Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of TNPO1 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Tnpo1 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TNPO1 mRNA | CTD | PMID:22206623 | 1-nitropyrene | increases expression | EXP | | 6480464 | 1-nitropyrene results in increased expression of TNPO1 mRNA | CTD | PMID:19041380 | 17alpha-ethynylestradiol | increases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | Ethinyl Estradiol results in increased expression of TNPO1 mRNA | CTD | PMID:29097150 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of TNPO1 mRNA | CTD | PMID:16514628 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TNPO1 mRNA | CTD | PMID:19465110 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TNPO1 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TNPO1 mRNA | CTD | PMID:22574217 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Tnpo1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TNPO1 mRNA | CTD | PMID:21570461 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:32109520 | 2,6-dinitrotoluene | affects expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of TNPO1 mRNA | CTD | PMID:21346803 | 2-methylcholine | affects expression | EXP | | 6480464 | beta-methylcholine affects the expression of TNPO1 mRNA | CTD | PMID:21179406 | 4,4'-sulfonyldiphenol | increases expression | EXP | | 6480464 | bisphenol S results in increased expression of TNPO1 protein | CTD | PMID:34186270 | acrolein | multiple interactions | EXP | | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of TNPO1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of TNPO1 mRNA | CTD | PMID:32699268 | afimoxifene | decreases expression | EXP | | 6480464 | afimoxifene results in decreased expression of TNPO1 mRNA | CTD | PMID:16514628 | aflatoxin B1 | increases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of TNPO1 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | EXP | | 6480464 | Aflatoxin B1 results in decreased methylation of TNPO1 gene and Aflatoxin B1 results in decreased methylation of TNPO1 intron | CTD | PMID:27153756 and PMID:30157460 | Aflatoxin B2 alpha | decreases methylation | EXP | | 6480464 | aflatoxin B2 results in decreased methylation of TNPO1 intron | CTD | PMID:30157460 | all-trans-retinoic acid | affects expression | EXP | | 6480464 | Tretinoin affects the expression of TNPO1 mRNA | CTD | PMID:15498508 | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of TNPO1 mRNA | CTD | PMID:33167477 | alpha-pinene | multiple interactions | EXP | | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of TNPO1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of TNPO1 mRNA | CTD | PMID:32699268 | aristolochic acid A | decreases expression | EXP | | 6480464 | aristolochic acid I results in decreased expression of TNPO1 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | EXP | | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to TNPO1 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | increases methylation | EXP | | 6480464 | Benzo(a)pyrene results in increased methylation of TNPO1 promoter | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of TNPO1 intron | CTD | PMID:30157460 | benzo[a]pyrene diol epoxide I | decreases expression | EXP | | 6480464 | 7 more ... | CTD | PMID:19150397 | bisphenol A | increases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of TNPO1 mRNA | CTD | PMID:32145629 and PMID:33296240 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TNPO1 protein | CTD | PMID:37567409 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TNPO1 protein | CTD | PMID:34186270 | bisphenol A | increases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of TNPO1 mRNA | CTD | PMID:33221593 | Bisphenol B | increases expression | EXP | | 6480464 | bisphenol B results in increased expression of TNPO1 protein | CTD | PMID:34186270 | butanal | decreases expression | EXP | | 6480464 | butyraldehyde results in decreased expression of TNPO1 mRNA | CTD | PMID:26079696 | cadmium atom | affects expression | EXP | | 6480464 | Cadmium affects the expression of TNPO1 mRNA | CTD | PMID:23369406 | cadmium dichloride | increases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in increased expression of TNPO1 mRNA | CTD | PMID:33453195 | cadmium sulfate | increases expression | EXP | | 6480464 | cadmium sulfate results in increased expression of TNPO1 mRNA | CTD | PMID:12064557 and PMID:14676411 | calcitriol | decreases expression | EXP | | 6480464 | Calcitriol results in decreased expression of TNPO1 mRNA | CTD | PMID:16847355 | calcitriol | decreases activity | EXP | | 6480464 | Calcitriol results in decreased activity of TNPO1 protein | CTD | PMID:10843682 | calcitriol | multiple interactions | EXP | | 6480464 | [Calcitriol promotes the reaction [TXNIP protein binds to TNPO1 protein]] which results in increased activity of MAP3K5 protein and Calcitriol promotes the reaction [TXNIP protein binds to TNPO1 protein] | CTD | PMID:10843682 | carbon nanotube | increases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | casticin | decreases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | casticin results in decreased expression of TNPO1 mRNA | CTD | PMID:28444820 | chlorpyrifos | decreases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of TNPO1 mRNA | CTD | PMID:37019170 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of TNPO1 mRNA | CTD | PMID:19376846 | copper(II) sulfate | increases expression | EXP | | 6480464 | Copper Sulfate results in increased expression of TNPO1 mRNA | CTD | PMID:19549813 | cyclosporin A | increases expression | EXP | | 6480464 | Cyclosporine results in increased expression of TNPO1 mRNA | CTD | PMID:20106945 and PMID:25562108 | dicrotophos | decreases expression | EXP | | 6480464 | dicrotophos results in decreased expression of TNPO1 mRNA | CTD | PMID:28302478 | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | elemental selenium | decreases expression | EXP | | 6480464 | Selenium results in decreased expression of TNPO1 mRNA | CTD | PMID:19244175 | entinostat | decreases expression | EXP | | 6480464 | entinostat results in decreased expression of TNPO1 mRNA | CTD | PMID:27188386 | enzyme inhibitor | multiple interactions | EXP | | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TNPO1 protein | CTD | PMID:23301498 | flutamide | increases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of TNPO1 mRNA | CTD | PMID:24136188 | folic acid | decreases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of TNPO1 mRNA | CTD | PMID:25629700 | folic acid | multiple interactions | ISO | Tnpo1 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TNPO1 mRNA | CTD | PMID:22206623 | fulvestrant | decreases expression | EXP | | 6480464 | fulvestrant results in decreased expression of TNPO1 mRNA | CTD | PMID:16514628 | hydrogen peroxide | affects expression | EXP | | 6480464 | Hydrogen Peroxide affects the expression of TNPO1 mRNA | CTD | PMID:20044591 | ionomycin | increases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | Ionomycin results in increased expression of TNPO1 mRNA | CTD | PMID:10843682 | isoprenaline | increases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | Isoproterenol results in increased expression of TNPO1 mRNA | CTD | PMID:20003209 | ivermectin | decreases expression | EXP | | 6480464 | Ivermectin results in decreased expression of TNPO1 protein | CTD | PMID:32959892 | ketamine | decreases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | Ketamine results in decreased expression of TNPO1 mRNA | CTD | PMID:20080153 | lipopolysaccharide | multiple interactions | EXP | | 6480464 | [Lipopolysaccharides co-treated with resveratrol] results in decreased expression of TNPO1 mRNA | CTD | PMID:26667767 | manumycin A | multiple interactions | EXP | | 6480464 | Acetylcysteine inhibits the reaction [manumycin results in decreased expression of TNPO1] | CTD | PMID:19409983 | methamphetamine | increases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | Methamphetamine results in increased expression of TNPO1 mRNA | CTD | PMID:19564919 | Methylazoxymethanol acetate | decreases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | Methylazoxymethanol Acetate results in decreased expression of TNPO1 mRNA | CTD | PMID:28349193 | methylmercury chloride | increases expression | EXP | | 6480464 | methylmercuric chloride results in increased expression of TNPO1 mRNA | CTD | PMID:23179753 | methylmercury chloride | decreases expression | EXP | | 6480464 | methylmercuric chloride results in decreased expression of TNPO1 mRNA | CTD | PMID:28001369 | microcystin-LR | decreases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | cyanoginosin LR results in decreased expression of TNPO1 protein | CTD | PMID:26984711 | N-acetyl-L-cysteine | multiple interactions | EXP | | 6480464 | Acetylcysteine inhibits the reaction [manumycin results in decreased expression of TNPO1] | CTD | PMID:19409983 | oxaliplatin | multiple interactions | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of TNPO1 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | EXP | | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of TNPO1 mRNA more ... | CTD | PMID:32699268 | paracetamol | affects expression | ISO | Tnpo1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of TNPO1 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of TNPO1 mRNA | CTD | PMID:26497421 and PMID:29067470 | PCB138 | decreases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:23829299 | pentachlorophenol | decreases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | Pentachlorophenol results in decreased expression of TNPO1 mRNA | CTD | PMID:23892564 | phenylmercury acetate | increases expression | EXP | | 6480464 | Phenylmercuric Acetate results in increased expression of TNPO1 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNPO1 mRNA | CTD | PMID:27188386 | pirinixic acid | decreases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of TNPO1 mRNA | CTD | PMID:18445702 | raloxifene | decreases expression | EXP | | 6480464 | Raloxifene Hydrochloride results in decreased expression of TNPO1 mRNA | CTD | PMID:16514628 | resveratrol | multiple interactions | EXP | | 6480464 | [Lipopolysaccharides co-treated with resveratrol] results in decreased expression of TNPO1 mRNA | CTD | PMID:26667767 | resveratrol | increases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | resveratrol results in increased expression of TNPO1 protein | CTD | PMID:25505154 | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | selenium atom | decreases expression | EXP | | 6480464 | Selenium results in decreased expression of TNPO1 mRNA | CTD | PMID:19244175 | sodium arsenite | decreases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | sodium arsenite results in decreased expression of TNPO1 protein | CTD | PMID:29459688 | Soman | increases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | Soman results in increased expression of TNPO1 mRNA | CTD | PMID:19281266 | sunitinib | increases expression | EXP | | 6480464 | Sunitinib results in increased expression of TNPO1 mRNA | CTD | PMID:31533062 | tamibarotene | decreases expression | EXP | | 6480464 | tamibarotene results in decreased expression of TNPO1 mRNA | CTD | PMID:15498508 | tert-butyl hydroperoxide | increases expression | EXP | | 6480464 | tert-Butylhydroperoxide results in increased expression of TNPO1 mRNA | CTD | PMID:15336504 | testosterone enanthate | affects expression | EXP | | 6480464 | testosterone enanthate affects the expression of TNPO1 mRNA | CTD | PMID:17440010 | thioacetamide | increases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of TNPO1 mRNA | CTD | PMID:23411599 and PMID:34492290 | topotecan | multiple interactions | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of TNPO1 mRNA | CTD | PMID:25729387 | trimellitic anhydride | increases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of TNPO1 mRNA | CTD | PMID:19042947 | triphenyl phosphate | increases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | triphenyl phosphate results in increased expression of TNPO1 mRNA | CTD | PMID:30589522 | Triptolide | increases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | triptolide results in increased expression of TNPO1 mRNA | CTD | PMID:32835833 | troglitazone | decreases expression | ISO | Tnpo1 (Mus musculus) | 6480464 | troglitazone results in decreased expression of TNPO1 mRNA | CTD | PMID:28973697 | uranium atom | affects expression | EXP | | 6480464 | Uranium affects the expression of TNPO1 mRNA | CTD | PMID:15672453 | urethane | increases expression | EXP | | 6480464 | Urethane results in increased expression of TNPO1 mRNA | CTD | PMID:28818685 | valdecoxib | increases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | valdecoxib results in increased expression of TNPO1 mRNA | CTD | PMID:24136188 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of TNPO1 mRNA | CTD | PMID:26272509 | valproic acid | decreases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | Valproic Acid results in decreased expression of TNPO1 mRNA | CTD | PMID:29427782 | valproic acid | affects splicing | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | Valproic Acid affects the splicing of TNPO1 mRNA | CTD | PMID:29427782 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of TNPO1 mRNA | CTD | PMID:23179753 and PMID:27188386 | valproic acid | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of TNPO1 mRNA | CTD | PMID:27188386 | vinclozolin | increases expression | ISO | Tnpo1 (Rattus norvegicus) | 6480464 | vinclozolin results in increased expression of TNPO1 mRNA | CTD | PMID:23034163 | vitamin E | decreases expression | EXP | | 6480464 | Vitamin E results in decreased expression of TNPO1 mRNA | CTD | PMID:19244175 | |