OARD1 (O-acyl-ADP-ribose deacylase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: OARD1 (O-acyl-ADP-ribose deacylase 1) Homo sapiens
Analyze
Symbol: OARD1
Name: O-acyl-ADP-ribose deacylase 1
RGD ID: 1317992
HGNC Page HGNC:21257
Description: Enables ADP-ribosylglutamate hydrolase activity; O-acetyl-ADP-ribose deacetylase activity; and purine nucleoside binding activity. Involved in DNA damage response and purine nucleoside metabolic process. Located in nucleolus; nucleoplasm; and site of DNA damage.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: [Protein ADP-ribosylglutamate] hydrolase OARD1; ADP-ribose glycohydrolase OARD1; C6orf130; dJ34B21.3; FLJ17636; hypothetical protein LOC221443; MGC19570; O-acetyl-ADP-ribose deacetylase 1; O-acetyl-ADP-ribose deacetylase C6orf130; O-acetyl-ADP-ribose deacetylase C6orf130 homolog; TARG1; terminal ADP-ribose protein glycohydrolase 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,064,772 - 41,097,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,033,627 - 41,097,787 (-)EnsemblGRCh38hg38GRCh38
GRCh37641,032,511 - 41,065,526 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,142,509 - 41,148,166 (-)NCBINCBI36Build 36hg18NCBI36
Build 34641,142,509 - 41,148,166NCBI
Celera642,587,212 - 42,592,869 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef640,752,283 - 40,757,940 (-)NCBIHuRef
CHM1_1641,037,034 - 41,042,691 (-)NCBICHM1_1
T2T-CHM13v2.0640,893,329 - 40,926,344 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
nucleolus  (IDA,IEA)
nucleoplasm  (IDA,IEA)
nucleus  (IEA)
site of DNA damage  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Barkauskaite E, etal., Mol Cell. 2015 Jun 18;58(6):935-46. doi: 10.1016/j.molcel.2015.05.007.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:14574404   PMID:15489334   PMID:17213182   PMID:21832049   PMID:21849506   PMID:21873635   PMID:22863883   PMID:23474714   PMID:23481255   PMID:26344197  
PMID:26496610   PMID:29712969   PMID:32296183   PMID:32427867   PMID:32513696   PMID:33596420   PMID:34508355   PMID:35831314   PMID:35944360   PMID:36724073  


Genomics

Comparative Map Data
OARD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,064,772 - 41,097,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,033,627 - 41,097,787 (-)EnsemblGRCh38hg38GRCh38
GRCh37641,032,511 - 41,065,526 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,142,509 - 41,148,166 (-)NCBINCBI36Build 36hg18NCBI36
Build 34641,142,509 - 41,148,166NCBI
Celera642,587,212 - 42,592,869 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef640,752,283 - 40,757,940 (-)NCBIHuRef
CHM1_1641,037,034 - 41,042,691 (-)NCBICHM1_1
T2T-CHM13v2.0640,893,329 - 40,926,344 (-)NCBIT2T-CHM13v2.0
Oard1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,717,028 - 48,724,298 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1748,717,042 - 48,724,294 (+)EnsemblGRCm39 Ensembl
GRCm381748,409,957 - 48,417,270 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,410,014 - 48,417,266 (+)EnsemblGRCm38mm10GRCm38
MGSCv371748,549,405 - 48,556,591 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361747,875,648 - 47,882,836 (+)NCBIMGSCv36mm8
Celera1751,841,704 - 51,848,680 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.99NCBI
Oard1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,074,507 - 20,084,946 (-)NCBIGRCr8
mRatBN7.2912,576,894 - 12,587,264 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,578,970 - 12,587,249 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx921,090,089 - 21,100,384 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,156,313 - 26,166,608 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0924,539,385 - 24,549,679 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0914,542,957 - 14,551,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,544,677 - 14,551,519 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0913,465,730 - 13,474,021 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.497,962,959 - 7,969,801 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.197,962,959 - 7,968,912 (-)NCBI
Celera910,354,797 - 10,361,197 (-)NCBICelera
Cytogenetic Map9q12NCBI
Oard1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554377,736,747 - 7,743,176 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554377,736,747 - 7,742,950 (-)NCBIChiLan1.0ChiLan1.0
OARD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2555,563,009 - 55,570,286 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1651,432,964 - 51,440,240 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0640,655,255 - 40,662,476 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1641,963,670 - 41,969,489 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl641,963,670 - 41,969,451 (-)Ensemblpanpan1.1panPan2
OARD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1129,821,947 - 9,828,062 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl129,822,483 - 9,827,974 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha129,852,188 - 9,858,286 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01210,301,427 - 10,307,919 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1210,301,433 - 10,307,844 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1129,833,719 - 9,839,809 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0129,915,534 - 9,921,992 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01210,010,217 - 10,016,316 (-)NCBIUU_Cfam_GSD_1.0
Oard1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,203,108 - 45,208,988 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647618,751,364 - 18,757,094 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647618,751,344 - 18,757,094 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OARD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,379,543 - 36,386,353 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1736,378,515 - 36,386,408 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2741,675,993 - 41,682,859 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OARD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11731,084,458 - 31,099,019 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1731,084,096 - 31,089,564 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604441,058,644 - 41,075,090 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oard1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475417,683,064 - 17,690,264 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475417,682,705 - 17,687,748 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in OARD1
23 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p21.2-21.1(chr6:37777369-45653843)x1 copy number loss See cases [RCV000052181] Chr6:37777369..45653843 [GRCh38]
Chr6:37745145..45621580 [GRCh37]
Chr6:37853123..45729558 [NCBI36]
Chr6:6p21.2-21.1		 pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
NM_001329686.2(OARD1):c.115C>T (p.Arg39Cys) single nucleotide variant Inborn genetic diseases [RCV003245921] Chr6:41071201 [GRCh38]
Chr6:41038940 [GRCh37]
Chr6:6p21.1		 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1		 pathogenic
NM_001329686.2(OARD1):c.357G>T (p.Arg119Ser) single nucleotide variant Inborn genetic diseases [RCV002774643] Chr6:41067437 [GRCh38]
Chr6:41035176 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001329686.2(OARD1):c.397T>A (p.Ser133Thr) single nucleotide variant Inborn genetic diseases [RCV002860867] Chr6:41067397 [GRCh38]
Chr6:41035136 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_002505.5(NFYA):c.1036G>C (p.Val346Leu) single nucleotide variant Inborn genetic diseases [RCV002864909] Chr6:41097402 [GRCh38]
Chr6:41065141 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001329686.2(OARD1):c.128G>A (p.Gly43Glu) single nucleotide variant Inborn genetic diseases [RCV002732301] Chr6:41071188 [GRCh38]
Chr6:41038927 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_002505.5(NFYA):c.120G>C (p.Gln40His) single nucleotide variant Inborn genetic diseases [RCV002907170] Chr6:41080855 [GRCh38]
Chr6:41048594 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_002505.5(NFYA):c.509A>G (p.Tyr170Cys) single nucleotide variant Inborn genetic diseases [RCV002887353] Chr6:41090271 [GRCh38]
Chr6:41058010 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001329686.2(OARD1):c.172C>T (p.Leu58Phe) single nucleotide variant Inborn genetic diseases [RCV002737925] Chr6:41071144 [GRCh38]
Chr6:41038883 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_002505.5(NFYA):c.704G>C (p.Gly235Ala) single nucleotide variant Inborn genetic diseases [RCV002887354] Chr6:41091684 [GRCh38]
Chr6:41059423 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_002505.5(NFYA):c.34A>G (p.Thr12Ala) single nucleotide variant Inborn genetic diseases [RCV002808558] Chr6:41079123 [GRCh38]
Chr6:41046862 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001329686.2(OARD1):c.208G>A (p.Val70Ile) single nucleotide variant Inborn genetic diseases [RCV003010985] Chr6:41070111 [GRCh38]
Chr6:41037850 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001329686.2(OARD1):c.65T>C (p.Phe22Ser) single nucleotide variant Inborn genetic diseases [RCV003214711] Chr6:41071251 [GRCh38]
Chr6:41038990 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001329686.2(OARD1):c.124G>A (p.Ala42Thr) single nucleotide variant Inborn genetic diseases [RCV003184379] Chr6:41071192 [GRCh38]
Chr6:41038931 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_002505.5(NFYA):c.999C>G (p.Asn333Lys) single nucleotide variant Inborn genetic diseases [RCV003210777] Chr6:41097365 [GRCh38]
Chr6:41065104 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001329686.2(OARD1):c.83A>C (p.Asp28Ala) single nucleotide variant Inborn genetic diseases [RCV003339406] Chr6:41071233 [GRCh38]
Chr6:41038972 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_002505.5(NFYA):c.658G>A (p.Val220Ile) single nucleotide variant Inborn genetic diseases [RCV003379847] Chr6:41091638 [GRCh38]
Chr6:41059377 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_001329686.2(OARD1):c.234A>G (p.Ile78Met) single nucleotide variant Inborn genetic diseases [RCV003345310] Chr6:41070085 [GRCh38]
Chr6:41037824 [GRCh37]
Chr6:6p21.1		 uncertain significance
GRCh37/hg19 6p21.31-21.1(chr6:35562152-42003452)x1 copy number loss not provided [RCV003485510] Chr6:35562152..42003452 [GRCh37]
Chr6:6p21.31-21.1		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3978
Count of miRNA genes:1060
Interacting mature miRNAs:1316
Transcripts:ENST00000244558, ENST00000373154, ENST00000424266, ENST00000463088, ENST00000464633, ENST00000465893, ENST00000467234, ENST00000468811, ENST00000469104, ENST00000471367, ENST00000479950, ENST00000480585, ENST00000482515, ENST00000482853, ENST00000486443, ENST00000488238
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH48345  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37641,034,612 - 41,034,781UniSTSGRCh37
Build 36641,142,590 - 41,142,759RGDNCBI36
Celera642,587,293 - 42,587,462RGD
Cytogenetic Map6p21.1UniSTS
HuRef640,752,364 - 40,752,533UniSTS
GeneMap99-GB4 RH Map6148.47UniSTS
G31080  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37641,034,211 - 41,034,354UniSTSGRCh37
Build 36641,142,189 - 41,142,332RGDNCBI36
Celera642,586,892 - 42,587,035RGD
Cytogenetic Map6p21.1UniSTS
HuRef640,751,963 - 40,752,106UniSTS
RH47657  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37641,037,988 - 41,038,111UniSTSGRCh37
Build 36641,145,966 - 41,146,089RGDNCBI36
Celera642,590,669 - 42,590,792RGD
Cytogenetic Map6p21.1UniSTS
HuRef640,755,740 - 40,755,863UniSTS
GeneMap99-GB4 RH Map6152.35UniSTS
NCBI RH Map6633.7UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1141 603 1209 249 1036 165 2550 462 1389 238 1148 1149 97 496 1516 2
Low 1298 2366 517 375 904 300 1806 1723 2345 180 311 463 78 1 708 1272 3 2
Below cutoff 22 11 10 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001329684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_138080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ420538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL031778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE267691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM353928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU740294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX758168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DT215423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000373154   ⟹   ENSP00000362247
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,066,788 - 41,072,529 (-)Ensembl
RefSeq Acc Id: ENST00000424266   ⟹   ENSP00000416829
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,064,772 - 41,072,356 (-)Ensembl
RefSeq Acc Id: ENST00000463088   ⟹   ENSP00000420193
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,066,475 - 41,072,489 (-)Ensembl
RefSeq Acc Id: ENST00000464633   ⟹   ENSP00000419875
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,067,146 - 41,072,534 (-)Ensembl
RefSeq Acc Id: ENST00000465893
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,069,038 - 41,072,468 (-)Ensembl
RefSeq Acc Id: ENST00000467234
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,071,499 - 41,072,563 (-)Ensembl
RefSeq Acc Id: ENST00000468811   ⟹   ENSP00000420601
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,067,181 - 41,071,840 (-)Ensembl
RefSeq Acc Id: ENST00000469104   ⟹   ENSP00000418966
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,070,825 - 41,072,490 (-)Ensembl
RefSeq Acc Id: ENST00000471367   ⟹   ENSP00000417333
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,071,041 - 41,072,320 (-)Ensembl
RefSeq Acc Id: ENST00000479950   ⟹   ENSP00000420484
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,064,778 - 41,072,591 (-)Ensembl
RefSeq Acc Id: ENST00000480585   ⟹   ENSP00000418400
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,066,939 - 41,097,758 (-)Ensembl
RefSeq Acc Id: ENST00000482515   ⟹   ENSP00000418098
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,067,127 - 41,072,614 (-)Ensembl
RefSeq Acc Id: ENST00000482853   ⟹   ENSP00000420472
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,033,627 - 41,071,217 (-)Ensembl
RefSeq Acc Id: ENST00000486443   ⟹   ENSP00000419175
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,067,197 - 41,072,524 (-)Ensembl
RefSeq Acc Id: ENST00000488238   ⟹   ENSP00000420414
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,067,401 - 41,097,787 (-)Ensembl
RefSeq Acc Id: ENST00000628419   ⟹   ENSP00000487484
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,066,793 - 41,072,577 (-)Ensembl
RefSeq Acc Id: NM_001329684   ⟹   NP_001316613
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,064,772 - 41,097,787 (-)NCBI
T2T-CHM13v2.0640,893,329 - 40,926,344 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001329685   ⟹   NP_001316614
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,066,788 - 41,072,614 (-)NCBI
T2T-CHM13v2.0640,895,345 - 40,901,171 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001329686   ⟹   NP_001316615
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,064,772 - 41,072,356 (-)NCBI
T2T-CHM13v2.0640,893,329 - 40,900,913 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001329688   ⟹   NP_001316617
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,064,772 - 41,071,840 (-)NCBI
T2T-CHM13v2.0640,893,329 - 40,900,397 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001329689   ⟹   NP_001316618
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,064,772 - 41,072,356 (-)NCBI
T2T-CHM13v2.0640,893,329 - 40,900,913 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001329690   ⟹   NP_001316619
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,064,772 - 41,097,787 (-)NCBI
T2T-CHM13v2.0640,893,329 - 40,926,344 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001329691   ⟹   NP_001316620
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,064,772 - 41,072,356 (-)NCBI
T2T-CHM13v2.0640,893,329 - 40,900,913 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001329692   ⟹   NP_001316621
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,066,788 - 41,072,614 (-)NCBI
T2T-CHM13v2.0640,895,345 - 40,901,171 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001329693   ⟹   NP_001316622
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,064,772 - 41,072,356 (-)NCBI
T2T-CHM13v2.0640,893,329 - 40,900,913 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001329694   ⟹   NP_001316623
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,064,772 - 41,072,356 (-)NCBI
T2T-CHM13v2.0640,893,329 - 40,900,913 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001329695   ⟹   NP_001316624
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,066,788 - 41,072,614 (-)NCBI
T2T-CHM13v2.0640,895,345 - 40,901,171 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001329696   ⟹   NP_001316625
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,064,772 - 41,071,840 (-)NCBI
T2T-CHM13v2.0640,893,329 - 40,900,397 (-)NCBI
Sequence:
RefSeq Acc Id: NM_145063   ⟹   NP_659500
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,064,772 - 41,072,356 (-)NCBI
GRCh37641,034,526 - 41,040,207 (-)NCBI
Build 36641,142,509 - 41,148,166 (-)NCBI Archive
Celera642,587,212 - 42,592,869 (-)RGD
HuRef640,752,283 - 40,757,940 (-)ENTREZGENE
CHM1_1641,037,034 - 41,042,691 (-)NCBI
T2T-CHM13v2.0640,893,329 - 40,900,913 (-)NCBI
Sequence:
RefSeq Acc Id: NR_138080
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,071,501 - 41,072,356 (-)NCBI
T2T-CHM13v2.0640,900,058 - 40,900,913 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001316613 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316614 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316615 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316617 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316618 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316619 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316620 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316621 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316622 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316623 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316624 (Get FASTA)   NCBI Sequence Viewer  
  NP_001316625 (Get FASTA)   NCBI Sequence Viewer  
  NP_659500 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH11709 (Get FASTA)   NCBI Sequence Viewer  
  AAH21579 (Get FASTA)   NCBI Sequence Viewer  
  BAF83628 (Get FASTA)   NCBI Sequence Viewer  
  BAG36161 (Get FASTA)   NCBI Sequence Viewer  
  EAX04010 (Get FASTA)   NCBI Sequence Viewer  
  EAX04011 (Get FASTA)   NCBI Sequence Viewer  
  EAX04012 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000362247
  ENSP00000362247.2
  ENSP00000416829
  ENSP00000416829.2
  ENSP00000417333.1
  ENSP00000418098
  ENSP00000418098.1
  ENSP00000418400
  ENSP00000418400.1
  ENSP00000418966.1
  ENSP00000419175
  ENSP00000419175.1
  ENSP00000419875
  ENSP00000419875.1
  ENSP00000420193
  ENSP00000420193.1
  ENSP00000420414
  ENSP00000420414.1
  ENSP00000420472.1
  ENSP00000420484
  ENSP00000420484.1
  ENSP00000420601
  ENSP00000420601.1
  ENSP00000487484
  ENSP00000487484.1
GenBank Protein Q9Y530 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_659500   ⟸   NM_145063
- Peptide Label: isoform a
- UniProtKB: A8K4H4 (UniProtKB/Swiss-Prot),   A6NEK4 (UniProtKB/Swiss-Prot),   Q96F23 (UniProtKB/Swiss-Prot),   Q9Y530 (UniProtKB/Swiss-Prot),   C9JNE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316619   ⟸   NM_001329690
- Peptide Label: isoform c
- UniProtKB: C9J5P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316613   ⟸   NM_001329684
- Peptide Label: isoform a
- UniProtKB: A8K4H4 (UniProtKB/Swiss-Prot),   A6NEK4 (UniProtKB/Swiss-Prot),   Q96F23 (UniProtKB/Swiss-Prot),   Q9Y530 (UniProtKB/Swiss-Prot),   C9JNE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316624   ⟸   NM_001329695
- Peptide Label: isoform d
- UniProtKB: C9JA90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316621   ⟸   NM_001329692
- Peptide Label: isoform c
- UniProtKB: C9J5P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316614   ⟸   NM_001329685
- Peptide Label: isoform a
- UniProtKB: A8K4H4 (UniProtKB/Swiss-Prot),   A6NEK4 (UniProtKB/Swiss-Prot),   Q96F23 (UniProtKB/Swiss-Prot),   Q9Y530 (UniProtKB/Swiss-Prot),   C9JNE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316618   ⟸   NM_001329689
- Peptide Label: isoform b
- UniProtKB: C9JXC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316623   ⟸   NM_001329694
- Peptide Label: isoform d
- UniProtKB: C9JA90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316622   ⟸   NM_001329693
- Peptide Label: isoform c
- UniProtKB: C9J5P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316620   ⟸   NM_001329691
- Peptide Label: isoform c
- UniProtKB: C9J5P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316615   ⟸   NM_001329686
- Peptide Label: isoform a
- UniProtKB: A8K4H4 (UniProtKB/Swiss-Prot),   A6NEK4 (UniProtKB/Swiss-Prot),   Q96F23 (UniProtKB/Swiss-Prot),   Q9Y530 (UniProtKB/Swiss-Prot),   C9JNE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316625   ⟸   NM_001329696
- Peptide Label: isoform d
- UniProtKB: C9JA90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316617   ⟸   NM_001329688
- Peptide Label: isoform a
- UniProtKB: A8K4H4 (UniProtKB/Swiss-Prot),   A6NEK4 (UniProtKB/Swiss-Prot),   Q96F23 (UniProtKB/Swiss-Prot),   Q9Y530 (UniProtKB/Swiss-Prot),   C9JNE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000420193   ⟸   ENST00000463088
RefSeq Acc Id: ENSP00000416829   ⟸   ENST00000424266
RefSeq Acc Id: ENSP00000419875   ⟸   ENST00000464633
RefSeq Acc Id: ENSP00000420484   ⟸   ENST00000479950
RefSeq Acc Id: ENSP00000362247   ⟸   ENST00000373154
RefSeq Acc Id: ENSP00000420601   ⟸   ENST00000468811
RefSeq Acc Id: ENSP00000418966   ⟸   ENST00000469104
RefSeq Acc Id: ENSP00000418400   ⟸   ENST00000480585
RefSeq Acc Id: ENSP00000418098   ⟸   ENST00000482515
RefSeq Acc Id: ENSP00000420472   ⟸   ENST00000482853
RefSeq Acc Id: ENSP00000487484   ⟸   ENST00000628419
RefSeq Acc Id: ENSP00000417333   ⟸   ENST00000471367
RefSeq Acc Id: ENSP00000419175   ⟸   ENST00000486443
RefSeq Acc Id: ENSP00000420414   ⟸   ENST00000488238
Protein Domains
Macro

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Y530-F1-model_v2 AlphaFold Q9Y530 1-152 view protein structure

Promoters
RGD ID:7207969
Promoter ID:EPDNEW_H9730
Type:initiation region
Name:OARD1_1
Description:O-acyl-ADP-ribose deacylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9731  EPDNEW_H9734  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,072,351 - 41,072,411EPDNEW
RGD ID:7207971
Promoter ID:EPDNEW_H9731
Type:initiation region
Name:OARD1_3
Description:O-acyl-ADP-ribose deacylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9730  EPDNEW_H9734  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,072,468 - 41,072,528EPDNEW
RGD ID:7207977
Promoter ID:EPDNEW_H9734
Type:multiple initiation site
Name:OARD1_2
Description:O-acyl-ADP-ribose deacylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9730  EPDNEW_H9731  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,097,797 - 41,097,857EPDNEW
RGD ID:6803826
Promoter ID:HG_KWN:53505
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000373154,   NM_021705,   NM_145063,   OTTHUMT00000040496,   UC003OPN.1,   UC003OPQ.1,   UC010JXG.1,   UC010JXH.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36641,147,996 - 41,149,632 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:21257 AgrOrtholog
COSMIC OARD1 COSMIC
Ensembl Genes ENSG00000124596 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000373154 ENTREZGENE
  ENST00000373154.6 UniProtKB/TrEMBL
  ENST00000424266 ENTREZGENE
  ENST00000424266.7 UniProtKB/Swiss-Prot
  ENST00000463088 ENTREZGENE
  ENST00000463088.5 UniProtKB/Swiss-Prot
  ENST00000464633 ENTREZGENE
  ENST00000464633.5 UniProtKB/TrEMBL
  ENST00000468811 ENTREZGENE
  ENST00000468811.5 UniProtKB/Swiss-Prot
  ENST00000469104.5 UniProtKB/TrEMBL
  ENST00000471367.1 UniProtKB/TrEMBL
  ENST00000479950 ENTREZGENE
  ENST00000479950.5 UniProtKB/Swiss-Prot
  ENST00000480585 ENTREZGENE
  ENST00000480585.5 UniProtKB/TrEMBL
  ENST00000482515 ENTREZGENE
  ENST00000482515.5 UniProtKB/TrEMBL
  ENST00000482853.5 UniProtKB/TrEMBL
  ENST00000486443 ENTREZGENE
  ENST00000486443.5 UniProtKB/TrEMBL
  ENST00000488238 ENTREZGENE
  ENST00000488238.5 UniProtKB/TrEMBL
  ENST00000628419 ENTREZGENE
  ENST00000628419.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.220.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000124596 GTEx
HGNC ID HGNC:21257 ENTREZGENE
Human Proteome Map OARD1 Human Proteome Map
InterPro Macro_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Macro_dom-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:221443 UniProtKB/Swiss-Prot
NCBI Gene 221443 ENTREZGENE
OMIM 614393 OMIM
PANTHER ADP-RIBOSE GLYCOHYDROLASE OARD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN C6ORF130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Macro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134879529 PharmGKB
PROSITE MACRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART A1pp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52949 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6NEK4 ENTREZGENE
  A8K4H4 ENTREZGENE
  C9IZY1_HUMAN UniProtKB/TrEMBL
  C9J5P1 ENTREZGENE, UniProtKB/TrEMBL
  C9JA90 ENTREZGENE, UniProtKB/TrEMBL
  C9JNE2 ENTREZGENE, UniProtKB/TrEMBL
  C9JXC3 ENTREZGENE, UniProtKB/TrEMBL
  H7C5Q1_HUMAN UniProtKB/TrEMBL
  OARD1_HUMAN UniProtKB/Swiss-Prot
  Q05CR9_HUMAN UniProtKB/TrEMBL
  Q96F23 ENTREZGENE
  Q9Y530 ENTREZGENE
UniProt Secondary A6NEK4 UniProtKB/Swiss-Prot
  A8K4H4 UniProtKB/Swiss-Prot
  Q96F23 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-15 OARD1  O-acyl-ADP-ribose deacylase 1  C6orf130  chromosome 6 open reading frame 130  Symbol and/or name change 5135510 APPROVED