Gene: Taf8 (TATA-box binding protein associated factor 8) Mus musculus
Analyze
Symbol:
Taf8
Name:
TATA-box binding protein associated factor 8
Description:
Predicted to have protein heterodimerization activity. Involved in inner cell mass cell proliferation. Predicted to localize to the cell; perinuclear region of cytoplasm; and transcription factor TFIID complex. Is expressed in several structures, including brain; early conceptus; heart; and placenta. Orthologous to human TAF8 (TATA-box binding protein associated factor 8); PARTICIPATES IN RNA polymerase II transcription initiation pathway; INTERACTS WITH carbon nanotube; ethanol; paracetamol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AW260255; TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factorq; taube nuss; Tbn; TBP-associated factor 8; transcription initiation factor TFIID subunit 8
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TAF8 (TATA-box binding protein associated factor 8)
HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Taf8 (TATA-box binding protein associated factor 8)
RGD
RGD
Chinchilla lanigera (long-tailed chinchilla):
Taf8 (TATA-box binding protein associated factor 8)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TAF8 (TATA-box binding protein associated factor 8)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TAF8 (TATA-box binding protein associated factor 8)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Taf8 (TATA-box binding protein associated factor 8)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TAF8 (TATA-box binding protein associated factor 8)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Taf8 (TATA-box binding protein associated factor 8)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
TAF8 (TATA-box binding protein associated factor 8)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
taf8 (TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
SA
Alliance
DIOPT (Ensembl Compara, OrthoFinder, TreeFam)
Drosophila melanogaster (fruit fly):
Taf8
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
taf-8
Alliance
DIOPT (Ensembl Compara, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Related Pseudogenes:
Gm19206
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 17 47,483,364 - 47,502,321 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 17 47,624,999 - 47,639,236 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 17 46,951,241 - 46,965,478 (-) NCBI mm8 Celera 17 50,921,899 - 50,936,194 (-) NCBI Celera Cytogenetic Map 17 C NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
acrylamide increases expression ISO RGD:1308423 6480464 Acrylamide results in increased expression of TAF8 mRNA CTD PMID:28959563 aflatoxin B1 increases methylation ISO RGD:1318181 6480464 Aflatoxin B1 results in increased methylation of TAF8 gene CTD PMID:27153756 bisphenol A affects expression ISO RGD:1308423 6480464 bisphenol A affects the expression of TAF8 mRNA CTD PMID:25181051 butanal decreases expression ISO RGD:1318181 6480464 butyraldehyde results in decreased expression of TAF8 mRNA CTD PMID:26079696 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of TAF8 mRNA, Nanotubes, Carbon results in decreased expression of TAF8 mRNA CTD PMID:25554681 crocidolite asbestos affects expression ISO RGD:1318181 6480464 Asbestos, Crocidolite affects the expression of TAF8 mRNA CTD PMID:17331233 CU-O LINKAGE increases expression ISO RGD:1318181 6480464 cupric oxide results in increased expression of TAF8 mRNA CTD PMID:22077320 dorsomorphin multiple interactions ISO RGD:1318181 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1318181 6480464 Doxorubicin results in decreased expression of TAF8 mRNA CTD PMID:29803840 ethanol affects expression EXP 6480464 Ethanol affects the expression of TAF8 mRNA CTD PMID:30319688 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of TAF8 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:1318181 6480464 Acetaminophen results in increased expression of TAF8 mRNA CTD PMID:22230336 phenylmercury acetate decreases expression ISO RGD:1318181 6480464 Phenylmercuric Acetate results in decreased expression of TAF8 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1318181 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TAF8 mRNA CTD PMID:27188386 SB 431542 multiple interactions ISO RGD:1318181 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Soman decreases expression ISO RGD:1308423 6480464 Soman results in decreased expression of TAF8 mRNA CTD PMID:19281266 urethane increases expression ISO RGD:1318181 6480464 Urethane results in increased expression of TAF8 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1318181 6480464 Valproic Acid affects the expression of TAF8 mRNA CTD PMID:25979313 valproic acid multiple interactions ISO RGD:1318181 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TAF8 mRNA CTD PMID:27188386 valproic acid decreases expression ISO RGD:1318181 6480464 Valproic Acid results in decreased expression of TAF8 mRNA CTD PMID:24935251 more ... vinclozolin decreases expression ISO RGD:1308423 6480464 vinclozolin results in decreased expression of TAF8 mRNA CTD PMID:23034163
Gene Ontology Annotations
Biological Process
cell differentiation IEA UniProtKB-KW:KW-0221 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 inner cell mass cell proliferation IMP MGI:MGI:3033758 2290270 (MGI:MGI:1926844, PMID:11076765) MGI MGI:MGI:1926844 , PMID:11076765 maintenance of protein location in nucleus ISO UniProtKB:Q7Z7C8 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 multicellular organism development IEA UniProtKB-KW:KW-0217 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 positive regulation of transcription, DNA-templated ISO UniProtKB:Q7Z7C8 2290270 (MGI:MGI:2679136, PMID:14580349) MGI MGI:MGI:2679136 , PMID:14580349 regulation of fat cell differentiation ISO UniProtKB:Q7Z7C8 2290270 (MGI:MGI:2679136, PMID:14580349) MGI MGI:MGI:2679136 , PMID:14580349
Cellular Component
cell ISO UniProtKB:Q7Z7C8 2290270 GOC GO_REF:0000096, MGI:MGI:4834177 cytoplasm IEA UniProtKB-KW:KW-0963 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 nucleoplasm ISO UniProtKB:Q7Z7C8 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleus ISO UniProtKB:Q7Z7C8 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 perinuclear region of cytoplasm ISO UniProtKB:Q7Z7C8 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 transcription factor TFIID complex ISO UniProtKB:Q7Z7C8 2290270 (MGI:MGI:2679136, PMID:14580349) MGI GO_REF:0000096 more ...
Molecular Function
protein binding IPI UniProtKB:P23611 2290270 (MGI:MGI:5618398, PMID:25331958) MGI MGI:MGI:5618398 , PMID:25331958 protein heterodimerization activity IEA InterPro:IPR009072 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098
Molecular Pathway Annotations
Phenotype Annotations
1300890 Bhr3_m bronchial hyperresponsiveness 3 (mouse) Not determined 17 3924615 48559063 Mouse 1357789 Kdnw3_m kidney weight 3 (mouse) Not determined 17 4804477 47574740 Mouse 4141272 Tfv1_m total food volume 1 (mouse) Not determined 4804477 65330362 Mouse 1301338 Lmr1_m leishmaniasis resistance 1 (mouse) Not determined 17 9862411 86688972 Mouse 4142150 Stheal11_m soft tissue heal 11 (mouse) Not determined 17 12067324 83054339 Mouse 11081168 Tir7_m trypanosome infection response 7 (mouse) 17 13904398 47904522 Mouse 1300914 Pcir4_m periosteal circumference 4 (mouse) Not determined 17 14842678 48842786 Mouse 1558886 Lgth9_m body length 9 (mouse) Not determined 17 14842678 48842786 Mouse 1302070 Tbbmd7_m total body bone mineral density 7 (mouse) Not determined 17 14842678 48842786 Mouse 1300995 Fembrs4_m femur breaking strength 4 (mouse) Not determined 17 14842678 48842786 Mouse 1302140 Wta4_m weight adult 4 (mouse) Not determined 17 16600747 50600869 Mouse 1302152 Skull25_m skull morphology 25 (mouse) Not determined 17 16600747 50600869 Mouse 1301505 Tir1_m trypanosome infection response 1 (mouse) Not determined 17 16600747 50600869 Mouse 10412083 Sm2_m susceptibility to Schistosoma mansoni infection 2 (mouse) Not determined 17 16810969 50811104 Mouse 1302042 Acsns3_m Angiostrongylus costaricensis nematode susceptibility 3 (mouse) Not determined 17 17243234 51243371 Mouse 1300535 Char3_m P. chabaudi malaria resistance QTL 3 (mouse) Not determined 17 17243234 51243371 Mouse 10412214 Sxbq3_m SGC/Knj cross B6 QTL 3 (mouse) Not determined 17 17243234 51243371 Mouse 13452396 Leusq3_m leucocytosis susceptibility QTL 3 (mouse) 17 17243234 51243371 Mouse 13452399 Leusq6_m leucocytosis susceptibility QTL 6 (mouse) 17 17243234 51243371 Mouse 1301840 Ssial4_m susceptibility to sialadenitiss 4 (mouse) Not determined 17 17956436 51959238 Mouse 1301331 Lbw1_m lupus NZB x NZW 1 (mouse) Not determined 17 18199381 52202007 Mouse 1301056 Pas2_m pulmonary adenoma susceptibility 2 (mouse) Not determined 17 18203165 52205351 Mouse 15039354 Nmrs36_m NAFLD-associated magnetic resonance shift 36 (mouse) 17 18834133 52834133 Mouse 1301454 Eae5_m susceptibility to experimental allergic encephalomyelitis 5 (mouse) Not determined 17 24301859 58301973 Mouse 10412198 Sst5_m susceptibility to tuberculosis 5 (mouse) Not determined 17 24857609 55405969 Mouse 10412204 Bbaa29_m B.burgdorferi-associated arthritis 29 (mouse) Not determined 17 25740294 59740461 Mouse 1558758 Kcal2_m kilocalorie 2 (mouse) Not determined 17 26182038 52604676 Mouse 1302005 Loco2_m locomotor activity 2 (mouse) Not determined 17 26574081 60574223 Mouse 15039348 Nmrs37_m NAFLD-associated magnetic resonance shift 37 (mouse) 17 27504322 61504322 Mouse 1300703 Uvbi2_m UVB induced immunosuppression 2 (mouse) Not determined 17 28311480 62311728 Mouse 1300589 Myaa2_m modifier of Yaa 2 (mouse) Not determined 17 29821629 63821740 Mouse 4140955 Plgr1_m plague resistance locus 1 (mouse) Not determined 30722575 64722705 Mouse 4141357 Mrdq1_m modifier of retinal degeneration QTL 1 (mouse) Not determined 30768929 47728778 Mouse 1300885 Mbis4_m Mycobacterium bovis-induced systemic lupus erythematosus 4 (mouse) Not determined 17 34956841 69858931 Mouse 10755514 Amzn2_m anatomical modifier of Zfp423 2 (mouse) 17 35659266 69659396 Mouse 12904951 Smmq2_m soleus muscle mass QTL 2 (mouse) 17 36482715 70482715 Mouse 1300592 Pcyts5_m plasmacytoma susceptibility 5 (mouse) Not determined 17 38405886 72405969 Mouse 10755525 Lymph2_m lymphocyte differential 2 (mouse) 17 38498625 72498625 Mouse 10755534 Lymph4_m lymphocyte differential 4 (mouse) 17 38498625 72498625 Mouse 4141319 Hmtb8_m hemostasis and thrombosis rebleeding time 8 (mouse) Not determined 40227447 74227623 Mouse 15039324 Nmrs48_m NAFLD-associated magnetic resonance shift 48 (mouse) 17 40632187 74632187 Mouse 4141478 Hbnr7_m Heligmosomoides bakeri nematode resistance 7 (mouse) Not determined 42740294 51432094 Mouse 12903997 Cfq4_m conditioned fear QTL 4 (mouse) 17 44705665 49059374 Mouse
Predicted Target Of
Count of predictions: 775 Count of miRNA genes: 447 Interacting mature miRNAs: 537 Transcripts: ENSMUST00000067103 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction