Actn2 (actinin alpha 2) - Rat Genome Database

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Gene: Actn2 (actinin alpha 2) Mus musculus
Analyze
Symbol: Actn2
Name: actinin alpha 2
RGD ID: 1317672
MGI Page MGI
Description: Enables several functions, including LIM domain binding activity; nuclear receptor coactivator activity; and transmembrane transporter binding activity. Involved in cardiac muscle cell development; positive regulation of transport; and protein localization to plasma membrane. Acts upstream of or within muscle contraction. Located in Z disc. Is expressed in several structures, including alimentary system; heart; limb; musculature; and trunk somite. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and dilated cardiomyopathy 1AA. Orthologous to human ACTN2 (actinin alpha 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; Entamoebiasis pathway; systemic lupus erythematosus pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110008F24Rik; alpha-actinin skeletal muscle; alpha-actinin-2; F-actin cross-linking protein; MGC107582
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391312,284,312 - 12,355,613 (-)NCBIGRCm39mm39
GRCm39 Ensembl1312,284,312 - 12,355,641 (-)Ensembl
GRCm381312,269,426 - 12,340,732 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1312,269,426 - 12,340,760 (-)EnsemblGRCm38mm10GRCm38
MGSCv371312,361,693 - 12,432,999 (-)NCBIGRCm37mm9NCBIm37
MGSCv361312,323,759 - 12,395,065 (-)NCBImm8
Celera1312,189,170 - 12,257,137 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7588068   PMID:8618961   PMID:9027500   PMID:9268580   PMID:9438383   PMID:10349636   PMID:10391924   PMID:10506186   PMID:10788519   PMID:10862698   PMID:10922068   PMID:11042159  
PMID:11076861   PMID:11114196   PMID:11381084   PMID:11440986   PMID:11724819   PMID:11780064   PMID:11842093   PMID:11988168   PMID:12477932   PMID:12782671   PMID:12837758   PMID:14610273  
PMID:14681479   PMID:15072553   PMID:15465019   PMID:15665106   PMID:15721864   PMID:15765519   PMID:15841212   PMID:16120608   PMID:16141072   PMID:16141073   PMID:16314518   PMID:16337936  
PMID:16407236   PMID:16585392   PMID:16635246   PMID:16638982   PMID:16710293   PMID:17110593   PMID:17360664   PMID:17904117   PMID:18425115   PMID:18554416   PMID:18761673   PMID:18799693  
PMID:18849322   PMID:19055765   PMID:19091769   PMID:19217425   PMID:19622544   PMID:19815520   PMID:19932097   PMID:19943616   PMID:20124353   PMID:20207226   PMID:20215401   PMID:20368620  
PMID:20558824   PMID:21289070   PMID:21364285   PMID:21379568   PMID:21536590   PMID:21659647   PMID:21677750   PMID:21750042   PMID:21873635   PMID:21884692   PMID:21940706   PMID:22343712  
PMID:22427672   PMID:22509354   PMID:22693585   PMID:22855565   PMID:23236519   PMID:23369715   PMID:23664615   PMID:23785297   PMID:24335256   PMID:24472646   PMID:24500875   PMID:24840128  
PMID:25299188   PMID:25348719   PMID:25787764   PMID:25987543   PMID:26075897   PMID:26113728   PMID:26143257   PMID:26212757   PMID:26688546   PMID:27333774   PMID:27348591   PMID:27405468  
PMID:27725084   PMID:28111199   PMID:28239148   PMID:28634551   PMID:28669819   PMID:28826478   PMID:29021295   PMID:29078393   PMID:29117561   PMID:29206857   PMID:29374072   PMID:29565969  
PMID:29891665   PMID:30121012   PMID:30335684   PMID:30457570   PMID:30562941   PMID:30947518   PMID:31201155   PMID:31467300   PMID:31513549   PMID:31573406   PMID:31581792   PMID:31688894  
PMID:32068311   PMID:32325033   PMID:32376900   PMID:32451822   PMID:32994313   PMID:33361330   PMID:33397958   PMID:33414188   PMID:33742095  


Genomics

Comparative Map Data
Actn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391312,284,312 - 12,355,613 (-)NCBIGRCm39mm39
GRCm39 Ensembl1312,284,312 - 12,355,641 (-)Ensembl
GRCm381312,269,426 - 12,340,732 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1312,269,426 - 12,340,760 (-)EnsemblGRCm38mm10GRCm38
MGSCv371312,361,693 - 12,432,999 (-)NCBIGRCm37mm9NCBIm37
MGSCv361312,323,759 - 12,395,065 (-)NCBImm8
Celera1312,189,170 - 12,257,137 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.54NCBI
ACTN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1236,664,141 - 236,764,631 (+)EnsemblGRCh38hg38GRCh38
GRCh381236,686,499 - 236,764,631 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371236,849,799 - 236,927,931 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361234,916,422 - 234,993,863 (+)NCBINCBI36hg18NCBI36
Build 341233,175,848 - 233,253,281NCBI
Celera1210,097,994 - 210,176,743 (+)NCBI
Cytogenetic Map1q43NCBI
HuRef1207,337,725 - 207,384,040 (+)NCBIHuRef
CHM1_11238,123,313 - 238,199,388 (+)NCBICHM1_1
Actn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21758,143,334 - 58,210,622 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1758,142,625 - 58,210,622 (+)Ensembl
Rnor_6.01766,304,530 - 66,397,647 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1766,304,501 - 66,397,653 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01768,050,946 - 68,143,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41768,705,160 - 68,773,261 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11768,681,756 - 68,784,094 (+)NCBI
Celera1762,323,048 - 62,390,681 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
Actn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554923,483,511 - 3,555,190 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554923,483,704 - 3,554,831 (-)NCBIChiLan1.0ChiLan1.0
ACTN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11217,276,899 - 217,321,103 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1217,272,597 - 217,321,103 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01212,245,742 - 212,323,387 (+)NCBIMhudiblu_PPA_v0panPan3
ACTN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.143,348,529 - 3,415,275 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl43,348,449 - 3,415,273 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha43,395,551 - 3,461,987 (-)NCBI
ROS_Cfam_1.043,368,361 - 3,435,149 (-)NCBI
UMICH_Zoey_3.143,368,494 - 3,434,944 (-)NCBI
UNSW_CanFamBas_1.043,498,915 - 3,565,693 (-)NCBI
UU_Cfam_GSD_1.043,719,762 - 3,786,237 (-)NCBI
Actn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934440,023,215 - 40,083,168 (-)NCBI
SpeTri2.0NW_00493648416,186,844 - 16,248,394 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1454,666,623 - 54,742,779 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11454,670,727 - 54,742,717 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21458,645,069 - 58,717,200 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12573,827,900 - 73,904,516 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2573,827,874 - 73,905,146 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605575,920,990 - 76,003,746 (+)NCBIVero_WHO_p1.0
Actn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477513,917,215 - 13,989,093 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D13Mit173  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381312,330,386 - 12,330,533UniSTSGRCm38
MGSCv371312,422,653 - 12,422,800UniSTSGRCm37
Celera1312,250,049 - 12,250,213UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
Whitehead Genetic132.2UniSTS
Whitehead/MRC_RH13189.5UniSTS
Whitehead_YAC13 UniSTS
Actn2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
Actn2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381312,309,671 - 12,310,923UniSTSGRCm38
MGSCv371312,401,938 - 12,403,190UniSTSGRCm37
Celera1312,229,337 - 12,230,589UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
Actn2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
Actn2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
cM Map12 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301661Tshp13_mtooth shape 13 (mouse)Not determined13123404636Mouse
1301227Skull19_mskull morphology 19 (mouse)Not determined13123404636Mouse
1301890Adip7_madiposity 7 (mouse)Not determined13123404636Mouse
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined13133994099Mouse
10449140Eosn2_meosinophil differential 2 (mouse)134672634046726Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)134672634046726Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13329344237293650Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13329344237293650Mouse
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13329344237293650Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13343134237431502Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13349603037496173Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13390000075900000Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13436402652947604Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:375
Count of miRNA genes:239
Interacting mature miRNAs:270
Transcripts:ENSMUST00000064204, ENSMUST00000110616, ENSMUST00000168193
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000064204   ⟹   ENSMUSP00000067708
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1312,284,312 - 12,355,641 (-)Ensembl
GRCm38.p6 Ensembl1312,269,426 - 12,340,760 (-)Ensembl
RefSeq Acc Id: ENSMUST00000110616
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1312,323,105 - 12,355,613 (-)Ensembl
GRCm38.p6 Ensembl1312,308,219 - 12,340,732 (-)Ensembl
RefSeq Acc Id: ENSMUST00000168193   ⟹   ENSMUSP00000129609
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1312,284,321 - 12,355,605 (-)Ensembl
GRCm38.p6 Ensembl1312,269,435 - 12,340,724 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221162   ⟹   ENSMUSP00000152121
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1312,289,964 - 12,297,433 (-)Ensembl
GRCm38.p6 Ensembl1312,275,078 - 12,282,547 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222034
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1312,284,364 - 12,288,982 (-)Ensembl
GRCm38.p6 Ensembl1312,269,478 - 12,274,096 (-)Ensembl
RefSeq Acc Id: NM_033268   ⟹   NP_150371
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391312,284,312 - 12,355,613 (-)NCBI
GRCm381312,269,426 - 12,340,732 (-)ENTREZGENE
MGSCv371312,361,693 - 12,432,999 (-)RGD
Celera1312,189,170 - 12,257,137 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036157837   ⟹   XP_036013730
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391312,284,312 - 12,325,821 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_150371   ⟸   NM_033268
- UniProtKB: Q9JI91 (UniProtKB/Swiss-Prot),   Q5FW75 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000129609   ⟸   ENSMUST00000168193
RefSeq Acc Id: ENSMUSP00000067708   ⟸   ENSMUST00000064204
RefSeq Acc Id: ENSMUSP00000152121   ⟸   ENSMUST00000221162
RefSeq Acc Id: XP_036013730   ⟸   XM_036157837
- Peptide Label: isoform X1
Protein Domains
Calponin-homology (CH)   EF-hand

Promoters
RGD ID:8679578
Promoter ID:EPDNEW_M17820
Type:multiple initiation site
Name:Actn2_1
Description:Mus musculus actinin alpha 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381312,340,732 - 12,340,792EPDNEW
RGD ID:6847023
Promoter ID:MM_ACW:12441
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ACTN2.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361312,365,761 - 12,366,261 (-)MPROMDB
RGD ID:6823630
Promoter ID:MM_KWN:13226
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:ENSMUST00000110616,   OTTMUST00000041266
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361312,432,626 - 12,433,126 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109192 AgrOrtholog
Ensembl Genes ENSMUSG00000052374 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000067708 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000129609 UniProtKB/Swiss-Prot
  ENSMUSP00000152121 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000064204 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000168193 UniProtKB/Swiss-Prot
  ENSMUST00000221162 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_Ca_insen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11472 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109192 ENTREZGENE
NCBI Gene 11472 ENTREZGENE
Pfam EF-hand_8 UniProtKB/TrEMBL
  EFhand_Ca_insen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Actn2 PhenoGen
PROSITE ACTININ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00033 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1Y7VMW4_MOUSE UniProtKB/TrEMBL
  ACTN2_MOUSE UniProtKB/Swiss-Prot
  Q5FW75 ENTREZGENE, UniProtKB/TrEMBL
  Q8K3Q4_MOUSE UniProtKB/TrEMBL
  Q9CTH3_MOUSE UniProtKB/TrEMBL
  Q9JI91 ENTREZGENE
UniProt Secondary G3UW84 UniProtKB/Swiss-Prot