RAD21 (RAD21 cohesin complex component) - Rat Genome Database

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Gene: RAD21 (RAD21 cohesin complex component) Homo sapiens
Analyze
Symbol: RAD21
Name: RAD21 cohesin complex component
RGD ID: 1317642
HGNC Page HGNC
Description: Predicted to have chromatin binding activity. Involved in positive regulation of sister chromatid cohesion; protein localization to chromatin; and regulation of transcription by RNA polymerase II. Localizes to cohesin complex; nuclear matrix; and nucleoplasm. Implicated in Cornelia de Lange syndrome 4.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDLS4; double-strand-break repair protein rad21 homolog; FLJ25655; FLJ40596; hHR21; HR21; HRAD21; KIAA0078; kleisin; MCD1; MGS; nuclear matrix protein 1; NXP-1; NXP1; protein involved in DNA double-strand break repair; RAD21 homolog; SCC1; SCC1 homolog; sister chromatid cohesion 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: RAD21P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8116,845,935 - 116,874,866 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl8116,845,934 - 116,874,776 (-)EnsemblGRCh38hg38GRCh38
GRCh388116,845,934 - 116,874,776 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378117,858,173 - 117,887,015 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368117,927,355 - 117,956,182 (-)NCBINCBI36hg18NCBI36
Build 348117,927,354 - 117,956,182NCBI
Celera8114,046,862 - 114,075,794 (-)NCBI
Cytogenetic Map8q24.11NCBI
HuRef8113,184,591 - 113,213,523 (-)NCBIHuRef
CHM1_18117,898,409 - 117,927,335 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormality of the autonomic nervous system  (IAGP)
Abnormality of the uterus  (IAGP)
Abnormally low-pitched voice  (IAGP)
Anteverted nares  (IAGP)
Anxiety  (IAGP)
Aplasia/Hypoplasia of the cerebellum  (IAGP)
Atresia of the external auditory canal  (IAGP)
Atrial septal defect  (IAGP)
Attention deficit hyperactivity disorder  (IAGP)
Autism  (IAGP)
Autosomal dominant inheritance  (IAGP)
Autosomal recessive inheritance  (IAGP)
Barrett esophagus  (IAGP)
Bilateral ptosis  (IAGP)
Bilateral single transverse palmar creases  (IAGP)
Blepharitis  (IAGP)
Brachycephaly  (IAGP)
Brachydactyly  (IAGP)
Cataract  (IAGP)
Cerebral cortical atrophy  (IAGP)
Choanal atresia  (IAGP)
Cleft palate  (IAGP)
Clinodactyly of the 5th finger  (IAGP)
Conductive hearing impairment  (IAGP)
Congenital diaphragmatic hernia  (IAGP)
Cryptorchidism  (IAGP)
Curly eyelashes  (IAGP)
Cutis marmorata  (IAGP)
Delayed eruption of teeth  (IAGP)
Delayed puberty  (IAGP)
Delayed skeletal maturation  (IAGP)
Depressed nasal bridge  (IAGP)
Downturned corners of mouth  (IAGP)
Elbow dislocation  (IAGP)
Exostoses  (IAGP)
Failure to thrive  (IAGP)
Feeding difficulties in infancy  (IAGP)
Gastroesophageal reflux  (IAGP)
Generalized hirsutism  (IAGP)
Glaucoma  (IAGP)
Global developmental delay  (IAGP)
Hemivertebrae  (IAGP)
High palate  (IAGP)
Highly arched eyebrow  (IAGP)
Hip dislocation  (IAGP)
Hip dysplasia  (IAGP)
Hypertonia  (IAGP)
Hypoperistalsis  (IAGP)
Hypoplasia of penis  (IAGP)
Hypoplastic labia majora  (IAGP)
Hypoplastic nipples  (IAGP)
Hypospadias  (IAGP)
Hypotonia  (IAGP)
Increased nuchal translucency  (IAGP)
Intellectual disability, severe  (IAGP)
Intestinal malrotation  (IAGP)
Intestinal pseudo-obstruction  (IAGP)
Intrauterine growth retardation  (IAGP)
Joint stiffness  (IAGP)
Long eyelashes  (IAGP)
Long philtrum  (IAGP)
Low anterior hairline  (IAGP)
Low posterior hairline  (IAGP)
Low-set, posteriorly rotated ears  (IAGP)
Macrotia  (IAGP)
Megaduodenum  (IAGP)
Microcephaly  (IAGP)
Microcornea  (IAGP)
Micrognathia  (IAGP)
Micromelia  (IAGP)
Multicystic kidney dysplasia  (IAGP)
Myopia  (IAGP)
Neurological speech impairment  (IAGP)
Nystagmus  (IAGP)
Obsessive-compulsive behavior  (IAGP)
Oligodactyly  (IAGP)
Pectus excavatum  (IAGP)
Perimembranous ventricular septal defect  (IAGP)
Peripheral neuropathy  (IAGP)
Phthisis bulbi  (IAGP)
Premature birth  (IAGP)
Prenatal movement abnormality  (IAGP)
Primary amenorrhea  (IAGP)
Proximal placement of thumb  (IAGP)
Ptosis  (IAGP)
Pulmonic stenosis  (IAGP)
Pyloric stenosis  (IAGP)
Radioulnar synostosis  (IAGP)
Renal hypoplasia  (IAGP)
Renal insufficiency  (IAGP)
Seizure  (IAGP)
Sensorineural hearing impairment  (IAGP)
Severe postnatal growth retardation  (IAGP)
Short 1st metacarpal  (IAGP)
Short foot  (IAGP)
Short neck  (IAGP)
Short nose  (IAGP)
Short stature  (IAGP)
Sleep disturbance  (IAGP)
Small hand  (IAGP)
Smooth philtrum  (IAGP)
Strabismus  (IAGP)
Syndactyly  (IAGP)
Synophrys  (IAGP)
Talipes  (IAGP)
Thick eyebrow  (IAGP)
Thin upper lip vermilion  (IAGP)
Thin vermilion border  (IAGP)
Toe syndactyly  (IAGP)
Tricuspid regurgitation  (IAGP)
Truncal obesity  (IAGP)
Ventricular septal defect  (IAGP)
Ventriculomegaly  (IAGP)
Vertebral clefting  (IAGP)
Vesicoureteral reflux  (IAGP)
Volvulus  (IAGP)
Wide nasal bridge  (IAGP)
Widely spaced teeth  (IAGP)
References

Additional References at PubMed
PMID:7584044   PMID:8812457   PMID:10207075   PMID:10623634   PMID:10931856   PMID:11073952   PMID:11076961   PMID:11111111   PMID:11243849   PMID:11483345   PMID:11509732   PMID:11590136  
PMID:11793857   PMID:11875078   PMID:12034751   PMID:12198550   PMID:12200439   PMID:12417729   PMID:12477932   PMID:12672959   PMID:12930902   PMID:14603436   PMID:14702039   PMID:15489334  
PMID:15737063   PMID:15767545   PMID:15837422   PMID:15855230   PMID:16159877   PMID:16344560   PMID:16416296   PMID:16802858   PMID:17043677   PMID:17105772   PMID:17112726   PMID:17113138  
PMID:17349791   PMID:17962804   PMID:18029348   PMID:18197499   PMID:18219272   PMID:18235444   PMID:18499658   PMID:18829510   PMID:18854154   PMID:19074885   PMID:19158269   PMID:19308699  
PMID:19322193   PMID:19369356   PMID:19468298   PMID:19629043   PMID:19696148   PMID:19946888   PMID:20056645   PMID:20085707   PMID:20301283   PMID:20301533   PMID:20301702   PMID:20360068  
PMID:20364118   PMID:20404533   PMID:20404544   PMID:20467437   PMID:20818333   PMID:21043528   PMID:21111234   PMID:21255398   PMID:21873635   PMID:21875947   PMID:21876002   PMID:21880767  
PMID:21987589   PMID:22075476   PMID:22145905   PMID:22242598   PMID:22293751   PMID:22537934   PMID:22586326   PMID:22623531   PMID:22628566   PMID:22633399   PMID:22751501   PMID:22885700  
PMID:22939629   PMID:23242214   PMID:23548868   PMID:23874961   PMID:24148822   PMID:24163370   PMID:24169447   PMID:24255178   PMID:24332808   PMID:24378232   PMID:24415941   PMID:24457600  
PMID:24548858   PMID:24981860   PMID:25006131   PMID:25173175   PMID:25184681   PMID:25299688   PMID:25414306   PMID:25416956   PMID:25464844   PMID:25575569   PMID:25737280   PMID:25881024  
PMID:25921289   PMID:26186194   PMID:26299517   PMID:26344197   PMID:26420833   PMID:26496610   PMID:26527279   PMID:26529363   PMID:26777405   PMID:27248496   PMID:27634302   PMID:27882533  
PMID:28426188   PMID:28434945   PMID:28514442   PMID:28515276   PMID:29263825   PMID:29346117   PMID:29507620   PMID:29509190   PMID:29564676   PMID:29568061   PMID:29587287   PMID:29844126  
PMID:29867216   PMID:29917110   PMID:30021884   PMID:30069982   PMID:30154076   PMID:30420784   PMID:30463901   PMID:30698808   PMID:30804502   PMID:30948266   PMID:31010829   PMID:31091453  
PMID:31180492   PMID:31515488   PMID:31527615   PMID:31586073   PMID:31678930   PMID:31685992   PMID:31729382   PMID:31781308   PMID:31884342   PMID:32193685   PMID:32416067   PMID:32572027  
PMID:32687945   PMID:32786267   PMID:32877691   PMID:33096935   PMID:33251678  


Genomics

Comparative Map Data
RAD21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8116,845,935 - 116,874,866 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl8116,845,934 - 116,874,776 (-)EnsemblGRCh38hg38GRCh38
GRCh388116,845,934 - 116,874,776 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378117,858,173 - 117,887,015 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368117,927,355 - 117,956,182 (-)NCBINCBI36hg18NCBI36
Build 348117,927,354 - 117,956,182NCBI
Celera8114,046,862 - 114,075,794 (-)NCBI
Cytogenetic Map8q24.11NCBI
HuRef8113,184,591 - 113,213,523 (-)NCBIHuRef
CHM1_18117,898,409 - 117,927,335 (-)NCBICHM1_1
Rad21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391551,826,000 - 51,856,934 (-)NCBIGRCm39mm39
GRCm39 Ensembl1551,825,636 - 51,855,143 (-)Ensembl
GRCm381551,962,604 - 51,993,538 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1551,962,240 - 51,991,747 (-)EnsemblGRCm38mm10GRCm38
MGSCv371551,794,150 - 51,823,306 (-)NCBIGRCm37mm9NCBIm37
MGSCv361551,792,680 - 51,821,636 (-)NCBImm8
Celera1553,535,633 - 53,555,853 (-)NCBICelera
Cytogenetic Map15CNCBI
Rad21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2783,287,867 - 83,314,810 (-)NCBI
Rnor_6.0 Ensembl791,511,756 - 91,538,673 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0791,511,755 - 91,538,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0792,155,546 - 92,182,749 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4788,267,648 - 88,294,703 (-)NCBIRGSC3.4rn4RGSC3.4
Celera780,164,565 - 80,191,459 (-)NCBICelera
Cytogenetic Map7q31NCBI
Rad21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541722,941,479 - 22,966,837 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541722,941,549 - 22,966,395 (-)NCBIChiLan1.0ChiLan1.0
RAD21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18116,063,503 - 116,092,421 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8116,063,503 - 116,092,421 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08113,520,456 - 113,549,339 (-)NCBIMhudiblu_PPA_v0panPan3
RAD21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11316,337,563 - 16,368,041 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1316,338,972 - 16,368,035 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1316,338,678 - 16,369,154 (-)NCBI
ROS_Cfam_1.01316,626,236 - 16,656,848 (-)NCBI
UMICH_Zoey_3.11316,369,666 - 16,400,273 (-)NCBI
UNSW_CanFamBas_1.01316,469,992 - 16,500,602 (-)NCBI
UU_Cfam_GSD_1.01316,711,252 - 16,741,853 (-)NCBI
Rad21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530321,951,734 - 21,978,780 (+)NCBI
SpeTri2.0NW_00493647029,377,793 - 29,403,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAD21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl421,772,888 - 21,809,435 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1421,772,821 - 21,802,453 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2423,059,570 - 23,262,558 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAD21
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18111,486,356 - 111,515,641 (-)NCBI
ChlSab1.1 Ensembl8111,486,048 - 111,507,729 (-)Ensembl
Vero_WHO_p1.0NW_02366603928,811,005 - 28,840,566 (+)NCBI
Rad21
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476315,131,106 - 15,157,512 (-)NCBI

Position Markers
RH25306  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378117,859,503 - 117,859,673UniSTSGRCh37
GRCh37X100,058,117 - 100,058,285UniSTSGRCh37
Build 36X99,944,773 - 99,944,941RGDNCBI36
Celera8114,048,192 - 114,048,362UniSTS
CeleraX100,576,908 - 100,577,076RGD
Cytogenetic MapXq22.1UniSTS
Cytogenetic Map8q24UniSTS
HuRef8113,185,921 - 113,186,091UniSTS
HuRefX89,857,158 - 89,857,326UniSTS
RH65259  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378117,858,622 - 117,858,773UniSTSGRCh37
Build 368117,927,803 - 117,927,954RGDNCBI36
Celera8114,047,311 - 114,047,462RGD
Cytogenetic Map8q24UniSTS
HuRef8113,185,040 - 113,185,191UniSTS
G42913  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378117,858,673 - 117,858,773UniSTSGRCh37
Build 368117,927,854 - 117,927,954RGDNCBI36
Celera8114,047,362 - 114,047,462RGD
Cytogenetic Map8q24UniSTS
HuRef8113,185,091 - 113,185,191UniSTS
G54034  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378117,858,344 - 117,858,482UniSTSGRCh37
Build 368117,927,525 - 117,927,663RGDNCBI36
Celera8114,047,033 - 114,047,171RGD
Cytogenetic Map8q24UniSTS
HuRef8113,184,762 - 113,184,900UniSTS
G59637  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378117,879,352 - 117,879,542UniSTSGRCh37
Build 368117,948,533 - 117,948,723RGDNCBI36
Celera8114,068,041 - 114,068,231RGD
Cytogenetic Map8q24UniSTS
HuRef8113,205,770 - 113,205,960UniSTS
TNG Radiation Hybrid Map858822.0UniSTS
D3S3884  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378117,859,376 - 117,859,488UniSTSGRCh37
GRCh37X100,058,295 - 100,058,407UniSTSGRCh37
Build 36X99,944,951 - 99,945,063RGDNCBI36
CeleraX100,577,086 - 100,577,198RGD
Celera8114,048,065 - 114,048,177UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic MapXq22.1UniSTS
HuRefX89,857,336 - 89,857,448UniSTS
HuRef8113,185,794 - 113,185,906UniSTS
TNG Radiation Hybrid MapX22438.0UniSTS
Stanford-G3 RH Map74892.0UniSTS
Whitehead-YAC Contig Map8 UniSTS
GeneMap99-G3 RH Map74892.0UniSTS
Bda37g02  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378117,859,065 - 117,859,195UniSTSGRCh37
Build 368117,928,246 - 117,928,376RGDNCBI36
Celera8114,047,754 - 114,047,884RGD
Cytogenetic Map8q24UniSTS
HuRef8113,185,483 - 113,185,613UniSTS
GeneMap99-GB4 RH Map8468.25UniSTS
SHGC-37645  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37X100,057,565 - 100,057,725UniSTSGRCh37
GRCh378117,862,906 - 117,864,246UniSTSGRCh37
Build 36X99,944,221 - 99,944,381RGDNCBI36
Celera8114,051,595 - 114,052,935UniSTS
CeleraX100,576,356 - 100,576,516RGD
Cytogenetic Map8q24UniSTS
Cytogenetic MapXq22.1UniSTS
HuRef8113,189,324 - 113,190,664UniSTS
HuRefX89,856,606 - 89,856,766UniSTS
GeneMap99-G3 RH MapX3249.0UniSTS
G29205  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378117,864,201 - 117,864,331UniSTSGRCh37
Build 368117,933,382 - 117,933,512RGDNCBI36
Celera8114,052,890 - 114,053,020RGD
Cytogenetic Map8q24UniSTS
HuRef8113,190,619 - 113,190,749UniSTS
WI-14191  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378117,858,217 - 117,858,323UniSTSGRCh37
GRCh37X100,059,443 - 100,059,548UniSTSGRCh37
Build 36X99,946,099 - 99,946,204RGDNCBI36
CeleraX100,578,234 - 100,578,339RGD
Celera8114,046,906 - 114,047,012UniSTS
Cytogenetic Map8q24UniSTS
HuRefX89,858,484 - 89,858,589UniSTS
HuRef8113,184,635 - 113,184,741UniSTS
GeneMap99-GB4 RH Map8468.63UniSTS
Whitehead-RH Map8631.3UniSTS
G54641  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378117,879,254 - 117,879,555UniSTSGRCh37
Celera8114,067,943 - 114,068,244UniSTS
Cytogenetic Map8q24UniSTS
HuRef8113,205,672 - 113,205,973UniSTS
STS-Z78334  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8q24UniSTS
GeneMap99-GB4 RH Map5590.59UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1150
Count of miRNA genes:522
Interacting mature miRNAs:574
Transcripts:ENST00000297338, ENST00000517485, ENST00000517749, ENST00000518055, ENST00000519469, ENST00000519837, ENST00000520992, ENST00000522699, ENST00000523547, ENST00000523986
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 2 1 6 1
Medium 2432 2789 1697 598 1853 440 4355 2101 3695 407 1441 1606 170 1203 2788 4
Low 195 26 24 93 24 91 13 11 1 2 1
Below cutoff 1 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000297338   ⟹   ENSP00000297338
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8116,845,934 - 116,874,776 (-)Ensembl
RefSeq Acc Id: ENST00000517485   ⟹   ENSP00000427923
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8116,857,279 - 116,874,528 (-)Ensembl
RefSeq Acc Id: ENST00000517749   ⟹   ENSP00000430273
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8116,847,227 - 116,849,483 (-)Ensembl
RefSeq Acc Id: ENST00000518055   ⟹   ENSP00000428003
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8116,847,334 - 116,852,251 (-)Ensembl
RefSeq Acc Id: ENST00000519469
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8116,863,117 - 116,866,991 (-)Ensembl
RefSeq Acc Id: ENST00000519837   ⟹   ENSP00000430524
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8116,861,843 - 116,874,360 (-)Ensembl
RefSeq Acc Id: ENST00000520992   ⟹   ENSP00000429342
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8116,857,271 - 116,874,424 (-)Ensembl
RefSeq Acc Id: ENST00000522699   ⟹   ENSP00000428158
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8116,861,854 - 116,874,360 (-)Ensembl
RefSeq Acc Id: ENST00000523547
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8116,857,289 - 116,874,328 (-)Ensembl
RefSeq Acc Id: ENST00000523986   ⟹   ENSP00000428513
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8116,846,905 - 116,852,252 (-)Ensembl
RefSeq Acc Id: NM_006265   ⟹   NP_006256
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388116,845,934 - 116,874,776 (-)NCBI
GRCh378117,858,173 - 117,887,105 (-)ENTREZGENE
GRCh378117,858,173 - 117,887,105 (-)NCBI
Build 368117,927,355 - 117,956,182 (-)NCBI Archive
HuRef8113,184,591 - 113,213,523 (-)ENTREZGENE
CHM1_18117,898,409 - 117,927,335 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_006256   ⟸   NM_006265
- UniProtKB: O60216 (UniProtKB/Swiss-Prot),   A0A024R9J0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000430273   ⟸   ENST00000517749
RefSeq Acc Id: ENSP00000427923   ⟸   ENST00000517485
RefSeq Acc Id: ENSP00000428003   ⟸   ENST00000518055
RefSeq Acc Id: ENSP00000430524   ⟸   ENST00000519837
RefSeq Acc Id: ENSP00000297338   ⟸   ENST00000297338
RefSeq Acc Id: ENSP00000429342   ⟸   ENST00000520992
RefSeq Acc Id: ENSP00000428158   ⟸   ENST00000522699
RefSeq Acc Id: ENSP00000428513   ⟸   ENST00000523986
Protein Domains
Rad21_Rec8   Rad21_Rec8_N

Promoters
RGD ID:7214029
Promoter ID:EPDNEW_H12760
Type:initiation region
Name:RAD21_1
Description:RAD21 cohesin complex component
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388116,874,776 - 116,874,836EPDNEW
RGD ID:6813496
Promoter ID:HG_ACW:78512
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:RAD21.LAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 368117,930,446 - 117,930,946 (-)MPROMDB
RGD ID:6806987
Promoter ID:HG_KWN:61958
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_006265
Position:
Human AssemblyChrPosition (strand)Source
Build 368117,956,014 - 117,956,514 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_006265.2(RAD21):c.1848G>A (p.Pro616=) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000551762] Chr8:116847548 [GRCh38]
Chr8:117859787 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.2(RAD21):c.1065G>A (p.Pro355=) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000543593] Chr8:116854341 [GRCh38]
Chr8:117866580 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.2(RAD21):c.1127C>G (p.Pro376Arg) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000029138] Chr8:116854279 [GRCh38]
Chr8:117866518 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.2(RAD21):c.1753T>C (p.Cys585Arg) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000029139] Chr8:116847643 [GRCh38]
Chr8:117859882 [GRCh37]
Chr8:8q24.11
pathogenic
GRCh38/hg38 8q23.3-24.3(chr8:113580402-145054634)x3 copy number gain See cases [RCV000050638] Chr8:113580402..145054634 [GRCh38]
Chr8:114592631..146280020 [GRCh37]
Chr8:114661807..146250824 [NCBI36]
Chr8:8q23.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q23.3-24.21(chr8:113288454-126716087)x1 copy number loss See cases [RCV000054301] Chr8:113288454..126716087 [GRCh38]
Chr8:114300683..127728332 [GRCh37]
Chr8:114369859..127797514 [NCBI36]
Chr8:8q23.3-24.21
pathogenic
NM_006265.2(RAD21):c.1034C>T (p.Ser345Leu) single nucleotide variant Malignant melanoma [RCV000068114] Chr8:116854372 [GRCh38]
Chr8:117866611 [GRCh37]
Chr8:117935792 [NCBI36]
Chr8:8q24.11
not provided
NM_006265.3(RAD21):c.9C>A (p.Tyr3Ter) single nucleotide variant Acute megakaryoblastic leukemia in down syndrome [RCV001293756] Chr8:116866721 [GRCh38]
Chr8:117878960 [GRCh37]
Chr8:8q24.11
likely pathogenic
NM_006265.2(RAD21):c.1440T>C (p.Ala480=) single nucleotide variant History of neurodevelopmental disorder [RCV000715392]|not specified [RCV000147376] Chr8:116851978 [GRCh38]
Chr8:117864217 [GRCh37]
Chr8:8q24.11
benign
NM_006265.2(RAD21):c.1617A>G (p.Glu539=) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000147377] Chr8:116850621 [GRCh38]
Chr8:117862860 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.2(RAD21):c.1782C>T (p.Ala594=) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000147378] Chr8:116847614 [GRCh38]
Chr8:117859853 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.2(RAD21):c.688+8G>A single nucleotide variant not specified [RCV000147379] Chr8:116857259 [GRCh38]
Chr8:117869498 [GRCh37]
Chr8:8q24.11
benign
NM_006265.2(RAD21):c.938-11T>C single nucleotide variant not specified [RCV000147380] Chr8:116854479 [GRCh38]
Chr8:117866718 [GRCh37]
Chr8:8q24.11
benign|likely benign|conflicting interpretations of pathogenicity
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q23.3-24.12(chr8:113418060-120975305)x1 copy number loss See cases [RCV000135291] Chr8:113418060..120975305 [GRCh38]
Chr8:114430289..121987545 [GRCh37]
Chr8:114499465..122056726 [NCBI36]
Chr8:8q23.3-24.12
pathogenic
GRCh38/hg38 8q23.3-24.12(chr8:112528342-120083041)x1 copy number loss See cases [RCV000135819] Chr8:112528342..120083041 [GRCh38]
Chr8:113540571..121095280 [GRCh37]
Chr8:113609747..121164461 [NCBI36]
Chr8:8q23.3-24.12
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q23.3-24.13(chr8:114560780-122594102)x1 copy number loss See cases [RCV000139027] Chr8:114560780..122594102 [GRCh38]
Chr8:115573009..123606341 [GRCh37]
Chr8:115642185..123675522 [NCBI36]
Chr8:8q23.3-24.13
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8q23.3-24.13(chr8:113933305-122621741)x1 copy number loss See cases [RCV000140680] Chr8:113933305..122621741 [GRCh38]
Chr8:114945534..123633980 [GRCh37]
Chr8:115014710..123703161 [NCBI36]
Chr8:8q23.3-24.13
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q23.3-24.11(chr8:116497730-117379167)x1 copy number loss See cases [RCV000142553] Chr8:116497730..117379167 [GRCh38]
Chr8:117509968..118391406 [GRCh37]
Chr8:117579149..118460587 [NCBI36]
Chr8:8q23.3-24.11
uncertain significance
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
NM_006265.2(RAD21):c.735C>T (p.Pro245=) single nucleotide variant not provided [RCV000945715]|not specified [RCV000194114] Chr8:116856725 [GRCh38]
Chr8:117868964 [GRCh37]
Chr8:8q24.11
likely benign|uncertain significance
NM_006265.2(RAD21):c.93T>C (p.His31=) single nucleotide variant not specified [RCV000195115] Chr8:116866637 [GRCh38]
Chr8:117878876 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.2(RAD21):c.1808T>C (p.Leu603Pro) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000198309] Chr8:116847588 [GRCh38]
Chr8:117859827 [GRCh37]
Chr8:8q24.11
likely pathogenic
NM_006265.2(RAD21):c.592_593dup microsatellite Cornelia de Lange syndrome 4 [RCV000192699] Chr8:116857361..116857362 [GRCh38]
Chr8:117869600..117869601 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.3(RAD21):c.1162-6del deletion not specified [RCV000193001] Chr8:116852714 [GRCh38]
Chr8:117864953 [GRCh37]
Chr8:8q24.11
benign
NM_006265.2(RAD21):c.56_62del (p.Leu19fs) deletion Cornelia de Lange syndrome 4 [RCV000194033] Chr8:116866668..116866674 [GRCh38]
Chr8:117878907..117878913 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.2(RAD21):c.579dup (p.Glu194fs) duplication Cornelia de Lange syndrome 4 [RCV000195046] Chr8:116857375..116857376 [GRCh38]
Chr8:117869614..117869615 [GRCh37]
Chr8:8q24.11
pathogenic
GRCh37/hg19 8q23.3-24.11(chr8:117649533-117863721)x3 copy number gain See cases [RCV000240077] Chr8:117649533..117863721 [GRCh37]
Chr8:8q23.3-24.11
uncertain significance
NM_006265.2(RAD21):c.1242T>G (p.Asp414Glu) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000872026]|History of neurodevelopmental disorder [RCV000716596] Chr8:116852628 [GRCh38]
Chr8:117864867 [GRCh37]
Chr8:8q24.11
benign
NM_006265.2(RAD21):c.1471-3A>G single nucleotide variant History of neurodevelopmental disorder [RCV000716214] Chr8:116850770 [GRCh38]
Chr8:117863009 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.815-5del deletion Cornelia de Lange syndrome 4 [RCV000624963] Chr8:116856293 [GRCh38]
Chr8:117868532 [GRCh37]
Chr8:8q24.11
likely benign
GRCh37/hg19 8q24.11(chr8:117714768-119072307)x1 copy number loss See cases [RCV000240065] Chr8:117714768..119072307 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.2(RAD21):c.1852A>G (p.Ser618Gly) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000678279]|not provided [RCV000518887] Chr8:116847544 [GRCh38]
Chr8:117859783 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.2(RAD21):c.1400C>T (p.Ala467Val) single nucleotide variant Inborn genetic diseases [RCV000623452] Chr8:116852018 [GRCh38]
Chr8:117864257 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.2(RAD21):c.1185G>A (p.Pro395=) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000948444]|not specified [RCV000254441] Chr8:116852685 [GRCh38]
Chr8:117864924 [GRCh37]
Chr8:8q24.11
likely benign
GRCh37/hg19 8q24.11(chr8:117845995-117878859)x3 copy number gain See cases [RCV000240455] Chr8:117845995..117878859 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.2(RAD21):c.786C>T (p.Asp262=) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000525617] Chr8:116856674 [GRCh38]
Chr8:117868913 [GRCh37]
Chr8:8q24.11
benign
NM_006265.2(RAD21):c.539A>C (p.Asp180Ala) single nucleotide variant not provided [RCV000272825] Chr8:116857416 [GRCh38]
Chr8:117869655 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.2(RAD21):c.578T>A (p.Leu193Ter) single nucleotide variant not provided [RCV000374189] Chr8:116857377 [GRCh38]
Chr8:117869616 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.2(RAD21):c.-32-1G>A single nucleotide variant not provided [RCV000514763]|not specified [RCV000605793] Chr8:116866762 [GRCh38]
Chr8:117879001 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.2(RAD21):c.1352T>G (p.Leu451Arg) single nucleotide variant History of neurodevelopmental disorder [RCV000718733]|Mungan syndrome [RCV000765986]|not specified [RCV000413657] Chr8:116852066 [GRCh38]
Chr8:117864305 [GRCh37]
Chr8:8q24.11
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_006265.2(RAD21):c.268C>T (p.Arg90Trp) single nucleotide variant not provided [RCV000418359] Chr8:116863136 [GRCh38]
Chr8:117875375 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.2(RAD21):c.1064C>T (p.Pro355Leu) single nucleotide variant not provided [RCV000440685] Chr8:116854342 [GRCh38]
Chr8:117866581 [GRCh37]
Chr8:8q24.11
uncertain significance
GRCh37/hg19 8q23.1-24.12(chr8:107032887-120742018)x1 copy number loss See cases [RCV000448650] Chr8:107032887..120742018 [GRCh37]
Chr8:8q23.1-24.12
pathogenic
GRCh37/hg19 8q23.3-24.11(chr8:116902507-118942698)x1 copy number loss See cases [RCV000448534] Chr8:116902507..118942698 [GRCh37]
Chr8:8q23.3-24.11
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
NM_006265.2(RAD21):c.1651del (p.Gln551fs) deletion not provided [RCV000479864] Chr8:116848999 [GRCh38]
Chr8:117861238 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.2(RAD21):c.269G>A (p.Arg90Gln) single nucleotide variant not specified [RCV000504222] Chr8:116863135 [GRCh38]
Chr8:117875374 [GRCh37]
Chr8:8q24.11
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_006265.2(RAD21):c.181_182dup (p.Gly62fs) duplication Cornelia de Lange syndrome 4 [RCV000500197] Chr8:116863221..116863222 [GRCh38]
Chr8:117875460..117875461 [GRCh37]
Chr8:8q24.11
pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
NM_006265.2(RAD21):c.1349G>A (p.Arg450His) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000678348]|not provided [RCV000952130]|not specified [RCV000494611] Chr8:116852069 [GRCh38]
Chr8:117864308 [GRCh37]
Chr8:8q24.11
likely benign|uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
NM_006265.2(RAD21):c.1576G>C (p.Glu526Gln) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000536874]|Inborn genetic diseases [RCV000624282] Chr8:116850662 [GRCh38]
Chr8:117862901 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.2(RAD21):c.-51A>T single nucleotide variant not specified [RCV000605524] Chr8:116874629 [GRCh38]
Chr8:117886868 [GRCh37]
Chr8:8q24.11
benign
NM_006265.2(RAD21):c.145-4A>G single nucleotide variant Cornelia de Lange syndrome 4 [RCV000650453]|History of neurodevelopmental disorder [RCV000716670] Chr8:116863263 [GRCh38]
Chr8:117875502 [GRCh37]
Chr8:8q24.11
benign|likely benign|uncertain significance
NM_006265.2(RAD21):c.1471-11A>G single nucleotide variant not specified [RCV000608953] Chr8:116850778 [GRCh38]
Chr8:117863017 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.2(RAD21):c.1515C>G (p.Pro505=) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000558404] Chr8:116850723 [GRCh38]
Chr8:117862962 [GRCh37]
Chr8:8q24.11
benign
GRCh37/hg19 8q23.3-24.3(chr8:114853126-146295771)x3 copy number gain See cases [RCV000512401] Chr8:114853126..146295771 [GRCh37]
Chr8:8q23.3-24.3
pathogenic
GRCh37/hg19 8q23.2-24.12(chr8:111137305-119897611)x1 copy number loss See cases [RCV000512409] Chr8:111137305..119897611 [GRCh37]
Chr8:8q23.2-24.12
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
NM_006265.2(RAD21):c.194G>A (p.Arg65Gln) single nucleotide variant Inborn genetic diseases [RCV000623219] Chr8:116863210 [GRCh38]
Chr8:117875449 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.2(RAD21):c.418G>A (p.Val140Met) single nucleotide variant Inborn genetic diseases [RCV000623395] Chr8:116858415 [GRCh38]
Chr8:117870654 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.2(RAD21):c.1503T>G (p.Pro501=) single nucleotide variant History of neurodevelopmental disorder [RCV000716520] Chr8:116850735 [GRCh38]
Chr8:117862974 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.2(RAD21):c.582G>A (p.Glu194=) single nucleotide variant History of neurodevelopmental disorder [RCV000717315] Chr8:116857373 [GRCh38]
Chr8:117869612 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.2(RAD21):c.1550dup (p.Glu518fs) duplication Cornelia de Lange syndrome 4 [RCV000680267] Chr8:116850687..116850688 [GRCh38]
Chr8:117862926..117862927 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.2(RAD21):c.1161+1G>A single nucleotide variant Cornelia de Lange syndrome 4 [RCV000680268] Chr8:116854244 [GRCh38]
Chr8:117866483 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.2(RAD21):c.1774_1776del (p.Gln592del) deletion Cornelia de Lange syndrome 4 [RCV000680272] Chr8:116847620..116847622 [GRCh38]
Chr8:117859859..117859861 [GRCh37]
Chr8:8q24.11
likely pathogenic
NM_006265.2(RAD21):c.208A>T (p.Lys70Ter) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000677715] Chr8:116863196 [GRCh38]
Chr8:117875435 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.2(RAD21):c.1320C>T (p.Ile440=) single nucleotide variant History of neurodevelopmental disorder [RCV000719519] Chr8:116852550 [GRCh38]
Chr8:117864789 [GRCh37]
Chr8:8q24.11
likely benign
GRCh37/hg19 8q23.1-24.13(chr8:110250943-123515785)x1 copy number loss not provided [RCV000683038] Chr8:110250943..123515785 [GRCh37]
Chr8:8q23.1-24.13
pathogenic
GRCh37/hg19 8q23.3-24.11(chr8:117623123-117862147)x3 copy number gain not provided [RCV000682952] Chr8:117623123..117862147 [GRCh37]
Chr8:8q23.3-24.11
uncertain significance
NM_006265.2(RAD21):c.1864G>A (p.Ala622Thr) single nucleotide variant Mungan syndrome [RCV000678504] Chr8:116847532 [GRCh38]
Chr8:117859771 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.2(RAD21):c.1629T>C (p.Asp543=) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000959746]|History of neurodevelopmental disorder [RCV000719112] Chr8:116849021 [GRCh38]
Chr8:117861260 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.2(RAD21):c.1532A>G (p.Asn511Ser) single nucleotide variant History of neurodevelopmental disorder [RCV000718575] Chr8:116850706 [GRCh38]
Chr8:117862945 [GRCh37]
Chr8:8q24.11
likely benign|uncertain significance
NM_006265.2(RAD21):c.1757G>A (p.Arg586Gln) single nucleotide variant History of neurodevelopmental disorder [RCV000718577] Chr8:116847639 [GRCh38]
Chr8:117859878 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.2(RAD21):c.1479G>C (p.Gln493His) single nucleotide variant History of neurodevelopmental disorder [RCV000720014] Chr8:116850759 [GRCh38]
Chr8:117862998 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.2(RAD21):c.363G>C (p.Leu121=) single nucleotide variant History of neurodevelopmental disorder [RCV000719370] Chr8:116861852 [GRCh38]
Chr8:117874091 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.2(RAD21):c.1724G>C (p.Gly575Ala) single nucleotide variant History of neurodevelopmental disorder [RCV000719230] Chr8:116847672 [GRCh38]
Chr8:117859911 [GRCh37]
Chr8:8q24.11
uncertain significance
Single allele deletion Trichorhinophalangeal dysplasia type I [RCV000735900] Chr8:114508086..129040004 [GRCh37]
Chr8:8q23.3-24.21
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_006265.2(RAD21):c.892C>G (p.Pro298Ala) single nucleotide variant not provided [RCV000762537] Chr8:116856211 [GRCh38]
Chr8:117868450 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.2(RAD21):c.1306C>T (p.Gln436Ter) single nucleotide variant Cornelia de Lange syndrome 4 [RCV001215062]|not provided [RCV000760801] Chr8:116852564 [GRCh38]
Chr8:117864803 [GRCh37]
Chr8:8q24.11
pathogenic|likely pathogenic
NC_000008.11:g.(?_116857267)_(116863259_?)del deletion Cornelia de Lange syndrome 4 [RCV001031432] Chr8:117869506..117875498 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.3(RAD21):c.1705-7A>T single nucleotide variant not provided [RCV000950421] Chr8:116847698 [GRCh38]
Chr8:117859937 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.1362A>G (p.Ser454=) single nucleotide variant not provided [RCV000881285] Chr8:116852056 [GRCh38]
Chr8:117864295 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.815-27_815-25dup duplication not provided [RCV000968467] Chr8:116856292..116856293 [GRCh38]
Chr8:117868531..117868532 [GRCh37]
Chr8:8q24.11
benign
NM_006265.3(RAD21):c.815-9_815-5del deletion not provided [RCV000949530] Chr8:116856293..116856297 [GRCh38]
Chr8:117868532..117868536 [GRCh37]
Chr8:8q24.11
benign
NM_006265.3(RAD21):c.497A>G (p.Asp166Gly) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000995850] Chr8:116857458 [GRCh38]
Chr8:117869697 [GRCh37]
Chr8:8q24.11
likely pathogenic
NM_006265.3(RAD21):c.3G>A (p.Met1Ile) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000995851] Chr8:116866727 [GRCh38]
Chr8:117878966 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.3(RAD21):c.741C>G (p.Ala247=) single nucleotide variant not provided [RCV000897005] Chr8:116856719 [GRCh38]
Chr8:117868958 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.159A>G (p.Leu53=) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000951482] Chr8:116863245 [GRCh38]
Chr8:117875484 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.1162-5A>G single nucleotide variant not provided [RCV000908899] Chr8:116852713 [GRCh38]
Chr8:117864952 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.663A>G (p.Gly221=) single nucleotide variant not provided [RCV000945108] Chr8:116857292 [GRCh38]
Chr8:117869531 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.450G>A (p.Gly150=) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000873247] Chr8:116858383 [GRCh38]
Chr8:117870622 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.815-5_815-4insTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT insertion not provided [RCV000880594] Chr8:116856292..116856293 [GRCh38]
Chr8:117868531..117868532 [GRCh37]
Chr8:8q24.11
benign
NM_006265.3(RAD21):c.807T>C (p.Asn269=) single nucleotide variant not provided [RCV000919265] Chr8:116856653 [GRCh38]
Chr8:117868892 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.2(RAD21):c.1621-248A>G single nucleotide variant not provided [RCV000828104] Chr8:116849277 [GRCh38]
Chr8:117861516 [GRCh37]
Chr8:8q24.11
benign
NM_006265.2(RAD21):c.1705-222A>G single nucleotide variant not provided [RCV000828106] Chr8:116847913 [GRCh38]
Chr8:117860152 [GRCh37]
Chr8:8q24.11
benign
NM_006265.2(RAD21):c.688+46T>C single nucleotide variant not provided [RCV000834398] Chr8:116857221 [GRCh38]
Chr8:117869460 [GRCh37]
Chr8:8q24.11
benign
NM_006265.3(RAD21):c.689-232del deletion not provided [RCV000828103] Chr8:116857003 [GRCh38]
Chr8:117869242 [GRCh37]
Chr8:8q24.11
benign
NM_006265.2(RAD21):c.1704+4T>C single nucleotide variant not provided [RCV000840657] Chr8:116848942 [GRCh38]
Chr8:117861181 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.540C>T (p.Asp180=) single nucleotide variant Cornelia de Lange syndrome 4 [RCV000914697] Chr8:116857415 [GRCh38]
Chr8:117869654 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.2(RAD21):c.481+216T>C single nucleotide variant not provided [RCV000827534] Chr8:116858136 [GRCh38]
Chr8:117870375 [GRCh37]
Chr8:8q24.11
benign
NM_006265.2(RAD21):c.144+134G>A single nucleotide variant not provided [RCV000829639] Chr8:116866452 [GRCh38]
Chr8:117878691 [GRCh37]
Chr8:8q24.11
benign
NM_006265.3(RAD21):c.1548delinsTC (p.Glu518fs) indel Cornelia de Lange syndrome 4 [RCV001072117] Chr8:116850690 [GRCh38]
Chr8:117862929 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.3:c.1217_1224del microsatellite Cornelia de Lange syndrome 4 [RCV001072119] Chr8:116852646..116852653 [GRCh38]
Chr8:117864885..117864892 [GRCh37]
Chr8:8q24.11
pathogenic
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
NM_006265.3(RAD21):c.1432C>T (p.Arg478Ter) single nucleotide variant Cornelia de Lange syndrome 4 [RCV001007933] Chr8:116851986 [GRCh38]
Chr8:117864225 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.3(RAD21):c.1142G>A (p.Trp381Ter) single nucleotide variant not provided [RCV001171624] Chr8:116854264 [GRCh38]
Chr8:117866503 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.3(RAD21):c.1711C>T (p.Leu571Phe) single nucleotide variant Cornelia de Lange syndrome 4 [RCV001234981] Chr8:116847685 [GRCh38]
Chr8:117859924 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.3(RAD21):c.850G>A (p.Val284Ile) single nucleotide variant Cornelia de Lange syndrome 4 [RCV001249742] Chr8:116856253 [GRCh38]
Chr8:117868492 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.3(RAD21):c.815-17_815-5del deletion Cornelia de Lange syndrome 4 [RCV000988108] Chr8:116856293..116856305 [GRCh38]
Chr8:117868532..117868544 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.428T>C (p.Ile143Thr) single nucleotide variant not provided [RCV001091703] Chr8:116858405 [GRCh38]
Chr8:117870644 [GRCh37]
Chr8:8q24.11
likely pathogenic
NM_006265.3(RAD21):c.1470+9G>A single nucleotide variant not provided [RCV000911000] Chr8:116851939 [GRCh38]
Chr8:117864178 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.815-5_815-4insTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGT insertion not provided [RCV000975190] Chr8:116856292..116856293 [GRCh38]
Chr8:117868531..117868532 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.1221A>G (p.Gly407=) single nucleotide variant not provided [RCV000910642] Chr8:116852649 [GRCh38]
Chr8:117864888 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.1251C>T (p.Leu417=) single nucleotide variant not provided [RCV000978477] Chr8:116852619 [GRCh38]
Chr8:117864858 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.1237T>C (p.Leu413=) single nucleotide variant not provided [RCV000960771] Chr8:116852633 [GRCh38]
Chr8:117864872 [GRCh37]
Chr8:8q24.11
benign
NM_006265.3(RAD21):c.815-10_815-5del deletion Cornelia de Lange syndrome 4 [RCV000974220] Chr8:116856293..116856298 [GRCh38]
Chr8:117868532..117868537 [GRCh37]
Chr8:8q24.11
benign
NM_006265.3(RAD21):c.1161+9G>A single nucleotide variant not provided [RCV000976014] Chr8:116854236 [GRCh38]
Chr8:117866475 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.645T>C (p.Tyr215=) single nucleotide variant not provided [RCV000887585] Chr8:116857310 [GRCh38]
Chr8:117869549 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.1471-9T>C single nucleotide variant not provided [RCV000913069] Chr8:116850776 [GRCh38]
Chr8:117863015 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.815-28_815-5dup duplication not provided [RCV000891510] Chr8:116856292..116856293 [GRCh38]
Chr8:117868531..117868532 [GRCh37]
Chr8:8q24.11
likely benign
NM_006265.3(RAD21):c.144+1G>A single nucleotide variant Cornelia de Lange syndrome 4 [RCV000988109] Chr8:116866585 [GRCh38]
Chr8:117878824 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.3(RAD21):c.589C>T (p.Gln197Ter) single nucleotide variant Cornelia de Lange syndrome 4 [RCV001072118] Chr8:116857366 [GRCh38]
Chr8:117869605 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.3(RAD21):c.1189G>A (p.Val397Ile) single nucleotide variant Cornelia de Lange syndrome 4 [RCV001041731] Chr8:116852681 [GRCh38]
Chr8:117864920 [GRCh37]
Chr8:8q24.11
uncertain significance
GRCh37/hg19 8q23.2-24.13(chr8:111514791-123192373)x1 copy number loss not provided [RCV001006131] Chr8:111514791..123192373 [GRCh37]
Chr8:8q23.2-24.13
pathogenic
NM_006265.3(RAD21):c.466C>T (p.Gln156Ter) single nucleotide variant Cornelia de Lange syndrome 4 [RCV001052591] Chr8:116858367 [GRCh38]
Chr8:117870606 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.3(RAD21):c.1843G>T (p.Glu615Ter) single nucleotide variant Cornelia de Lange syndrome 4 [RCV001260876] Chr8:116847553 [GRCh38]
Chr8:117859792 [GRCh37]
Chr8:8q24.11
pathogenic
GRCh37/hg19 8q23.1-24.13(chr8:108421573-123429638)x3 copy number gain not provided [RCV001259025] Chr8:108421573..123429638 [GRCh37]
Chr8:8q23.1-24.13
pathogenic
NM_006265.3(RAD21):c.1222G>T (p.Gly408Ter) single nucleotide variant Inborn genetic diseases [RCV001266571] Chr8:116852648 [GRCh38]
Chr8:117864887 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.3(RAD21):c.273A>G (p.Pro91=) single nucleotide variant Cornelia de Lange syndrome 4 [RCV001262369] Chr8:116863131 [GRCh38]
Chr8:117875370 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.3(RAD21):c.1252A>C (p.Lys418Gln) single nucleotide variant not specified [RCV001264428] Chr8:116852618 [GRCh38]
Chr8:117864857 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.3(RAD21):c.235A>G (p.Asn79Asp) single nucleotide variant Inborn genetic diseases [RCV001266970] Chr8:116863169 [GRCh38]
Chr8:117875408 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.3(RAD21):c.976G>T (p.Val326Phe) single nucleotide variant Inborn genetic diseases [RCV001267523] Chr8:116854430 [GRCh38]
Chr8:117866669 [GRCh37]
Chr8:8q24.11
uncertain significance
NM_006265.3(RAD21):c.704del (p.Ser235fs) deletion Cornelia de Lange syndrome 4 [RCV001281378] Chr8:116856756 [GRCh38]
Chr8:117868995 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.3(RAD21):c.85delinsCCT (p.Lys29fs) indel Cornelia de Lange syndrome 4 [RCV001336935] Chr8:116866645 [GRCh38]
Chr8:117878884 [GRCh37]
Chr8:8q24.11
pathogenic
NM_006265.3(RAD21):c.482-3del deletion Cornelia de Lange syndrome 4 [RCV001303944] Chr8:116857476 [GRCh38]
Chr8:117869715 [GRCh37]
Chr8:8q24.11
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9811 AgrOrtholog
COSMIC RAD21 COSMIC
Ensembl Genes ENSG00000164754 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000297338 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000427923 UniProtKB/TrEMBL
  ENSP00000428003 UniProtKB/TrEMBL
  ENSP00000428158 UniProtKB/TrEMBL
  ENSP00000428513 UniProtKB/TrEMBL
  ENSP00000429342 UniProtKB/TrEMBL
  ENSP00000430273 UniProtKB/TrEMBL
  ENSP00000430524 UniProtKB/TrEMBL
Ensembl Transcript ENST00000297338 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000517485 UniProtKB/TrEMBL
  ENST00000517749 UniProtKB/TrEMBL
  ENST00000518055 UniProtKB/TrEMBL
  ENST00000519837 UniProtKB/TrEMBL
  ENST00000520992 UniProtKB/TrEMBL
  ENST00000522699 UniProtKB/TrEMBL
  ENST00000523986 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.580 UniProtKB/TrEMBL
GTEx ENSG00000164754 GTEx
HGNC ID HGNC:9811 ENTREZGENE
Human Proteome Map RAD21 Human Proteome Map
InterPro Rad21/Rec8-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rad21/Rec8_C_eu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rad21_Rec8_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ScpA-like_C UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5885 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5885 ENTREZGENE
OMIM 606462 OMIM
  611376 OMIM
  614701 OMIM
PANTHER PTHR12585 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Rad21_Rec8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rad21_Rec8_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA34170 PharmGKB
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R9J0 ENTREZGENE, UniProtKB/TrEMBL
  E5RFV8_HUMAN UniProtKB/TrEMBL
  E5RFZ5_HUMAN UniProtKB/TrEMBL
  E5RG18_HUMAN UniProtKB/TrEMBL
  E5RI01_HUMAN UniProtKB/TrEMBL
  E5RIN7_HUMAN UniProtKB/TrEMBL
  E5RJK5_HUMAN UniProtKB/TrEMBL
  E5RJW1_HUMAN UniProtKB/TrEMBL
  O60216 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A8K0E0 UniProtKB/Swiss-Prot
  Q15001 UniProtKB/Swiss-Prot
  Q99568 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-30 RAD21  RAD21 cohesin complex component    RAD21 homolog (S. pombe)  Symbol and/or name change 5135510 APPROVED
2011-08-16 RAD21  RAD21 homolog (S. pombe)  RAD21  RAD21 homolog (S. pombe)  Symbol and/or name change 5135510 APPROVED