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Gene: RAG1 (recombination activating 1) Homo sapiens
Symbol: RAG1
Name: recombination activating 1
Description: Predicted to contribute to double-stranded DNA endodeoxyribonuclease activity. Involved in V(D)J recombination. Predicted to localize to DNA recombinase complex; endodeoxyribonuclease complex; and nucleus. Implicated in Omenn syndrome; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC43321; RAG-1; recombination activating gene 1; recombination activating protein 1; RING finger protein 74; RNF74; V(D)J recombination-activating protein 1
Mus musculus (house mouse) : Rag1 (recombination activating 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rag1 (recombination activating 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rag1 (recombination activating 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RAG1 (recombination activating 1)
Canis lupus familiaris (dog) : RAG1 (recombination activating 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rag1 (recombination activating 1)
Sus scrofa (pig) : RAG1 (recombination activating 1)
Chlorocebus sabaeus (African green monkey) : RAG1 (recombination activating 1)
Heterocephalus glaber (naked mole-rat) : Rag1 (recombination activating 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1136,510,709 - 36,593,156 (+)EnsemblGRCh38hg38GRCh38
GRCh381136,510,353 - 36,579,762 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371136,532,053 - 36,601,312 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361136,546,139 - 36,557,851 (+)NCBINCBI36hg18NCBI36
Build 341136,546,138 - 36,557,871NCBI
Celera1136,741,994 - 36,753,743 (+)NCBI
Cytogenetic Map11p12NCBI
HuRef1136,292,349 - 36,304,098 (+)NCBIHuRef
CHM1_11136,588,249 - 36,599,998 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RAG1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317876
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.