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Gene: TCL1A (TCL1 family AKT coactivator A) Homo sapiens
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Symbol: TCL1A
Name: TCL1 family AKT coactivator A
Description: Exhibits identical protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activator activity. Involved in several processes, including cellular response to tumor necrosis factor; positive regulation of mitochondrial membrane potential; and positive regulation of protein phosphorylation. Localizes to several cellular components, including cytosol; endoplasmic reticulum; and nucleoplasm. Biomarker of T-cell lymphoblastic leukemia/lymphoma.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: oncogene TCL-1; oncogene TCL1; protein p14 TCL1; T cell leukemia/lymphoma 1A; T-cell leukemia/lymphoma 1A; T-cell leukemia/lymphoma protein 1A; T-cell lymphoma-1; T-cell lymphoma-1A; TCL1
Orthologs:
Mus musculus (house mouse) : Tcl1 (T cell lymphoma breakpoint 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tcl1a (Tcl1 family Akt coactivator A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tcl1a (TCL1 family AKT coactivator A)
Pan paniscus (bonobo/pygmy chimpanzee) : TCL1A (TCL1 family AKT coactivator A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tcl1a (TCL1 family AKT coactivator A)
Sus scrofa (pig) : TCL1A (TCL1 family AKT coactivator A)
Chlorocebus sabaeus (African green monkey) : TCL1A (TCL1 family AKT coactivator A)
Heterocephalus glaber (naked mole-rat) : Tcl1a (TCL1 family AKT coactivator A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1495,709,947 - 95,714,196 (-)EnsemblGRCh38hg38GRCh38
GRCh381495,694,160 - 95,714,155 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371496,176,304 - 96,180,533 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,246,057 - 95,250,286 (-)NCBINCBI36hg18NCBI36
Build 341495,246,057 - 95,250,201NCBI
Celera1476,232,053 - 76,236,282 (-)NCBI
Cytogenetic Map14q32.13NCBI
HuRef1476,361,876 - 76,366,105 (-)NCBIHuRef
CHM1_11496,114,282 - 96,118,511 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TCL1A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318064
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.