KLK9 (kallikrein related peptidase 9)

Gene: KLK9 (kallikrein related peptidase 9) Homo sapiens

Analyze

Symbol:

KLK9

Name:

kallikrein related peptidase 9

RGD ID:

1317964

HGNC Page

HGNC:6370

Description:

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular space. Predicted to be active in secretory granule.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

kallikrein 9; kallikrein-9; kallikrein-like protein 3; kallikrein-related peptidase 9; KLK-L3; KLK8; KLKL3; MGC50513

RGD Orthologs

Alliance Genes

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

NCBI Annotation Information:

Note: The KLK9 gene is immediately upstream of the KLK8 gene. There are a few transcripts (DQ267419, DQ267420, AY566267, and BC040887) that span the gap between these two genes and which suggest the presence of a bicistronic transcript. However, there is no published support for that, so they will continue to be represented as separate genes. [13 Feb 2013]

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	51,002,508 - 51,009,592 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	51,002,508 - 51,009,634 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	51,505,764 - 51,512,848 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	56,197,581 - 56,204,702 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	56,197,580 - 56,204,702	NCBI
Celera	19	48,557,813 - 48,564,935 (-)	NCBI		Celera
Cytogenetic Map	19	q13.41	NCBI
HuRef	19	47,838,535 - 47,845,658 (-)	NCBI		HuRef
CHM1_1	19	51,507,767 - 51,514,843 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	54,090,979 - 54,098,065 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (ISO)

4,4'-sulfonyldiphenol (ISO)

arsane (EXP)

arsenic atom (EXP)

benzo[a]pyrene (EXP)

bisphenol A (EXP,ISO)

C60 fullerene (ISO)

cadmium atom (EXP)

cadmium dichloride (EXP)

cisplatin (EXP)

doxorubicin (ISO)

paracetamol (ISO)

potassium dichromate (ISO)

sodium arsenate (EXP)

tamoxifen (ISO)

titanium dioxide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis (IEA)

Cellular Component

extracellular region (IEA)

secretory granule (IBA,IEA)

Molecular Function

serine-type endopeptidase activity (IEA,NAS)

serine-type peptidase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10652563	PMID:10783266	PMID:11054574	PMID:11691797	PMID:12477932	PMID:15057824	PMID:16800723	PMID:16800724	PMID:20424135	PMID:21832049	PMID:21873635	PMID:25640309
PMID:25747782	PMID:26231762	PMID:28559305	PMID:29095848	PMID:29229980	PMID:33961781	PMID:34857952	PMID:36373674

Genomics

Comparative Map Data

KLK9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	51,002,508 - 51,009,592 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	51,002,508 - 51,009,634 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	51,505,764 - 51,512,848 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	56,197,581 - 56,204,702 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	56,197,580 - 56,204,702	NCBI
Celera	19	48,557,813 - 48,564,935 (-)	NCBI		Celera
Cytogenetic Map	19	q13.41	NCBI
HuRef	19	47,838,535 - 47,845,658 (-)	NCBI		HuRef
CHM1_1	19	51,507,767 - 51,514,843 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	54,090,979 - 54,098,065 (-)	NCBI		T2T-CHM13v2.0

Klk9
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	43,441,048 - 43,446,182 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	43,441,315 - 43,446,181 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	43,791,625 - 43,796,758 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	43,791,891 - 43,796,757 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	51,047,261 - 51,052,126 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	43,660,003 - 43,664,440 (+)	NCBI		MGSCv36	mm8
Celera	7	39,258,543 - 39,263,406 (+)	NCBI		Celera
Cytogenetic Map	7	B3	NCBI
cM Map	7	28.26	NCBI

Klk9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	103,382,888 - 103,387,180 (+)	NCBI		GRCr8
mRatBN7.2	1	94,246,339 - 94,250,631 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	94,246,339 - 94,250,631 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	99,631,747 - 99,636,039 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	108,104,418 - 108,108,710 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	101,394,055 - 101,398,347 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	99,729,704 - 99,733,996 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	99,729,704 - 99,733,996 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	100,798,462 - 100,802,754 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	94,221,721 - 94,226,013 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	94,299,870 - 94,303,908 (+)	NCBI
Celera	1	88,514,875 - 88,519,167 (+)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

Klk9
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955558	1,473,365 - 1,478,287 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955558	1,472,423 - 1,478,767 (+)	NCBI	ChiLan1.0	ChiLan1.0

KLK9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	57,072,157 - 57,079,196 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	58,993,660 - 59,000,700 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	47,970,000 - 47,977,034 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	56,859,371 - 56,866,436 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	56,859,371 - 56,866,436 (-)	Ensembl	panpan1.1		panPan2

KLK9
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	105,868,147 - 105,873,147 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	105,868,147 - 105,873,147 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	105,440,559 - 105,445,559 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	106,376,952 - 106,381,948 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	106,376,952 - 106,382,511 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	106,048,402 - 106,053,397 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	105,689,796 - 105,694,802 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	106,485,276 - 106,490,280 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101956728
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	22,778,707 - 22,784,033 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936889	655,242 - 660,513 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936889	655,242 - 659,938 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KLK9
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	55,662,096 - 55,669,713 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	55,662,108 - 55,669,463 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

KLK9
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	44,022,545 - 44,030,503 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	44,023,146 - 44,029,455 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	24,068,618 - 24,075,439 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Klk9
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624832	3,757,147 - 3,762,739 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624832	3,757,251 - 3,763,348 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in KLK9
6 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 19q13.33-13.43(chr19:50191219-58535818)x3	copy number gain	See cases [RCV000050883]	Chr19:50191219..58535818 [GRCh38] Chr19:50694476..59047185 [GRCh37] Chr19:55386288..63738997 [NCBI36] Chr19:19q13.33-13.43	pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:49907832-58557889)x3	copy number gain	See cases [RCV000052925]	Chr19:49907832..58557889 [GRCh38] Chr19:50411089..59069256 [GRCh37] Chr19:55102901..63761068 [NCBI36] Chr19:19q13.33-13.43	pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3	copy number gain	See cases [RCV000052914]	Chr19:47908540..58539965 [GRCh38] Chr19:48411797..59051332 [GRCh37] Chr19:53103609..63743144 [NCBI36] Chr19:19q13.33-13.43	pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3	copy number gain	See cases [RCV000052915]	Chr19:47929575..58572206 [GRCh38] Chr19:48432832..59083573 [GRCh37] Chr19:53124644..63775385 [NCBI36] Chr19:19q13.33-13.43	pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:50152520-58581203)x3	copy number gain	See cases [RCV000135843]	Chr19:50152520..58581203 [GRCh38] Chr19:50655777..59092570 [GRCh37] Chr19:55347589..63784382 [NCBI36] Chr19:19q13.33-13.43	pathogenic
GRCh37/hg19 19q13.41(chr19:51509726-51514622)x1	copy number loss	not provided [RCV000752740]	Chr19:51509726..51514622 [GRCh37] Chr19:19q13.41	benign
GRCh37/hg19 19q13.41(chr19:51506148-51514437)x1	copy number loss	not provided [RCV000752739]	Chr19:51506148..51514437 [GRCh37] Chr19:19q13.41	benign
GRCh37/hg19 19q13.41(chr19:51509934-51520487)x1	copy number loss	not provided [RCV000752741]	Chr19:51509934..51520487 [GRCh37] Chr19:19q13.41	benign
GRCh37/hg19 19q13.33-13.43(chr19:50489390-59095359)x3	copy number gain	See cases [RCV000445925]	Chr19:50489390..59095359 [GRCh37] Chr19:19q13.33-13.43	pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3	copy number gain	See cases [RCV000511289]	Chr19:260912..58956888 [GRCh37] Chr19:19p13.3-q13.43	pathogenic\|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)	copy number gain	See cases [RCV000512296]	Chr19:260912..58956888 [GRCh37] Chr19:19p13.3-q13.43	pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3	copy number gain	not provided [RCV000752444]	Chr19:260912..59097160 [GRCh37] Chr19:19p13.3-q13.43	pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3	copy number gain	not provided [RCV000752439]	Chr19:68029..59110290 [GRCh37] Chr19:19p13.3-q13.43	pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:50740074-59097160)x3	copy number gain	not provided [RCV000740208]	Chr19:50740074..59097160 [GRCh37] Chr19:19q13.33-13.43	pathogenic
GRCh37/hg19 19q13.33-13.41(chr19:50469730-51916485)x3	copy number gain	not provided [RCV001007055]	Chr19:50469730..51916485 [GRCh37] Chr19:19q13.33-13.41	uncertain significance
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3	copy number gain	not provided [RCV001007050]	Chr19:44738088..53621561 [GRCh37] Chr19:19q13.31-13.42	pathogenic
GRCh37/hg19 19q13.32-13.42(chr19:47939842-54626871)	copy number gain	not provided [RCV001249294]	Chr19:47939842..54626871 [GRCh37] Chr19:19q13.32-13.42	not provided
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3	copy number gain	not provided [RCV001259944]	Chr19:48463931..57095254 [GRCh37] Chr19:19q13.33-13.43	pathogenic
GRCh37/hg19 19q13.33-13.41(chr19:49911081-53127438)	copy number gain	not specified [RCV002052689]	Chr19:49911081..53127438 [GRCh37] Chr19:19q13.33-13.41	likely pathogenic
NM_012315.2(KLK9):c.313G>A (p.Ala105Thr)	single nucleotide variant	Inborn genetic diseases [RCV002728654]	Chr19:51006611 [GRCh38] Chr19:51509867 [GRCh37] Chr19:19q13.41	uncertain significance
NM_012315.2(KLK9):c.214C>T (p.Arg72Cys)	single nucleotide variant	Inborn genetic diseases [RCV002990702]	Chr19:51006710 [GRCh38] Chr19:51509966 [GRCh37] Chr19:19q13.41	uncertain significance
NM_012315.2(KLK9):c.406T>C (p.Cys136Arg)	single nucleotide variant	Inborn genetic diseases [RCV002734314]	Chr19:51006518 [GRCh38] Chr19:51509774 [GRCh37] Chr19:19q13.41	uncertain significance
NM_012315.2(KLK9):c.715C>T (p.His239Tyr)	single nucleotide variant	Inborn genetic diseases [RCV002792723]	Chr19:51003149 [GRCh38] Chr19:51506405 [GRCh37] Chr19:19q13.41	uncertain significance
NM_012315.2(KLK9):c.568G>A (p.Ala190Thr)	single nucleotide variant	Inborn genetic diseases [RCV002793230]	Chr19:51003739 [GRCh38] Chr19:51506995 [GRCh37] Chr19:19q13.41	uncertain significance
NM_012315.2(KLK9):c.149C>T (p.Ala50Val)	single nucleotide variant	Inborn genetic diseases [RCV003348420]	Chr19:51009234 [GRCh38] Chr19:51512490 [GRCh37] Chr19:19q13.41	uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:49625130-57647352)x3	copy number gain	not provided [RCV003485200]	Chr19:49625130..57647352 [GRCh37] Chr19:19q13.33-13.43	likely pathogenic
GRCh37/hg19 19q13.33-13.41(chr19:48905537-51614930)x3	copy number gain	not specified [RCV003986127]	Chr19:48905537..51614930 [GRCh37] Chr19:19q13.33-13.41	likely pathogenic

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	2262
Count of miRNA genes:	747
Interacting mature miRNAs:	873
Transcripts:	ENST00000250366, ENST00000376832, ENST00000544410, ENST00000594211, ENST00000599166
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

KLK9_3646

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	19	51,505,643 - 51,506,411	UniSTS	GRCh37
Build 36	19	56,197,455 - 56,198,223	RGD	NCBI36
Celera	19	48,557,687 - 48,558,455	RGD
HuRef	19	47,838,409 - 47,839,177	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

adipose tissue

appendage

High

Medium

468

344

Low

827

128

351

Below cutoff

308

279

157

173

425

345

559

542

210

145

325

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_027832	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_012315	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC011473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF135026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF243527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY551001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068259	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CS300780	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX571238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX571239	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX571240	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX571241	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX571242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX571243	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX571244	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX571245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX571246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX571247	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000250366 ⟹ ENSP00000250366

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	19	51,000,550 - 51,009,581 (-)	Ensembl

RefSeq Acc Id:

ENST00000544410 ⟹ ENSP00000443289

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	19	51,003,111 - 51,009,634 (-)	Ensembl

RefSeq Acc Id:

ENST00000594211 ⟹ ENSP00000469417

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	19	51,002,508 - 51,009,592 (-)	Ensembl

RefSeq Acc Id:

ENST00000599166 ⟹ ENSP00000471395

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	19	50,996,018 - 51,003,829 (-)	Ensembl

RefSeq Acc Id:

NM_012315 ⟹ NP_036447

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	19	51,002,508 - 51,009,592 (-)	NCBI
GRCh37	19	51,505,769 - 51,512,890 (-)	RGD
Build 36	19	56,197,581 - 56,204,702 (-)	NCBI Archive
Celera	19	48,557,813 - 48,564,935 (-)	RGD
HuRef	19	47,838,535 - 47,845,658 (-)	ENTREZGENE
CHM1_1	19	51,507,767 - 51,514,843 (-)	NCBI
T2T-CHM13v2.0	19	54,090,979 - 54,098,065 (-)	NCBI

Sequence:

show sequence

ACTGGACGCCGGGTGCACGTTCCAGGATCCAGGTGCCCAGGGGTCATGAAGCTGGGACTCCTCT
GTGCTCTGCTCTCTCTGCTGGCAGGGCATGGCTGGGCAGACACCCGTGCCATCGGGGCCGAGGA
ATGTCGCCCCAACTCCCAGCCTTGGCAGGCCGGCCTCTTCCACCTTACTCGGCTCTTCTGTGGG
GCGACCCTCATCAGTGACCGCTGGCTGCTCACAGCTGCCCACTGCCGCAAGCCGTATCTGTGGG
TCCGCCTTGGAGAGCACCACCTCTGGAAATGGGAGGGTCCGGAGCAGCTGTTCCGGGTTACGGA
CTTCTTCCCCCACCCTGGCTTCAACAAGGACCTCAGCGCCAATGACCACAATGATGACATCATG
CTGATCCGCCTGCCCAGGCAGGCACGTCTGAGTCCTGCTGTGCAGCCCCTCAACCTCAGCCAGA
CCTGTGTCTCCCCAGGCATGCAGTGTCTCATCTCAGGCTGGGGGGCCGTGTCCAGCCCCAAGGC
GCTGTTTCCAGTCACACTGCAGTGTGCCAACATCAGCATCCTGGAGAACAAACTCTGTCACTGG
GCATACCCTGGACACATCTCGGACAGCATGCTCTGTGCGGGCCTGTGGGAGGGGGGCCGAGGTT
CCTGCCAGGGTGACTCTGGGGGCCCCCTGGTTTGCAATGGAACCTTGGCAGGCGTGGTGTCTGG
GGGTGCTGAGCCCTGCTCCAGACCCCGGCGCCCCGCAGTCTACACCAGCGTATGCCACTACCTT
GACTGGATCCAAGAAATCATGGAGAACTGAGCCCGCGCGCCACGGGGGCACCTTGGAAGACCAA
GAGAGGCCGAAGGGCACGGGGTAGGGGGTTCTCGTAGGGTCCCAGCCTCAATGGTTCCCGCCCT
GGACCTCCAGCTGCCCTGACTCCCCTCTGGACACTAAGACTCCGCCCCTGAGGCTCCGCCCCCT
CACGAGGTCAAGCAAGACACAGTCGCGCCCCCTCGGAACGGAGCAGGGACACGCCCTTCAGAGC
CCGTCTCTATGACGTCACCGACAGCCATCACCTCCTTCTTGGAACAGCACAGCCTGTGGCTCCG
CCCCAAGGAACCACTTACACAAAATAGCTCCGCCCCTCGGAACTTTGCCCAGTGGGACTTCCCC
TCGGGACTCCACCCCTTGTGGCCCCGCCTCCTTCACCAGAGATCTCGCCCCTCGTGATGTCAGG
GGCGCAGTAGCTCCGCCCACGTGGAGCTCGGGCGGTGTAGAGCTCAGCCCCTTGTGGCCCCGTC
CTGGGCGTGTGCTGGGTTTGAATCCTGGCGGAGACCTGGGGGGAAATTGAGGGAGGGTCTGGAT
ACCTTTAGAGCCAATGCAACGGATGATTTTTCAGTAAACGCGGGAAACCTCACCTTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_036447	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD26427	(Get FASTA)	NCBI Sequence Viewer
	AAG22845	(Get FASTA)	NCBI Sequence Viewer
	AAG23255	(Get FASTA)	NCBI Sequence Viewer
	AAG33362	(Get FASTA)	NCBI Sequence Viewer
	AAS55655	(Get FASTA)	NCBI Sequence Viewer
	AQR57586	(Get FASTA)	NCBI Sequence Viewer
	AQR57587	(Get FASTA)	NCBI Sequence Viewer
	AQR57588	(Get FASTA)	NCBI Sequence Viewer
	AQR57589	(Get FASTA)	NCBI Sequence Viewer
	AQR57590	(Get FASTA)	NCBI Sequence Viewer
	AQR57591	(Get FASTA)	NCBI Sequence Viewer
	AQR57592	(Get FASTA)	NCBI Sequence Viewer
	CAK32444	(Get FASTA)	NCBI Sequence Viewer
	EAW71965	(Get FASTA)	NCBI Sequence Viewer
	EAW71966	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000443289.1
	ENSP00000469417
	ENSP00000469417.1
	ENSP00000471395.1
GenBank Protein	Q9UKQ9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_036447 ⟸ NM_012315
- Peptide Label:	precursor
- UniProtKB:	Q6QA55 (UniProtKB/Swiss-Prot), Q9UKQ9 (UniProtKB/Swiss-Prot), Q2XQG6 (UniProtKB/TrEMBL), A0A1R3UF82 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKLGLLCALLSLLAGHGWADTRAIGAEECRPNSQPWQAGLFHLTRLFCGATLISDRWLLTAAHC RKPYLWVRLGEHHLWKWEGPEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPRQARLSPAVQ PLNLSQTCVSPGMQCLISGWGAVSSPKALFPVTLQCANISILENKLCHWAYPGHISDSMLCAGL WEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYTSVCHYLDWIQEIMEN hide sequence

RefSeq Acc Id:

ENSP00000443289 ⟸ ENST00000544410

RefSeq Acc Id:

ENSP00000471395 ⟸ ENST00000599166

RefSeq Acc Id:

ENSP00000250366 ⟸ ENST00000250366

RefSeq Acc Id:

ENSP00000469417 ⟸ ENST00000594211

Protein Domains

Peptidase S1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9UKQ9-F1-model_v2	AlphaFold	Q9UKQ9	1-250	view protein structure

Promoters

RGD ID:

13205325

Promoter ID:

EPDNEW_H26243

Type:

initiation region

Name:

KLK9_2

Description:

kallikrein related peptidase 9

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H26244

Experiment Methods:

Single-end sequencing.; Paired-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	19	51,009,253 - 51,009,313	EPDNEW

RGD ID:

13205327

Promoter ID:

EPDNEW_H26244

Type:

initiation region

Name:

KLK9_1

Description:

kallikrein related peptidase 9

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H26243

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	19	51,009,532 - 51,009,592	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:6370	AgrOrtholog
COSMIC	KLK9	COSMIC
Ensembl Genes	ENSG00000213022	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSG00000269741	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENST00000544410.1	UniProtKB/Swiss-Prot
	ENST00000594211	ENTREZGENE
	ENST00000594211.2	UniProtKB/Swiss-Prot
	ENST00000599166.5	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	ENSG00000213022	GTEx
	ENSG00000269741	GTEx
HGNC ID	HGNC:6370	ENTREZGENE
Human Proteome Map	KLK9	Human Proteome Map
InterPro	Peptidase_S1_PA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:284366	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	284366	ENTREZGENE
OMIM	605504	OMIM
PANTHER	KALLIKREIN-9	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	KALLIKREIN-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	TRYPSIN-RELATED	UniProtKB/TrEMBL
Pfam	Trypsin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA30159	PharmGKB
PRINTS	CHYMOTRYPSIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	TRYPSIN_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	Tryp_SPc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A1R3UF82	ENTREZGENE, UniProtKB/TrEMBL
	A0A2H4GSS5_HUMAN	UniProtKB/TrEMBL
	A0A2I2MP56_HUMAN	UniProtKB/TrEMBL
	A0A2I2MP57_HUMAN	UniProtKB/TrEMBL
	A0A2I2MP58_HUMAN	UniProtKB/TrEMBL
	A0A2I2MP59_HUMAN	UniProtKB/TrEMBL
	A0A2I2MP60_HUMAN	UniProtKB/TrEMBL
	A0A2I2MP61_HUMAN	UniProtKB/TrEMBL
	KLK9_HUMAN	UniProtKB/Swiss-Prot
	Q2XQG4_HUMAN	UniProtKB/TrEMBL
	Q2XQG6	ENTREZGENE, UniProtKB/TrEMBL
	Q6QA55	ENTREZGENE
	Q9HC80_HUMAN	UniProtKB/TrEMBL
	Q9UKQ9	ENTREZGENE
UniProt Secondary	Q6QA55	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-17	KLK9	kallikrein related peptidase 9		kallikrein-related peptidase 9	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar