Dmrta2 (doublesex and mab-3 related transcription factor like family A2) - Rat Genome Database

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Gene: Dmrta2 (doublesex and mab-3 related transcription factor like family A2) Mus musculus
Analyze
Symbol: Dmrta2
Name: doublesex and mab-3 related transcription factor like family A2
RGD ID: 1317797
MGI Page MGI
Description: Enables identical protein binding activity and sequence-specific DNA binding activity. Acts upstream of or within nervous system development; positive regulation of neuroblast proliferation; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human DMRTA2 (DMRT like family A2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Dmrt; Dmrt5; doublesex- and mab-3-related transcription factor 5; doublesex- and mab-3-related transcription factor A2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394109,835,222 - 109,840,896 (+)NCBIGRCm39mm39
GRCm39 Ensembl4109,835,250 - 109,840,884 (+)Ensembl
GRCm384109,977,989 - 109,983,691 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4109,978,053 - 109,983,687 (+)EnsemblGRCm38mm10GRCm38
MGSCv374109,650,630 - 109,656,289 (+)NCBIGRCm37mm9NCBIm37
MGSCv364109,475,985 - 109,481,616 (+)NCBImm8
Celera4108,318,012 - 108,323,671 (+)NCBICelera
Cytogenetic Map4C7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, etal., Genome Res 2000 Oct;10(10):1617-30.
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12609607   PMID:14681479   PMID:15618518   PMID:16141072   PMID:16141073   PMID:17605809   PMID:17720152   PMID:21267068  
PMID:21576465   PMID:21677750   PMID:21873635   PMID:22147266   PMID:22235033   PMID:22923088   PMID:23056351   PMID:24014668   PMID:24948604   PMID:25082981   PMID:28031177   PMID:28655839  
PMID:29025924   PMID:30143575   PMID:30529950   PMID:31371378   PMID:31845734   PMID:33707608   PMID:34163074  


Genomics

Comparative Map Data
Dmrta2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394109,835,222 - 109,840,896 (+)NCBIGRCm39mm39
GRCm39 Ensembl4109,835,250 - 109,840,884 (+)Ensembl
GRCm384109,977,989 - 109,983,691 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4109,978,053 - 109,983,687 (+)EnsemblGRCm38mm10GRCm38
MGSCv374109,650,630 - 109,656,289 (+)NCBIGRCm37mm9NCBIm37
MGSCv364109,475,985 - 109,481,616 (+)NCBImm8
Celera4108,318,012 - 108,323,671 (+)NCBICelera
Cytogenetic Map4C7NCBI
DMRTA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38150,417,550 - 50,423,443 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl150,417,550 - 50,423,443 (-)EnsemblGRCh38hg38GRCh38
GRCh37150,883,222 - 50,889,115 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36150,655,812 - 50,661,729 (-)NCBINCBI36hg18NCBI36
Build 34150,596,127 - 50,599,063NCBI
Celera149,169,119 - 49,175,035 (-)NCBI
Cytogenetic Map1p32.3NCBI
HuRef149,001,308 - 49,007,204 (-)NCBIHuRef
CHM1_1151,000,873 - 51,006,767 (-)NCBICHM1_1
T2T-CHM13v2.0150,297,157 - 50,303,048 (-)NCBI
Dmrta2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25124,805,883 - 124,811,694 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5124,805,883 - 124,811,630 (+)Ensembl
Rnor_6.05129,754,295 - 129,760,045 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5129,756,149 - 129,758,986 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05133,586,293 - 133,592,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45131,410,451 - 131,416,198 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15131,417,530 - 131,420,383 (+)NCBI
Celera5123,544,868 - 123,550,615 (+)NCBICelera
Cytogenetic Map5q35NCBI
Dmrta2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554648,495,055 - 8,497,909 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554648,493,392 - 8,498,007 (+)NCBIChiLan1.0ChiLan1.0
DMRTA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1151,166,161 - 51,170,399 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0149,659,379 - 49,665,262 (-)NCBIMhudiblu_PPA_v0panPan3
DMRTA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11510,706,096 - 10,710,506 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1510,856,530 - 10,860,875 (+)NCBI
ROS_Cfam_1.01510,842,633 - 10,846,982 (+)NCBI
ROS_Cfam_1.0 Ensembl1510,844,098 - 10,846,907 (+)Ensembl
UMICH_Zoey_3.11510,642,900 - 10,647,244 (+)NCBI
UNSW_CanFamBas_1.01510,731,267 - 10,735,476 (+)NCBI
UU_Cfam_GSD_1.01510,748,208 - 10,752,562 (+)NCBI
Dmrta2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505865,233,995 - 65,240,604 (-)NCBI
SpeTri2.0NW_00493652210,175,742 - 10,181,596 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DMRTA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6161,616,646 - 161,621,904 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16161,616,646 - 161,622,591 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26149,319,448 - 149,324,965 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DMRTA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12082,489,938 - 82,496,302 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2082,492,299 - 82,495,173 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603334,697,589 - 34,703,671 (-)NCBIVero_WHO_p1.0
Dmrta2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248592,645,733 - 2,648,559 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248592,644,569 - 2,649,581 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Dmrta2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4C7UniSTS
cM Map4 UniSTS
Dmrta2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4C7UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
27095939Ulnl9_mulna length 9, 16 week (mouse)465318237118857197Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
1301597Anxty_manxiety (mouse)Not determined474137574128009280Mouse
1301545Gauc_mglucose area under curve (mouse)Not determined476763107110763305Mouse
1300697Sle2_msystemic lupus erythmatosus susceptibility 2 (mouse)Not determined477957579111957775Mouse
11039504Ltpr4a_mLeishmania tropica response 4a (mouse)479365751113365867Mouse
11039505Ltpr4c_mLeishmania tropica response 4c (mouse)479365751113365867Mouse
11039506Ltpr4b_mLeishmania tropica response 4b (mouse)479365751113365867Mouse
11039517Ltpr4_mLeishmania tropica response 4 (mouse)479365751113365867Mouse
12904933Edlmmq3_mextensor digitorum longus muscle mass QTL 3 (mouse)481213991115213991Mouse
1302204Spm1_msplenomegaly modifier (mouse)Not determined482244395116244582Mouse
1301867Idd11_minsulin dependent diabetes susceptibility 11 (mouse)Not determined483604870117605006Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485428838119429037Mouse
1301556Cd4vts1_mCD4 virgin T cell subset 1 (mouse)Not determined485428838119429037Mouse
1301930Papg1_mpulmonary adenoma progression 1 (mouse)Not determined485781167119781279Mouse
1301118Bbaa23_mB.burgdorferi-associated arthritis 23 (mouse)Not determined485781167119781279Mouse
27226716Metcl2_mmetatarsal-calcaneal length 2, 5 week (mouse)488118237118557197Mouse
11532738Abd1_mautoimmune biliary disease 1 (mouse)488982069116271120Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
13824982Svwq1_mseminal vesicle weight QTL 1 (mouse)489888237118857197Mouse
1300918Stheal4_msoft tissue heal 4 (mouse)Not determined489969627123969747Mouse
11553870Cmmm_mcarcinoma modifier of MSM (mouse)490590668124590781Mouse
15039368Nmrs19_mNAFLD-associated magnetic resonance shift 19 (mouse)490882780124882780Mouse
27226782Tibl2_mtibia length 2, 5 week (mouse)490888237111257197Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)492975790126975790Mouse
1301731Cafq2_mcaffeine metabolism QTL 2 (mouse)Not determined494732255128732454Mouse
1301233Sbw2_msplenomegaly-NZB x NZW 2 (mouse)Not determined494957579128009280Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
14696687Gdq1_mgrooming duration QTL 1, males (mouse)496888237111857197Mouse
1300580Lbw2_mlupus NZB x NZW 2 (mouse)Not determined498545539128009280Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
14696689Gdq2_mgrooming duration QTL 2, females (mouse)4100857197124893793Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
1300689Dob1_mDietary obesity 1 (mouse)Body weight4101574601123127211Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10412072Ssen1_msuseptibility to Sendai virus 1 (mouse)Not determined4109658132133154782Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:446
Count of miRNA genes:290
Interacting mature miRNAs:340
Transcripts:ENSMUST00000061187
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000061187   ⟹   ENSMUSP00000060441
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4109,835,250 - 109,840,884 (+)Ensembl
GRCm38.p6 Ensembl4109,978,053 - 109,983,687 (+)Ensembl
RefSeq Acc Id: NM_172296   ⟹   NP_758500
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394109,835,222 - 109,840,881 (+)NCBI
GRCm384109,978,025 - 109,983,684 (+)NCBI
MGSCv374109,650,630 - 109,656,289 (+)RGD
Celera4108,318,012 - 108,323,671 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006503093   ⟹   XP_006503156
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394109,835,451 - 109,840,888 (+)NCBI
GRCm384109,977,989 - 109,983,691 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006503094   ⟹   XP_006503157
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394109,835,737 - 109,840,896 (+)NCBI
GRCm384109,978,526 - 109,983,691 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_758500 (Get FASTA)   NCBI Sequence Viewer  
  XP_006503156 (Get FASTA)   NCBI Sequence Viewer  
  XP_006503157 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A2A9A2 (Get FASTA)   NCBI Sequence Viewer  
  AAN10254 (Get FASTA)   NCBI Sequence Viewer  
  EDL30694 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_758500   ⟸   NM_172296
- UniProtKB: A2A9A2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006503156   ⟸   XM_006503093
- Peptide Label: isoform X1
- UniProtKB: A2A9A2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006503157   ⟸   XM_006503094
- Peptide Label: isoform X1
- UniProtKB: A2A9A2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000060441   ⟸   ENSMUST00000061187
Protein Domains
DMA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A2A9A2-F1-model_v2 AlphaFold A2A9A2 1-531 view protein structure

Promoters
RGD ID:6835164
Promoter ID:MM_KWN:38985
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4
Transcripts:OTTMUST00000019303,   OTTMUST00000019304,   OTTMUST00000019305
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364109,650,366 - 109,650,937 (+)MPROMDB
RGD ID:6849176
Promoter ID:MM_XEF:5065
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:NM_001007064,   NM_001037950,   NM_001095679,   NM_001103073,   NM_001103281,   NM_079704
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364109,652,396 - 109,652,896 (+)MPROMDB
RGD ID:6884178
Promoter ID:EPDNEW_M5540
Type:initiation region
Name:Dmrta2_1
Description:Mus musculus doublesex and mab-3 related transcription factorlike family A2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384109,977,978 - 109,978,038EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2653629 AgrOrtholog
Ensembl Genes ENSMUSG00000047143 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000060441 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000061187 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.1040.10 UniProtKB/Swiss-Prot
InterPro DM_DNA-bd UniProtKB/Swiss-Prot
  DM_DNA-bd_sf UniProtKB/Swiss-Prot
  DMA UniProtKB/Swiss-Prot
  DMRT/dsx/mab-3 UniProtKB/Swiss-Prot
  UBA-like_sf UniProtKB/Swiss-Prot
KEGG Report mmu:242620 UniProtKB/Swiss-Prot
MGD MGI:2653629 ENTREZGENE
NCBI Gene 242620 ENTREZGENE
PANTHER PTHR12322 UniProtKB/Swiss-Prot
Pfam DMA UniProtKB/Swiss-Prot
  PF00751 UniProtKB/Swiss-Prot
PhenoGen Dmrta2 PhenoGen
PROSITE DM_1 UniProtKB/Swiss-Prot
  DM_2 UniProtKB/Swiss-Prot
SMART SM00301 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46934 UniProtKB/Swiss-Prot
  SSF82927 UniProtKB/Swiss-Prot
UniProt A2A9A2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8CFF8 UniProtKB/Swiss-Prot