Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Frs2 (fibroblast growth factor receptor substrate 2) Mus musculus
Symbol: Frs2
Name: fibroblast growth factor receptor substrate 2
RGD ID: 1317843
Description: Exhibits transmembrane receptor protein tyrosine kinase adaptor activity. Involved in several processes, including animal organ development; organ induction; and regulation of MAPK cascade. Localizes to cell-cell junction; cytoplasm; and plasma membrane. Is expressed in several structures, including alimentary system; blastocyst; central nervous system; liver; and metanephros. Orthologous to human FRS2 (fibroblast growth factor receptor substrate 2); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; fibroblast growth factor signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
Also known as: 4732458E18; C330018A15Rik; FGFR substrate 2; FGFR-signaling adaptor SNT; Frs; FRS2-alpha; Frs2alpha; SN; SNT-1; SNT1; suc1-associated neurotrophic factor target 1
Homo sapiens (human) : FRS2 (fibroblast growth factor receptor substrate 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Frs2 (fibroblast growth factor receptor substrate 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Frs2 (fibroblast growth factor receptor substrate 2)
Pan paniscus (bonobo/pygmy chimpanzee) : FRS2 (fibroblast growth factor receptor substrate 2)
Canis lupus familiaris (dog) : FRS2 (fibroblast growth factor receptor substrate 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Frs2 (fibroblast growth factor receptor substrate 2)
Sus scrofa (pig) : FRS2 (fibroblast growth factor receptor substrate 2)
Chlorocebus sabaeus (African green monkey) : FRS2 (fibroblast growth factor receptor substrate 2)
Heterocephalus glaber (naked mole-rat) : Frs2 (fibroblast growth factor receptor substrate 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910116,905,330 - 116,984,442 (-)NCBI
GRCm3810117,070,127 - 117,148,474 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,069,427 - 117,148,534 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710116,507,183 - 116,585,530 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610116,474,237 - 116,552,584 (-)NCBImm8
Celera10119,013,278 - 119,091,626 (-)NCBICelera
Cytogenetic Map10D2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Frs2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317843
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.