Jph3 (junctophilin 3) - Rat Genome Database
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Gene: Jph3 (junctophilin 3) Mus musculus
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Symbol: Jph3
Name: junctophilin 3
RGD ID: 1318171
Description: Involved in several processes, including exploration behavior; learning or memory; and regulation of ryanodine-sensitive calcium-release channel activity. Localizes to several cellular components, including endoplasmic reticulum; endoplasmic reticulum membrane; and junctional membrane complex. Is expressed in brain. Human ortholog(s) of this gene implicated in Huntington's disease-like 2. Orthologous to human JPH3 (junctophilin 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: JP-; JP-3; Jp3; junctophilin type 3; junctophilin-3; MGC124338; MGC124339; MGC124340
Orthologs:
Homo sapiens (human) : JPH3 (junctophilin 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Jph3 (junctophilin 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jph3 (junctophilin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : JPH3 (junctophilin 3)
Canis lupus familiaris (dog) : JPH3 (junctophilin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jph3 (junctophilin 3)
Sus scrofa (pig) : JPH3 (junctophilin 3)
Chlorocebus sabaeus (African green monkey) : JPH3 (junctophilin 3)
Heterocephalus glaber (naked mole-rat) : Jph3 (junctophilin 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398122,457,298 - 122,517,822 (+)NCBI
GRCm388121,730,559 - 121,791,083 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,729,623 - 121,794,276 (+)EnsemblGRCm38mm10GRCm38
MGSCv378124,254,463 - 124,314,721 (+)NCBIGRCm37mm9NCBIm37
MGSCv368124,616,653 - 124,676,911 (+)NCBImm8
Celera8125,951,307 - 126,011,917 (+)NCBICelera
Cytogenetic Map8E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10942252   PMID:10949023   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11906164   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16452087  
PMID:16602821   PMID:16809425   PMID:17114649   PMID:17347645   PMID:17904530   PMID:21267068   PMID:21677750   PMID:21873635   PMID:27336719   PMID:31461656  


Genomics

Comparative Map Data
Jph3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398122,457,298 - 122,517,822 (+)NCBI
GRCm388121,730,559 - 121,791,083 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,729,623 - 121,794,276 (+)EnsemblGRCm38mm10GRCm38
MGSCv378124,254,463 - 124,314,721 (+)NCBIGRCm37mm9NCBIm37
MGSCv368124,616,653 - 124,676,911 (+)NCBImm8
Celera8125,951,307 - 126,011,917 (+)NCBICelera
Cytogenetic Map8E1NCBI
JPH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1687,601,835 - 87,698,156 (+)EnsemblGRCh38hg38GRCh38
GRCh381687,601,835 - 87,698,156 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371687,635,441 - 87,731,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361686,194,000 - 86,289,263 (+)NCBINCBI36hg18NCBI36
Build 341686,193,999 - 86,289,263NCBI
Celera1671,933,529 - 72,028,806 (+)NCBI
Cytogenetic Map16q24.2NCBI
HuRef1673,376,273 - 73,472,834 (+)NCBIHuRef
CHM1_11689,047,216 - 89,143,211 (+)NCBICHM1_1
Jph3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01954,553,419 - 54,613,477 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1954,553,419 - 54,613,477 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01965,267,451 - 65,327,679 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41951,975,477 - 52,037,634 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11951,963,537 - 52,041,163 (+)NCBI
Celera1949,040,036 - 49,100,583 (+)NCBICelera
Cytogenetic Map19q12NCBI
Jph3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555411,969,194 - 2,017,588 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555411,969,197 - 2,020,868 (+)NCBIChiLan1.0ChiLan1.0
JPH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11687,596,820 - 87,698,034 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1687,596,814 - 87,700,235 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01668,276,459 - 68,379,909 (+)NCBIMhudiblu_PPA_v0panPan3
JPH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl565,451,050 - 65,530,294 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1565,445,329 - 65,530,288 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Jph3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366411,619,640 - 1,668,480 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JPH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.161,677,132 - 1,767,010 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.261,765,733 - 1,855,707 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JPH3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl572,972,361 - 73,094,231 (+)Ensembl
ChlSab1.1572,972,373 - 73,095,710 (+)NCBI
Jph3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247463,193,695 - 3,243,916 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889000000130800000Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined895518613129018580Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)896900000129401213Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)897663894129401213Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined897836895129401213Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899101792129401213Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899101792129401213Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100238570129401213Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8102716921127055036Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8104307238129401213Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8104307238129401213Mouse
14746994Manh65_mmandible shape 65 (mouse)8105762890129401213Mouse
10412273Fcd1_mfunctional capillary density 1 (mouse)Not determined8109688333129401213Mouse
10412274Leci1_mleukocyte endothelial cell interactions 1 (mouse)Not determined8109688333129401213Mouse
12904938Edlmmq7_mextensor digitorum longus muscle mass QTL 7 (mouse)8110755016129401213Mouse
12904960Gmmq6_mgastrocnemius muscle mass QTL 6 (mouse)8110755016129401213Mouse
4141546Mrdq3_mmodifier of retinal degeneration QTL 3 (mouse)Not determined113712788125329141Mouse
26884375Skwq2_mskull length QTL 2, 5 week (mouse)8120000000131200000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1125
Count of miRNA genes:568
Interacting mature miRNAs:694
Transcripts:ENSMUST00000026357, ENSMUST00000167439, ENSMUST00000169735, ENSMUST00000172209
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000026357   ⟹   ENSMUSP00000026357
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl8121,730,563 - 121,790,821 (+)Ensembl
RefSeq Acc Id: ENSMUST00000167439   ⟹   ENSMUSP00000126190
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl8121,730,567 - 121,794,276 (+)Ensembl
RefSeq Acc Id: ENSMUST00000169735
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl8121,729,623 - 121,789,617 (+)Ensembl
RefSeq Acc Id: ENSMUST00000172209
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl8121,753,476 - 121,782,570 (+)Ensembl
RefSeq Acc Id: NM_020605   ⟹   NP_065630
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398122,457,298 - 122,517,822 (+)NCBI
GRCm388121,730,559 - 121,791,083 (+)ENTREZGENE
MGSCv378124,254,463 - 124,314,721 (+)RGD
Celera8125,951,307 - 126,012,023 (+)NCBI
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_065630   ⟸   NM_020605
- UniProtKB: Q9ET77 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000026357   ⟸   ENSMUST00000026357
RefSeq Acc Id: ENSMUSP00000126190   ⟸   ENSMUST00000167439

Promoters
RGD ID:8668497
Promoter ID:EPDNEW_M12277
Type:single initiation site
Name:Jph3_1
Description:Mus musculus junctophilin 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388121,730,589 - 121,730,649EPDNEW
RGD ID:6848310
Promoter ID:MM_ACW:49138
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:JPH3.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368124,276,896 - 124,277,396 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1891497 AgrOrtholog
Ensembl Genes ENSMUSG00000025318 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000026357 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000126190 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000026357 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000167439 UniProtKB/Swiss-Prot
InterPro Junctophilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MORN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:57340 UniProtKB/Swiss-Prot
MGD MGI:1891497 ENTREZGENE
NCBI Gene 57340 ENTREZGENE
PANTHER PTHR23085 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MORN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Jph3 PhenoGen
PIRSF Junctophilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MORN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.306870 ENTREZGENE
UniProt JPH3_MOUSE UniProtKB/Swiss-Prot
  Q8BR43_MOUSE UniProtKB/TrEMBL
  Q9ET77 ENTREZGENE
UniProt Secondary Q3ZAS3 UniProtKB/Swiss-Prot
  Q8BNM7 UniProtKB/Swiss-Prot
  Q9EQZ2 UniProtKB/Swiss-Prot