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Gene: GRHPR (glyoxylate and hydroxypyruvate reductase) Homo sapiens
Symbol: GRHPR
Name: glyoxylate and hydroxypyruvate reductase
Description: Exhibits NADPH binding activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and protein homodimerization activity. Involved in several processes, including excretion; glyoxylate metabolic process; and protein complex oligomerization. Localizes to the cytoplasm. Implicated in primary hyperoxaluria.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GLXR; glycerate-2-dehydrogenase; GLYD; glyoxylate reductase and hydroxypyruvate reductase; glyoxylate reductase/hydroxypyruvate reductase; PH2
Mus musculus (house mouse) : Grhpr (glyoxylate reductase/hydroxypyruvate reductase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Grhpr (glyoxylate and hydroxypyruvate reductase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grhpr (glyoxylate and hydroxypyruvate reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : GRHPR (glyoxylate and hydroxypyruvate reductase)
Canis lupus familiaris (dog) : GRHPR (glyoxylate and hydroxypyruvate reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grhpr (glyoxylate and hydroxypyruvate reductase)
Sus scrofa (pig) : GRHPR (glyoxylate and hydroxypyruvate reductase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38937,422,435 - 37,438,952 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37937,422,693 - 37,436,990 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36937,412,707 - 37,426,986 (+)NCBINCBI36hg18NCBI36
Build 34937,412,706 - 37,426,986NCBI
Celera937,355,941 - 37,370,220 (+)NCBI
Cytogenetic Map9p13.2NCBI
HuRef937,374,615 - 37,388,916 (+)NCBIHuRef
CHM1_1937,424,404 - 37,438,680 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GRHPR
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318860
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.