Apc2 (APC regulator of WNT signaling pathway 2) - Rat Genome Database

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Gene: Apc2 (APC regulator of WNT signaling pathway 2) Mus musculus
Analyze
Symbol: Apc2
Name: APC regulator of WNT signaling pathway 2
RGD ID: 1317927
MGI Page MGI
Description: Predicted to enable beta-catenin binding activity; gamma-catenin binding activity; and microtubule binding activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of canonical Wnt signaling pathway; and negative regulation of microtubule depolymerization. Predicted to be located in several cellular components, including cytoskeleton; lamellipodium membrane; and midbody. Predicted to be part of beta-catenin destruction complex; catenin complex; and filamentous actin. Predicted to be active in postsynapse. Predicted to colocalize with cytoplasmic microtubule. Is expressed in several structures, including appendicular skeleton; axial skeleton; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Sotos syndrome 3; autosomal recessive intellectual developmental disorder 74; and complex cortical dysplasia with other brain malformations. Orthologous to human APC2 (APC regulator of WNT signaling pathway 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A; adenomatosis polyposis coli 2; adenomatous polyposis coli protein 2; AI852447; APCL; R75424
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,131,790 - 80,154,091 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,131,811 - 80,154,097 (+)EnsemblGRCm39 Ensembl
GRCm381080,295,956 - 80,318,257 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,295,977 - 80,318,263 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,764,565 - 79,781,001 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,704,967 - 79,719,154 (+)NCBIMGSCv36mm8
Celera1081,316,697 - 81,333,128 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genome-wide methylation in alcohol use disorder subjects: implications for an epigenetic regulation of the cortico-limbic glucocorticoid receptors (NR3C1). Gatta E, etal., Mol Psychiatry. 2021 Mar;26(3):1029-1041. doi: 10.1038/s41380-019-0449-6. Epub 2019 Jun 25.
2. Methylation of APC2, NR3C1, and DRD2 gene promoters in turkish patients with tobacco use disorder. Halit C, etal., Niger J Clin Pract. 2022 Feb;25(2):160-166. doi: 10.4103/njcp.njcp_25_21.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9601641   PMID:10021369   PMID:10349636   PMID:10516441   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12471060   PMID:12477932   PMID:15018807  
PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:21191042   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22573669   PMID:24504701   PMID:24952961   PMID:25535916  
PMID:25753423   PMID:26516211   PMID:27694902   PMID:28671696   PMID:29027285   PMID:31291912   PMID:32325033   PMID:32581705   PMID:35915179  


Genomics

Comparative Map Data
Apc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,131,790 - 80,154,091 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,131,811 - 80,154,097 (+)EnsemblGRCm39 Ensembl
GRCm381080,295,956 - 80,318,257 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,295,977 - 80,318,263 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,764,565 - 79,781,001 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,704,967 - 79,719,154 (+)NCBIMGSCv36mm8
Celera1081,316,697 - 81,333,128 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
APC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,446,230 - 1,473,244 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,446,302 - 1,473,244 (+)EnsemblGRCh38hg38GRCh38
GRCh37191,450,120 - 1,473,243 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,401,148 - 1,424,243 (+)NCBINCBI36Build 36hg18NCBI36
Build 34191,401,147 - 1,424,243NCBI
Celera191,384,145 - 1,407,242 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef191,224,572 - 1,247,128 (+)NCBIHuRef
CHM1_1191,450,140 - 1,473,245 (+)NCBICHM1_1
T2T-CHM13v2.0191,416,241 - 1,443,282 (+)NCBIT2T-CHM13v2.0
Apc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,043,010 - 10,065,037 (-)NCBIGRCr8
mRatBN7.279,392,336 - 9,414,364 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,392,336 - 9,414,310 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,269,150 - 12,285,377 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,144,492 - 14,160,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,011,953 - 12,028,180 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,258,468 - 12,280,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,258,468 - 12,275,609 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,428,263 - 12,450,249 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,903,675 - 10,920,010 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,906,422 - 10,920,010 (-)NCBI
Celera77,569,129 - 7,585,464 (-)NCBICelera
Cytogenetic Map7q11NCBI
Apc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,467,357 - 6,489,633 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,466,434 - 6,489,612 (-)NCBIChiLan1.0ChiLan1.0
APC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,792,156 - 5,819,568 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,029,060 - 5,053,706 (+)NCBINHGRI_mPanPan1
APC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,380,472 - 57,395,249 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,380,460 - 57,395,226 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,172,171 - 57,194,303 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,111,433 - 58,133,576 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,113,852 - 58,133,525 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,167,636 - 57,189,566 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,647,109 - 57,669,227 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,849,121 - 57,871,249 (-)NCBIUU_Cfam_GSD_1.0
Apc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,047,462 - 217,067,723 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588767,066 - 786,951 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588767,115 - 787,321 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,005,706 - 77,034,561 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,005,706 - 77,034,583 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,897,990 - 77,926,867 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.161,218,684 - 1,244,343 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660817,607,781 - 7,635,123 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,223,251 - 7,247,421 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,220,768 - 7,247,395 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apc2
346 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2749
Count of miRNA genes:661
Interacting mature miRNAs:821
Transcripts:ENSMUST00000020349, ENSMUST00000105359, ENSMUST00000138909, ENSMUST00000140658, ENSMUST00000140828, ENSMUST00000154212
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse

Markers in Region
AI852447  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381080,318,073 - 80,318,222UniSTSGRCm38
MGSCv371079,780,818 - 79,780,967UniSTSGRCm37
Celera1081,332,945 - 81,333,094UniSTS
Cytogenetic Map10B5-C2UniSTS
Cytogenetic Map10C1UniSTS
Whitehead/MRC_RH10915.98UniSTS
RH125236  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381080,317,987 - 80,318,145UniSTSGRCm38
MGSCv371079,780,732 - 79,780,890UniSTSGRCm37
Celera1081,332,859 - 81,333,017UniSTS
Cytogenetic Map10B5-C2UniSTS
Cytogenetic Map10C1UniSTS
Apc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381080,311,421 - 80,312,391UniSTSGRCm38
Celera1081,326,293 - 81,327,263UniSTS
Cytogenetic Map10B5-C2UniSTS
cM Map1039.72UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001372237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001372238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001372239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001372240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001372241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC140229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC152062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ130783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ130784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ130785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ130786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ130787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ130788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ130789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ130790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ130791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ130792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ130793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ130794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ130795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ130796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC119475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF481611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000020349   ⟹   ENSMUSP00000020349
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1080,137,654 - 80,154,090 (+)Ensembl
GRCm38.p6 Ensembl1080,301,820 - 80,318,256 (+)Ensembl
Ensembl Acc Id: ENSMUST00000105359   ⟹   ENSMUSP00000100996
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1080,131,811 - 80,154,097 (+)Ensembl
GRCm38.p6 Ensembl1080,295,977 - 80,318,263 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138909   ⟹   ENSMUSP00000116795
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1080,136,869 - 80,138,240 (+)Ensembl
GRCm38.p6 Ensembl1080,301,035 - 80,302,406 (+)Ensembl
Ensembl Acc Id: ENSMUST00000140658
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1080,136,681 - 80,139,189 (+)Ensembl
GRCm38.p6 Ensembl1080,300,847 - 80,303,355 (+)Ensembl
Ensembl Acc Id: ENSMUST00000140828   ⟹   ENSMUSP00000121324
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1080,136,868 - 80,138,181 (+)Ensembl
GRCm38.p6 Ensembl1080,301,034 - 80,302,347 (+)Ensembl
Ensembl Acc Id: ENSMUST00000154212   ⟹   ENSMUSP00000118171
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1080,134,925 - 80,138,195 (+)Ensembl
GRCm38.p6 Ensembl1080,299,091 - 80,302,361 (+)Ensembl
RefSeq Acc Id: NM_001372237   ⟹   NP_001359166
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,131,790 - 80,154,091 (+)NCBI
GRCm381080,295,956 - 80,318,257 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001372238   ⟹   NP_001359167
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,131,790 - 80,154,091 (+)NCBI
GRCm381080,295,956 - 80,318,257 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001372239   ⟹   NP_001359168
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,134,937 - 80,154,091 (+)NCBI
GRCm381080,299,103 - 80,318,257 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001372240   ⟹   NP_001359169
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,136,876 - 80,154,091 (+)NCBI
GRCm381080,301,042 - 80,318,257 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001372241   ⟹   NP_001359170
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,136,876 - 80,154,091 (+)NCBI
GRCm381080,301,042 - 80,318,257 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011789   ⟹   NP_035919
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,137,654 - 80,154,090 (+)NCBI
GRCm381080,301,820 - 80,318,256 (+)NCBI
MGSCv371079,764,565 - 79,781,001 (+)RGD
Celera1081,316,697 - 81,333,128 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006513646   ⟹   XP_006513709
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391080,134,900 - 80,154,091 (+)NCBI
GRCm381080,298,927 - 80,318,257 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035919   ⟸   NM_011789
- Peptide Label: isoform 5
- UniProtKB: Q9Z1K7 (UniProtKB/Swiss-Prot),   G5E832 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006513709   ⟸   XM_006513646
- Peptide Label: isoform X1
- UniProtKB: Q9Z1K7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001359167   ⟸   NM_001372238
- Peptide Label: isoform 3 precursor
- UniProtKB: Q9Z1K7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001359166   ⟸   NM_001372237
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9Z1K7 (UniProtKB/Swiss-Prot),   D3YTR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001359168   ⟸   NM_001372239
- Peptide Label: isoform 4
- UniProtKB: Q9Z1K7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001359169   ⟸   NM_001372240
- Peptide Label: isoform 1
- UniProtKB: Q9Z1K7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001359170   ⟸   NM_001372241
- Peptide Label: isoform 6
- UniProtKB: Q9Z1K7 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000100996   ⟸   ENSMUST00000105359
Ensembl Acc Id: ENSMUSP00000116795   ⟸   ENSMUST00000138909
Ensembl Acc Id: ENSMUSP00000020349   ⟸   ENSMUST00000020349
Ensembl Acc Id: ENSMUSP00000121324   ⟸   ENSMUST00000140828
Ensembl Acc Id: ENSMUSP00000118171   ⟸   ENSMUST00000154212
Protein Domains
Adenomatous polyposis coli N-terminal dimerisation   Adenomatous polyposis coli protein basic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1K7-F1-model_v2 AlphaFold Q9Z1K7 1-2274 view protein structure

Promoters
RGD ID:6818996
Promoter ID:MM_KWN:4859
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000105359
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361079,757,726 - 79,758,812 (+)MPROMDB
RGD ID:6818997
Promoter ID:MM_KWN:4860
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000045730
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361079,761,761 - 79,762,261 (+)MPROMDB
RGD ID:6818998
Promoter ID:MM_KWN:4861
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_011789,   OTTMUST00000045731,   OTTMUST00000045732,   OTTMUST00000045733
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361079,763,686 - 79,764,186 (+)MPROMDB
RGD ID:6846690
Promoter ID:MM_ACW:5361
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell
Transcripts:APC2.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361079,767,706 - 79,768,206 (+)MPROMDB
RGD ID:6846691
Promoter ID:MM_ACW:5362
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Brain
Transcripts:APC2.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361079,776,861 - 79,777,522 (+)MPROMDB
RGD ID:8672642
Promoter ID:EPDNEW_M14352
Type:single initiation site
Name:Apc2_1
Description:Mus musculus adenomatosis polyposis coli 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381080,301,285 - 80,301,345EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346052 AgrOrtholog
Ensembl Genes ENSMUSG00000020135 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020349 ENTREZGENE
  ENSMUST00000020349.7 UniProtKB/TrEMBL
  ENSMUST00000105359 ENTREZGENE
  ENSMUST00000105359.8 UniProtKB/TrEMBL
  ENSMUST00000138909.8 UniProtKB/TrEMBL
  ENSMUST00000140828.8 UniProtKB/TrEMBL
  ENSMUST00000154212.8 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro APC_basic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Apc_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Armadillo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1346052 ENTREZGENE
NCBI Gene 23805 ENTREZGENE
PANTHER PTHR12607 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12607:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam APC_basic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_N_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_r UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arm_APC_u3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Suppressor_APC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Apc2 PhenoGen
SMART ARM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF58050 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82931 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt APCL_MOUSE UniProtKB/Swiss-Prot
  D3YTR0 ENTREZGENE, UniProtKB/TrEMBL
  D3YYQ9_MOUSE UniProtKB/TrEMBL
  D3Z344_MOUSE UniProtKB/TrEMBL
  D3Z3K9_MOUSE UniProtKB/TrEMBL
  G5E832 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z1K7 ENTREZGENE
  W6CPJ9_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-27 Apc2  APC regulator of WNT signaling pathway 2  Apc2  adenomatosis polyposis coli 2  Symbol and/or name change 5135510 APPROVED