NCBI

Sequence:

show sequence

GGAAGAAGGGAAGTGGCCGCCAAGGCAGTCGCGGCTGGACAGTGCTCAGGCCCGAGGACCAGTG
GTGCCCAGACTTACCTTTGACCTTTCCCTGCCCGCCTTCCGCCTAGCTTTTGAACCACACCTCC
TCCAAGTTTTTCTGATCCAGCGCATTAGACCTGCACCCAAATCATGTTCCCGGTAAAGGTGAAA
GTGGAGAAATCAGTTGGTCTCTCCACTGAGTGGCACTAAAGCTGCTTTCCAAGTAACTGGACCA
GACAGGACGTAGGATCGCCTCCCACGGCGAATGTGGGAGGCGCACACAGAGCTGATTCCTACCT
TCTACCCTCAGAGATGGAGATGGCCAAAGCCCGGAACCAGCTGGATGCCGTTCTTCAGTGTCTG
CTGGAGAAGAGTCACATGGACAGGGAACGCCTGGATGAAGAAGCTGGGAAAACCCCCTTGGATA
CGCACAACAAGGATTGTTCCATTGCTGCCACAGGCAAAAGGCCATCTGCCCGCTTCCCCCACCA
GCGGAGGAAGAAGAGGAGGGAGATGGACGATGGGCTCGCTGAGGGGGGTCCTCAGAGATCCAAT
ACGTATGTGATCAAGCTATTTGACCGGAGTGTGGACTTGGCCCAGTTCAGTGAGAACACACCAC
TGTACCCCATCTGCCGCGCCTGGATGCGCAACAGCCCCACAGTGCGAGAGCGCGAGCGCTCACC
CGGCTCACCGCTGCCTCCTCTGCCCGAGGATGGAGAGGGTTCAGAGGTCATCAACAGCAAAAAC
CGTGATGTGTACAAGCTGCCTCCACCCACAGCTCCTGGACCACTTGGAGATGCCTGTAGATCCA
GAATTCCATCCCCACTGCAGCCTGAGACCGAGGGTACCCCCGATGATGAACCTTCCGAGCCTGA
ACCTTCTCCTTCCACACTTATCTATCGCAACATGCAACGTTGGAAACGCATACGCCAGAGGTGG
AAGGAGGCATCTCATCGGAACCAGCTTCGCTACTCAGAAAGTATGAAGATCCTACGGGAGATGT
ATGACCGGCAGTGACCTTCCCAGGAACCCCACCCCAATAAATGTGCCCCCCAACCCACACTGGC
CAGGCCATCGTTCCTGGCCCAGACATAAGGCAGTTG

hide sequence

RefSeq Acc Id:

NM_029377 ⟹ NP_083653

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	30,254,866 - 30,259,071 (-)	NCBI
GRCm38	7	30,555,441 - 30,559,646 (-)	NCBI
MGSCv37	7	31,340,460 - 31,344,665 (-)	RGD
Celera	7	25,147,203 - 25,151,408 (-)	RGD
cM Map	7		ENTREZGENE

Sequence:

show sequence

GGAAGAAGGGAAGTGGCCGCCAAGGCAGTCGCGGCTGGACAGTGCTCAGGCCCGAGGACCAGTG
GTGCCCAGACTTACCTTTGACCTTTCCCTGCCCGCCTTCCGCCTAGCTTTTGAACCACACCTCC
TCCAAGTTTTTCTGATCCAGCGCATTAGACCTGCACCCAAATCATGTTCCCGGTAAAGGTGAAA
GTGGAGAAATCAGAGATGGAGATGGCCAAAGCCCGGAACCAGCTGGATGCCGTTCTTCAGTGTC
TGCTGGAGAAGAGTCACATGGACAGGGAACGCCTGGATGAAGAAGCTGGGAAAACCCCCTTGGA
TACGCACAACAAGGATTGTTCCATTGCTGCCACAGGCAAAAGGCCATCTGCCCGCTTCCCCCAC
CAGCGGAGGAAGAAGAGGAGGGAGATGGACGATGGGCTCGCTGAGGGGGGTCCTCAGAGATCCA
ATACGTATGTGATCAAGCTATTTGACCGGAGTGTGGACTTGGCCCAGTTCAGTGAGAACACACC
ACTGTACCCCATCTGCCGCGCCTGGATGCGCAACAGCCCCACAGTGCGAGAGCGCGAGCGCTCA
CCCGGCTCACCGCTGCCTCCTCTGCCCGAGGATGGAGAGGGTTCAGAGGTCATCAACAGCAAAA
ACCGTGATGTGTACAAGCTGCCTCCACCCACAGCTCCTGGACCACTTGGAGATGCCTGTAGATC
CAGAATTCCATCCCCACTGCAGCCTGAGACCGAGGGTACCCCCGATGATGAACCTTCCGAGCCT
GAACCTTCTCCTTCCACACTTATCTATCGCAACATGCAACGTTGGAAACGCATACGCCAGAGGT
GGAAGGAGGCATCTCATCGGAACCAGCTTCGCTACTCAGAAAGTATGAAGATCCTACGGGAGAT
GTATGACCGGCAGTGACCTTCCCAGGAACCCCACCCCAATAAATGTGCCCCCCAACCCACACTG
GCCAGGCCATCGTTCCTGGCCCAGACATAAGGCAGTTG

hide sequence

RefSeq Acc Id:

XM_011250734 ⟹ XP_011249036

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	30,254,870 - 30,259,289 (-)	NCBI
GRCm38	7	30,555,445 - 30,559,720 (-)	NCBI

Sequence:

show sequence

CTCCGTCTTGAGCCTCGGAAGTTTGAATCACAACCCCCACCTCCGCCCCCCAGGTGCCTGGCTT
GTCGTTGGTTTGTTTCCGGATACAGGGCCTCGGGAAGGTGGAGCCTAAGGCTGGGAGCCAATAG
TACAGGCTGTCAATTGGCCAGCAAATGAAATTGACGTTTTCATCAACTAGTGGGAAAAAGCAGT
TGCCAAAGGGTCCCGCCTACAGAAGGGGAAGAAGGGAAGTGGCCGCCAAGGCAGTCGCGGCTGG
ACAGTGCTCAGGCCCGAGGACCAGTGGTGCCCAGACTTACCTTTGACCTTTCCCTGCCCGCCTT
CCGCCTAGCTTTTGAACCACACCTCCTCCAAGTTTTTCTGATCCAGCGCATTAGACCTGCACCC
AAATCATGTTCCCGGTAAAGGTGAAAGTGGAGAAATCAGAGATGGAGATGGCCAAAGCCCGGAA
CCAGCTGGATGCCGTTCTTCAGTGTCTGCTGGAGAAGAGTCACATGGACAGGTTGGAACCTGGT
CCAGCCTGGGGAACCACAGGGGAACGCCTGGATGAAGAAGCTGGGAAAACCCCCTTGGATACGC
ACAACAAGGATTGTTCCATTGCTGCCACAGGCAAAAGGCCATCTGCCCGCTTCCCCCACCAGCG
GAGGAAGAAGAGGAGGGAGATGGACGATGGGCTCGCTGAGGGGGGTCCTCAGAGATCCAATACG
TATGTGATCAAGCTATTTGACCGGAGTGTGGACTTGGCCCAGTTCAGTGAGAACACACCACTGT
ACCCCATCTGCCGCGCCTGGATGCGCAACAGCCCCACAGTGCGAGAGCGCGAGCGCTCACCCGG
CTCACCGCTGCCTCCTCTGCCCGAGGATGGAGAGGGTTCAGAGGTCATCAACAGCAAAAACCGT
GATGTGTACAAGCTGCCTCCACCCACAGCTCCTGGACCACTTGGAGATGCCTGTAGATCCAGAA
TTCCATCCCCACTGCAGCCTGAGACCGAGGGTACCCCCGATGATGAACCTTCCGAGCCTGAACC
TTCTCCTTCCACACTTATCTATCGCAACATGCAACGTTGGAAACGCATACGCCAGAGGTGGAAG
GAGGCATCTCATCGGAACCAGCTTCGCTACTCAGAAAGTATGAAGATCCTACGGGAGATGTATG
ACCGGCAGTGACCTTCCCAGGAACCCCACCCCAATAAATGTGCCCCCCAACCCACACTGGCCAG
GCCATCGTTCCTGGCCCAGACATAAGGCA

hide sequence

RefSeq Acc Id:

XM_017312369 ⟹ XP_017167858

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	30,254,870 - 30,259,062 (-)	NCBI
GRCm38	7	30,555,445 - 30,559,721 (-)	NCBI

Sequence:

show sequence

GAAGTGGCCGCCAAGGCAGTCGCGGCTGGACAGTGCTCAGGCCCGAGGACCAGTGGTGCCCAGA
CTTACCTTTGACCTTTCCCTGCCCGCCTTCCGCCTAGCTTTTGAACCACACCTCCTCCAAGTTT
TTCTGATCCAGCGCATTAGACCTGCACCCAAATCATGTTCCCGGTAAAGGTGAAAGTGGAGAAA
TCAGTTGGTCTCTCCACTGAGTGGCACTAAAGCTGCTTTCCAAGTAACTGGACCAGACAGGACG
TAGGATCGCCTCCCACGGCGAATGTGGGAGGCGCACACAGAGCTGATTCCTACCTTCTACCCTC
AGAGATGGAGATGGCCAAAGCCCGGAACCAGCTGGATGCCGTTCTTCAGTGTCTGCTGGAGAAG
AGTCACATGGACAGGTTGGAACCTGGTCCAGCCTGGGGAACCACAGGGGAACGCCTGGATGAAG
AAGCTGGGAAAACCCCCTTGGATACGCACAACAAGGATTGTTCCATTGCTGCCACAGGCAAAAG
GCCATCTGCCCGCTTCCCCCACCAGCGGAGGAAGAAGAGGAGGGAGATGGACGATGGGCTCGCT
GAGGGGGGTCCTCAGAGATCCAATACGTATGTGATCAAGCTATTTGACCGGAGTGTGGACTTGG
CCCAGTTCAGTGAGAACACACCACTGTACCCCATCTGCCGCGCCTGGATGCGCAACAGCCCCAC
AGTGCGAGAGCGCGAGCGCTCACCCGGCTCACCGCTGCCTCCTCTGCCCGAGGATGGAGAGGGT
TCAGAGGTCATCAACAGCAAAAACCGTGATGTGTACAAGCTGCCTCCACCCACAGCTCCTGGAC
CACTTGGAGATGCCTGTAGATCCAGAATTCCATCCCCACTGCAGCCTGAGACCGAGGGTACCCC
CGATGATGAACCTTCCGAGCCTGAACCTTCTCCTTCCACACTTATCTATCGCAACATGCAACGT
TGGAAACGCATACGCCAGAGGTGGAAGGAGGCATCTCATCGGAACCAGCTTCGCTACTCAGAAA
GTATGAAGATCCTACGGGAGATGTATGACCGGCAGTGACCTTCCCAGGAACCCCACCCCAATAA
ATGTGCCCCCCAACCCACACTGGCCAGGCCATCGTTCCTGGCCCAGACATAAGGCA

hide sequence

RefSeq Acc Id:

XM_036153535 ⟹ XP_036009428

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	30,254,870 - 30,259,079 (-)	NCBI

Sequence:

show sequence

ACAGAAGGGGAAGAAGGGAAGTGGCCGCCAAGGCAGTCGCGGCTGGACAGTGCTCAGGCCCGAG
GACCAGTGGTGCCCAGACTTACCTTTGACCTTTCCCTGCCCGCCTTCCGCCTAGCTTTTGAACC
ACACCTCCTCCAAGTTTTTCTGATCCAGCGCATTAGACCTGCACCCAAATCATGTTCCCGGTAA
AGGTGAAAGTGGAGAAATCAGAGATGGAGATGGCCAAAGCCCGGAACCAGCTGGATGCCGTTCT
TCAGTGTCTGCTGGAGAAGAGTCACATGGACAGGGAACGCCTGGATGAAGAAGCTGGGAAAACC
CCCTTGGATACGCACAACAAAGCTAGCGATAGAACCCCAGGGCTTTTGCCCATGCTAGGCAAAT
GCTCTGTTCCTGAACTACGTCACTTCCACCTTGGGGGGCAGCGTTGAGCAGCTGTTTATTAAAG
CCTCCTGACACCATGTCTCTCCCTGCAGGGATTGTTCCATTGCTGCCACAGGCAAAAGGCCATC
TGCCCGCTTCCCCCACCAGCGGAGGAAGAAGAGGAGGGAGATGGACGATGGGCTCGCTGAGGGG
GGTCCTCAGAGATCCAATACGTATGTGATCAAGCTATTTGACCGGAGTGTGGACTTGGCCCAGT
TCAGTGAGAACACACCACTGTACCCCATCTGCCGCGCCTGGATGCGCAACAGCCCCACAGTGCG
AGAGCGCGAGCGCTCACCCGGCTCACCGCTGCCTCCTCTGCCCGAGGATGGAGAGGGTTCAGAG
GTCATCAACAGCAAAAACCGTGATGTGTACAAGCTGCCTCCACCCACAGCTCCTGGACCACTTG
GAGATGCCTGTAGATCCAGAATTCCATCCCCACTGCAGCCTGAGACCGAGGGTACCCCCGATGA
TGAACCTTCCGAGCCTGAACCTTCTCCTTCCACACTTATCTATCGCAACATGCAACGTTGGAAA
CGCATACGCCAGAGGTGGAAGGAGGCATCTCATCGGAACCAGCTTCGCTACTCAGAAAGTATGA
AGATCCTACGGGAGATGTATGACCGGCAGTGACCTTCCCAGGAACCCCACCCCAATAAATGTGC
CCCCCAACCCACACTGGCCAGGCCATCGTTCCTGGCCCAGACATAAGGCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001277498	(Get FASTA)	NCBI Sequence Viewer
	NP_083653	(Get FASTA)	NCBI Sequence Viewer
	XP_011249036	(Get FASTA)	NCBI Sequence Viewer
	XP_017167858	(Get FASTA)	NCBI Sequence Viewer
	XP_036009428	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH13546	(Get FASTA)	NCBI Sequence Viewer
	AAR06606	(Get FASTA)	NCBI Sequence Viewer
	BAB25310	(Get FASTA)	NCBI Sequence Viewer
	EDL24011	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000048557
	ENSMUSP00000048557.5
	ENSMUSP00000103799
	ENSMUSP00000103799.2
	ENSMUSP00000122248.2
GenBank Protein	Q9D8N6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_083653 ⟸ NM_029377
- Peptide Label:	isoform 1
- UniProtKB:	Q9D8N6 (UniProtKB/Swiss-Prot), Q91WQ7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFPVKVKVEKSEMEMAKARNQLDAVLQCLLEKSHMDRERLDEEAGKTPLDTHNKDCSIAATGKR PSARFPHQRRKKRREMDDGLAEGGPQRSNTYVIKLFDRSVDLAQFSENTPLYPICRAWMRNSPT VRERERSPGSPLPPLPEDGEGSEVINSKNRDVYKLPPPTAPGPLGDACRSRIPSPLQPETEGTP DDEPSEPEPSPSTLIYRNMQRWKRIRQRWKEASHRNQLRYSESMKILREMYDRQ hide sequence

RefSeq Acc Id:	NP_001277498 ⟸ NM_001290569
- Peptide Label:	isoform 2
- UniProtKB:	E9Q0Q9 (UniProtKB/TrEMBL), Q91WQ7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEMAKARNQLDAVLQCLLEKSHMDRERLDEEAGKTPLDTHNKDCSIAATGKRPSARFPHQRRKK RREMDDGLAEGGPQRSNTYVIKLFDRSVDLAQFSENTPLYPICRAWMRNSPTVRERERSPGSPL PPLPEDGEGSEVINSKNRDVYKLPPPTAPGPLGDACRSRIPSPLQPETEGTPDDEPSEPEPSPS TLIYRNMQRWKRIRQRWKEASHRNQLRYSESMKILREMYDRQ hide sequence

RefSeq Acc Id:	XP_011249036 ⟸ XM_011250734
- Peptide Label:	isoform X1
- UniProtKB:	Q91WQ7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFPVKVKVEKSEMEMAKARNQLDAVLQCLLEKSHMDRLEPGPAWGTTGERLDEEAGKTPLDTHN KDCSIAATGKRPSARFPHQRRKKRREMDDGLAEGGPQRSNTYVIKLFDRSVDLAQFSENTPLYP ICRAWMRNSPTVRERERSPGSPLPPLPEDGEGSEVINSKNRDVYKLPPPTAPGPLGDACRSRIP SPLQPETEGTPDDEPSEPEPSPSTLIYRNMQRWKRIRQRWKEASHRNQLRYSESMKILREMYDR Q hide sequence

RefSeq Acc Id:	XP_017167858 ⟸ XM_017312369
- Peptide Label:	isoform X2
- UniProtKB:	Q91WQ7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEMAKARNQLDAVLQCLLEKSHMDRLEPGPAWGTTGERLDEEAGKTPLDTHNKDCSIAATGKRP SARFPHQRRKKRREMDDGLAEGGPQRSNTYVIKLFDRSVDLAQFSENTPLYPICRAWMRNSPTV RERERSPGSPLPPLPEDGEGSEVINSKNRDVYKLPPPTAPGPLGDACRSRIPSPLQPETEGTPD DEPSEPEPSPSTLIYRNMQRWKRIRQRWKEASHRNQLRYSESMKILREMYDRQ hide sequence

RefSeq Acc Id:

ENSMUSP00000103799 ⟸ ENSMUST00000108164

RefSeq Acc Id:

ENSMUSP00000048557 ⟸ ENSMUST00000043975

RefSeq Acc Id:

ENSMUSP00000122248 ⟸ ENSMUST00000156241

RefSeq Acc Id:	XP_036009428 ⟸ XM_036153535
- Peptide Label:	isoform X3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9D8N6-F1-model_v2	AlphaFold	Q9D8N6	1-246	view protein structure

Promoters

RGD ID:

6892634

Promoter ID:

EPDNEW_M9767

Type:

initiation region

Name:

Lin37_1

Description:

Mus musculus lin-37 homolog , transcript variant 1, mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	7	30,559,636 - 30,559,696	EPDNEW

RGD ID:

6841422

Promoter ID:

MM_KWN:49830

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Brain, MEF_B6

Transcripts:

OTTMUST00000064786

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	7	31,340,716 - 31,342,027 (-)	MPROMDB

RGD ID:

6841423

Promoter ID:

MM_KWN:49831

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

NM_029377, OTTMUST00000064784, OTTMUST00000064785, UC009GEY.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	7	31,344,546 - 31,345,567 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1922910	AgrOrtholog
Ensembl Genes	ENSMUSG00000036845	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000043975	ENTREZGENE
	ENSMUST00000043975.11	UniProtKB/Swiss-Prot
	ENSMUST00000108164	ENTREZGENE
	ENSMUST00000108164.8	UniProtKB/TrEMBL
	ENSMUST00000156241.2	UniProtKB/TrEMBL
InterPro	LIN37	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:75660	UniProtKB/Swiss-Prot
MGD	MGI:1922910	ENTREZGENE
NCBI Gene	75660	ENTREZGENE
PANTHER	PROTEIN LIN-37 HOMOLOG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR31336	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	LIN37	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Lin37	PhenoGen
UniProt	D3Z769_MOUSE	UniProtKB/TrEMBL
	E9Q0Q9	ENTREZGENE, UniProtKB/TrEMBL
	LIN37_MOUSE	UniProtKB/Swiss-Prot
	Q91WQ7	ENTREZGENE, UniProtKB/TrEMBL
	Q9D8N6	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-06-29	Lin37	lin-37 DREAM MuvB core complex component	Lin37	lin-37 homolog (C. elegans)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar