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Gene: SPRED1 (sprouty related EVH1 domain containing 1) Homo sapiens
Symbol: SPRED1
Name: sprouty related EVH1 domain containing 1
Description: The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EVH1/Sprouty domain containing protein; FLJ33903; hSpred1; LGSS; NFLS; PPP1R147; spred-1; sprouty related, EVH1 domain containing 1; sprouty-related, EVH1 domain containing 1; sprouty-related, EVH1 domain-containing protein 1; suppressor of Ras/MAPK activation
Mus musculus (house mouse) : Spred1 (sprouty protein with EVH-1 domain 1, related sequence)  MGI  Alliance
Rattus norvegicus (Norway rat) : Spred1 (sprouty-related, EVH1 domain containing 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spred1 (sprouty related EVH1 domain containing 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SPRED1 (sprouty related EVH1 domain containing 1)
Canis lupus familiaris (dog) : SPRED1 (sprouty related EVH1 domain containing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spred1 (sprouty related EVH1 domain containing 1)
Sus scrofa (pig) : SPRED1 (sprouty related EVH1 domain containing 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381538,252,087 - 38,357,249 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371538,544,925 - 38,649,450 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361536,331,808 - 36,433,533 (+)NCBINCBI36hg18NCBI36
Build 341536,331,807 - 36,433,533NCBI
Celera1515,312,281 - 15,416,681 (+)NCBI
Cytogenetic Map15q14NCBI
HuRef1515,389,475 - 15,493,873 (+)NCBIHuRef
CHM1_11538,664,324 - 38,768,708 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SPRED1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318683
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.