Nxnl1 (nucleoredoxin-like 1) - Rat Genome Database

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Gene: Nxnl1 (nucleoredoxin-like 1) Mus musculus
Analyze
Symbol: Nxnl1
Name: nucleoredoxin-like 1
RGD ID: 1317988
MGI Page MGI
Description: Involved in photoreceptor cell maintenance. Located in mitochondrion. Is expressed in several structures, including cerebellum external granule cell layer; neural retina; and olfactory epithelium. Orthologous to human NXNL1 (nucleoredoxin like 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A930031O08Rik; MGC27601; MGC28867; nucleoredoxin-like protein 1; RdC; RdCVF; rod-derived cone viability factor; thioredoxin-like 6; thioredoxin-like protein 6; Txn; Txnl6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,013,211 - 72,019,291 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,013,199 - 72,019,245 (-)EnsemblGRCm39 Ensembl
GRCm38871,560,555 - 71,566,649 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,560,555 - 71,566,601 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,084,454 - 74,090,548 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36874,489,544 - 74,495,590 (-)NCBIMGSCv36mm8
Celera874,071,252 - 74,073,239 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:14651853   PMID:15220920   PMID:15226823   PMID:16141072   PMID:16141073   PMID:17764561   PMID:19279044   PMID:19843539   PMID:20139892  
PMID:20949100   PMID:21677750   PMID:25596499   PMID:25957687   PMID:27025156   PMID:32290105   PMID:34932831  


Genomics

Comparative Map Data
Nxnl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,013,211 - 72,019,291 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,013,199 - 72,019,245 (-)EnsemblGRCm39 Ensembl
GRCm38871,560,555 - 71,566,649 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,560,555 - 71,566,601 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,084,454 - 74,090,548 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36874,489,544 - 74,495,590 (-)NCBIMGSCv36mm8
Celera874,071,252 - 74,073,239 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
NXNL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,455,425 - 17,460,926 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1917,455,425 - 17,460,926 (-)EnsemblGRCh38hg38GRCh38
GRCh371917,566,234 - 17,571,735 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,427,234 - 17,432,725 (-)NCBINCBI36Build 36hg18NCBI36
Build 341917,427,235 - 17,432,725NCBI
Celera1917,467,985 - 17,473,494 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,131,793 - 17,137,523 (-)NCBIHuRef
CHM1_11917,565,780 - 17,571,275 (-)NCBICHM1_1
T2T-CHM13v2.01917,590,193 - 17,595,708 (-)NCBIT2T-CHM13v2.0
Nxnl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,303,454 - 18,311,510 (-)NCBIGRCr8
mRatBN7.21618,270,604 - 18,279,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,262,688 - 18,279,987 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,322,531 - 18,327,498 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,454,475 - 19,459,400 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,375,468 - 18,380,435 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,992,211 - 19,996,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,992,984 - 19,996,836 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,847,552 - 19,857,599 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,766,955 - 18,767,525 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,738,023 - 18,767,517 (-)NCBI
Celera1618,480,208 - 18,480,533 (-)NCBICelera
Cytogenetic Map16p14NCBI
Nxnl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955524826,388 - 827,170 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955524825,818 - 827,167 (+)NCBIChiLan1.0ChiLan1.0
NXNL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,325,893 - 22,333,191 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,332,484 - 21,339,800 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01916,942,887 - 16,948,655 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11917,916,159 - 17,922,126 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1917,916,159 - 17,922,126 (-)Ensemblpanpan1.1panPan2
NXNL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,348,890 - 45,351,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2045,262,931 - 45,265,416 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,836,047 - 45,838,766 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,836,047 - 45,838,766 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12045,072,450 - 45,075,163 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,482,468 - 45,484,967 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,758,504 - 45,760,982 (+)NCBIUU_Cfam_GSD_1.0
NXNL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,244,646 - 60,251,582 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1260,244,592 - 60,249,696 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,863,727 - 59,869,499 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NXNL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,948,401 - 15,951,390 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl615,948,514 - 15,951,096 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660743,480,400 - 3,488,768 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nxnl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624908551,921 - 554,427 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624908549,989 - 554,902 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nxnl1
232 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1452
Count of miRNA genes:474
Interacting mature miRNAs:579
Transcripts:ENSMUST00000048243, ENSMUST00000163659
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84474791478748059Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84809006482090180Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84809006482090180Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84819016882190288Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
11039503Ccc4_mcolitis susceptibility in the Collaborative Cross 4 (mouse)86517423778002730Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86872247983326976Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7158942790929226Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000048243   ⟹   ENSMUSP00000039294
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl872,013,200 - 72,019,245 (-)Ensembl
GRCm38.p6 Ensembl871,560,556 - 71,566,601 (-)Ensembl
RefSeq Acc Id: ENSMUST00000163659   ⟹   ENSMUSP00000127094
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl872,013,199 - 72,019,245 (-)Ensembl
GRCm38.p6 Ensembl871,560,555 - 71,566,601 (-)Ensembl
RefSeq Acc Id: NM_145598   ⟹   NP_663573
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,013,211 - 72,019,291 (-)NCBI
GRCm38871,560,555 - 71,566,649 (-)NCBI
MGSCv37874,084,454 - 74,090,548 (-)RGD
Celera874,071,252 - 74,073,239 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_663573 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH21911 (Get FASTA)   NCBI Sequence Viewer  
  EDL28938 (Get FASTA)   NCBI Sequence Viewer  
  EDL28939 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000039294.7
  ENSMUSP00000127094
  ENSMUSP00000127094.2
GenBank Protein Q8VC33 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_663573   ⟸   NM_145598
- UniProtKB: Q91W38 (UniProtKB/Swiss-Prot),   Q8VC33 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000127094   ⟸   ENSMUST00000163659
RefSeq Acc Id: ENSMUSP00000039294   ⟸   ENSMUST00000048243
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VC33-F1-model_v2 AlphaFold Q8VC33 1-217 view protein structure

Promoters
RGD ID:8667411
Promoter ID:EPDNEW_M11737
Type:initiation region
Name:Nxnl1_1
Description:Mus musculus nucleoredoxin-like 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38871,566,647 - 71,566,707EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1924446 AgrOrtholog
Ensembl Genes ENSMUSG00000034829 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000048243.7 UniProtKB/Swiss-Prot
  ENSMUST00000163659 ENTREZGENE
  ENSMUST00000163659.3 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
InterPro RdCVF UniProtKB/Swiss-Prot
  Thioredoxin-like_fold UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report mmu:234404 UniProtKB/Swiss-Prot
MGD MGI:1924446 ENTREZGENE
NCBI Gene 234404 ENTREZGENE
PANTHER NUCLEOREDOXIN-LIKE PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR47109 UniProtKB/Swiss-Prot
Pfam Thioredoxin_8 UniProtKB/Swiss-Prot
PhenoGen Nxnl1 PhenoGen
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt NXNL1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q91W38 ENTREZGENE
UniProt Secondary Q91W38 UniProtKB/Swiss-Prot