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Gene: DDX4 (DEAD-box helicase 4) Homo sapiens
Symbol: DDX4
Name: DEAD-box helicase 4
Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; DEAD box protein 4; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4; MGC111074; probable ATP-dependent RNA helicase DDX4; VASA; vasa homolog
Mus musculus (house mouse) : Ddx4 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ddx4 (DEAD-box helicase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddx4 (DEAD-box helicase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : DDX4 (DEAD-box helicase 4)
Canis lupus familiaris (dog) : DDX4 (DEAD-box helicase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddx4 (DEAD-box helicase 4)
Sus scrofa (pig) : DDX4 (DEAD-box helicase 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38555,737,994 - 55,817,146 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37555,033,845 - 55,112,975 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36555,070,533 - 55,148,362 (+)NCBINCBI36hg18NCBI36
Build 34555,070,532 - 55,148,363NCBI
Celera551,987,565 - 52,066,696 (+)NCBI
Cytogenetic Map5q11.2NCBI
HuRef552,007,082 - 52,086,270 (+)NCBIHuRef
CHM1_1555,038,024 - 55,117,130 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DDX4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318770
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.