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Gene: SPAST (spastin) Homo sapiens
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Symbol: SPAST
Name: spastin
Description: Exhibits microtubule-severing ATPase activity and tubulin binding activity. Involved in several processes, including exit from mitosis; microtubule cytoskeleton organization; and protein complex oligomerization. Localizes to several cellular components, including the endoplasmic reticulum tubular network; midbody; and nucleus. Colocalizes with the endoplasmic reticulum; endosome; and microtubule cytoskeleton. Implicated in hereditary spastic paraplegia 4.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADPSP; FSP2; KIAA1083; spastic paraplegia 4 (autosomal dominant); spastic paraplegia 4 (autosomal dominant, spastin); spastic paraplegia 4 protein; SPG4
Orthologs:
Mus musculus (house mouse) : Spast (spastin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Spast (spastin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spast (spastin)
Pan paniscus (bonobo/pygmy chimpanzee) : SPAST (spastin)
Canis lupus familiaris (dog) : SPAST (spastin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spast (spastin)
Sus scrofa (pig) : SPAST (spastin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38232,063,551 - 32,157,637 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37232,288,660 - 32,382,706 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36232,142,184 - 32,236,210 (+)NCBINCBI36hg18NCBI36
Build 34232,200,330 - 32,294,356NCBI
Celera232,133,566 - 32,227,549 (+)NCBI
Cytogenetic Map2p22.3NCBI
HuRef232,027,230 - 32,121,818 (+)NCBIHuRef
CHM1_1232,218,851 - 32,312,626 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on SPAST
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318293
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.