Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1-dichloroethene | decreases expression | EXP | | 6480464 | vinylidene chloride results in decreased expression of PAPOLA mRNA | CTD | PMID:26682919 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of PAPOLA mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PAPOLA mRNA | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Estradiol results in increased expression of PAPOLA mRNA | CTD | PMID:11179685 | 17beta-estradiol | multiple interactions | ISO | PAPOLA (Homo sapiens) | 6480464 | 3 more ... | CTD | PMID:11179685 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | PAPOLA (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of PAPOLA mRNA] | CTD | PMID:11179685 | 2,4,6-tribromophenol | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 3,3'-diindolylmethane | multiple interactions | ISO | PAPOLA (Homo sapiens) | 6480464 | 3 and 3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of PAPOLA mRNA] | CTD | PMID:11179685 | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PAPOLA mRNA | CTD | PMID:26251327 | 3,4-methylenedioxymethamphetamine | increases methylation | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased methylation of PAPOLA promoter | CTD | PMID:26251327 | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of PAPOLA mRNA | CTD | PMID:18648102 | acrolein | multiple interactions | ISO | PAPOLA (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PAPOLA mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | acrylamide | increases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Acrylamide results in increased expression of PAPOLA mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of PAPOLA mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of PAPOLA mRNA | CTD | PMID:15498508 | alpha-pinene | multiple interactions | ISO | PAPOLA (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PAPOLA mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PAPOLA mRNA | CTD | PMID:32699268 | AM-251 | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | AM 251 results in decreased expression of PAPOLA mRNA | CTD | PMID:16500647 | Aroclor 1254 | decreases expression | EXP | | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of PAPOLA mRNA | CTD | PMID:23650126 | arsane | affects methylation | ISO | PAPOLA (Homo sapiens) | 6480464 | Arsenic affects the methylation of PAPOLA gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | PAPOLA (Homo sapiens) | 6480464 | Arsenic affects the methylation of PAPOLA gene | CTD | PMID:25304211 | benzo[a]pyrene | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of PAPOLA protein | CTD | PMID:32717239 | benzo[a]pyrene | decreases methylation | ISO | PAPOLA (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of PAPOLA promoter | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PAPOLA mRNA | CTD | PMID:27858113 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20018196 and PMID:26238291 | benzo[b]fluoranthene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PAPOLA mRNA | CTD | PMID:27858113 | bisphenol A | affects expression | ISO | Papola (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of PAPOLA mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of PAPOLA protein | CTD | PMID:31675489 | bisphenol A | increases methylation | ISO | Papola (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of PAPOLA gene | CTD | PMID:28505145 | bortezomib | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Bortezomib results in decreased expression of PAPOLA mRNA | CTD | PMID:20977926 | cadmium dichloride | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of PAPOLA mRNA | CTD | PMID:18560533 | cadmium dichloride | increases expression | ISO | Papola (Rattus norvegicus) | 6480464 | Cadmium Chloride results in increased expression of PAPOLA mRNA | CTD | PMID:33453195 | caffeine | decreases phosphorylation | ISO | PAPOLA (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of PAPOLA protein | CTD | PMID:35688186 | casticin | decreases expression | EXP | | 6480464 | casticin results in decreased expression of PAPOLA mRNA | CTD | PMID:28444820 | chrysene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PAPOLA mRNA | CTD | PMID:27858113 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of PAPOLA mRNA | CTD | PMID:21139344 | cobalt dichloride | increases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of PAPOLA mRNA | CTD | PMID:19376846 | copper(II) sulfate | increases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of PAPOLA mRNA | CTD | PMID:19549813 | coumestrol | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of PAPOLA mRNA | CTD | PMID:19167446 | crocidolite asbestos | decreases expression | EXP | | 6480464 | Asbestos and Crocidolite results in decreased expression of PAPOLA mRNA | CTD | PMID:29279043 | CU-O LINKAGE | increases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | cupric oxide results in increased expression of PAPOLA mRNA | CTD | PMID:22077320 | cyclosporin A | increases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of PAPOLA mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of PAPOLA mRNA | CTD | PMID:25562108 | decabromodiphenyl ether | increases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | decabromobiphenyl ether results in increased expression of PAPOLA protein | CTD | PMID:31675489 | diazinon | increases methylation | ISO | PAPOLA (Homo sapiens) | 6480464 | Diazinon results in increased methylation of PAPOLA gene | CTD | PMID:22964155 | dorsomorphin | multiple interactions | ISO | PAPOLA (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAPOLA mRNA | CTD | PMID:27188386 | enzyme inhibitor | multiple interactions | ISO | PAPOLA (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PAPOLA protein | CTD | PMID:23301498 | ethanol | affects expression | EXP | | 6480464 | Ethanol affects the expression of PAPOLA mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of PAPOLA mRNA | CTD | PMID:23649840 | finasteride | increases expression | ISO | Papola (Rattus norvegicus) | 6480464 | Finasteride results in increased expression of PAPOLA mRNA | CTD | PMID:24136188 | flutamide | increases expression | ISO | Papola (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of PAPOLA mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PAPOLA mRNA | CTD | PMID:22206623 | formaldehyde | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of PAPOLA mRNA | CTD | PMID:23649840 | FR900359 | decreases phosphorylation | ISO | PAPOLA (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of PAPOLA protein | CTD | PMID:37730182 | hypochlorous acid | increases expression | EXP | | 6480464 | Hypochlorous Acid results in increased expression of PAPOLA mRNA | CTD | PMID:19376150 | ivermectin | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of PAPOLA protein | CTD | PMID:32959892 | ketamine | decreases expression | ISO | Papola (Rattus norvegicus) | 6480464 | Ketamine results in decreased expression of PAPOLA mRNA | CTD | PMID:20080153 | lead(0) | affects splicing | ISO | PAPOLA (Homo sapiens) | 6480464 | Lead affects the splicing of PAPOLA mRNA | CTD | PMID:28903495 | methapyrilene | decreases expression | ISO | Papola (Rattus norvegicus) | 6480464 | Methapyrilene results in decreased expression of PAPOLA mRNA | CTD | PMID:30467583 | methotrexate | affects response to substance | ISO | PAPOLA (Homo sapiens) | 6480464 | PAPOLA protein affects the susceptibility to Methotrexate | CTD | PMID:16217747 | methyl methanesulfonate | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of PAPOLA mRNA | CTD | PMID:23649840 | methylmercury chloride | increases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of PAPOLA mRNA | CTD | PMID:26272509 | ochratoxin A | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | ochratoxin A results in decreased expression of PAPOLA mRNA | CTD | PMID:22124623 | ozone | multiple interactions | ISO | PAPOLA (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PAPOLA mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | p-toluidine | increases expression | ISO | Papola (Rattus norvegicus) | 6480464 | 4-toluidine results in increased expression of PAPOLA mRNA | CTD | PMID:27638505 | paracetamol | decreases expression | ISO | Papola (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of PAPOLA mRNA | CTD | PMID:33387578 | pentachlorophenol | decreases expression | EXP | | 6480464 | Pentachlorophenol results in decreased expression of PAPOLA mRNA | CTD | PMID:23892564 | perfluorooctanoic acid | increases expression | ISO | Papola (Rattus norvegicus) | 6480464 | perfluorooctanoic acid results in increased expression of PAPOLA mRNA | CTD | PMID:19162173 | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of PAPOLA mRNA | CTD | PMID:23091169 | PhIP | increases expression | ISO | Papola (Rattus norvegicus) | 6480464 | 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of PAPOLA mRNA | CTD | PMID:15215175 | raloxifene | affects expression | ISO | Papola (Rattus norvegicus) | 6480464 | Raloxifene Hydrochloride affects the expression of PAPOLA mRNA | CTD | PMID:16079270 | resveratrol | multiple interactions | ISO | PAPOLA (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of PAPOLA mRNA | CTD | PMID:23557933 | rotenone | increases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Rotenone results in increased expression of PAPOLA mRNA | CTD | PMID:33512557 | SB 431542 | multiple interactions | ISO | PAPOLA (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAPOLA mRNA | CTD | PMID:27188386 | sodium arsenite | affects methylation | ISO | PAPOLA (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of PAPOLA gene | CTD | PMID:28589171 | Soman | increases expression | ISO | Papola (Rattus norvegicus) | 6480464 | Soman results in increased expression of PAPOLA mRNA | CTD | PMID:19281266 | sunitinib | increases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PAPOLA mRNA | CTD | PMID:31533062 | tamibarotene | affects expression | ISO | PAPOLA (Homo sapiens) | 6480464 | tamibarotene affects the expression of PAPOLA mRNA | CTD | PMID:15498508 | tert-butyl hydroperoxide | increases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in increased expression of PAPOLA mRNA | CTD | PMID:15336504 | tetraphene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PAPOLA mRNA | CTD | PMID:27858113 | thapsigargin | decreases expression | EXP | | 6480464 | Thapsigargin results in decreased expression of PAPOLA protein | CTD | PMID:24648495 | toluene | increases expression | ISO | Papola (Rattus norvegicus) | 6480464 | Toluene results in increased expression of PAPOLA mRNA | CTD | PMID:22967744 | trichloroethene | increases methylation | ISO | Papola (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased methylation of PAPOLA gene | CTD | PMID:27618143 | trichostatin A | increases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | trichostatin A results in increased expression of PAPOLA mRNA | CTD | PMID:24935251 | trichostatin A | multiple interactions | ISO | PAPOLA (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAPOLA mRNA | CTD | PMID:27188386 | trichostatin A | decreases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of PAPOLA mRNA | CTD | PMID:26272509 | triphenyl phosphate | increases expression | ISO | Papola (Rattus norvegicus) | 6480464 | triphenyl phosphate results in increased expression of PAPOLA mRNA | CTD | PMID:30589522 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of PAPOLA mRNA | CTD | PMID:17963808 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of PAPOLA mRNA | CTD | PMID:21427059 | valproic acid | affects expression | ISO | PAPOLA (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PAPOLA mRNA | CTD | PMID:23179753 | versicolorin A | increases expression | ISO | PAPOLA (Homo sapiens) | 6480464 | versicolorin A results in increased expression of PAPOLA mRNA | CTD | PMID:32106047 | vinclozolin | affects expression | ISO | Papola (Rattus norvegicus) | 6480464 | vinclozolin affects the expression of PAPOLA mRNA | CTD | PMID:19015723 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors. | Gruber AR, etal., Wiley Interdiscip Rev RNA. 2014 Mar-Apr;5(2):183-96. doi: 10.1002/wrna.1206. Epub 2013 Nov 14. |
| 2. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 3. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 4. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 5. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:8628305 | PMID:10349636 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:11389549 | PMID:11544199 | PMID:11716503 | PMID:12471261 | PMID:12477932 | PMID:12520002 |
| PMID:12904583 | PMID:14610273 | PMID:14681479 | PMID:15782199 | PMID:16141072 | PMID:16141073 | PMID:17967808 | PMID:18084034 | PMID:18554416 | PMID:18799693 | PMID:19224921 | PMID:20059953 |
| PMID:21677750 | PMID:21873635 | PMID:32325033 |
Genomics
Comparative Map Data
| Papola (Mus musculus - house mouse) |
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| PAPOLA (Homo sapiens - human) |
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| Papola (Rattus norvegicus - Norway rat) |
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| Papola (Chinchilla lanigera - long-tailed chinchilla) |
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| PAPOLA (Pan paniscus - bonobo/pygmy chimpanzee) |
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| PAPOLA (Canis lupus familiaris - dog) |
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| Papola (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| PAPOLA (Sus scrofa - pig) |
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| PAPOLA (Chlorocebus sabaeus - green monkey) |
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| Papola (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Papola
1993 total Variants 
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