Abhd17c (abhydrolase domain containing 17C) - Rat Genome Database

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Gene: Abhd17c (abhydrolase domain containing 17C) Mus musculus
Analyze
Symbol: Abhd17c
Name: abhydrolase domain containing 17C
RGD ID: 1317856
MGI Page MGI
Description: Enables palmitoyl-(protein) hydrolase activity. Involved in negative regulation of protein localization to microtubule and positive regulation of protein localization to endosome. Located in postsynaptic density. Is expressed in several structures, including alimentary system; cortical plate; cranial ganglion; genitourinary system; and skin. Orthologous to human ABHD17C (abhydrolase domain containing 17C, depalmitoylase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2210412D01Rik; abhydrolase domain-containing protein 17C; abhydrolase domain-containing protein FAM108C1; AL023007; alpha/beta hydrolase domain-containing protein 17C; Fam108; Fam108c; Fam108c1; family with sequence similarity 108, member C
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39783,758,564 - 83,801,101 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl783,758,564 - 83,801,101 (-)EnsemblGRCm39 Ensembl
GRCm38784,109,356 - 84,151,893 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl784,109,356 - 84,151,893 (-)EnsemblGRCm38mm10GRCm38
MGSCv37791,257,866 - 91,300,403 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36783,985,544 - 84,028,078 (-)NCBIMGSCv36mm8
Celera781,514,016 - 81,556,779 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map748.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7671812   PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:19521500  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:27307232   PMID:28521134   PMID:32325033  


Genomics

Comparative Map Data
Abhd17c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39783,758,564 - 83,801,101 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl783,758,564 - 83,801,101 (-)EnsemblGRCm39 Ensembl
GRCm38784,109,356 - 84,151,893 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl784,109,356 - 84,151,893 (-)EnsemblGRCm38mm10GRCm38
MGSCv37791,257,866 - 91,300,403 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36783,985,544 - 84,028,078 (-)NCBIMGSCv36mm8
Celera781,514,016 - 81,556,779 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map748.35NCBI
ABHD17C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381580,695,310 - 80,755,621 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1580,679,684 - 80,755,621 (+)EnsemblGRCh38hg38GRCh38
GRCh371580,987,651 - 81,047,962 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361578,774,707 - 78,835,017 (+)NCBINCBI36Build 36hg18NCBI36
Celera1557,925,147 - 57,985,463 (+)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1557,745,874 - 57,806,199 (+)NCBIHuRef
CHM1_11581,105,630 - 81,165,886 (+)NCBICHM1_1
T2T-CHM13v2.01578,558,868 - 78,619,168 (+)NCBIT2T-CHM13v2.0
Abhd17c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81147,493,755 - 147,534,715 (-)NCBIGRCr8
mRatBN7.21138,084,632 - 138,125,595 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1138,084,634 - 138,125,595 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1146,025,382 - 146,066,369 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01153,194,395 - 153,235,385 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01146,069,595 - 146,110,583 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01146,248,505 - 146,289,465 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1146,248,503 - 146,289,465 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01147,177,240 - 147,218,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41140,382,433 - 140,423,393 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11140,460,837 - 140,617,700 (-)NCBI
Celera1130,105,101 - 130,146,062 (-)NCBICelera
Cytogenetic Map1q31NCBI
Abhd17c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541611,495,651 - 11,543,405 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541611,495,651 - 11,543,276 (+)NCBIChiLan1.0ChiLan1.0
ABHD17C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21669,961,549 - 70,022,177 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11574,123,788 - 74,184,270 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01559,676,295 - 59,736,771 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11578,633,494 - 78,693,159 (+)NCBIpanpan1.1PanPan1.1panPan2
ABHD17C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1356,881,405 - 56,928,305 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha359,530,349 - 59,578,106 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0357,304,187 - 57,351,926 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl357,304,187 - 57,353,444 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1356,814,246 - 56,861,971 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0357,020,436 - 57,068,329 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0357,359,618 - 57,407,376 (-)NCBIUU_Cfam_GSD_1.0
Abhd17c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640126,369,887 - 126,425,663 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648319,908,853 - 19,964,627 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABHD17C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl749,540,879 - 49,599,319 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1749,540,698 - 49,599,323 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2755,050,036 - 55,108,571 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABHD17C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1262,633,997 - 2,695,187 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048139,191,530 - 139,252,924 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abhd17c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476821,046,247 - 21,094,399 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476821,045,019 - 21,094,621 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abhd17c
1269 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:560
Count of miRNA genes:373
Interacting mature miRNAs:448
Transcripts:ENSMUST00000117085, ENSMUST00000131505
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
10053685Eae43_mexperimental allergic encephalomyelitis susceptibility 43 (mouse)Not determined75112495485125093Mouse
10054064Bwq11_mbody weight QTL 11 (mouse)Not determined75112495485125093Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
12880418V125Dq6_mvitamin D active form serum level QTL 6 (mouse)75214974886149748Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75588950887142720Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75732612191326352Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75732612191326352Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75732612191326352Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
1301383Aem2_manti-erythrocyte autoantibody modifier 2 (mouse)Not determined76413542498135653Mouse
26884381Bzwq2_mbi-zygomatic width QTL 2, 5 week (mouse)76524974896949207Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)76578898699788986Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)76578898699788986Mouse
27095937Ulnl7_mulna length 7, 10 week (mouse)76644974898349207Mouse
12801463Rta1_mretinal aging 1 (mouse)76716802789089989Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
4142319Powg_mpost-ovarectomy weight gain (mouse)Not determined7285710592582163Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)773725965107725965Mouse
4142212Png1_mPostnatal growth 1 (mouse)Not determined7432612192394346Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse
14746989Manh62_mmandible shape 62 (mouse)775742528109742528Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780551681114551791Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80551681114551791Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse

Markers in Region
RH125397  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38784,109,557 - 84,109,835UniSTSGRCm38
MGSCv37791,258,067 - 91,258,345UniSTSGRCm37
Celera781,514,216 - 81,514,494UniSTS
Cytogenetic Map7D3UniSTS
RH138465  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38784,109,797 - 84,109,922UniSTSGRCm38
MGSCv37791,258,307 - 91,258,432UniSTSGRCm37
Celera781,514,456 - 81,514,581UniSTS
Cytogenetic Map7D3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000117085   ⟹   ENSMUSP00000112988
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl783,758,564 - 83,801,101 (-)Ensembl
GRCm38.p6 Ensembl784,109,356 - 84,151,893 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131505
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl783,763,459 - 83,797,023 (-)Ensembl
GRCm38.p6 Ensembl784,114,251 - 84,147,815 (-)Ensembl
RefSeq Acc Id: ENSMUST00000208271
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl783,798,299 - 83,800,878 (-)Ensembl
GRCm38.p6 Ensembl784,149,091 - 84,151,670 (-)Ensembl
RefSeq Acc Id: NM_133722   ⟹   NP_598483
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39783,758,564 - 83,801,101 (-)NCBI
GRCm38784,109,356 - 84,151,893 (-)ENTREZGENE
MGSCv37791,257,866 - 91,300,403 (-)RGD
Celera781,514,016 - 81,556,779 (-)RGD
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_598483 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH18511 (Get FASTA)   NCBI Sequence Viewer  
  EDL06861 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000112988
  ENSMUSP00000112988.2
GenBank Protein Q8VCV1 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_598483   ⟸   NM_133722
- UniProtKB: Q8VCV1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000112988   ⟸   ENSMUST00000117085

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VCV1-F1-model_v2 AlphaFold Q8VCV1 1-320 view protein structure

Promoters
RGD ID:8664681
Promoter ID:EPDNEW_M10372
Type:initiation region
Name:Abhd17c_1
Description:Mus musculus abhydrolase domain containing 17C , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38784,151,914 - 84,151,974EPDNEW
RGD ID:6841066
Promoter ID:MM_KWN:51407
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:OTTMUST00000071677
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36791,296,311 - 91,296,811 (-)MPROMDB
RGD ID:6840544
Promoter ID:MM_KWN:51408
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung
Transcripts:NM_133722,   UC009IEE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36791,299,266 - 91,300,977 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917428 AgrOrtholog
Ensembl Genes ENSMUSG00000038459 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000117085 ENTREZGENE
  ENSMUST00000117085.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  Hydrolase_4 UniProtKB/Swiss-Prot
KEGG Report mmu:70178 UniProtKB/Swiss-Prot
MGD MGI:1917428 ENTREZGENE
NCBI Gene 70178 ENTREZGENE
PANTHER ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN 17C UniProtKB/Swiss-Prot
Pfam Hydrolase_4 UniProtKB/Swiss-Prot
PhenoGen Abhd17c PhenoGen
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt AB17C_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-02 Abhd17c  abhydrolase domain containing 17C  Fam108c  family with sequence similarity 108, member C  Symbol and/or name change 5135510 APPROVED