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Gene: FBXO46 (F-box protein 46) Homo sapiens
Symbol: FBXO46
Name: F-box protein 46
Description: Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 20D7-FC4; F-box only protein 34-like; F-box only protein 46; Fbx46; FBXO34L
Mus musculus (house mouse) : Fbxo46 (F-box protein 46)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fbxo46 (F-box protein 46)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fbxo46 (F-box protein 46)
Pan paniscus (bonobo/pygmy chimpanzee) : FBXO46 (F-box protein 46)
Canis lupus familiaris (dog) : FBXO46 (F-box protein 46)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fbxo46 (F-box protein 46)
Sus scrofa (pig) : FBXO46 (F-box protein 46)
Chlorocebus sabaeus (African green monkey) : FBXO46 (F-box protein 46)
Heterocephalus glaber (naked mole-rat) : Fbxo46 (F-box protein 46)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1945,710,629 - 45,730,896 (-)EnsemblGRCh38hg38GRCh38
GRCh381945,710,629 - 45,733,177 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371946,213,887 - 46,234,151 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,905,727 - 50,925,991 (-)NCBINCBI36hg18NCBI36
Celera1943,020,015 - 43,040,278 (-)NCBI
Cytogenetic Map19q13.32NCBI
HuRef1942,642,747 - 42,663,036 (-)NCBIHuRef
CHM1_11946,217,358 - 46,237,620 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on FBXO46
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318136
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.